{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:09:09Z","timestamp":1782245349911,"version":"3.54.5"},"reference-count":186,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016608","name":"Rainwater Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008539","name":"CurePSP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.neurot.2024.e00499","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T07:45:04Z","timestamp":1733298304000},"page":"e00499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond"],"prefix":"10.1016","volume":"22","author":[{"given":"C. Alexander","family":"Sandhof","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heide F.B.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Catarina","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Haggarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurot.2024.e00499_bib1","series-title":"Global status report on the public health response to dementia","year":"2020"},{"key":"10.1016\/j.neurot.2024.e00499_bib2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer's disease continuum","volume":"19","author":"Gustavsson","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neurot.2024.e00499_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/science.1255555","article-title":"Alzheimer's and Parkinson's diseases: the prion concept in relation to assembled Abeta, tau, and alpha-synuclein","volume":"349","author":"Goedert","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib4","unstructured":"Alzforum Donanemab [online]. Available at: https:\/\/www.alzforum.org\/therapeutics\/donanemab Accessed: July 9th, 2024."},{"key":"10.1016\/j.neurot.2024.e00499_bib5","unstructured":"Alzforum Leqembi [online]. Available at: https:\/\/www.alzforum.org\/therapeutics\/leqembi Accessed: July 9th, 2024."},{"key":"10.1016\/j.neurot.2024.e00499_bib6","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1093\/brain\/awad188","article-title":"Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics","volume":"146","author":"Hampel","year":"2023","journal-title":"Brain : J Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/jnen\/nlaa014","article-title":"Concordance of clinical alzheimer diagnosis and neuropathological features at autopsy","volume":"79","author":"Gauthreaux","year":"2020","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib8","article-title":"Clinical spectrum of tauopathies","volume":"13","author":"Olfati","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/cells11050840","article-title":"What's in a gene? The outstanding diversity of MAPT","volume":"11","author":"Ruiz-Gabarre","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.neurot.2024.e00499_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0896-6273(89)90210-9","article-title":"Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease","volume":"3","author":"Goedert","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.neurot.2024.e00499_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0195771","article-title":"High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development","volume":"13","author":"Hefti","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.neurot.2024.e00499_bib12","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1073\/pnas.72.5.1858","article-title":"A\u00a0protein factor essential for microtubule assembly","volume":"72","author":"Weingarten","year":"1975","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrn.2015.1","article-title":"Tau in physiology and pathology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.neurot.2024.e00499_bib14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00401-020-02196-w","article-title":"The physiological roles of tau and Abeta: implications for Alzheimer's disease pathology and therapeutics","volume":"140","author":"Kent","year":"2020","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurot.2024.e00499_bib15","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41580-024-00753-9","article-title":"Cellular and pathological functions of tau","volume":"11","author":"Parra Bravo","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib16","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/gb-2004-6-1-204","article-title":"The MAP2\/Tau family of microtubule-associated proteins","volume":"6","author":"Dehmelt","year":"2005","journal-title":"Genome Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib17","article-title":"Cell autonomous microglia defects in a stem cell model of frontotemporal dementia","author":"Iyer","year":"2024","journal-title":"medRxiv"},{"key":"10.1016\/j.neurot.2024.e00499_bib18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fnagi.2019.00204","article-title":"Role of tau as a microtubule-associated protein: structural and functional aspects","volume":"11","author":"Barbier","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.neurot.2024.e00499_bib19","doi-asserted-by":"crossref","first-page":"38559","DOI":"10.1074\/jbc.M112.369785","article-title":"Tau protein diffuses along the microtubule lattice","volume":"287","author":"Hinrichs","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib20","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1371\/journal.pbio.1000034","article-title":"Structural polymorphism of 441-residue tau at single residue resolution","volume":"7","author":"Mukrasch","year":"2009","journal-title":"PLoS Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib21","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1021\/bi0521543","article-title":"Global hairpin folding of tau in solution","volume":"45","author":"Jeganathan","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.neurot.2024.e00499_bib22","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1126\/science.aat1780","article-title":"Near-atomic model of microtubule-tau interactions","volume":"360","author":"Kellogg","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib23","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1523\/JNEUROSCI.3439-13.2014","article-title":"Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging","volume":"34","author":"Ma","year":"2014","journal-title":"J\u00a0Neurosci : Offi J Soc Neurosci"},{"key":"10.1016\/j.neurot.2024.e00499_bib24","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1016\/S0021-9258(17)42989-9","article-title":"Phosphorylation