{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:31:44Z","timestamp":1792809104312,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["1R21TR003941-01"],"award-info":[{"award-number":["1R21TR003941-01"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.neurot.2026.e00890","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T21:49:01Z","timestamp":1775598541000},"page":"e00890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nervonic acid supplementation mitigates disease severity biomarkers in adrenoleukodystrophy"],"prefix":"10.1016","volume":"23","author":[{"given":"Chenxu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Braaten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann B.","family":"Moser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wedad","family":"Fallatah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie","family":"Lorentson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzette","family":"Huguenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Torrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia R.","family":"Terluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willa","family":"Durose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Staley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subbaya","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troy C.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena V.","family":"Kartha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neurot.2026.e00890_bib1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/humu.1227","article-title":"ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: role in diagnosis and clinical correlations","volume":"18","author":"Kemp","year":"2001","journal-title":"Hum Mutat"},{"key":"10.1016\/j.neurot.2026.e00890_bib2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/jdn.10003","article-title":"X-linked adrenoleukodystrophy: pathology, pathophysiology, diagnostic testing, newborn screening and therapies","volume":"80","author":"Turk","year":"2020","journal-title":"Int J Dev Neurosci Off J Int Soc Dev Neurosci"},{"key":"10.1016\/j.neurot.2026.e00890_bib3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13023-024-03105-0","article-title":"The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology","volume":"19","author":"Yska","year":"2024","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.neurot.2026.e00890_bib4","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.bbadis.2012.02.005","article-title":"Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases?","volume":"1822","author":"Galea","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neurot.2026.e00890_bib5","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1093\/hmg\/ddn066","article-title":"Toxic effects of X-linked adrenoleukodystrophy-associated, very long chain fatty acids on glial cells and neurons from rat hippocampus in culture","volume":"17","author":"Hein","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurot.2026.e00890_bib6","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1750-3639.2010.00392.x","article-title":"Pathomechanisms underlying X-adrenoleukodystrophy: a three-hit hypothesis","volume":"20","author":"Singh","year":"2010","journal-title":"Brain Pathol Zurich Switz"},{"key":"10.1016\/j.neurot.2026.e00890_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1750-1172-7-51","article-title":"X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management","volume":"7","author":"Engelen","year":"2012","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.neurot.2026.e00890_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13023-019-1008-6","article-title":"Disease progression in women with X-linked adrenoleukodystrophy is slow","volume":"14","author":"Huffnagel","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.neurot.2026.e00890_bib9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/1531-8249(20010201)49:2<186::AID-ANA38>3.0.CO;2-R","article-title":"Evolution of phenotypes in adult male patients with X-linked adrenoleukodystrophy","volume":"49","author":"van Geel","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurot.2026.e00890_bib10","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/14712598.2022.2124857","article-title":"Treatment of cerebral adrenoleukodystrophy: allogeneic transplantation and lentiviral gene therapy","volume":"22","author":"Gupta","year":"2022","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.neurot.2026.e00890_bib11","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1182\/bloodadvances.2021005294","article-title":"Variables affecting outcomes after allogeneic hematopoietic stem cell transplant for cerebral adrenoleukodystrophy","volume":"6","author":"Chiesa","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.neurot.2026.e00890_bib12","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJMoa2400442","article-title":"Lentiviral gene therapy for cerebral adrenoleukodystrophy","volume":"391","author":"Eichler","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurot.2026.e00890_bib13","first-page":"1007","article-title":"Nervonic acid attenuates accumulation of very long-chain fatty acids and is a potential therapy for adrenoleukodystrophy","volume":"19","author":"Terluk","year":"2022","journal-title":"Neurother J Am Soc Exp Neurother"},{"key":"10.1016\/j.neurot.2026.e00890_bib14","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1111\/bph.70044","article-title":"Nervonic acid, a long chain monounsaturated fatty acid, improves mitochondrial