{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T08:40:24Z","timestamp":1794472824934,"version":"4.9.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.neurot.2026.e00883","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:59:26Z","timestamp":1773320366000},"page":"e00883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diabetes mellitus and efficacy of dual antiplatelet in acute ischemic stroke: A post hoc analysis of the ATAMIS trial"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-9435","authenticated-orcid":false,"given":"Xiao-Wen","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ting","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-1992","authenticated-orcid":false,"given":"Hui-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurot.2026.e00883_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1560045","article-title":"Safety and efficacy of add-on intra-arterial thrombolysis after intravenous thrombolysis and mechanical thrombectomy in patients with ischemic stroke and cerebral vessel occlusion","volume":"16","author":"Diel","year":"2025","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.neurot.2026.e00883_bib2","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jacasi.2024.12.010","article-title":"Outcomes of time to treatment with reteplase for acute ischemic stroke: the RAISE trial subgroup","volume":"5","author":"Wang","year":"2025","journal-title":"JACC Asia"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00883_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1215340","article-title":"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack","volume":"369","author":"Wang","year":"2013","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.neurot.2026.e00883_bib4","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1056\/NEJMoa1800410","article-title":"Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA","volume":"379","author":"Johnston","year":"2018","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.neurot.2026.e00883_bib5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/jamaneurol.2024.0146","article-title":"Clopidogrel plus aspirin vs aspirin alone in patients with acute mild to moderate stroke: the ATAMIS randomized clinical trial","volume":"81","author":"Chen","year":"2024","journal-title":"JAMA Neurol"},{"issue":"4","key":"10.1016\/j.neurot.2026.e00883_bib6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.amjms.2016.01.011","article-title":"Diabetes and stroke: epidemiology, pathophysiology, pharmaceuticals and outcomes","volume":"351","author":"Chen","year":"2016","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.neurot.2026.e00883_bib7","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.2147\/DMSO.S513652","article-title":"Effect of insulin resistance on prognosis of intravenous thrombolysis in acute ischemic stroke patients with or without type 2 diabetes mellitus","volume":"18","author":"Sun","year":"2025","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"3","key":"10.1016\/j.neurot.2026.e00883_bib8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.jcbfm.9600355","article-title":"Hyperglycemia in acute ischemic stroke: a vascular perspective","volume":"27","author":"Martini","year":"2007","journal-title":"J Cerebr Blood Flow Metabol"},{"issue":"3","key":"10.1016\/j.neurot.2026.e00883_bib9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1474-4422(12)70005-4","article-title":"Diabetes, hyperglycaemia, and acute ischaemic stroke","volume":"11","author":"Luitse","year":"2012","journal-title":"Lancet Neurol"},{"issue":"6","key":"10.1016\/j.neurot.2026.e00883_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005446","article-title":"Recurrent stroke in minor ischemic stroke or transient ischemic attack with metabolic syndrome and\/or diabetes mellitus","volume":"6","author":"Chen","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"10.1016\/j.neurot.2026.e00883_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/svn-2018-000148","article-title":"Antiplatelet therapy in acute mild-moderate ischemic Stroke (ATAMIS): a parallel, randomised, open-label, multicentre, prospective study","volume":"3","author":"Hou","year":"2018","journal-title":"Stroke Vasc Neurol"},{"issue":"10","key":"10.1016\/j.neurot.2026.e00883_bib12","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1007\/s00415-018-8998-1","article-title":"Aspirin plus clopidogrel may reduce the risk of early neurologic deterioration in ischemic stroke patients carrying CYP2C19\u22172 reduced- function alleles","volume":"265","author":"Yi","year":"2018","journal-title":"J Neurol"},{"issue":"7","key":"10.1016\/j.neurot.2026.e00883_bib13","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1161\/STR.0b013e318296aeca","article-title":"An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American heart association\/american stroke association","volume":"44","author":"Sacco","year":"2013","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00883_bib14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of org 10172 in acute stroke treatment","volume":"24","author":"Adams","year":"1993","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00883_bib15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s12035-025-05557-2","article-title":"Impact of diabetes on oxidative stress, mitochondrial function, and neurological outcomes following ischemic stroke: a sex-based experimental analysis","volume":"63","author":"Machado","year":"2025","journal-title":"Mol Neurobiol"},{"issue":"3","key":"10.1016\/j.neurot.2026.e00883_bib16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.23736\/S0392-9590.24.05260-X","article-title":"Specificities of primary and secondary prevention of lower extremity artery disease in patients with diabetes mellitus","volume":"43","author":"Stanek","year":"2024","journal-title":"Int Angiol"},{"key":"10.1016\/j.neurot.2026.e00883_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.712024","article-title":"Impact of diabetes on platelet function in acute ischemic stroke patients taking dual antiplatelet