affects the ability of tau protein to promote microtubule assembly","volume":"259","author":"Lindwall","year":"1984","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib25","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","article-title":"Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration","volume":"68","author":"Hoover","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.neurot.2024.e00499_bib26","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.neuron.2018.02.015","article-title":"Tau kinetics in neurons and the human central nervous system","volume":"97","author":"Sato","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neurot.2024.e00499_bib27","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/s41591-024-02869-z","article-title":"Highly accurate blood test for Alzheimer's disease is similar or superior to clinical cerebrospinal fluid tests","volume":"30","author":"Barthelemy","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.neurot.2024.e00499_bib28","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41591-021-01382-x","article-title":"Biomarkers for neurodegenerative diseases","volume":"27","author":"Hansson","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.neurot.2024.e00499_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0896-6273(93)90279-Z","article-title":"Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding","volume":"11","author":"Biernat","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.neurot.2024.e00499_bib30","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/0896-6273(93)90057-X","article-title":"Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding","volume":"10","author":"Bramblett","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.neurot.2024.e00499_bib31","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","article-title":"Tau PTM profiles identify patient heterogeneity and stages of Alzheimer's disease","volume":"183","author":"Wesseling","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib32","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76494","article-title":"Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy","volume":"11","author":"Lovestam","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.neurot.2024.e00499_bib33","first-page":"146","article-title":"\u00dcber eine eigenartige Erkrankung der Hirnrinde","author":"Alzheimer","year":"1907","journal-title":"Allgemeine Zeitschrift fur Psychiatrie und Psychisch-gerichtliche Medizin"},{"key":"10.1016\/j.neurot.2024.e00499_bib34","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1073\/pnas.85.11.4051","article-title":"Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau","volume":"85","author":"Goedert","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib35","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","article-title":"Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease","volume":"83","author":"Kosik","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib36","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of Alzheimer paired helical filaments","volume":"261","author":"Grundke-Iqbal","year":"1986","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib37","series-title":"Mise en \u00e9vidence immunologique de la prot\u00e9ine tau au niveau des l\u00e9sions de d\u00e9g\u00e9n\u00e9rescence neurofibrillaire de la maladie d'Alzheimer","author":"Brion","year":"1985"},{"key":"10.1016\/j.neurot.2024.e00499_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.599384","article-title":"Tauopathy and movement disorders-unveiling the chameleons and mimics","volume":"11","author":"Ganguly","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12792","article-title":"Classification of diseases with accumulation of Tau protein","volume":"48","author":"Kovacs","year":"2022","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.neurot.2024.e00499_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41586-021-03911-7","article-title":"Structure-based classification of tauopathies","volume":"598","author":"Shi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.neurot.2024.e00499_bib41","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1523\/JNEUROSCI.4674-06.2007","article-title":"Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2\/Par-1","volume":"27","author":"Thies","year":"2007","journal-title":"J\u00a0Neurosci : Off J Soc Neurosci"},{"key":"10.1016\/j.neurot.2024.e00499_bib42","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1126\/science.1178250","article-title":"An analytical solution to the kinetics of breakable filament assembly","volume":"326","author":"Knowles","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib43","doi-asserted-by":"crossref","first-page":"8667","DOI":"10.1039\/C8CC02204F","article-title":"Secondary nucleation in amyloid formation","volume":"54","author":"Tornquist","year":"2018","journal-title":"Chem Commun"},{"key":"10.1016\/j.neurot.2024.e00499_bib44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.6801762","article-title":"Novel proteinaceous infectious particles cause scrapie","volume":"216","author":"Prusiner","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib45","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/infdis\/153.5.848","article-title":"Scrapie and cellular prion proteins share polypeptide epitopes","volume":"153","author":"Barry","year":"1986","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.neurot.2024.e00499_bib46","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1073\/pnas.90.23.10962","article-title":"Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins","volume":"90","author":"Pan","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib47","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.molmed.2020.03.012","article-title":"Cell-to-Cell transmission of tau and alpha-synuclein","volume":"26","author":"Uemura","year":"2020","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.neurot.2024.e00499_bib48","doi-asserted-by":"crossref","first-page":"12845","DOI":"10.1074\/jbc.M808759200","article-title":"Propagation of tau misfolding from the outside to the inside of a cell","volume":"284","author":"Frost","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib49","doi-asserted-by":"crossref","first-page":"12445","DOI":"10.1074\/jbc.M115.709485","article-title":"Extracellular