{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:36:54Z","timestamp":1780403814274,"version":"3.54.1"},"reference-count":203,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020884","name":"National Agency for Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11171155"],"award-info":[{"award-number":["11171155"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.neurot.2025.e00523","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T13:22:01Z","timestamp":1737552121000},"page":"e00523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of astrocytes connexins - pannexins in acute brain injury"],"prefix":"10.1016","volume":"22","author":[{"given":"Juan E.","family":"Tichauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Rovegno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13054-015-0887-8","article-title":"Neuroprotection in acute brain injury: an up-to-date review","volume":"19","author":"Stocchetti","year":"2015","journal-title":"Crit Care"},{"issue":"10","key":"10.1016\/j.neurot.2025.e00523_bib2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"20","author":"Feigin","year":"2021","journal-title":"Lancet Neurol"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib3","first-page":"272","article-title":"Actual data on epidemiological evolution and prevention endeavours regarding traumatic brain injury","volume":"8","author":"Popescu","year":"2015","journal-title":"J\u00a0Med Life"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib4","first-page":"216","article-title":"The role of secondary brain injury in determining outcome from severe head injury","volume":"34","author":"Chesnut","year":"1993","journal-title":"J\u00a0Trauma"},{"issue":"7","key":"10.1016\/j.neurot.2025.e00523_bib5","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/jnnp.2009.174425","article-title":"Spontaneous hyperventilation and brain tissue hypoxia in patients with severe brain injury","volume":"81","author":"Carrera","year":"2010","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib6","first-page":"1134","article-title":"Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study","volume":"61","author":"Chi","year":"2006","journal-title":"J\u00a0Trauma"},{"issue":"12","key":"10.1016\/j.neurot.2025.e00523_bib7","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1097\/CCM.0b013e31818f4026","article-title":"Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study","volume":"36","author":"Oddo","year":"2008","journal-title":"Crit Care Med"},{"issue":"19","key":"10.1016\/j.neurot.2025.e00523_bib8","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1001\/jama.2024.20424","article-title":"Restrictive vs liberal transfusion strategy in patients with acute brain injury: the TRAIN randomized clinical trial","volume":"332","author":"Taccone","year":"2024","journal-title":"JAMA"},{"issue":"8999","key":"10.1016\/j.neurot.2025.e00523_bib9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0140-6736(96)90008-2","article-title":"Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome","volume":"347","author":"Reith","year":"1996","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/biology11010027","article-title":"Gap junctions and hemichannels composed of connexins and pannexins mediate the secondary brain injury following intracerebral hemorrhage","volume":"11","author":"Zhang","year":"2021","journal-title":"Biology"},{"issue":"June","key":"10.1016\/j.neurot.2025.e00523_bib11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fncel.2017.00174","article-title":"Connexin-dependent neuroglial networking as a new therapeutic target","volume":"11","author":"Charv\u00e9riat","year":"2017","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib12","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/2210","article-title":"Gap-junction-mediated propagation and amplification of cell injury","volume":"1","author":"Lin","year":"1998","journal-title":"Nat Neurosci"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/jnr.24088","article-title":"Connexins and pannexins: at the junction of neuro-glial homeostasis & disease","volume":"96","author":"Lapato","year":"2018","journal-title":"J\u00a0Neurosci Res"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00004647-200204000-00009","article-title":"Ischemia-induced brain damage depends on specific gap-junctional coupling","volume":"22","author":"Frantseva","year":"2002","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib15","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1523\/JNEUROSCI.22-03-00644.2002","article-title":"Specific gap junctions enhance the neuronal vulnerability to brain traumatic injury","volume":"22","author":"Frantseva","year":"2002","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.neurot.2025.e00523_bib16","doi-asserted-by":"crossref","DOI":"10.1177\/1759091419847090","article-title":"Small interference RNA targeting connexin-43 improves motor function and limits astrogliosis after juvenile traumatic brain injury","volume":"11","author":"Ichkova","year":"2019","journal-title":"ASN Neuro"},{"issue":"27","key":"10.1016\/j.neurot.2025.e00523_bib17","doi-asserted-by":"crossref","first-page":"18143","DOI":"10.1074\/jbc.M109.004804","article-title":"The pannexin 1 channel activates the inflammasome in neurons and astrocytes","volume":"284","author":"Silverman","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.neurot.2025.e00523_bib18","doi-asserted-by":"crossref","first-page":"117218","DOI":"10.1016\/j.cca.2023.117218","article-title":"Increased serum pannexin-1 concentrations reflect illness severity and predict a poor prognosis after acute supratentorial intracerebral hemorrhage: a prospective longitudinal cohort study","volume":"540","author":"Zhang","year":"2023","journal-title":"Clin Chim Acta"},{"issue":"March","key":"10.1016\/j.neurot.2025.e00523_bib19","doi-asserted-by":"crossref","first-page":"854671","DOI":"10.3389\/fneur.2022.854671","article-title":"Probenecid-blocked pannexin-1 channel protects against early brain injury via inhibiting neuronal AIM2 inflammasome activation after subarachnoid hemorrhage","volume":"13","author":"Zheng","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.neurot.2025.e00523_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.brainres.2016.05.002","article-title":"Probenecid protects against oxygen\u2013glucose deprivation injury in primary astrocytes by regulating inflammasome activity","volume":"1643","author":"Jian","year":"2016","journal-title":"Brain Res"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004137","article-title":"The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels","volume":"11","author":"Sibille","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib22","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuint.2007.10.015","article-title":"Regulation of pH in the mammalian central nervous system under normal and pathological conditions: facts and hypotheses","volume":"52","author":"Obara","year":"2008","journal-title":"Neurochem Int"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0024-3205(01)01142-0","article-title":"Glutamate release and neuronal damage in ischemia","volume":"69","author":"Nishizawa","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.neurot.2025.e00523_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/232105","article-title":"Astrocyte-synapse structural plasticity","volume":"2014","author":"Bernardinelli","year":"2014","journal-title":"Neural