function in adrenomyeloneuropathy fibroblasts","volume":"182","author":"Li","year":"2025","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.neurot.2026.e00890_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115411","article-title":"Integrated metabolomics and transcriptomics reveal the neuroprotective effect of nervonic acid on LPS-induced AD model mice","volume":"209","author":"Wang","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neurot.2026.e00890_bib16","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1002\/fsn3.3533","article-title":"Nervonic acid reduces the cognitive and neurological disturbances induced by combined doses of D-galactose\/AlCl3 in mice","volume":"11","author":"Aihaiti","year":"2023","journal-title":"Food Sci Nutr"},{"key":"10.1016\/j.neurot.2026.e00890_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150696","article-title":"Nervonic acid improves depression like behaviors and demyelination of medial prefrontal cortex in chronic restraint stress mice","volume":"733","author":"Ma","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neurot.2026.e00890_bib18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.14715\/cmb\/2024.70.4.16","article-title":"Nervonic acid alleviates MPTP-induced Parkinson's disease via MEK\/ERK pathway","volume":"70","author":"Zhang","year":"2024","journal-title":"Cell Mol Biol Noisy--Gd Fr"},{"key":"10.1016\/j.neurot.2026.e00890_bib19","doi-asserted-by":"crossref","first-page":"9366","DOI":"10.1073\/pnas.94.17.9366","article-title":"A mouse model for X-linked adrenoleukodystrophy","volume":"94","author":"Lu","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.neurot.2026.e00890_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1417981","article-title":"Microbiota gut-brain axis: implications for pediatric-onset leukodystrophies","volume":"11","author":"Vaia","year":"2024","journal-title":"Front Nutr"},{"key":"10.1016\/j.neurot.2026.e00890_bib21","first-page":"67","article-title":"Effect of Lorenzo's oil on hepatic gene expression and the serum fatty acid level in abcd1-Deficient mice","volume":"38","author":"Morita","year":"2017","journal-title":"JIMD Rep"},{"key":"10.1016\/j.neurot.2026.e00890_bib22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neurot.2026.e00890_bib23","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/mgme.2001.3170","article-title":"Quantitative determination of plasma c8-c26 total fatty acids for the biochemical diagnosis of nutritional and metabolic disorders","volume":"73","author":"Lagerstedt","year":"2001","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurot.2026.e00890_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ymgme.2006.05.001","article-title":"Combined liquid chromatography-tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: preliminary findings","volume":"89","author":"Hubbard","year":"2006","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurot.2026.e00890_bib25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ymgme.2009.03.010","article-title":"Newborn screening for X-linked adrenoleukodystrophy (X-ALD): validation of a combined liquid chromatography-tandem mass spectrometric (LC-MS\/MS) method","volume":"97","author":"Hubbard","year":"2009","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.neurot.2026.e00890_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154597","article-title":"C26:0-Carnitine is a new biomarker for X-Linked adrenoleukodystrophy in mice and man","volume":"11","author":"van de Beek","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.neurot.2026.e00890_bib27","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.neurot.2026.e00890_bib28","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s40168-018-0549-6","article-title":"Predicting recurrence of Clostridium difficile infection following encapsulated fecal microbiota transplantation","volume":"6","author":"Staley","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.neurot.2026.e00890_bib29","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1093\/nar\/gkm864","article-title":"SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB","volume":"35","author":"Pruesse","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neurot.2026.e00890_bib30","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"Edgar","year":"2011","journal-title":"Bioinforma Oxf Engl"},{"key":"10.1016\/j.neurot.2026.e00890_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/mSphereDirect.00073-17","article-title":"OptiClust, an improved method for assigning amplicon-based sequence data to operational taxonomic units","volume":"2","author":"Westcott","year":"2017","journal-title":"mSphere"},{"key":"10.1016\/j.neurot.2026.e00890_bib32","doi-asserted-by":"crossref","first-page":"D141","DOI":"10.1093\/nar\/gkn879","article-title":"The ribosomal database project: improved alignments and new tools for rRNA analysis","volume":"37","author":"Cole","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neurot.2026.e00890_bib33","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.neurot.2026.e00890_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1442-9993.1993.tb00438.x","article-title":"Non-parametric multivariate analyses of changes in community structure","volume":"18","author":"Clarke","year":"1993","journal-title":"Aust J Ecol"},{"key":"10.1016\/j.neurot.2026.e00890_bib35","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3389\/fmicb.2018.00785","article-title":"SplinectomeR enables group comparisons in longitudinal microbiome studies","volume":"9","author":"Shields-Cutler","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.neurot.2026.e00890_bib36","unstructured":"Body weight info - B6J (000664) | The Jackson Laboratory. https:\/\/www.jax.org\/jax-mice-and-services\/strain-data-sheet-pages\/body-weight-chart-000664 (accessed 27 November 2025)."