vesicles isolated from the brains of rTg4510 mice seed tau protein aggregation in a threshold-dependent manner","volume":"291","author":"Polanco","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib50","doi-asserted-by":"crossref","first-page":"E3138","DOI":"10.1073\/pnas.1301440110","article-title":"Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds","volume":"110","author":"Holmes","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib51","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1073\/pnas.1301175110","article-title":"Brain homogenates from human tauopathies induce tau inclusions in mouse brain","volume":"110","author":"Clavaguera","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib52","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/srep00700","article-title":"Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau","volume":"2","author":"Lasagna-Reeves","year":"2012","journal-title":"Sci Rep"},{"key":"10.1016\/j.neurot.2024.e00499_bib53","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.neuron.2014.04.047","article-title":"Distinct tau prion strains propagate in cells and mice and define different tauopathies","volume":"82","author":"Sanders","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neurot.2024.e00499_bib54","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.conb.2019.11.008","article-title":"To stage, or not to stage","volume":"61","author":"Del Tredici","year":"2019","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.neurot.2024.e00499_bib55","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41398-021-01602-5","article-title":"Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study","volume":"11","author":"Chen","year":"2021","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.neurot.2024.e00499_bib56","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.celrep.2018.04.056","article-title":"Unconventional secretion mediates the trans-cellular spreading of tau","volume":"23","author":"Katsinelos","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.neurot.2024.e00499_bib57","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.15252\/embj.201593489","article-title":"DnaJ\/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins","volume":"35","author":"Fontaine","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.neurot.2024.e00499_bib58","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41586-020-2156-5","article-title":"LRP1 is a master regulator of tau uptake and spread","volume":"580","author":"Rauch","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neurot.2024.e00499_bib59","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fncel.2019.00403","article-title":"Normal and pathological tau uptake mediated by M1\/M3 muscarinic receptors promotes opposite neuronal changes","volume":"13","author":"Morozova","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neurot.2024.e00499_bib60","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/brain\/awaa376","article-title":"Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons","volume":"144","author":"Ruan","year":"2021","journal-title":"Brain : J Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib61","article-title":"Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease","author":"Fowler","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.neurot.2024.e00499_bib62","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cell.2021.12.041","article-title":"Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration","volume":"4","author":"Tracy","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib63","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.redox.2017.03.008","article-title":"Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration","volume":"12","author":"Esteras","year":"2017","journal-title":"Redox Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bbadis.2004.06.014","article-title":"Transgenic animal models of tauopathies","volume":"1739","author":"Lee","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neurot.2024.e00499_bib65","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1038\/s41467-017-01575-4","article-title":"Discovery and characterization of stable and toxic Tau\/phospholipid oligomeric complexes","volume":"8","author":"Ait-Bouziad","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.neurot.2024.e00499_bib66","doi-asserted-by":"crossref","first-page":"14234","DOI":"10.1523\/JNEUROSCI.1523-15.2015","article-title":"Internalized tau oligomers cause neurodegeneration by inducing accumulation of pathogenic tau in human neurons derived from induced pluripotent stem cells","volume":"35","author":"Usenovic","year":"2015","journal-title":"J\u00a0Neurosci : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.neurot.2024.e00499_bib67","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2353\/ajpath.2009.080814","article-title":"The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus","volume":"174","author":"Hoozemans","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.neurot.2024.e00499_bib68","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1750-1326-6-39","article-title":"Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice","volume":"6","author":"Lasagna-Reeves","year":"2011","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.neurot.2024.e00499_bib69","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1074\/jbc.M507753200","article-title":"Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs","volume":"281","author":"Khlistunova","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib70","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13024-016-0096-1","article-title":"Tau mutant A152T, a risk factor for FTD\/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model","volume":"11","author":"Pir","year":"2016","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.neurot.2024.e00499_bib71","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12692","article-title":"Interplay of pathogenic forms of human tau with different autophagic pathways","volume":"17","author":"Caballero","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib72","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.celrep.2019.08.104","article-title":"Tau-mediated