therapy","volume":"12","author":"Guo","year":"2021","journal-title":"Front Neurol"},{"issue":"10","key":"10.1016\/j.neurot.2026.e00883_bib18","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1161\/STROKEAHA.111.621649","article-title":"Diabetes and poor outcomes within 6 months after acute ischemic stroke: the China national stroke registry","volume":"42","author":"Jia","year":"2011","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.neurot.2026.e00883_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.17219\/acem\/146273","article-title":"Impact of diabetes on clinical and safety outcomes in acute ischemic stroke patients receiving reperfusion therapy: a meta-analysis","volume":"31","author":"Bradley","year":"2022","journal-title":"Adv Clin Exp Med"},{"issue":"7","key":"10.1016\/j.neurot.2026.e00883_bib20","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1161\/CIRCULATIONAHA.109.913376","article-title":"Diabetes and antiplatelet therapy in acute coronary syndrome","volume":"123","author":"Ferreiro","year":"2011","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.neurot.2026.e00883_bib21","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.2337\/diabetes.54.8.2430","article-title":"Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment","volume":"54","author":"Angiolillo","year":"2005","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00883_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/dmd.109.029132","article-title":"Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite","volume":"38","author":"Kazui","year":"2010","journal-title":"Drug Metab Dispos"},{"issue":"1 Suppl","key":"10.1016\/j.neurot.2026.e00883_bib23","doi-asserted-by":"crossref","first-page":"39S","DOI":"10.1378\/chest.119.1_suppl.39S","article-title":"Platelet-active drugs: the relationships among dose, effectiveness, and side effects","volume":"119","author":"Patrono","year":"2001","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00883_bib24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s40120-025-00866-z","article-title":"Elevated blood alcohol concentration at stroke onset predicts poor clinical outcomes and mortality after intracerebral hemorrhage: a retrospective cohort study","volume":"15","author":"\u00c1roksz\u00e1ll\u00e1si","year":"2026","journal-title":"Neurol Ther"},{"issue":"11","key":"10.1016\/j.neurot.2026.e00883_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2025.108438","article-title":"Exploring the efficacy and safety of dual antiplatelet therapy in patients with embolic stroke of undetermined source according to stroke risk stratification: propensity-score matched analysis","volume":"34","author":"Kim","year":"2025","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"11","key":"10.1016\/j.neurot.2026.e00883_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/jch.70187","article-title":"Blood pressure variability and 90-day functional outcome in branch atheromatous disease-related stroke: a multicenter prospective study","volume":"27","author":"Zhou","year":"2025","journal-title":"J Clin Hypertens"},{"issue":"10363","key":"10.1016\/j.neurot.2026.e00883_bib27","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/S0140-6736(22)01882-7","article-title":"Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2\/MT): a multicentre, open-label, binded-endpoint, randomised controlled trial","volume":"400","author":"Yang","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00883_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.21037\/atm.2019.12.36","article-title":"Association between neurological deterioration and outcomes in patients with stroke","volume":"8","author":"Liu","year":"2020","journal-title":"Ann Transl Med"},{"issue":"2","key":"10.1016\/j.neurot.2026.e00883_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.5853\/jos.2016.00073","article-title":"Early neurologic deterioration after stroke depends on vascular territory and stroke etiology","volume":"18","author":"Siegler","year":"2016","journal-title":"J Stroke"},{"issue":"9733","key":"10.1016\/j.neurot.2026.e00883_bib30","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/S0140-6736(10)60484-9","article-title":"Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies","volume":"375","author":"Emerging Risk Factors Collaboration","year":"2010","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.neurot.2026.e00883_bib31","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1212\/WNL.0000000000003031","article-title":"Association between diabetes mellitus and the occurrence and outcome of intracerebral hemorrhage","volume":"87","author":"Boulanger","year":"2016","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.neurot.2026.e00883_bib32","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1001\/jamaneurol.2019.0932","article-title":"Risk for major hemorrhages in patients receiving clopidogrel and aspirin compared with aspirin alone after transient ischemic attack or minor ischemic stroke: a secondary analysis of the POINT randomized clinical trial","volume":"76","author":"Tillman","year":"2019","journal-title":"JAMA Neurol"},{"issue":"8","key":"10.1016\/j.neurot.2026.e00883_bib33","article-title":"Efficacy and safety of adding clopidogrel to aspirin on stroke prevention among high vascular risk patients: a meta-analysis of randomized controlled trials","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792600053X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187874792600053X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:05:46Z","timestamp":1781640346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187874792600053X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S187874792600053X"],"URL":"https:\/\/doi.org\/10.1016\/j.neurot.2026.e00883","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes mellitus and efficacy of dual antiplatelet in acute ischemic stroke: A post hoc analysis of the ATAMIS trial","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurot.2026.e00883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics.","name":"copyright","label":"Copyright"}],"article-number":"e00883"}}