Plast"},{"issue":"8","key":"10.1016\/j.neurot.2025.e00523_bib25","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tins.2009.05.001","article-title":"Tripartite synapses: astrocytes process and control synaptic information","volume":"32","author":"Perea","year":"2009","journal-title":"Trends Neurosci"},{"issue":"5593","key":"10.1016\/j.neurot.2025.e00523_bib26","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1126\/science.298.5593.556","article-title":"New insights into neuron-glia communication","volume":"298","author":"Fields","year":"2002","journal-title":"Science"},{"issue":"May","key":"10.1016\/j.neurot.2025.e00523_bib48","first-page":"1","article-title":"Astroglial connexins in neurodegenerative diseases","volume":"14","author":"Huang","year":"2021","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib49","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbamem.2017.05.008","article-title":"The connexin 43 C-terminus: a tail of many tales","volume":"1860","author":"Leithe","year":"2018","journal-title":"Biochim Biophys acta Biomembr"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib50","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1084\/jem.20171452","article-title":"et\u00a0al.Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke","volume":"216","author":"Freitas-Andrade","year":"2019","journal-title":"J\u00a0Exp Med"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib51","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3390\/ijms19061659","article-title":"Cx43 channel gating and permeation: multiple phosphorylation-dependent roles of the carboxyl terminus","volume":"19","author":"Ek-Vitor\u00edn","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"December","key":"10.1016\/j.neurot.2025.e00523_bib61","first-page":"1","article-title":"Synaptic functions of hemichannels and pannexons: a double-edged sword","volume":"11","author":"Abudara","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"36","key":"10.1016\/j.neurot.2025.e00523_bib97","doi-asserted-by":"crossref","first-page":"12579","DOI":"10.1523\/JNEUROSCI.1267-12.2012","article-title":"Anoxia-induced NMDA receptor activation opens pannexin channels via Src family kinases","volume":"32","author":"Weilinger","year":"2012","journal-title":"J\u00a0Neurosci"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib193","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1091\/mbc.E19-10-0585","article-title":"Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein","volume":"32","author":"Nouri-Nejad","year":"2021","journal-title":"Mol Biol Cell"},{"issue":"7317","key":"10.1016\/j.neurot.2025.e00523_bib55","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nature09413","article-title":"Pannexin 1 channels mediate \u201cfind-me\u201d signal release and membrane permeability during apoptosis","volume":"467","author":"Chekeni","year":"2010","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3390\/cells13020148","article-title":"Astroglial cells: emerging therapeutic targets in the management of traumatic brain injury","volume":"13","author":"Czy\u017cewski","year":"2024","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib28","doi-asserted-by":"crossref","first-page":"166992","DOI":"10.1016\/j.bbadis.2023.166992","article-title":"The role of astrocyte in neuroinflammation in traumatic brain injury","volume":"1870","author":"He","year":"2024","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib31","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41392-023-01628-9","article-title":"Astrocytes in human central nervous system diseases: a frontier for new therapies","volume":"8","author":"Verkhratsky","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib32","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"issue":"January","key":"10.1016\/j.neurot.2025.e00523_bib33","first-page":"1","article-title":"Connexins in astrocyte migration","volume":"10","author":"Lagos-Cabr\u00e9","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.neurot.2025.e00523_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbr.2015.05.049","article-title":"A\u00a0novel cognitive impairment mechanism that astrocytic p-connexin 43 promotes neuronic autophagy via activation of P2X7R and down-regulation of GLT-1 expression in the hippocampus\u00a0following traumatic brain injury in rats","volume":"291","author":"Sun","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"10","key":"10.1016\/j.neurot.2025.e00523_bib35","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1523\/JNEUROSCI.1067-18.2018","article-title":"Repetitive diffuse mild traumatic brain injury causes an atypical astrocyte response and spontaneous recurrent seizures","volume":"39","author":"Shandra","year":"2019","journal-title":"J\u00a0Neurosci"},{"issue":"7","key":"10.1016\/j.neurot.2025.e00523_bib36","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1089\/neu.2009.1234","article-title":"Temporal and spatial profile of phosphorylated connexin43 after traumatic brain injury in rats","volume":"27","author":"Ohsumi","year":"2010","journal-title":"J\u00a0Neurotrauma"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1179\/1743132813Y.0000000165","article-title":"Antisense oligodeoxynucleotides targeting connexin43 reduce cerebral astrocytosis and edema in a rat model of traumatic brain injury","volume":"35","author":"Wu","year":"2013","journal-title":"Neurol Res"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s13018-024-04879-6","article-title":"Repetitive transcranial magnetic stimulation promotes motor function recovery in mice after spinal cord injury via regulation of the Cx43-autophagy loop","volume":"19","author":"Zhang","year":"2024","journal-title":"J\u00a0Orthop Surg Res"},{"issue":"15","key":"10.1016\/j.neurot.2025.e00523_bib39","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.7150\/thno.31942","article-title":"Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.neurot.2025.e00523_bib40","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/glia.22826","article-title":"Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats","volume":"63","author":"Li","year":"2015","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib41","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s11064-013-1212-z","article-title":"Probenecid protects against transient focal cerebral ischemic injury by inhibiting HMGB1 release and attenuating AQP4 expression in mice","volume":"39","author":"Xiong","year":"2014","journal-title":"Neurochem Res"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-018-1069-9","article-title":"Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice","volume":"15","author":"Garg","year":"2018","journal-title":"J\u00a0Neuroinflammation"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3390\/ijms24010085","article-title":"A\u00a0single episode of cortical spreading depolarization increases mRNA levels of proinflammatory cytokines, calcitonin gene-related peptide and pannexin-1 channels in the cerebral cortex","volume":"24","author":"Volobueva","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4\u20136","key":"10.1016\/j.neurot.2025.e00523_bib44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/cac.10.4-6.173.180","article-title":"An update on connexin genes and their nomenclature in mouse and man","volume":"10","author":"S\u00f6hl","year":"2003","journal-title":"Cell Commun Adhes"},{"issue":"1\u20132","key":"10.1016\/j.neurot.2025.e00523_bib45","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.brainresrev.2009.11.005","article-title":"Pharmacological and genetic approaches to study connexin-mediated channels in glial cells of the central nervous system","volume":"63","author":"Giaume","year":"2010","journal-title":"Brain Res Rev"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib46","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1152\/physrev.00007.2003","article-title":"Plasma membrane channels formed by connexins: their regulation and functions","volume":"83","author":"Saez","year":"2003","journal-title":"Physiol. Rev."