{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:38:14Z","timestamp":1792723094058,"version":"4.5.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG072474"],"award-info":[{"award-number":["R01AG072474"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG076383"],"award-info":[{"award-number":["R01AG076383"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG066462"],"award-info":[{"award-number":["P30AG066462"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG054070"],"award-info":[{"award-number":["R01AG054070"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG079519"],"award-info":[{"award-number":["RF1AG079519"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UG3AG090558"],"award-info":[{"award-number":["UG3AG090558"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17CSA33550004"],"award-info":[{"award-number":["17CSA33550004"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R21NS138995"],"award-info":[{"award-number":["R21NS138995"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS"],"award-info":[{"award-number":["R01NS"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["UG3NS130228"],"award-info":[{"award-number":["UG3NS130228"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01MD016178"],"award-info":[{"award-number":["R01MD016178"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NR018335"],"award-info":[{"award-number":["R01NR018335"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01NS106513"],"award-info":[{"award-number":["U01NS106513"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U24NS107136"],"award-info":[{"award-number":["U24NS107136"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U24NS107215"],"award-info":[{"award-number":["U24NS107215"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS11072"],"award-info":[{"award-number":["R01NS11072"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01EB301114"],"award-info":[{"award-number":["R01EB301114"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R03NS112859"],"award-info":[{"award-number":["R03NS112859"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["VCID-UMD-26-1530947"],"award-info":[{"award-number":["VCID-UMD-26-1530947"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["22-AAIIA-970107"],"award-info":[{"award-number":["22-AAIIA-970107"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","neurotherapeuticsjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurotherapeutics"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neurot.2026.e01068","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:41:51Z","timestamp":1789119711000},"page":"e01068","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The path to treating multiple-etiology dementia: Combining vascular risk control and disease-modifying neurodegenerative therapies"],"prefix":"10.1016","volume":"23","author":[{"given":"Adam","family":"de Havenon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin N.","family":"Sheth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn A.","family":"Fredericks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10452","key":"10.1016\/j.neurot.2026.e01068_bib1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet Lond Engl"},{"issue":"Suppl 1","key":"10.1016\/j.neurot.2026.e01068_bib2","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1093\/geronb\/gbx147","article-title":"The impact of changes in population health and mortality on future prevalence of Alzheimer's disease and other dementias in the United States","volume":"73","author":"Zissimopoulos","year":"2018","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"issue":"10248","key":"10.1016\/j.neurot.2026.e01068_bib4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet Lond Engl"},{"issue":"suppl_1","key":"10.1016\/j.neurot.2026.e01068_bib5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/geronb\/gby007","article-title":"Introduction to a supplement on population level trends in dementia: causes, disparities, and projections","volume":"73","author":"Schoeni","year":"2018","journal-title":"J Gerontol Ser B"},{"issue":"23","key":"10.1016\/j.neurot.2026.e01068_bib6","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1001\/jama.292.23.2901","article-title":"Mixed DementiaEmerging concepts and therapeutic implications","volume":"292","author":"Langa","year":"2004","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.neurot.2026.e01068_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-015-0104-7","article-title":"Clinical and imaging features of mixed alzheimer and vascular pathologies","volume":"7","author":"Chui","year":"2015","journal-title":"Alzheimers Res Ther"},{"issue":"4","key":"10.1016\/j.neurot.2026.e01068_bib8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1590\/1980-57642016dn11-040005","article-title":"Mixed dementia: A review of the evidence","volume":"11","author":"Custodio","year":"2017","journal-title":"Dement Neuropsychol"},{"issue":"12","key":"10.1016\/j.neurot.2026.e01068_bib9","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1001\/jamaneurol.2022.3472","article-title":"Frequency and underlying pathology of pure vascular cognitive impairment","volume":"79","author":"Oveisgharan","year":"2022","journal-title":"JAMA