{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:55:25Z","timestamp":1790855725265,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002736","name":"Citizens United for Research in Epilepsy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","award":["1U54 HD083092"],"award-info":[{"award-number":["1U54 HD083092"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS105913"],"award-info":[{"award-number":["RO1 NS105913"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R61\/R33 NS112553"],"award-info":[{"award-number":["R61\/R33 NS112553"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.neurot.2024.e00477","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:57:27Z","timestamp":1731031047000},"page":"e00477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution"],"prefix":"10.1016","volume":"22","author":[{"given":"Carlos J.","family":"Ballester-Rosado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang T.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James D.","family":"Frost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Swann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.neurot.2024.e00477_bib1","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1111\/j.1528-1167.2010.02657.x","article-title":"Infantile spasms: a U.S. consensus report","volume":"51","author":"Pellock","year":"2010","journal-title":"Epilepsia"},{"issue":"12","key":"10.1016\/j.neurot.2024.e00477_bib2","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1111\/j.0013-9580.2003.29203.x","article-title":"Infantile spasms in remission may reemerge as intractable epileptic spasms","volume":"44","author":"Camfield","year":"2003","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.neurot.2024.e00477_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ana.410060306","article-title":"Precise characterization and quantification of infantile spasms","volume":"6","author":"Kellaway","year":"1979","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.neurot.2024.e00477_bib4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1542\/peds.13.1.66","article-title":"Diagnosis and prognosis of hypsarhythmia and infantile spasms","volume":"13","author":"Gibbs","year":"1954","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.neurot.2024.e00477_bib5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ana.24594","article-title":"Response to treatment in a prospective national infantile spasms cohort","volume":"79","author":"Knupp","year":"2016","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurot.2024.e00477_bib6","series-title":"Infantile spasms","author":"Frost","year":"2003"},{"issue":"7","key":"10.1016\/j.neurot.2024.e00477_bib7","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1111\/j.1528-1167.2011.03127.x","article-title":"The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: evidence from the United Kingdom Infantile Spasms Study","volume":"52","author":"O'Callaghan","year":"2011","journal-title":"Epilepsia"},{"key":"10.1016\/j.neurot.2024.e00477_bib8","series-title":"Jasper's basic mechanisms of the epilepsies","article-title":"On the basic mechanisms of infantile spasms","author":"Swann","year":"2012"},{"issue":"1","key":"10.1016\/j.neurot.2024.e00477_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/children7010005","article-title":"Infantile spasms: an update on pre-clinical models and EEG mechanisms","volume":"7","author":"Janicot","year":"2020","journal-title":"Children"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1515\/revneuro-2019-0030","article-title":"Seizure initiation in infantile spasms vs. focal seizures: proposed common cellular mechanisms","volume":"31","author":"Traub","year":"2020","journal-title":"Rev Neurosci"},{"issue":"12","key":"10.1016\/j.neurot.2024.e00477_bib11","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1007\/s10072-020-04600-5","article-title":"West syndrome: a comprehensive review","volume":"41","author":"Pavone","year":"2020","journal-title":"Neurol Sci"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/humu.10310","article-title":"Mutations of ARX are associated with striking pleiotropy and consistent genotype-phenotype correlation","volume":"23","author":"Kato","year":"2004","journal-title":"Hum Mutat"},{"issue":"2-3","key":"10.1016\/j.neurot.2024.e00477_bib13","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.eplepsyres.2008.03.019","article-title":"Combination of infantile spasms, non-epileptic seizures and complex movement\u00a0disorder: a new case of ARX-related epilepsy","volume":"80","author":"Poirier","year":"2008","journal-title":"Epilepsy Res"},{"issue":"3","key":"10.1016\/j.neurot.2024.e00477_bib14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/ng1009","article-title":"Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans","volume":"32","author":"Kitamura","year":"2002","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.neurot.2024.e00477_bib15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/08830738050200042001","article-title":"X-linked lissencephaly with abnormal genitalia as a tangential migration disorder causing intractable epilepsy: proposal for a new term, \"interneuronopathy\"","volume":"20","author":"Kato","year":"2005","journal-title":"J\u00a0Child