},{"issue":"50","key":"10.1016\/j.neurot.2025.e00523_bib47","doi-asserted-by":"crossref","first-page":"13781","DOI":"10.1523\/JNEUROSCI.2042-07.2007","article-title":"Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia","volume":"27","author":"Retamal","year":"2007","journal-title":"J\u00a0Neurosci"},{"issue":"9","key":"10.1016\/j.neurot.2025.e00523_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/brb3.770","article-title":"Correlation between connexin and traumatic brain injury in patients","volume":"7","author":"Chen","year":"2017","journal-title":"Brain Behav"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib182","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3892\/mmr.2013.1787","article-title":"Astrocytic p-connexin 43 regulates neuronal autophagy in the hippocampus following traumatic brain injury in rats","volume":"9","author":"Sun","year":"2014","journal-title":"Mol Med Rep"},{"issue":"50","key":"10.1016\/j.neurot.2025.e00523_bib183","doi-asserted-by":"crossref","first-page":"114876","DOI":"10.1016\/j.expneurol.2024.114876","article-title":"Hydrogen mitigates brain injury by prompting NEDD4-CX43- mediated mitophagy in traumatic brain injury","volume":"379","author":"Wu","year":"2024","journal-title":"Exp Neurol"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib184","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/s10753-021-01443-w","article-title":"MiR-23a is involved in myocardial ischemia\/reperfusion injury by directly targeting CX43 and regulating mitophagy","volume":"44","author":"Wang","year":"2021","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40659-024-00519-9","article-title":"Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression","volume":"57","author":"Tichauer","year":"2024","journal-title":"Biol Res"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib186","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/neu.2016.4625","article-title":"Systemic administration of Connexin43 mimetic peptide improves functional recovery after traumatic spinal cord injury in adult rats","volume":"34","author":"Mao","year":"2017","journal-title":"J\u00a0Neurotrauma"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib187","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/glia.23255","article-title":"Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice","volume":"66","author":"Morioka","year":"2018","journal-title":"Glia"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib188","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134611","article-title":"Inhibition of astrocyte hemichannel improves recovery from spinal cord injury","volume":"6","author":"Zhang","year":"2021","journal-title":"JCI insight"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib189","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/glia.23770","article-title":"Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation","volume":"68","author":"Li","year":"2020","journal-title":"Glia"},{"issue":"October","key":"10.1016\/j.neurot.2025.e00523_bib190","first-page":"1","article-title":"Inhibition of connexin 43 hemichannels alleviates cerebral ischemia\/reperfusion injury via the TLR4 signaling pathway","volume":"12","author":"Chen","year":"2018","journal-title":"Front Cell Neurosci"},{"issue":"November 2023","key":"10.1016\/j.neurot.2025.e00523_bib191","doi-asserted-by":"crossref","first-page":"114611","DOI":"10.1016\/j.expneurol.2023.114611","article-title":"Blockade of connexin hemichannels with tonabersat protects against mild hypoxic ischemic brain injury in neonatal rats","volume":"371","author":"McDouall","year":"2024","journal-title":"Exp Neurol"},{"issue":"23","key":"10.1016\/j.neurot.2025.e00523_bib53","doi-asserted-by":"crossref","first-page":"13644","DOI":"10.1073\/pnas.2233464100","article-title":"Pannexins, a family of gap junction proteins expressed in brain","volume":"100","author":"Bruzzone","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib54","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ygeno.2003.09.025","article-title":"The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins","volume":"83","author":"Baranova","year":"2004","journal-title":"Genomics"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib203","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s11302-021-09804-8","article-title":"Pannexin 1 as a driver of inflammation and ischemia\u2013reperfusion injury","volume":"17","author":"Koval","year":"2021","journal-title":"Purinergic Signal"},{"issue":"November","key":"10.1016\/j.neurot.2025.e00523_bib56","first-page":"1","article-title":"Pannexin1 channels\u2014a potential therapeutic target in inflammation","volume":"10","author":"Rusiecka","year":"2022","journal-title":"Front Cell Dev Biol"},{"issue":"October 2018","key":"10.1016\/j.neurot.2025.e00523_bib57","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cca.2018.11.015","article-title":"Evaluation of serum pannexin-1 as a prognostic biomarker for traumatic brain injury","volume":"488","author":"Ni","year":"2019","journal-title":"Clin Chim Acta"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib58","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/jcbfm.2014.262","article-title":"Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage","volume":"35","author":"Cisneros-Mejorado","year":"2015","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"51","key":"10.1016\/j.neurot.2025.e00523_bib192","doi-asserted-by":"crossref","first-page":"20772","DOI":"10.1073\/pnas.1018262108","article-title":"Pannexins in ischemia-induced neurodegeneration","volume":"108","author":"Bargiotas","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neurot.2025.e00523_bib59","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroscience.2015.04.035","article-title":"Astrocytes in neuroprotection and neurodegeneration: the role of connexin43 and pannexin1","volume":"323","author":"Freitas-Andrade","year":"2016","journal-title":"Neuroscience"},{"issue":"June","key":"10.1016\/j.neurot.2025.e00523_bib60","first-page":"193","article-title":"Hemichannels: new roles in astroglial function","volume":"5","author":"Orellana","year":"2014","journal-title":"Front Physiol"},{"issue":"46","key":"10.1016\/j.neurot.2025.e00523_bib62","doi-asserted-by":"crossref","first-page":"15339","DOI":"10.1523\/JNEUROSCI.0861-15.2015","article-title":"Astroglial connexin 43 hemichannels modulate olfactory bulb slow oscillations","volume":"35","author":"Roux","year":"2015","journal-title":"J\u00a0Neurosci"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib63","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41467-022-28331-7","article-title":"Physiological synaptic activity and recognition memory require astroglial glutamine","volume":"13","author":"Cheung","year":"2022","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib64","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100798RR","article-title":"Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR-dependent