disruption of the spliceosome triggers cryptic RNA splicing and neurodegeneration in Alzheimer's disease","volume":"29","author":"Hsieh","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.neurot.2024.e00499_bib73","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1016\/j.cell.2021.07.003","article-title":"ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids","volume":"184","author":"Bowles","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib74","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.stemcr.2016.08.001","article-title":"Human iPSC-derived neuronal model of tau-a152t frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability","volume":"7","author":"Silva","year":"2016","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.neurot.2024.e00499_bib75","unstructured":"Alzforum Living Among Us: People Whose Alzheimer's Is Already Being Prevented [online]. Available at: https:\/\/www.alzforum.org\/news\/conference-coverage\/living-among-us-people-whose-alzheimers-already-being-prevented Accessed: August 16th, 2024."},{"key":"10.1016\/j.neurot.2024.e00499_bib76","series-title":"15th clinical trials on alzheimer's disease conference","article-title":"Dare we say consensus achieved: lecanemab slows the disease","author":"Alzforum","year":"2022"},{"key":"10.1016\/j.neurot.2024.e00499_bib77","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.neurot.2024.e00499_bib78","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1056\/NEJMc2215148","article-title":"Multiple cerebral hemorrhages in a patient receiving lecanemab and treated with t-PA for stroke","volume":"388","author":"Reish","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.neurot.2024.e00499_bib79","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1186\/s12967-024-05248-x","article-title":"Passive immunotherapy for Alzheimer's disease: challenges & future directions","volume":"22","author":"Yi","year":"2024","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.neurot.2024.e00499_bib80","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1038\/s41467-023-43933-5","article-title":"Fatal iatrogenic cerebral beta-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease","volume":"14","author":"Solopova","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.neurot.2024.e00499_bib81","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat Aging"},{"key":"10.1016\/j.neurot.2024.e00499_bib82","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.neurobiolaging.2011.11.009","article-title":"Autophagic degradation of tau in primary neurons and its enhancement by trehalose","volume":"33","author":"Kr\u00fcger","year":"2012","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neurot.2024.e00499_bib83","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1093\/brain\/aws143","article-title":"Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy","volume":"135","author":"Schaeffer","year":"2012","journal-title":"Brain : J Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib84","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1038\/s41467-020-16984-1","article-title":"Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons","volume":"11","author":"Silva","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.neurot.2024.e00499_bib85","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1016\/j.cell.2021.03.048","article-title":"Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome","volume":"184","author":"Bourdenx","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib86","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.aax3769","article-title":"Cellular quality control by the ubiquitin-proteasome system and autophagy","volume":"366","author":"Pohl","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib87","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41586-018-0736-4","article-title":"Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome","volume":"565","author":"Dong","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neurot.2024.e00499_bib88","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1039\/D2CS00200K","article-title":"Target and tissue selectivity of PROTAC degraders","volume":"51","author":"Guenette","year":"2022","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.neurot.2024.e00499_bib89","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41580-018-0001-6","article-title":"The coming of age of chaperone-mediated autophagy","volume":"19","author":"Kaushik","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib90","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4161\/auto.7.7.15450","article-title":"The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy","volume":"7","author":"Lee","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.neurot.2024.e00499_bib91","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.molcel.2019.09.005","article-title":"A\u00a0diversity of selective autophagy receptors determines the specificity of the autophagy pathway","volume":"76","author":"Kirkin","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib92","first-page":"1","article-title":"VERITAC-2: a Phase III study of vepdegestrant, a PROTAC ER degrader, versus fulvestrant in ER+\/HER2- advanced breast cancer","author":"Hamilton","year":"2024","journal-title":"Future Oncol"},{"key":"10.1016\/j.neurot.2024.e00499_bib93","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41392-022-00966-4","article-title":"Targeted protein degradation: mechanisms, strategies and application","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.neurot.2024.e00499_bib94","doi-asserted-by":"crossref","first-page":"8554","DOI":"10.1073\/pnas.141230798","article-title":"Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation","volume":"98","author":"Sakamoto","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib95","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.chembiol.2016.02.016","article-title":"Specific knockdown of endogenous tau protein by peptide-directed ubiquitin-proteasome degradation","volume":"23","author":"Chu","year":"2016","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib96","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejmech.2018.01.063","article-title":"Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway","volume":"146","author":"Lu","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib97","article-title":"Systemic