Neurol"},{"issue":"3","key":"10.1016\/j.neurot.2026.e01068_bib11","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/S2666-7568(23)00019-3","article-title":"The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia","volume":"4","author":"Nichols","year":"2023","journal-title":"Lancet Healthy Longev"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1212\/WNL.0000000000001831","article-title":"Multiple pathologies are common and related to dementia in the oldest-old","volume":"85","author":"Kawas","year":"2015","journal-title":"Neurology"},{"issue":"1\u20132","key":"10.1016\/j.neurot.2026.e01068_bib13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000448243","article-title":"Impact of Alzheimer's, lewy body, and vascular co-pathologies on clinical transition to dementia in a national autopsy cohort","volume":"42","author":"Pillai","year":"2016","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"1\u20132","key":"10.1016\/j.neurot.2026.e01068_bib14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jns.2007.01.045","article-title":"Neuropathological evaluation of mixed dementia","volume":"257","author":"Jellinger","year":"2007","journal-title":"J Neurol Sci"},{"issue":"24","key":"10.1016\/j.neurot.2026.e01068_bib15","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"Schneider","year":"2007","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-017-1717-7","article-title":"Impact of multiple pathologies on the threshold for clinically overt dementia","volume":"134","author":"Kapasi","year":"2017","journal-title":"Acta Neuropathol (Berl)"},{"issue":"9","key":"10.1016\/j.neurot.2026.e01068_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-014-0082-1","article-title":"Prevalence of mixed pathologies in the aging brain","volume":"6","author":"Rahimi","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.neurot.2026.e01068_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/908915","article-title":"Global epidemiology of dementia: Alzheimer's and vascular types","volume":"2014","author":"Rizzi","year":"2014","journal-title":"BioMed Res Int"},{"issue":"8","key":"10.1016\/j.neurot.2026.e01068_bib19","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1161\/ATVBAHA.119.311908","article-title":"Epidemiology of vascular dementia","volume":"39","author":"Wolters","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"10.1016\/j.neurot.2026.e01068_bib20","doi-asserted-by":"crossref","first-page":"e596","DOI":"10.1016\/S2214-109X(19)30074-9","article-title":"Population attributable fractions for risk factors for dementia in low-income and middle-income countries: an analysis using cross-sectional survey data","volume":"7","author":"Mukadam","year":"2019","journal-title":"Lancet Global Health"},{"issue":"7","key":"10.1016\/j.neurot.2026.e01068_bib21","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.19672","article-title":"Variation in population attributable fraction of dementia associated with potentially modifiable risk factors by race and ethnicity in the US","volume":"5","author":"Lee","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.neurot.2026.e01068_bib22","series-title":"The truth about aging and dementia | CDC","year":"2019"},{"issue":"7","key":"10.1016\/j.neurot.2026.e01068_bib23","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/alz.12291","article-title":"Concomitant neurodegenerative pathologies contribute to the transition from mild cognitive impairment to dementia","volume":"17","author":"McAleese","year":"2021","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.neurot.2026.e01068_bib24","article-title":"Additive effects of white matter hyperintensity and APOE \u03b54 status on risk of incident dementia in two large longitudinal cohorts","volume":"21","author":"de Havenon","year":"2025","journal-title":"Ann Neurol"},{"issue":"10","key":"10.1016\/j.neurot.2026.e01068_bib25","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1002\/alz.14126","article-title":"White matter hyperintensity on MRI and plasma A\u03b242\/40 ratio additively increase the risk of cognitive impairment in hypertensive adults","volume":"20","author":"de Havenon","year":"2024","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.1016\/j.neurot.2026.e01068_bib26","first-page":"165","article-title":"Body mass index in midlife and dementia: systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies","volume":"8","author":"Albanese","year":"2017","journal-title":"Alzheimer's Dement"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib27","article-title":"Effect of the treatment of type 2 diabetes mellitus on the development of cognitive impairment and dementia","volume":"6","author":"Areosa","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib28","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2337\/dc15-1588","article-title":"Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia","volume":"39","author":"Chatterjee","year":"2016","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.neurot.2026.e01068_bib29","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S1474-4422(19)30228-5","article-title":"Associations between blood pressure across adulthood and late-life brain structure and pathology in the neuroscience substudy of the 1946 British birth cohort (insight 46): an epidemiological study","volume":"18","author":"Lane","year":"2019","journal-title":"Lancet Neurol"},{"issue":"18","key":"10.1016\/j.neurot.2026.e01068_bib30","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1093\/cvr\/cvaf010","article-title":"Blood pressure and the brain: the conundrum of hypertension and dementia","volume":"120","author":"Gottesman","year":"2024","journal-title":"Cardiovasc Res"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib31","first-page":"363","article-title":"Vascular risk factors, cognitive decline, and dementia","volume":"4","author":"Duron","year":"2008","journal-title":"Vasc Health Risk Manag"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jama.2018.21442","article-title":"Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial","volume":"321","author":"Williamson","year":"2019","journal-title":"JAMA"},{"issue":"22","key":"10.1016\/j.neurot.2026.e01068_bib33","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","article-title":"A randomized trial of intensive versus standard blood-pressure control","volume":"373","author":"Wright","year":"2015","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib34","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1038\/s41591-025-03616-8","article-title":"Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial","volume":"31","author":"He","year":"2025","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.neurot.2026.e01068_bib35","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S1474-4422(11)70188-0","article-title":"Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy","volume":"10","author":"Launer","year":"2011","journal-title":"Lancet Neurol"},{"issue":"24","key":"10.1016\/j.neurot.2026.e01068_bib36","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1056\/NEJMoa0802743","article-title":"Effects of intensive glucose lowering in type 2 diabetes","volume":"358","author":"null","year":"2008","journal-title":"N Engl J Med"},{"issue":"24","key":"10.1016\/j.neurot.2026.e01068_bib37","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1056\/NEJMoa0802987","article-title":"Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes","volume":"358","year":"2008","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.neurot.2026.e01068_bib38","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1001\/jamaneurol.2025.0353","article-title":"GLP-1RA and SGLT2i medications for type 2 diabetes and alzheimer disease and related dementias","volume":"82","author":"Tang","year":"2025","journal-title":"JAMA Neurol"},{"issue":"5","key":"10.1016\/j.neurot.2026.e01068_bib39","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/jamaneurol.2025.0360","article-title":"Cardioprotective glucose-lowering agents and dementia risk: a systematic review and meta-analysis","volume":"82","author":"Seminer","year":"2025","journal-title":"JAMA Neurol"},{"issue":"10544","key":"10.1016\/j.neurot.2026.e01068_bib40","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(26)00459-9","article-title":"Efficacy and safety of oral semaglutide 14 mg (Flexible dose) in early-stage symptomatic alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials","volume":"407","author":"Cummings","year":"2026","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.neurot.2026.e01068_bib41","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1001\/jama.300.9.1027","article-title":"Effect of physical activity on cognitive function in older adults at risk for alzheimer disease: a randomized trial","volume":"300","author":"Lautenschlager","year":"2008","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3233\/JAD-150817","article-title":"Moderate-to-High intensity physical exercise in patients with Alzheimer's disease: a randomized controlled trial","volume":"50","author":"Hoffmann","year":"2016","journal-title":"J Alzheimers Dis JAD"},{"issue":"7","key":"10.1016\/j.neurot.2026.e01068_bib43","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.24465","article-title":"Effects of exercise alone or combined with cognitive training and vitamin D supplementation to improve cognition in adults with mild cognitive impairment: a randomized clinical trial","volume":"6","author":"Montero-Odasso","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.neurot.2026.e01068_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2023.114228","article-title":"A randomized controlled trial examining the effects of behavioral weight loss treatment on hippocampal volume and neurocognition","volume":"267","author":"Chao","year":"2023","journal-title":"Physiol Behav"},{"issue":"11","key":"10.1016\/j.neurot.2026.e01068_bib45","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1467-789X.2011.00903.x","article-title":"Intentional weight loss in overweight and Obese individuals and cognitive function: a systematic review and meta-analysis","volume":"12","author":"Siervo","year":"2011","journal-title":"Obes Rev Off J Int Assoc Study Obes"},{"issue":"3","key":"10.1016\/j.neurot.2026.e01068_bib46","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1210\/jc.2015-2315","article-title":"Cognitive effects of intentional weight loss in elderly Obese individuals with mild cognitive