Neurol"},{"issue":"27","key":"10.1016\/j.neurot.2024.e00477_bib16","doi-asserted-by":"crossref","first-page":"8752","DOI":"10.1523\/JNEUROSCI.0915-09.2009","article-title":"A\u00a0triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment","volume":"29","author":"Price","year":"2009","journal-title":"J\u00a0Neurosci"},{"issue":"8","key":"10.1016\/j.neurot.2024.e00477_bib17","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1523\/JNEUROSCI.0572-22.2022","article-title":"Cortical parvalbumin-positive interneuron development and function are altered in the APC conditional knockout mouse model of infantile and epileptic spasms syndrome","volume":"43","author":"Ryner","year":"2023","journal-title":"J\u00a0Neurosci"},{"issue":"Suppl Suppl 2","key":"10.1016\/j.neurot.2024.e00477_bib18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/epi4.12280","article-title":"Acquired parvalbumin-selective interneuronopathy in the multiple-hit model of infantile spasms: a putative basis for the partial responsiveness to vigabatrin analogs?","volume":"3","author":"Katsarou","year":"2018","journal-title":"Epilepsia Open"},{"issue":"Pt 6","key":"10.1016\/j.neurot.2024.e00477_bib19","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/brain\/awp107","article-title":"Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females","volume":"132","author":"Marsh","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neurot.2024.e00477_bib20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1203\/PDR.0b013e31819d9076","article-title":"Infantile spasms and down syndrome: a new animal model","volume":"65","author":"Cortez","year":"2009","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1212\/WNL.34.2.235","article-title":"Cerebrospinal fluid GABA levels in children with infantile spasms","volume":"34","author":"Ito","year":"1984","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.neurot.2024.e00477_bib22","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1528-1157.1985.tb05656.x","article-title":"Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment","volume":"26","author":"Loscher","year":"1985","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.neurot.2024.e00477_bib23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0387-7604(12)80345-7","article-title":"The concentrations of GABA, 5-HIAA and HVA in the cerebrospinal fluid of children with infantile spasms and the effects of ACTH treatment","volume":"14","author":"Airaksinen","year":"1992","journal-title":"Brain Dev"},{"issue":"7","key":"10.1016\/j.neurot.2024.e00477_bib24","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1111\/j.1528-1167.2009.02499.x","article-title":"Insulin-like growth factor-1 is associated with cognitive outcome in infantile spasms","volume":"51","author":"Riikonen","year":"2010","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.neurot.2024.e00477_bib25","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.yfrne.2012.06.002","article-title":"Neurodevelopmental effects of insulin-like growth factor signaling","volume":"33","author":"O'Kusky","year":"2012","journal-title":"Front Neuroendocrinol"},{"issue":"8","key":"10.1016\/j.neurot.2024.e00477_bib26","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1111\/j.0953-816X.2004.03320.x","article-title":"In vivo effects of insulin-like growth factor-I (IGF-I) on prenatal and early postnatal development of the central nervous system","volume":"19","author":"Popken","year":"2004","journal-title":"Eur J Neurosci"},{"issue":"13","key":"10.1016\/j.neurot.2024.e00477_bib27","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1002\/jnr.22129","article-title":"Type 1 insulin-like growth factor receptor signaling is essential for the development of the hippocampal formation and dentate gyrus","volume":"87","author":"Liu","year":"2009","journal-title":"J\u00a0Neurosci Res"},{"issue":"22","key":"10.1016\/j.neurot.2024.e00477_bib28","doi-asserted-by":"crossref","first-page":"8435","DOI":"10.1523\/JNEUROSCI.20-22-08435.2000","article-title":"Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development","volume":"20","author":"O'Kusky","year":"2000","journal-title":"J\u00a0Neurosci"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib29","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1528-1167.2007.01377.x","article-title":"A\u00a0new animal model of infantile spasms with unprovoked persistent seizures","volume":"49","author":"Lee","year":"2008","journal-title":"Epilepsia"},{"key":"10.1016\/j.neurot.2024.e00477_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2015.04.019","article-title":"Vigabatrin therapy implicates neocortical high frequency oscillations in an animal model of infantile spasms","volume":"82","author":"Frost","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neurot.2024.e00477_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2021.107786","article-title":"Acthar(R) Gel (repository corticotropin injection) dose-response relationships in an animal model of epileptic spasms","volume":"116","author":"Le","year":"2021","journal-title":"Epilepsy Behav : E&B."