},{"key":"10.1016\/j.neurot.2026.e00890_bib37","doi-asserted-by":"crossref","first-page":"e1306","DOI":"10.1210\/clinem\/dgad286","article-title":"Early detection of adrenal insufficiency: the impact of newborn screening for adrenoleukodystrophy","volume":"108","author":"Ramirez Alcantara","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.neurot.2026.e00890_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/acn3.70314","article-title":"Clinically relevant outcome measures in women with adrenoleukodystrophy","author":"Yan","year":"2026","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.neurot.2026.e00890_bib39","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S1474-4422(07)70177-1","article-title":"Survival analysis of haematopoietic cell transplantation for childhood cerebral X-linked adrenoleukodystrophy: a comparison study","volume":"6","author":"Mahmood","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurot.2026.e00890_bib40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1212\/WNL.36.3.357","article-title":"Adrenoleukodystrophy: oleic acid lowers fibroblast saturated C22-26 fatty acids","volume":"36","author":"Rizzo","year":"1986","journal-title":"Neurology"},{"key":"10.1016\/j.neurot.2026.e00890_bib41","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1212\/WNL.39.11.1415","article-title":"Dietary erucic acid therapy for X-linked adrenoleukodystrophy","volume":"39","author":"Rizzo","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.neurot.2026.e00890_bib42","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/bcp.12897","article-title":"A model-based approach to assess the exposure-response relationship of Lorenzo's oil in adrenoleukodystrophy","volume":"81","author":"Ahmed","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.neurot.2026.e00890_bib43","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/jnnp.67.3.290","article-title":"Progression of abnormalities in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy despite treatment with \u2018Lorenzo's oil\u2019","volume":"67","author":"van Geel","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.neurot.2026.e00890_bib44","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJM199309093291101","article-title":"A two-year trial of oleic and erucic acids (\u2018Lorenzo's oil\u2019) as treatment for adrenomyeloneuropathy","volume":"329","author":"Aubourg","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurot.2026.e00890_bib45","first-page":"261","article-title":"Cardiac lesions in rats fed rapeseed oils","volume":"39","author":"Charlton","year":"1975","journal-title":"Can J Comp Med Rev Can Med Comp"},{"key":"10.1016\/j.neurot.2026.e00890_bib46","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1046\/j.1471-4159.1998.71062528.x","article-title":"Fatty acid composition of human brain phospholipids during normal development","volume":"71","author":"Mart\u00ednez","year":"1998","journal-title":"J Neurochem"},{"key":"10.1016\/j.neurot.2026.e00890_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.125286","article-title":"A mini review of nervonic acid: source, production, and biological functions","volume":"301","author":"Li","year":"2019","journal-title":"Food Chem"},{"key":"10.1016\/j.neurot.2026.e00890_bib48","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0306-9877(94)90122-8","article-title":"Nervonic acid and demyelinating disease","volume":"42","author":"Sargent","year":"1994","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.neurot.2026.e00890_bib49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s43856-024-00605-9","article-title":"Lipidomic biomarkers in plasma correlate with disease severity in adrenoleukodystrophy","volume":"4","author":"Jaspers","year":"2024","journal-title":"Commun Med"},{"key":"10.1016\/j.neurot.2026.e00890_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103265","article-title":"Safety and efficacy of leriglitazone in childhood cerebral adrenoleukodystrophy (NEXUS): an interim analysis of an open-label, phase 2\/3 trial","volume":"84","author":"Garc\u00eda-Cazorla","year":"2025","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.neurot.2026.e00890_bib51","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1093\/brain\/awae169","article-title":"Leriglitazone halts disease progression in adult patients with early cerebral adrenoleukodystrophy","volume":"147","author":"Golse","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.neurot.2026.e00890_bib52","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1474-4422(22)00495-1","article-title":"Safety and efficacy of leriglitazone for preventing disease progression in men with adrenomyeloneuropathy (ADVANCE): a randomised, double-blind, multi-centre, placebo-controlled phase 2\u20133 trial","volume":"22","author":"K\u00f6hler","year":"2023","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.neurot.2026.e00890_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.645646","article-title":"Lipid transport and metabolism at the blood-brain interface: implications in health and disease","volume":"12","author":"Pifferi","year":"2021","journal-title":"Front Physiol"},{"key":"10.1016\/j.neurot.2026.e00890_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11103-5","article-title":"Astrocytes