transmission and short-term fear memory in the basolateral amygdala","volume":"36","author":"Linsambarth","year":"2022","journal-title":"FASEB J"},{"key":"10.1016\/j.neurot.2025.e00523_bib65","doi-asserted-by":"crossref","first-page":"120049","DOI":"10.1016\/j.lfs.2021.120049","article-title":"Connexin43 hemichannels contribute to working memory and excitatory synaptic transmission of pyramidal neurons in the prefrontal cortex of rats","volume":"286","author":"Tao","year":"2021","journal-title":"Life Sci"},{"key":"10.1016\/j.neurot.2025.e00523_bib66","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fncel.2016.00288","article-title":"Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory","volume":"10","author":"Walrave","year":"2016","journal-title":"Front Cell Neurosci"},{"issue":"9","key":"10.1016\/j.neurot.2025.e00523_bib67","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1096\/fj.11-198416","article-title":"Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala","volume":"26","author":"Stehberg","year":"2012","journal-title":"FASEB J"},{"issue":"37","key":"10.1016\/j.neurot.2025.e00523_bib68","doi-asserted-by":"crossref","first-page":"9064","DOI":"10.1523\/JNEUROSCI.2204-16.2017","article-title":"Contribution of astroglial Cx43 hemichannels to the modulation of glutamatergic currents by D-serine in the mouse prefrontal cortex","volume":"37","author":"Meunier","year":"2017","journal-title":"J\u00a0Neurosci"},{"issue":"34","key":"10.1016\/j.neurot.2025.e00523_bib69","doi-asserted-by":"crossref","first-page":"11228","DOI":"10.1523\/JNEUROSCI.0015-14.2014","article-title":"Astroglial Connexin43 hemichannels tune basal excitatory synaptic transmission","volume":"34","author":"Chever","year":"2014","journal-title":"J\u00a0Neurosci"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib70","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0959-4388(00)00223-3","article-title":"A\u00a0neuron-glia signalling network in the active brain","volume":"11","author":"Bezzi","year":"2001","journal-title":"Curr Opin Neurobiol"},{"issue":"9","key":"10.1016\/j.neurot.2025.e00523_bib71","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1073\/pnas.0809269106","article-title":"Radially expanding transglial calcium waves in the intact cerebellum","volume":"106","author":"Hoogland","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/physrev.00043.2018","article-title":"Glial connexins and pannexins in the healthy and diseased brain","volume":"101","author":"Giaume","year":"2021","journal-title":"Physiol Rev"},{"key":"10.1016\/j.neurot.2025.e00523_bib73","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fnint.2016.00026","article-title":"Role of astroglial hemichannels and pannexons in memory and neurodegenerative diseases","volume":"10","author":"Orellana","year":"2016","journal-title":"Front Integr Neurosci"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib74","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1085\/jgp.200509397","article-title":"Regulation of connexin hemichannels by monovalent cations","volume":"127","author":"Srinivas","year":"2006","journal-title":"J\u00a0Gen Physiol"},{"issue":"7","key":"10.1016\/j.neurot.2025.e00523_bib75","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/glia.22808","article-title":"Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers","volume":"63","author":"Rovegno","year":"2015","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib76","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.febslet.2005.12.004","article-title":"Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium","volume":"580","author":"Locovei","year":"2006","journal-title":"FEBS Lett"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib77","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/sj.emboj.7600908","article-title":"Intracellular calcium changes trigger connexin 32 hemichannel opening","volume":"25","author":"De Vuyst","year":"2006","journal-title":"EMBO J"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib78","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.3171\/foc.2007.22.5.6","article-title":"Tissue hyperosmolality and brain edema in cerebral contusion","volume":"22","author":"Kawamata","year":"2007","journal-title":"Neurosurg Focus"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib79","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/01.STR.8.1.51","article-title":"Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia","volume":"8","author":"Astrup","year":"1977","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc13916","article-title":"Higher brain extracellular potassium is associated with brain metabolic distress and poor outcome after aneurysmal subarachnoid hemorrhage","volume":"18","author":"Antunes","year":"2014","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib81","first-page":"289","article-title":"Brain oxygenation and energy metabolism: part I-biological function and pathophysiology","volume":"51","author":"Zauner","year":"2002","journal-title":"Neurosurgery"},{"issue":"2\u20133","key":"10.1016\/j.neurot.2025.e00523_bib82","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0022-510X(78)90124-7","article-title":"Ischaemic brain damage in fatal non-missile head injuries","volume":"39","author":"Graham","year":"1978","journal-title":"J\u00a0Neurol Sci"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib83","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2013.246","article-title":"Delayed neurological deterioration after subarachnoid haemorrhage","volume":"10","author":"Macdonald","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib84","first-page":"1","article-title":"Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a \u201ctwo-hit\u201d model","volume":"21","author":"Sekhon","year":"2017","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib85","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12028-008-9119-2","article-title":"Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity","volume":"9","author":"Abate","year":"2008","journal-title":"Neurocritical Care"},{"issue":"54","key":"10.1016\/j.neurot.2025.e00523_bib86","first-page":"1","article-title":"Lateral fluid percussion: model of traumatic brain injury in mice","volume":"22","author":"Alder","year":"2011","journal-title":"J\u00a0Vis Exp"},{"key":"10.1016\/j.neurot.2025.e00523_bib87","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-4939-2152-2_15","article-title":"In vitro oxygen-glucose deprivation to study ischemic cell death","volume":"1254","author":"Tasca","year":"2015","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.neurot.2025.e00523_bib88","doi-asserted-by":"crossref","first-page":"149306","DOI":"10.1016\/j.brainres.2024.149306","article-title":"Astrocytic Gap Junctions protein Cx43\/Cx30 modulate EAAT1 and glutamate to mediate cerebral ischemia\u2013reperfusion injury","volume":"1847","author":"Li","year":"2025","journal-title":"Brain Res"},{"issue":"8","key":"10.1016\/j.neurot.2025.e00523_bib89","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00702-014-1180-8","article-title":"Glutamate as a neurotransmitter in the healthy brain","volume":"121","author":"Zhou","year":"2014","journal-title":"J\u00a0Neural Transm"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib90","doi-asserted-by":"crossref","first-page":"a005710","DOI":"10.1101\/cshperspect.a005710","article-title":"NMDA receptor-dependent long-term potentiation and long-term depression (LTP\/LTD)","volume":"4","author":"L\u00fcscher","year":"2012","journal-title":"Cold Spring Harbor Perspect Biol"},{"issue":"7","key":"10.1016\/j.neurot.2025.e00523_bib91","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s10571-020-00924-0","article-title":"Building a bridge between NMDAR-mediated excitotoxicity and mitochondrial dysfunction in chronic and acute diseases","volume":"41","author":"Mira","year":"2021","journal-title":"Cell Mol Neurobiol."