},{"key":"10.1016\/j.neurot.2024.e00477_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/ana.26383","article-title":"A\u00a0role for insulin-like growth factor 1 in the generation of epileptic spasms","volume":"92","author":"Ballester-Rosado","year":"2022","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.neurot.2024.e00477_bib33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s003350010037","article-title":"Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes","volume":"11","author":"Dietrich","year":"2000","journal-title":"Mamm Genome"},{"issue":"1","key":"10.1016\/j.neurot.2024.e00477_bib34","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1528-1167.2010.02887.x","article-title":"High frequency EEG activity associated with ictal events in an animal model of infantile spasms","volume":"52","author":"Frost","year":"2011","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.neurot.2024.e00477_bib35","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.bone.2004.10.008","article-title":"Three-dimensional reconstruction of chick calvarial osteocytes and their cell processes using confocal microscopy","volume":"36","author":"Sugawara","year":"2005","journal-title":"Bone"},{"key":"10.1016\/j.neurot.2024.e00477_bib36","first-page":"153","article-title":"A\u00a0method for the three-dimensional reconstruction of Neurobiotin-filled neurons and the location of their synaptic inputs","volume":"7","author":"Fogarty","year":"2013","journal-title":"Front Neural Circ"},{"issue":"12","key":"10.1016\/j.neurot.2024.e00477_bib37","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/nprot.2015.125","article-title":"Sample preparation for high-resolution 3D confocal imaging of mouse skeletal tissue","volume":"10","author":"Kusumbe","year":"2015","journal-title":"Nat Protoc"},{"issue":"6","key":"10.1016\/j.neurot.2024.e00477_bib38","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/s41596-019-0160-8","article-title":"High-resolution 3D imaging of fixed and cleared organoids","volume":"14","author":"Dekkers","year":"2019","journal-title":"Nat Protoc"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib39","article-title":"Optimization of 3D immunofluorescence analysis and visualization using IMARIS and MeshLab","volume":"12","author":"Abu","year":"2023","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib40","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/bpa.12505","article-title":"Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi","volume":"28","author":"Smith","year":"2018","journal-title":"Brain Pathol"},{"issue":"1","key":"10.1016\/j.neurot.2024.e00477_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/cpns.92","article-title":"High-resolution three-dimensional imaging of individual\u00a0astrocytes using confocal microscopy","volume":"91","author":"Testen","year":"2020","journal-title":"Curr Protoc Neurosci"},{"issue":"26","key":"10.1016\/j.neurot.2024.e00477_bib42","doi-asserted-by":"crossref","first-page":"9633","DOI":"10.1073\/pnas.1404651111","article-title":"Transcellular degradation of axonal mitochondria","volume":"111","author":"Davis","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"10.1016\/j.neurot.2024.e00477_bib43","first-page":"1241","article-title":"A\u00a0compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions","volume":"128","author":"Zahavi","year":"2015","journal-title":"J\u00a0Cell Sci"},{"issue":"1","key":"10.1016\/j.neurot.2024.e00477_bib44","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/jmi.12760","article-title":"Quantitative colocalization analysis of DNA delivery by PEI-mediated cationic polymers in mammalian cells","volume":"273","author":"Gonzalez-Dominguez","year":"2019","journal-title":"J\u00a0Microsc"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ana.25935","article-title":"Neocortical slow oscillations implicated in the generation of epileptic spasms","volume":"89","author":"Lee","year":"2021","journal-title":"Ann Neurol"},{"issue":"6196","key":"10.1016\/j.neurot.2024.e00477_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/science.1255263","article-title":"Interneurons. Fast-spiking, parvalbumin(+) GABAergic interneurons: from cellular design to microcircuit function","volume":"345","author":"Hu","year":"2014","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib47","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrn1845","article-title":"Dendritic peptide release and peptide-dependent behaviours","volume":"7","author":"Ludwig","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib48","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.cell.2011.03.034","article-title":"Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10","volume":"145","author":"Cao","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.neurot.2024.e00477_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035323","article-title":"Synaptotagmin-2 is a reliable marker for parvalbumin\u00a0positive inhibitory boutons in the mouse visual cortex","volume":"7","author":"Sommeijer","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.neurot.2024.e00477_bib50","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.celrep.2016.12.067","article-title":"Synaptotagmin 2 is the fast Ca2+ sensor at a central inhibitory synapse","volume":"18","author":"Chen","year":"2017","journal-title":"Cell Rep"},{"issue":"Suppl 2","key":"10.1016\/j.neurot.2024.e00477_bib51","first-page":"739","article-title":"Clinical relevance of systemic and local IGF-I: lessons from animal models","volume":"5","author":"LeRoith","year":"2008","journal-title":"Pediatr Endocrinol Rev"},{"issue":"1","key":"10.1016\/j.neurot.2024.e00477_bib52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF00191452","article-title":"Postnatal development of parvalbumin and calbindin D28K immunoreactivities in the cerebral cortex of the