{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:13:28Z","timestamp":1793168008146,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7242082"],"award-info":[{"award-number":["7242082"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.neurot.2026.e00894","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:44:58Z","timestamp":1775137498000},"page":"e00894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility and safety of vertebrobasilar artery cooling infusion (VACI) following thrombectomy for acute posterior circulation ischemic stroke: A pilot randomized controlled trial"],"prefix":"10.1016","volume":"23","author":[{"given":"Zhe","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Rajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokun","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10029","key":"10.1016\/j.neurot.2026.e00894_bib1","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","article-title":"Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials","volume":"387","author":"Goyal","year":"2016","journal-title":"Lancet"},{"issue":"15","key":"10.1016\/j.neurot.2026.e00894_bib2","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1056\/NEJMoa2207576","article-title":"Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion","volume":"387","author":"Jovin","year":"2022","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.neurot.2026.e00894_bib3","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1056\/NEJMoa2206317","article-title":"Trial of endovascular treatment of acute basilar-artery occlusion","volume":"387","author":"Tao","year":"2022","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00894_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/bc.bc_9_24","article-title":"Impacts of futile reperfusion and reperfusion injury in acute ischemic stroke","volume":"10","author":"Elmadhoun","year":"2024","journal-title":"Brain Circ"},{"issue":"23","key":"10.1016\/j.neurot.2026.e00894_bib5","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neurot.2026.e00894_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c363","article-title":"Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data","volume":"340","author":"Edwards","year":"2010","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.neurot.2026.e00894_bib7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrneurol.2012.21","article-title":"Hypothermia for acute brain injury--mechanisms and practical aspects","volume":"8","author":"Choi","year":"2012","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"10.1016\/j.neurot.2026.e00894_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4103\/bc.bc_27_22","article-title":"Perspectives on benefit of early and prereperfusion hypothermia by pharmacological approach in stroke","volume":"8","author":"Li","year":"2022","journal-title":"Brain Circ"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00894_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0271678X211055959","article-title":"Selective therapeutic cooling: to maximize benefits and minimize side effects related to hypothermia","volume":"42","author":"Wu","year":"2022","journal-title":"J Cerebr Blood Flow Metabol : Off J Int Soc Cerebr Blood Flow Metabol"},{"issue":"12","key":"10.1016\/j.neurot.2026.e00894_bib10","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1177\/0271678X18790139","article-title":"Safety, feasibility, and potential efficacy of intraarterial selective cooling infusion for stroke patients treated with mechanical thrombectomy","volume":"38","author":"Wu","year":"2018","journal-title":"J Cerebr Blood Flow Metabol: Off J Int Soc Cerebr Blood Flow Metabol"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00894_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/bc.bc_88_22","article-title":"Research progress of selective brain cooling methods in the prehospital care for stroke patients: a narrative review","volume":"9","author":"Chen","year":"2023","journal-title":"Brain Circ"},{"key":"10.1016\/j.neurot.2026.e00894_bib12","doi-asserted-by":"crossref","DOI":"10.1177\/15910199241285157","article-title":"Selective intra-arterial hypothermia combined with endovascular thrombectomy for large vessel occlusion: a systematic review and meta-analysis","author":"Alturki","year":"2024","journal-title":"Intervent Neuroradiol : J Peritherap Neuroradiol Surg Proc Relat Neurosci"},{"key":"10.1016\/j.neurot.2026.e00894_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1149767","article-title":"Vertebrobasilar artery cooling infusion in acute ischemic stroke for posterior circulation following thrombectomy: rationale, design and protocol for a prospective randomized controlled trial","volume":"17","author":"Cheng","year":"2023","journal-title":"Front Neurosci"},{"issue":"12","key":"10.1016\/j.neurot.2026.e00894_bib14","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1161\/STROKEAHA.109.561365","article-title":"Quantifying the value of stroke disability outcomes: WHO global burden of disease project disability weights for each level of the modified Rankin scale","volume":"40","author":"Hong","year":"2009","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.neurot.2026.e00894_bib15","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s13311-020-00979-3","article-title":"Adjuvant high-flow normobaric oxygen after mechanical thrombectomy for anterior circulation stroke: a randomized clinical trial","volume":"18","author":"Cheng","year":"2021","journal-title":"Neurotherapeutics"},{"issue":"9","key":"10.1016\/j.neurot.2026.e00894_bib16","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1161\/STROKEAHA.117.017182","article-title":"Rethinking thrombolysis in cerebral infarction 2b: which thrombolysis in cerebral infarction scales best define near complete recanalization in the modern thrombectomy era?","volume":"48","author":"Tung","year":"2017","journal-title":"Stroke"},{"issue":"9136","key":"10.1016\/j.neurot.2026.e00894_bib17","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0140-6736(98)08020-9","article-title":"Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study investigators","volume":"352","author":"Hacke","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.neurot.2026.e00894_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.951586","article-title":"Therapeutic hypothermia for stroke: unique challenges at the bedside","volume":"13","author":"You","year":"2022","journal-title":"Front Neurol"},{"issue":"2","key":"10.1016\/j.neurot.2026.e00894_bib19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/STROKEAHA.119.026523","article-title":"New endovascular approach for hypothermia with intrajugular