},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib92","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00424-004-1318-x","article-title":"Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy","volume":"449","author":"Allen","year":"2004","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib93","first-page":"507","article-title":"Factors affecting excitatory amino acid release following severe human head injury","volume":"89","author":"Bullock","year":"1998","journal-title":"J\u00a0Neurosurg"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib94","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/glia.20926","article-title":"Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels","volume":"58","author":"Orellana","year":"2010","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib95","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1046\/j.1471-4159.1997.69031060.x","article-title":"Transient ischemia differentially increases tyrosine phosphorylation of NMDA receptor subunits 2A and 2B","volume":"69","author":"Takagi","year":"1997","journal-title":"J\u00a0Neurochem"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib96","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2011.08390.x","article-title":"Dysregulated Src upregulation of NMDA receptor activity: a common link in chronic pain and schizophrenia","volume":"279","author":"Salter","year":"2012","journal-title":"FEBS J"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib98","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/nn.4236","article-title":"Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity","volume":"19","author":"Weilinger","year":"2016","journal-title":"Nat Neurosci"},{"issue":"17","key":"10.1016\/j.neurot.2025.e00523_bib99","doi-asserted-by":"crossref","first-page":"9503","DOI":"10.3390\/ijms22179503","article-title":"Astroglial hemichannels and pannexons: the hidden link between maternal inflammation and neurological disorders","volume":"22","author":"Prieto-Villalobos","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib100","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1523\/JNEUROSCI.2439-14.2015","article-title":"DAMP signaling is a key pathway inducing immune modulation after brain injury","volume":"35","author":"Liesz","year":"2015","journal-title":"J\u00a0Neurosci"},{"issue":"March","key":"10.1016\/j.neurot.2025.e00523_bib101","first-page":"1","article-title":"Neuroinflammation following traumatic brain injury: take it seriously or not","volume":"13","author":"Zheng","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.neurot.2025.e00523_bib102","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu Rev Immunol"},{"issue":"2\u20133","key":"10.1016\/j.neurot.2025.e00523_bib103","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000111560","article-title":"Opposing roles for reactive astrocytes following traumatic brain injury","volume":"16","author":"Laird","year":"2008","journal-title":"Neurosignals"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib104","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12975-018-0614-2","article-title":"Interleukin 6-mediated endothelial barrier disturbances can Be attenuated by blockade of the IL6 receptor expressed in brain microvascular endothelial cells","volume":"9","author":"Blecharz-Lang","year":"2018","journal-title":"Transl Stroke Res"},{"issue":"1\u20132","key":"10.1016\/j.neurot.2025.e00523_bib105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0165-5728(97)00057-X","article-title":"The induction of ICAM-1 in human cerebromicrovascular endothelial cells (HCEC) by ischemia-like conditions promotes enhanced neutrophil\/HCEC adhesion","volume":"76","author":"Stanimirovic","year":"1997","journal-title":"J\u00a0Neuroimmunol"},{"issue":"1\u20132","key":"10.1016\/j.neurot.2025.e00523_bib106","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-5728(98)00270-7","article-title":"TNF\u03b1 and IL-1\u03b2 mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury","volume":"95","author":"Kyrkanides","year":"1999","journal-title":"J\u00a0Neuroimmunol"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib107","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1742-2094-8-41","article-title":"Increased expression of the chemokines CXCL1 and MIP-1\u03b1 by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats","volume":"8","author":"Johnson","year":"2011","journal-title":"J\u00a0Neuroinflammation"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib108","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/jcbfm.2009.240","article-title":"Role of chemokines in CNS health and pathology: a focus on the CCL2\/CCR2 and CXCL8\/CXCR2 networks","volume":"30","author":"Semple","year":"2010","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"22","key":"10.1016\/j.neurot.2025.e00523_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.aax8847","article-title":"Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury","volume":"6","author":"Vaibhav","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.neurot.2025.e00523_bib110","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainres.2015.03.026","article-title":"Interaction of astrocytes and T cells in physiological and pathological conditions","volume":"1623","author":"Xie","year":"2015","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib111","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12974-019-1550-0","article-title":"Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-\u03b3 gene expression in acute experimental traumatic brain injury","volume":"16","author":"Kr\u00e4mer","year":"2019","journal-title":"J\u00a0Neuroinflammation"},{"issue":"18","key":"10.1016\/j.neurot.2025.e00523_bib112","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1523\/JNEUROSCI.3233-16.2017","article-title":"ST2\/IL-33-Dependent microglial response limits acute ischemic brain injury","volume":"37","author":"Yang","year":"2017","journal-title":"J\u00a0Neurosci"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib113","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.immuni.2016.04.024","article-title":"Making ends meet: myeloid cells catalyze blood vessel repair in the brain","volume":"44","author":"Deczkowska","year":"2016","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib114","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mcn.2010.05.007","article-title":"Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective","volume":"45","author":"Froger","year":"2010","journal-title":"Mol Cell Neurosci"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib115","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3390\/biomedicines10061445","article-title":"Connexins, pannexins and gap junctions in perinatal brain injury","volume":"10","author":"McDouall","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.neurot.2025.e00523_bib162","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuroscience.2015.03.002","article-title":"Astrocyte