rat","volume":"188","author":"Alcantara","year":"1993","journal-title":"Anat Embryol"},{"issue":"3","key":"10.1016\/j.neurot.2024.e00477_bib53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0304-3940(84)90515-9","article-title":"Development of GABAergic neurons in rat visual cortex as identified by glutamate decarboxylase-like immunoreactivity","volume":"47","author":"Wolff","year":"1984","journal-title":"Neurosci Lett"},{"issue":"5","key":"10.1016\/j.neurot.2024.e00477_bib54","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neuron.2010.08.007","article-title":"Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS","volume":"67","author":"Nishijima","year":"2010","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neurot.2024.e00477_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/NPM-200606","article-title":"Primary neuronal dysmaturation in preterm brain: important and likely modifiable","volume":"14","author":"Volpe","year":"2021","journal-title":"J\u00a0Neonatal Perinat Med"},{"issue":"1-2","key":"10.1016\/j.neurot.2024.e00477_bib56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/pr.2013.189","article-title":"What brakes the preterm brain? An arresting story","volume":"75","author":"Dean","year":"2014","journal-title":"Pediatr Res"},{"issue":"168","key":"10.1016\/j.neurot.2024.e00477_bib57","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004669","article-title":"Prenatal cerebral ischemia disrupts MRI-defined cortical microstructure through disturbances in neuronal arborization","volume":"5","author":"Dean","year":"2013","journal-title":"Sci Transl Med"},{"issue":"49","key":"10.1016\/j.neurot.2024.e00477_bib58","doi-asserted-by":"crossref","first-page":"11912","DOI":"10.1523\/JNEUROSCI.2396-17.2017","article-title":"Transient hypoxemia chronically disrupts maturation of preterm fetal ovine subplate neuron arborization and activity","volume":"37","author":"McClendon","year":"2017","journal-title":"J\u00a0Neurosci"},{"issue":"12","key":"10.1016\/j.neurot.2024.e00477_bib59","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1007\/s12325-008-0124-9","article-title":"Recombinant human insulin-like growth factor-I therapy for children with growth disorders","volume":"25","author":"Richmond","year":"2008","journal-title":"Adv Ther"},{"issue":"5","key":"10.1016\/j.neurot.2024.e00477_bib60","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nn1689","article-title":"Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex","volume":"9","author":"Tropea","year":"2006","journal-title":"Nat Neurosci"},{"issue":"2","key":"10.1016\/j.neurot.2024.e00477_bib61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.npep.2004.11.001","article-title":"Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat","volume":"39","author":"Baker","year":"2005","journal-title":"Neuropeptides"},{"issue":"3","key":"10.1016\/j.neurot.2024.e00477_bib62","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1152\/japplphysiol.01264.2001","article-title":"Invited Review: autocrine\/paracrine IGF-I and skeletal muscle adaptation","volume":"93","author":"Adams","year":"2002","journal-title":"J\u00a0Appl Physiol"},{"issue":"12","key":"10.1016\/j.neurot.2024.e00477_bib63","doi-asserted-by":"crossref","first-page":"5092","DOI":"10.1523\/JNEUROSCI.13-12-05092.1993","article-title":"Correlation between insulin-like growth factor (IGF)-binding protein 5 and IGF-I gene expression during brain development","volume":"13","author":"Bondy","year":"1993","journal-title":"J\u00a0Neurosci"},{"issue":"31","key":"10.1016\/j.neurot.2024.e00477_bib64","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg0666","article-title":"Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors","volume":"9","author":"Tu","year":"2023","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.neurot.2024.e00477_bib65","first-page":"3","article-title":"Insulin-like growth factors and their binding proteins: biological actions","volume":"16","author":"Jones","year":"1995","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.neurot.2024.e00477_bib66","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1073\/pnas.0812394106","article-title":"Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice","volume":"106","author":"Tropea","year":"2009","journal-title":"ProcNatlAcadSciUSA"},{"issue":"6","key":"10.1016\/j.neurot.2024.e00477_bib67","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1038\/s41591-023-02398-1","article-title":"Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study","volume":"29","author":"Neul","year":"2023","journal-title":"Nat Med"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747924001648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747924001648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:24:52Z","timestamp":1740122692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747924001648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1878747924001648"],"URL":"https:\/\/doi.org\/10.1016\/j.neurot.2024.e00477","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.13.618035","asserted-by":"object"}]},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGF-1 impacts neocortical interneuron connectivity in epileptic spasm generation and resolution","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurot.2024.e00477","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics.","name":"copyright","label":"Copyright"}],"article-number":"e00477"}}