and oligodendrocytes in grey and white matter regions of the brain metabolize fatty acids","volume":"7","author":"Hofmann","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.neurot.2026.e00890_bib55","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/labinvest.3700512","article-title":"The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), not Abcd1 (ALD), causes oxidative damage","volume":"87","author":"Lu","year":"2007","journal-title":"Lab Investig J Tech Methods Pathol"},{"key":"10.1016\/j.neurot.2026.e00890_bib56","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1210\/en.2017-00505","article-title":"Regeneration of functional adrenal tissue following bilateral adrenalectomy","volume":"159","author":"Gotlieb","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.neurot.2026.e00890_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109813","article-title":"Integrated metabolome and microbiome strategy reveals the therapeutic effect of nervonic acid on Alzheimer's disease rats","volume":"137","author":"Chen","year":"2025","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.neurot.2026.e00890_bib58","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300671","article-title":"Dietary supplementation with nervonic acid ameliorates cerebral ischemia-reperfusion injury by modulating of gut microbiota composition-fecal metabolites interaction","volume":"68","author":"Zhou","year":"2024","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.neurot.2026.e00890_bib59","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2019.12.025","article-title":"Establishing or exaggerating causality for the gut microbiome: lessons from human microbiota-associated rodents","volume":"180","author":"Walter","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.neurot.2026.e00890_bib60","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.3390\/biomedicines12122764","article-title":"Fecal nervonic acid as a biomarker for diagnosing and monitoring inflammatory bowel disease","volume":"12","author":"Kunst","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.neurot.2026.e00890_bib61","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/hmg\/11.5.499","article-title":"Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy","volume":"11","author":"Pujol","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neurot.2026.e00890_bib62","first-page":"272","article-title":"Targeted brain delivery of Dendrimer-4-Phenylbutyrate ameliorates neurological deficits in a long-term ABCD1-Deficient mouse model of X-Linked adrenoleukodystrophy","volume":"20","author":"Nemeth","year":"2023","journal-title":"Neurother J Am Soc Exp Neurother"},{"key":"10.1016\/j.neurot.2026.e00890_bib63","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/ana.27117","article-title":"A novel mouse model for cerebral inflammatory demyelination in X-linked adrenoleukodystrophy: insights into pathogenesis and potential therapeutic targets","volume":"97","author":"Hashemi","year":"2025","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neurot.2026.e00890_bib64","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jb\/mvs105","article-title":"Very long-chain fatty acids: elongation, physiology and related disorders","volume":"152","author":"Kihara","year":"2012","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.neurot.2026.e00890_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113248","article-title":"Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophy","volume":"28","author":"Huang","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.neurot.2026.e00890_bib66","doi-asserted-by":"crossref","first-page":"17777","DOI":"10.1021\/acs.jmedchem.1c00948","article-title":"Discovery of novel, orally bioavailable pyrimidine ether-based inhibitors of ELOVL1","volume":"64","author":"Boyd","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.neurot.2026.e00890_bib67","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s40001-023-01523-7","article-title":"A comprehensive review of the family of very-long-chain fatty acid elongases: structure, function, and implications in physiology and pathology","volume":"28","author":"Wang","year":"2023","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.neurot.2026.e00890_bib68","doi-asserted-by":"crossref","first-page":"9764","DOI":"10.1021\/acsomega.3c00056","article-title":"Therapeutic role of ELOVL in neurological diseases","volume":"8","author":"Siddiqui","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.neurot.2026.e00890_bib69","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1194\/jlr.M044586","article-title":"Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid","volume":"55","author":"Sassa","year":"2014","journal-title":"J Lipid Res"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747926000607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747926000607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:57:20Z","timestamp":1789243040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747926000607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1878747926000607"],"URL":"https:\/\/doi.org\/10.1016\/j.neurot.2026.e00890","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nervonic acid supplementation mitigates disease severity biomarkers in adrenoleukodystrophy","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurot.2026.e00890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics.","name":"copyright","label":"Copyright"}],"article-number":"e00890"}}