administration of neurotransmitter-derived lipidoids-PROTACs-DNA nanocomplex promotes tau clearance and cognitive recovery for Alzheimer's disease therapy","author":"Gong","year":"2024","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.neurot.2024.e00499_bib98","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1016\/j.bmcl.2008.07.114","article-title":"Targeted intracellular protein degradation induced by a small molecule: en route to chemical proteomics","volume":"18","author":"Schneekloth","year":"2008","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.neurot.2024.e00499_bib99","doi-asserted-by":"crossref","first-page":"20S","DOI":"10.2967\/jnumed.121.263196","article-title":"Tau PET imaging in neurodegenerative disorders","volume":"63","author":"Groot","year":"2022","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.neurot.2024.e00499_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2023.168025","article-title":"Cryo-EM structures of chronic traumatic encephalopathy tau filaments with PET ligand flortaucipir","volume":"435","author":"Shi","year":"2023","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib101","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45457","article-title":"Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models","volume":"8","author":"Silva","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.neurot.2024.e00499_bib102","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s12035-021-02557-w","article-title":"Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis","volume":"59","author":"Petrozziello","year":"2022","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neurot.2024.e00499_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.801179","article-title":"Discovery and optimization of tau targeted protein degraders enabled by patient induced pluripotent stem cells-derived neuronal models of tauopathy","volume":"16","author":"Silva","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.neurot.2024.e00499_bib104","series-title":"Tau-protein targeting compounds and associated","author":"Crew","year":"2023"},{"key":"10.1016\/j.neurot.2024.e00499_bib105","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.7150\/thno.55680","article-title":"A\u00a0novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.neurot.2024.e00499_bib106","doi-asserted-by":"crossref","first-page":"814","DOI":"10.2174\/156720501209151019104951","article-title":"Identification of small molecule inhibitors of tau aggregation by targeting monomeric tau as a potential therapeutic approach for tauopathies","volume":"12","author":"Pickhardt","year":"2015","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.neurot.2024.e00499_bib107","doi-asserted-by":"crossref","first-page":"26308","DOI":"10.1021\/acsomega.2c02130","article-title":"Design, synthesis, and bioactivity of novel bifunctional small molecules for Alzheimer's disease","volume":"7","author":"Liang","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.neurot.2024.e00499_bib108","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1093\/brain\/awu064","article-title":"Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET","volume":"137","author":"Okamura","year":"2014","journal-title":"Brain : J Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib109","doi-asserted-by":"crossref","first-page":"11558","DOI":"10.1039\/C8CC06897F","article-title":"Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer's models","volume":"54","author":"Zhu","year":"2018","journal-title":"Chem Commun"},{"key":"10.1016\/j.neurot.2024.e00499_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1351792","article-title":"Selective degradation of hyperphosphorylated tau by proteolysis-targeting chimeras ameliorates cognitive function in Alzheimer's disease model mice","volume":"15","author":"Yao","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.neurot.2024.e00499_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/alz.075453","article-title":"PROTAC tau degrader for the treatment of Alzheimer's disease and primary tauopathies","volume":"19","author":"Zhang","year":"2023","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.neurot.2024.e00499_bib112","author":"Jang","year":"2022","journal-title":"inventors; Aprinoia Therapeutics Limited, assignee. COMPOUNDS FOR DEGRADING TAU PROTEIN AGGREGATES AND USES THEREOF US"},{"key":"10.1016\/j.neurot.2024.e00499_bib113","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1021\/acs.jmedchem.3c01719","article-title":"Discovery of effective dual PROTAC degraders for neurodegenerative disease-associated aggregates","volume":"67","author":"Zhu","year":"2024","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib114","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nchembio.597","article-title":"Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins","volume":"7","author":"Neklesa","year":"2011","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib115","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1021\/cb400569k","article-title":"A\u00a0bidirectional system for the dynamic small molecule control of intracellular fusion proteins","volume":"8","author":"Neklesa","year":"2013","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib116","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","article-title":"The proteostasis network and its decline in ageing","volume":"20","author":"Hipp","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib117","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/embo-reports\/kve246","article-title":"CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein","volume":"2","author":"Murata","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.neurot.2024.e00499_bib118","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1021\/acschembio.6b00656","article-title":"Boc(3)Arg-Linked ligands induce degradation by localizing target proteins to the 20S proteasome","volume":"11","author":"Shi","year":"2016","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib119","doi-asserted-by":"crossref","first-page":"40362","DOI":"10.1039\/C7RA05347A","article-title":"Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau","volume":"7","author":"Gao","year":"2017","journal-title":"RSC