sodium signaling and neuro-metabolic coupling in the brain","volume":"323","author":"Rose","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.neurot.2025.e00523_bib194","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neubiorev.2017.03.002","article-title":"Astrocytic modulation of neuronal excitability through K+spatial buffering","volume":"77","author":"Bellot-Saez","year":"2017","journal-title":"Neurosci Biobehav Rev"},{"issue":"S1","key":"10.1016\/j.neurot.2025.e00523_bib195","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12860-016-0120-x","article-title":"Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease","volume":"18","author":"Belousov","year":"2017","journal-title":"BMC Cell Biol"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib128","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2008.04.021","article-title":"Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition","volume":"45","author":"Hansson","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"April","key":"10.1016\/j.neurot.2025.e00523_bib196","first-page":"1","article-title":"Connexin-mediated functional and metabolic coupling between astrocytes and neurons","volume":"11","author":"Mayorquin","year":"2018","journal-title":"Front Mol Neurosci"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib197","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1523\/JNEUROSCI.3902-05.2006","article-title":"P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling","volume":"26","author":"Suadicani","year":"2006","journal-title":"J\u00a0Neurosci"},{"issue":"7","key":"10.1016\/j.neurot.2025.e00523_bib198","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/glia.20649","article-title":"Mechanisms of ATP- and glutamate-mediated calcium signaling in white matter astrocytes","volume":"56","author":"Hamilton","year":"2008","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib199","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3390\/ijms21020485","article-title":"Calmodulin-mediated regulation of gap junction channels","volume":"21","author":"Peracchia","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib200","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ceca.2009.07.002","article-title":"Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cells","volume":"46","author":"De Vuyst","year":"2009","journal-title":"Cell Calcium"},{"issue":"1\u20133","key":"10.1016\/j.neurot.2025.e00523_bib201","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.febslet.2004.07.009","article-title":"Pannexin membrane channels are mechanosensitive conduits for ATP","volume":"572","author":"Bao","year":"2004","journal-title":"FEBS Lett"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib202","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/jnc.15004","article-title":"Pannexin-1 in the CNS: emerging concepts in health and disease","volume":"154","author":"Yeung","year":"2020","journal-title":"J\u00a0Neurochem"},{"issue":"April","key":"10.1016\/j.neurot.2025.e00523_bib116","doi-asserted-by":"crossref","first-page":"113307","DOI":"10.1016\/j.expneurol.2020.113307","article-title":"Mitochondrial damage & lipid signaling in traumatic brain injury","volume":"329","author":"Lamade","year":"2020","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neurot.2025.e00523_bib117","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-981-10-4567-7_4","article-title":"Endoplasmic reticulum-mitochondria communication through Ca2+ signaling: the importance of mitochondria-associated membranes (MAMs)","volume":"997","author":"Marchi","year":"2017","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib118","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1016\/S0021-9258(19)67802-6","article-title":"The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A","volume":"266","author":"Szab\u00f3","year":"1991","journal-title":"J\u00a0Biol Chem"},{"issue":"10","key":"10.1016\/j.neurot.2025.e00523_bib120","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/01.STR.0000182239.75969.d8","article-title":"Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia","volume":"36","author":"de Pina-Benabou","year":"2005","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib121","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.22654","article-title":"Connexin hemichannel blockade improves outcomes in a model of fetal ischemia","volume":"71","author":"Davidson","year":"2012","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib122","doi-asserted-by":"crossref","first-page":"C707","DOI":"10.1152\/ajpcell.00061.2010","article-title":"Calcium-induced permeability transition in rat brain mitochondria is promoted by carbenoxolone through targeting connexin43","volume":"300","author":"Azarashvili","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib123","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1111\/jcmm.12792","article-title":"New protein\u2013protein interactions of mitochondrial connexin 43 in mouse heart","volume":"20","author":"Denuc","year":"2016","journal-title":"J\u00a0Cell Mol Med"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib204","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cardiores.2005.04.014","article-title":"Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning","volume":"67","author":"Boengler","year":"2005","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib124","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3390\/ijms17050679","article-title":"Mechanism of mitochondrial Connexin43\u2019s protection of the neurovascular unit under acute cerebral ischemia-reperfusion injury","volume":"17","author":"Hou","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"21","key":"10.1016\/j.neurot.2025.e00523_bib125","doi-asserted-by":"crossref","first-page":"13000","DOI":"10.3390\/ijms232113000","article-title":"Oxidative stress in traumatic brain injury","volume":"23","author":"Fesharaki-Zadeh","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.neurot.2025.e00523_bib126","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1089\/ars.2012.4981","article-title":"Traumatic brain injury: oxidative stress and neuroprotection","volume":"19","author":"Cornelius","year":"2013","journal-title":"Antioxidants Redox Signal"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib127","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00018-003-3319-x","article-title":"Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury","volume":"61","author":"Arundine","year":"2004","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib129","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/cvr\/cvv044","article-title":"Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria","volume":"106","author":"Sun","year":"2015","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00395-017-0618-1","article-title":"Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart","volume":"112","author":"Gadicherla","year":"2017","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib131","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1007\/s001340050625","article-title":"Mortality of space-occupying (\u2019malignant\u2019) middle cerebral artery infarction under conservative intensive care","volume":"24","author":"Berrouschot","year":"1998","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005072-196701000-00001","article-title":"Presidental address. Neuropathological aspects of brain edema","volume":"26","author":"Klatzo","year":"1967","journal-title":"J\u00a0Neuropathol