cooling and neuroprotective effect in ischemic stroke","volume":"51","author":"Duan","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.neurot.2026.e00894_bib20","article-title":"Neuroprotective effects of early hypothermia induced by phenothiazines and DHC in ischemic stroke","volume":"2021","author":"Han","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"issue":"4","key":"10.1016\/j.neurot.2026.e00894_bib21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4103\/bc.bc_59_21","article-title":"Protection of multiple ischemic organs by controlled reperfusion","volume":"7","author":"Ma","year":"2021","journal-title":"Brain Circ"},{"issue":"11","key":"10.1016\/j.neurot.2026.e00894_bib22","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1161\/hs1101.097382","article-title":"Endovascular cooling for moderate hypothermia in patients with acute stroke: first results of a novel approach","volume":"32","author":"Georgiadis","year":"2001","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.neurot.2026.e00894_bib23","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1161\/STROKEAHA.116.014200","article-title":"Results of the ICTuS 2 trial (intravascular cooling in the treatment of stroke 2)","volume":"47","author":"Lyden","year":"2016","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.neurot.2026.e00894_bib24","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1161\/STROKEAHA.110.592295","article-title":"Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results","volume":"41","author":"Hemmen","year":"2010","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.neurot.2026.e00894_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/neurintsurg-2011-010150","article-title":"Brain temperature changes during selective cooling with endovascular intracarotid cold saline infusion: simulation using human data fitted with an integrated mathematical model","volume":"5","author":"Neimark","year":"2013","journal-title":"J Neurointerventional Surg"},{"issue":"4","key":"10.1016\/j.neurot.2026.e00894_bib26","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1152\/japplphysiol.00805.2006","article-title":"A theoretical model of selective cooling using intracarotid cold saline infusion in the human brain","volume":"102","author":"Konstas","year":"2007","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"10.1016\/j.neurot.2026.e00894_bib27","doi-asserted-by":"crossref","DOI":"10.3171\/2017.1.FOCUS16514","article-title":"Neuroprotective delivery platforms as an adjunct to mechanical thrombectomy","volume":"42","author":"Babadjouni","year":"2017","journal-title":"Neurosurg Focus"},{"issue":"3","key":"10.1016\/j.neurot.2026.e00894_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.14336\/AD.2019.0715","article-title":"Neuroprotective effects of endogenous secretory receptor for advanced glycation end-products in brain ischemia","volume":"11","author":"Shimizu","year":"2020","journal-title":"Aging Dise"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00894_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/bc.bc_58_19","article-title":"Multiphase adjuvant neuroprotection: a novel paradigm for improving acute ischemic stroke outcomes","volume":"6","author":"Zhao","year":"2020","journal-title":"Brain Circ"},{"issue":"8","key":"10.1016\/j.neurot.2026.e00894_bib30","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/01616412.2020.1782122","article-title":"Ligustilide provides neuroprotection by promoting angiogenesis after cerebral ischemia","volume":"42","author":"Ren","year":"2020","journal-title":"Neurol Res"},{"issue":"1","key":"10.1016\/j.neurot.2026.e00894_bib31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.14336\/AD.2020.0406","article-title":"Brain-derived CCR5 contributes to neuroprotection and brain repair after experimental stroke","volume":"12","author":"Ping","year":"2021","journal-title":"Aging Dise"},{"issue":"4","key":"10.1016\/j.neurot.2026.e00894_bib32","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4103\/bc.bc_165_24","article-title":"Neuroprotective strategies in acute ischemic stroke: a narrative review of recent advances and clinical outcomes","volume":"10","author":"Zhao","year":"2024","journal-title":"Brain Circ"},{"issue":"5","key":"10.1016\/j.neurot.2026.e00894_bib33","doi-asserted-by":"crossref","first-page":"928","DOI":"10.3174\/ajnr.A1961","article-title":"Selective brain cooling with endovascular intracarotid infusion of cold saline: a pilot feasibility study","volume":"31","author":"Choi","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"10.1016\/j.neurot.2026.e00894_bib34","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/str.33.3.877","article-title":"Re: feasibility and safety of moderate hypothermia after massive hemispheric infarction","volume":"33","author":"Leker","year":"2002","journal-title":"Stroke"},{"issue":"9","key":"10.1016\/j.neurot.2026.e00894_bib35","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1161\/01.STR.31.9.2251","article-title":"Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: a case-control study: the Copenhagen stroke study","volume":"31","author":"Kammersgaard","year":"2000","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.neurot.2026.e00894_bib36","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/jon.13235","article-title":"Perfusion imaging predicts short-term clinical outcome in isolated posterior cerebral artery occlusion stroke","volume":"34","author":"Salim","year":"2024","journal-title":"J Neuroimag"},{"issue":"2","key":"10.1016\/j.neurot.2026.e00894_bib37","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/23969873241291465","article-title":"Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: a multinational multicenter propensity score-weighted study","volume":"10","author":"Salim","year":"2025","journal-title":"Eur Stroke J"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747926000644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747926000644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:23:15Z","timestamp":1780777395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747926000644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1878747926000644"],"URL":"https:\/\/doi.org\/10.1016\/j.neurot.2026.e00894","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Feasibility and safety of vertebrobasilar artery cooling infusion (VACI) following thrombectomy for acute posterior circulation ischemic stroke: A pilot randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurot.2026.e00894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics.","name":"copyright","label":"Copyright"}],"article-number":"e00894"}}