Adv"},{"key":"10.1016\/j.neurot.2024.e00499_bib120","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41392-021-00669-2","article-title":"A\u00a0novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies","volume":"6","author":"Zheng","year":"2021","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.neurot.2024.e00499_bib121","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0896-6273(00)80250-0","article-title":"Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A","volume":"17","author":"Sontag","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neurot.2024.e00499_bib122","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40035-023-00379-5","article-title":"A\u00a0novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau","volume":"12","author":"Gao","year":"2023","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.neurot.2024.e00499_bib123","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/s41401-024-01326-4","article-title":"A\u00a0new tau dephosphorylation-targeting chimera for the treatment of tauopathies","volume":"45","author":"Su","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.neurot.2024.e00499_bib124","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.chembiol.2024.09.003","article-title":"A\u00a0tau dephosphorylation-targeting chimera selectively recruits protein phosphatase-1 to ameliorate Alzheimer's disease and tauopathies","volume":"31","author":"Xiao","year":"2024","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib125","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nchem.2889","article-title":"Structure-based inhibitors of tau aggregation","volume":"10","author":"Seidler","year":"2018","journal-title":"Nat Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib126","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1021\/acschembio.1c00693","article-title":"Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs)","volume":"16","author":"Chen","year":"2021","journal-title":"ACS Chem Biol"},{"issue":"7","key":"10.1016\/j.neurot.2024.e00499_bib127","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1021\/jacs.2c11706","article-title":"Targeted dephosphorylation of tau by phosphorylation targeting chimeras (PhosTACs) as a therapeutic modality","volume":"145","author":"Hu","year":"2023","journal-title":"J\u00a0Am Chem Soc"},{"key":"10.1016\/j.neurot.2024.e00499_bib128","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1007\/s00259-019-04397-2","article-title":"Discovery and preclinical characterization of [(18)F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies","volume":"46","author":"Kroth","year":"2019","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"10.1016\/j.neurot.2024.e00499_bib129","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba3916","article-title":"Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution","volume":"6","author":"Ukmar-Godec","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.neurot.2024.e00499_bib130","article-title":"Intracellular degradation of tau assemblies via cytosolic antibody receptor TRIM21","author":"McEwan","year":"2024","journal-title":"Presented at: Tau2024 Global Conference March 25"},{"key":"10.1016\/j.neurot.2024.e00499_bib131","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.793328","article-title":"Selective autophagy receptor p62\/SQSTM1, a pivotal player in stress and aging","volume":"10","author":"Kumar","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib132","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/BF02976748","article-title":"P62 and the sequestosome, a novel mechanism for protein metabolism","volume":"21","author":"Shin","year":"1998","journal-title":"Arch Pharm Res (Seoul)"},{"key":"10.1016\/j.neurot.2024.e00499_bib133","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1073\/pnas.93.12.5991","article-title":"Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain","volume":"93","author":"Joung","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib134","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798308","article-title":"p62 filaments capture and present ubiquitinated cargos for autophagy","volume":"37","author":"Zaffagnini","year":"2018","journal-title":"EMBO J"},{"key":"10.1016\/j.neurot.2024.e00499_bib135","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.08941","article-title":"Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy","volume":"4","author":"Wurzer","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.neurot.2024.e00499_bib136","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.neurot.2024.e00499_bib137","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1083\/jcb.200507002","article-title":"p62\/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death","volume":"171","author":"Bj\u00f8rk\u00f8y","year":"2005","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib138","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-017-00085-7","article-title":"p62\/SQSTM1\/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis","volume":"8","author":"Cha-Molstad","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.neurot.2024.e00499_bib139","doi-asserted-by":"crossref","first-page":"E2716","DOI":"10.1073\/pnas.1719110115","article-title":"N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis","volume":"115","author":"Yoo","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib140","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.molcel.2019.06.028","article-title":"The N-degron pathway mediates ER-phagy","volume":"75","author":"Ji","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib141","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/s41467-022-28520-4","article-title":"The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system","volume":"13","author":"Ji","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.neurot.2024.e00499_bib142","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4161\/pri.28938","article-title":"The therapeutic potential of chemical chaperones in protein folding