Exp Neurol"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib133","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S1474-4422(07)70055-8","article-title":"Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications","volume":"6","author":"Simard","year":"2007","journal-title":"Lancet Neurol"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib134","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1054\/jocn.2001.1031","article-title":"Ischaemic brain oedema","volume":"9","author":"Ayata","year":"2002","journal-title":"J\u00a0Clin Neurosci"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib135","first-page":"720","article-title":"Predominance of cellular edema in traumatic brain swelling in patients with severe head injuries","volume":"104","author":"Marmarou","year":"2006","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.neurot.2025.e00523_bib136","first-page":"289","article-title":"Pathogenesis of the mass effect of cerebral contusions: rapid increase in osmolality within the contusion necrosis","volume":"71","author":"Katayama","year":"1998","journal-title":"Acta Neurochir Suppl"},{"issue":"August 2018","key":"10.1016\/j.neurot.2025.e00523_bib137","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuropharm.2018.08.004","article-title":"Pathophysiology and treatment of cerebral edema in traumatic brain injury","volume":"145","author":"Jha","year":"2019","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib138","first-page":"1","article-title":"Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence","volume":"5","author":"Lyden","year":"1993","journal-title":"Cerebrovasc Brain Metab Rev"},{"issue":"10","key":"10.1016\/j.neurot.2025.e00523_bib139","doi-asserted-by":"crossref","first-page":"113128","DOI":"10.1016\/j.celrep.2023.113128","article-title":"Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts","volume":"42","author":"Weilinger","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.neurot.2025.e00523_bib140","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.sbi.2015.08.004","article-title":"Structural insights into aquaporin selectivity and regulation","volume":"33","author":"Kreida","year":"2015","journal-title":"Curr Opin Struct Biol"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib141","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1523\/JNEUROSCI.17-01-00171.1997","article-title":"Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain","volume":"17","author":"Nielsen","year":"1997","journal-title":"J\u00a0Neurosci"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib142","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","article-title":"Spreading depression of activity in the cerebral cortex","volume":"7","author":"Leao","year":"1944","journal-title":"J\u00a0Neurophysiol"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib143","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1152\/jn.1975.38.4.822","article-title":"Neuronal and glial activity during spreading depression in cerebral cortex of cat","volume":"38","author":"Sugaya","year":"1975","journal-title":"J\u00a0Neurophysiol"},{"issue":"11","key":"10.1016\/j.neurot.2025.e00523_bib144","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/0306-4522(78)90122-7","article-title":"Extracellular ionic variations during spreading depression","volume":"3","author":"Kraig","year":"1978","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib145","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrn3770","article-title":"Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations","volume":"15","author":"Pietrobon","year":"2014","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib146","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm.2333","article-title":"The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease","volume":"17","author":"Dreier","year":"2011","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib147","doi-asserted-by":"crossref","first-page":"109794","DOI":"10.1016\/j.celrep.2021.109794","article-title":"Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury","volume":"37","author":"Zhao","year":"2021","journal-title":"Cell Rep"},{"issue":"Pt 11","key":"10.1016\/j.neurot.2025.e00523_bib148","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1093\/brain\/awu241","article-title":"Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma","volume":"137","author":"Hinzman","year":"2014","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.neurot.2025.e00523_bib149","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/jcbfm.2010.17","article-title":"Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study","volume":"30","author":"Feuerstein","year":"2010","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib150","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/jamaneurol.2019.4476","article-title":"Prognostic value of spreading depolarizations in patients with severe traumatic brain injury","volume":"77","author":"Hartings","year":"2020","journal-title":"JAMA Neurol"},{"issue":"8","key":"10.1016\/j.neurot.2025.e00523_bib151","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1093\/brain\/aws152","article-title":"Effect of analgesics and sedatives on the occurrence of spreading depolarizations accompanying acute brain injury","volume":"135","author":"Hertle","year":"2012","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.neurot.2025.e00523_bib152","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/jcbfm.2009.73","article-title":"Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex","volume":"29","author":"Piilgaard","year":"2009","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"8","key":"10.1016\/j.neurot.2025.e00523_bib153","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/sj.jcbfm.9600252","article-title":"Vasoconstrictive neurovascular coupling during focal ischemic depolarizations","volume":"26","author":"Shin","year":"2006","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib154","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0014-4886(87)90095-1","article-title":"Potassium translocation and spreading depression induced by electrical stimulation of the brain","volume":"97","author":"Reid","year":"1987","journal-title":"Exp Neurol"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib155","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1152\/jn.2000.83.3.1338","article-title":"Extracellular pH changes and accompanying cation shifts during ouabain-induced spreading depression","volume":"83","author":"Menna","year":"2000","journal-title":"J\u00a0Neurophysiol"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib156","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.neuron.2020.11.018","article-title":"Non-canonical glutamate signaling in a genetic model of migraine with aura","volume":"109","author":"Parker","year":"2021","journal-title":"Neuron"},{"issue":"20","key":"10.1016\/j.neurot.2025.e00523_bib157","doi-asserted-by":"crossref","first-page":"13284","DOI":"10.1073\/pnas.192242399","article-title":"Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons","volume":"99","author":"Tottene","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib158","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s10194-023-01643-9","article-title":"Mechanisms\u00a0of\u00a0initiation of cortical spreading depression","volume":"24","author":"Vitale","year":"2023","journal-title":"J\u00a0Headache