diseases","volume":"8","author":"Cortez","year":"2014","journal-title":"Prion"},{"key":"10.1016\/j.neurot.2024.e00499_bib143","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00401-013-1114-9","article-title":"Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease","volume":"125","author":"Wagner","year":"2013","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurot.2024.e00499_bib144","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69744-y","article-title":"Effects of pharmacological modulators of alpha-synuclein and tau aggregation and internalization","volume":"10","author":"Dominguez-Meijide","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.neurot.2024.e00499_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104021","article-title":"Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: a randomised, double-blind, placebo-controlled phase 1a trial","volume":"80","author":"Levin","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.neurot.2024.e00499_bib146","article-title":"Targeted degradation of \u237a-synuclein aggregates in Parkinson's disease using the AUTOTAC technology","volume":"18","author":"Lee","year":"2023","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.neurot.2024.e00499_bib147","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/15548627.2023.2274711","article-title":"Targeted degradation of SNCA\/\u03b1-synuclein aggregates in neurodegeneration using the AUTOTAC chemical platform","volume":"20","author":"Lee","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.neurot.2024.e00499_bib148","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ni.2548","article-title":"Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21","volume":"14","author":"McEwan","year":"2013","journal-title":"Nat Immunol"},{"key":"10.1016\/j.neurot.2024.e00499_bib149","doi-asserted-by":"crossref","first-page":"19985","DOI":"10.1073\/pnas.1014074107","article-title":"Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)","volume":"107","author":"Mallery","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib150","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41594-021-00560-2","article-title":"Target-induced clustering activates Trim-Away of pathogens and proteins","volume":"28","author":"Zeng","year":"2021","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib151","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.3389\/fimmu.2019.02049","article-title":"TRIM21-From intracellular immunity to therapy","volume":"10","author":"Foss","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.neurot.2024.e00499_bib152","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.cell.2017.10.033","article-title":"A\u00a0method for the acute and rapid degradation of endogenous proteins","volume":"171","author":"Clift","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib153","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1073\/pnas.1607215114","article-title":"Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation","volume":"114","author":"McEwan","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib154","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.abn1366","article-title":"Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models","volume":"379","author":"Mukadam","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib155","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.adp5186","article-title":"Aggregate-selective removal of pathological tau by clustering-activated degraders","volume":"385","author":"Benn","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib156","series-title":"Selective degradation of aggregated tau protein via vectored nanobody-TRIM21 RING fusion constructs","author":"Benn","year":"2023"},{"key":"10.1016\/j.neurot.2024.e00499_bib157","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1016\/j.cell.2024.08.024","article-title":"Co-opting templated aggregation to degrade pathogenic tau assemblies and improve motor function","volume":"187","author":"Miller","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib158","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/brain\/awab091","article-title":"Human tauopathy-derived tau strains determine the substrates recruited for templated amplification","volume":"144","author":"Tarutani","year":"2021","journal-title":"Brain : J Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib159","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/hum.1994.5.5-595","article-title":"Intracellular antibodies as a new class of therapeutic molecules for gene therapy","volume":"5","author":"Chen","year":"1994","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.neurot.2024.e00499_bib160","first-page":"2638","article-title":"A\u00a0new means of inducibly inactivating a cellular protein","volume":"8","author":"Carlson","year":"1988","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib161","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1126\/science.3140379","article-title":"Single-chain antigen-binding proteins","volume":"242","author":"Bird","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib162","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.1073\/pnas.90.16.7889","article-title":"Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody","volume":"90","author":"Marasco","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib163","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/jmbi.2002.5392","article-title":"The intracellular antibody capture technology (IACT): towards a consensus sequence for intracellular antibodies","volume":"317","author":"Visintin","year":"2002","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib164","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jmb.2007.09.053","article-title":"A\u00a0protein silencing switch by ligand-induced proteasome-targeting intrabodies","volume":"374","author":"Melchionna","year":"2007","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib165","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13024-019-0340-6","article-title":"Targeting tauopathy with engineered tau-degrading intrabodies","volume":"14","author":"Gallardo","year":"2019","journal-title":"Mol Neurodegener"},{"issue":"28","key":"10.1016\/j.neurot.2024.e00499_bib166","article-title":"Fully human bifunctional intrabodies achieve graded reduction of intracellular tau and rescue survival of MAPT mutation iPSC-derived