Pain"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib159","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/00004647-200002000-00024","article-title":"Glutamate does not mediate acute neuronal damage after spreading depression induced by O2\/glucose deprivation in the hippocampal slice","volume":"20","author":"Obeidat","year":"2000","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib160","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nn1902","article-title":"Cortical spreading depression causes and coincides with tissue hypoxia","volume":"10","author":"Takano","year":"2007","journal-title":"Nat Neurosci"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib161","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate","volume":"16","author":"Rothstein","year":"1996","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib163","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0304-3940(92)90502-X","article-title":"Coordination of ATP production and consumption in brain: parallel regulation of cytochrome oxidase and Na+, K(+)-ATPase","volume":"138","author":"Hevner","year":"1992","journal-title":"Neurosci Lett"},{"issue":"9","key":"10.1016\/j.neurot.2025.e00523_bib164","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/iub.98","article-title":"Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia","volume":"60","author":"Grewer","year":"2008","journal-title":"IUBMB Life"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib165","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/sj.jcbfm.9600050","article-title":"Transient changes in cortical glucose and lactate levels associated with peri-infarct depolarisations, studied with rapid-sampling microdialysis","volume":"25","author":"Hopwood","year":"2005","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"7","key":"10.1016\/j.neurot.2025.e00523_bib166","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/jcbfm.2008.30","article-title":"Role of cortical spreading depressions for secondary brain damage after traumatic brain injury in mice","volume":"28","author":"von Baumgarten","year":"2008","journal-title":"J\u00a0Cerebr Blood Flow Metabol"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib167","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1152\/jn.00231.2001","article-title":"Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices","volume":"87","author":"Fayuk","year":"2002","journal-title":"J\u00a0Neurophysiol"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib168","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1089\/neu.2005.22.277","article-title":"Spreading depression expands traumatic injury in neocortical brain slices","volume":"22","author":"Church","year":"2005","journal-title":"J\u00a0Neurotrauma"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib169","first-page":"1311","article-title":"Mechanisms of neuronal silencing after cortical spreading depression","volume":"27","author":"Sawant-Pokam","year":"2017","journal-title":"Cerebr Cortex"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib170","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/j.1460-9568.2006.04643.x","article-title":"Effect of cortical spreading depression on synaptic transmission of rat hippocampal tissues","volume":"23","author":"Wernsmann","year":"2006","journal-title":"Eur J Neurosci"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib171","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/1073858412463168","article-title":"Functional connectivity in the normal and injured brain","volume":"19","author":"Gillebert","year":"2013","journal-title":"Neuroscientist"},{"issue":"3","key":"10.1016\/j.neurot.2025.e00523_bib172","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1152\/physrev.2001.81.3.1065","article-title":"Mechanisms of spreading depression and hypoxic spreading depression-like depolarization","volume":"81","author":"Somjen","year":"2001","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.neurot.2025.e00523_bib173","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1152\/jn.2000.84.4.1869","article-title":"Na(+) dependence and the role of glutamate receptors and Na(+) channels in ion fluxes during hypoxia of rat hippocampal slices","volume":"84","author":"M\u00fcller","year":"2000","journal-title":"J\u00a0Neurophysiol"},{"issue":"12","key":"10.1016\/j.neurot.2025.e00523_bib174","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1097\/00001756-199908200-00039","article-title":"Effects of ionotropic glutamate receptor blockade and 5-HT1A receptor activation on spreading depression in rat neocortical slices","volume":"10","author":"Kr\u00fcger","year":"1999","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib175","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0006-8993(88)90690-7","article-title":"Evidence for a role of the N-methyl-D-aspartate (NMDA) receptor in cortical spreading depression in the rat","volume":"457","author":"Marrannes","year":"1988","journal-title":"Brain Res"},{"issue":"6","key":"10.1016\/j.neurot.2025.e00523_bib176","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/01.STR.0000166023.51307.e0","article-title":"Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia","volume":"36","author":"Petzold","year":"2005","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib177","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1152\/jn.1995.73.5.2107","article-title":"High extracellular potassium, and not extracellular glutamate, is required for the propagation of spreading depression","volume":"73","author":"Obrenovitch","year":"1995","journal-title":"J\u00a0Neurophysiol"},{"issue":"2","key":"10.1016\/j.neurot.2025.e00523_bib178","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neucli.2021.01.004","article-title":"Cortical spreading depolarization and ketamine: a short systematic review","volume":"51","author":"Telles","year":"2021","journal-title":"Neurophysiol Clin"},{"issue":"1","key":"10.1016\/j.neurot.2025.e00523_bib179","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-019-2711-3","article-title":"Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study","volume":"23","author":"Santos","year":"2019","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.neurot.2025.e00523_bib180","first-page":"1513","article-title":"Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial","volume":"130","author":"Carlson","year":"2019","journal-title":"J\u00a0Neurosurg"},{"issue":"Suppl 1","key":"10.1016\/j.neurot.2025.e00523_bib181","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12028-017-0451-2","article-title":"Emergency neurological life support: airway, ventilation, and sedation","volume":"27","author":"Rajajee","year":"2017","journal-title":"Neurocritical Care"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747925000017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747925000017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T05:54:22Z","timestamp":1740635662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747925000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":203,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1878747925000017"],"URL":"https:\/\/doi.org\/10.1016\/j.neurot.2025.e00523","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of astrocytes connexins - pannexins in acute brain injury","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurot.2025.e00523","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics.","name":"copyright","label":"Copyright"}],"article-number":"e00523"}}