neurons","volume":"5","author":"D'Brant","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.neurot.2024.e00499_bib167","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.1103966","article-title":"Autophagy defends cells against invading group A Streptococcus","volume":"306","author":"Nakagawa","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neurot.2024.e00499_bib168","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.molcel.2013.10.024","article-title":"Endogenous nitrated nucleotide is a key mediator of autophagy and innate defense against bacteria","volume":"52","author":"Ito","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib169","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.molcel.2019.09.009","article-title":"AUTACs: cargo-specific degraders using selective autophagy","volume":"76","author":"Takahashi","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.neurot.2024.e00499_bib170","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-019-1722-1","article-title":"Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds","volume":"575","author":"Li","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neurot.2024.e00499_bib171","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/15548627.2019.1688556","article-title":"ATTEC: a potential new approach to target proteinopathies","volume":"16","author":"Li","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.neurot.2024.e00499_bib172","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.chembiol.2024.05.004","article-title":"Molecular glues and bifunctional compounds: therapeutic modalities based on induced proximity","volume":"31","author":"Schreiber","year":"2024","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib173","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/s41422-021-00532-7","article-title":"Degradation of lipid droplets by chimeric autophagy-tethering compounds","volume":"31","author":"Fu","year":"2021","journal-title":"Cell Res"},{"key":"10.1016\/j.neurot.2024.e00499_bib174","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.scib.2023.10.021","article-title":"Targeted clearance of mitochondria by an autophagy-tethering compound (ATTEC) and its potential therapeutic effects","volume":"68","author":"Tan","year":"2023","journal-title":"Sci Bull"},{"key":"10.1016\/j.neurot.2024.e00499_bib175","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1038\/s41589-024-01741-y","article-title":"Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins","volume":"20","author":"Seabrook","year":"2024","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib176","doi-asserted-by":"crossref","first-page":"E5317","DOI":"10.1073\/pnas.1804091115","article-title":"Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking","volume":"115","author":"Albrecht","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2024.e00499_bib177","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/s41589-021-00770-1","article-title":"LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation","volume":"17","author":"Ahn","year":"2021","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib178","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41586-020-2545-9","article-title":"Lysosome-targeting chimaeras for degradation of extracellular proteins","volume":"584","author":"Banik","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.neurot.2024.e00499_bib179","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrm1050","article-title":"Mannose 6-phosphate receptors: new twists in the tale","volume":"4","author":"Ghosh","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.neurot.2024.e00499_bib180","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/13543784.2023.2233892","article-title":"Clinical development of passive tau-based immunotherapeutics for treating primary and secondary tauopathies","volume":"32","author":"Panza","year":"2023","journal-title":"Expet Opin Invest Drugs"},{"key":"10.1016\/j.neurot.2024.e00499_bib181","unstructured":"Alzforum Therapeutics [online]. Available at: https:\/\/www.alzforum.org\/therapeutics\/search?fda_statuses=&target_types%5B%5D=177&therapy_types%5B%5D=164&therapy_types%5B%5D=161&therapy_types%5B%5D=162&conditions=&keywords-entry=&keywords= Accessed: July 31st, 2024."},{"key":"10.1016\/j.neurot.2024.e00499_bib182","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s43587-021-00070-2","article-title":"ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer's disease","volume":"1","author":"Novak","year":"2021","journal-title":"Nat Aging"},{"key":"10.1016\/j.neurot.2024.e00499_bib183","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41582-023-00883-2","article-title":"Tau-targeting therapies for Alzheimer disease: current status and future directions","volume":"19","author":"Congdon","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib184","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00401-021-02318-y","article-title":"Tau immunotherapy is associated with glial responses in FTLD-tau","volume":"142","author":"Kim","year":"2021","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neurot.2024.e00499_bib185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrneurol.2017.148","article-title":"Antisense oligonucleotides: the next frontier for treatment of neurological disorders","volume":"14","author":"Rinaldi","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.neurot.2024.e00499_bib186","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1001\/jamaneurol.2023.3861","article-title":"Exploratory tau biomarker results from a multiple ascending-dose study of BIIB080 in alzheimer disease: a randomized clinical trial","volume":"80","author":"Edwards","year":"2023","journal-title":"JAMA Neurol"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747924001867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747924001867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:09:40Z","timestamp":1762560580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747924001867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":186,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1878747924001867"],"URL":"https:\/\/doi.org\/10.1016\/j.neurot.2024.e00499","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurot.2024.e00499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics.","name":"copyright","label":"Copyright"}],"article-number":"e00499"}}