impairment","volume":"101","author":"Horie","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.neurot.2026.e01068_bib47","article-title":"Post-stroke cognitive impairment: epidemiology, mechanisms and management","volume":"2","author":"Sun","year":"2014","journal-title":"Ann Transl Med"},{"issue":"11","key":"10.1016\/j.neurot.2026.e01068_bib48","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(09)70236-4","article-title":"Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis","volume":"8","author":"Pendlebury","year":"2009","journal-title":"Lancet Neurol"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib49","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.005788","article-title":"Time course of evolution of disability and cause-specific mortality after ischemic stroke: implications for trial design","volume":"6","author":"Ganesh","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"12","key":"10.1016\/j.neurot.2026.e01068_bib50","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STR.0000000000000475","article-title":"2024 Guideline for the primary prevention of stroke: A guideline from the American Heart Association\/American Stroke Association","volume":"55","author":"Bushnell","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.neurot.2026.e01068_bib51","series-title":"Traumatic brain injury & concussion","year":"2025"},{"key":"10.1016\/j.neurot.2026.e01068_bib52","series-title":"Traumatic brain injury: a roadmap for accelerating progress","article-title":"The scope and burden of traumatic brain injury","author":"Matney","year":"2022"},{"issue":"0","key":"10.1016\/j.neurot.2026.e01068_bib53","article-title":"Heart disease and stroke statistics: A report of US and global data from the American Heart Association","volume":"0","author":"Palaniappan","year":"2026","journal-title":"Circulation"},{"key":"10.1016\/j.neurot.2026.e01068_bib54","series-title":"Traumatic brain injury & concussion","year":"2025"},{"issue":"1","key":"10.1016\/j.neurot.2026.e01068_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","article-title":"Lecanemab in early alzheimer's disease","volume":"388","author":"van Dyck","year":"2023","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib56","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.neurot.2026.e01068_bib57","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1001\/jamaneurol.2021.5205","article-title":"Amyloid-related imaging abnormalities and \u03b2-Amyloid\u2013Targeting antibodies: A systematic review","volume":"79","author":"Filippi","year":"2022","journal-title":"JAMA Neurol"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib58","article-title":"Alzheimer's disease drug development pipeline: 2025","volume":"11","author":"Cummings","year":"2025","journal-title":"Alzheimers Dement Transl Res Clin Interv"},{"issue":"18","key":"10.1016\/j.neurot.2026.e01068_bib59","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","article-title":"Donanemab in early alzheimer's disease","volume":"384","author":"Mintun","year":"2021","journal-title":"N Engl J Med"},{"issue":"20","key":"10.1016\/j.neurot.2026.e01068_bib60","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1056\/NEJMoa2304430","article-title":"Two phase 3 trials of gantenerumab in early Alzheimer's disease","volume":"389","author":"Bateman","year":"2023","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.14283\/jpad.2022.30","article-title":"Two randomized phase 3 studies of aducanumab in early Alzheimer's disease","volume":"9","author":"Budd","year":"2022","journal-title":"J Prev Alzheimers Dis"},{"issue":"12","key":"10.1016\/j.neurot.2026.e01068_bib62","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa2305032","article-title":"Trial of solanezumab in preclinical Alzheimer's disease","volume":"389","author":"Sperling","year":"2023","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.neurot.2026.e01068_bib63","doi-asserted-by":"crossref","first-page":"e1837","DOI":"10.1212\/WNL.0000000000207770","article-title":"Eligibility for anti-amyloid treatment in a population-based study of cognitive aging","volume":"101","author":"Pittock","year":"2023","journal-title":"Neurology"},{"issue":"16","key":"10.1016\/j.neurot.2026.e01068_bib64","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1001\/jama.2021.15286","article-title":"Representativeness of participants eligible to be enrolled in clinical trials of aducanumab for alzheimer disease compared with medicare beneficiaries with alzheimer disease and mild cognitive impairment","volume":"326","author":"Anderson","year":"2021","journal-title":"JAMA"},{"issue":"9984","key":"10.1016\/j.neurot.2026.e01068_bib65","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.neurot.2026.e01068_bib66","series-title":"Understanding psychological assessment","first-page":"19","article-title":"Wechsler adult intelligence Scale-III","author":"Ryan","year":"2001"},{"issue":"1","key":"10.1016\/j.neurot.2026.e01068_bib67","first-page":"50","article-title":"Clinical validation of the oral trail making test","volume":"9","author":"Ricker","year":"1996","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib68","first-page":"167","article-title":"Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming","volume":"14","author":"Tombaugh","year":"1999","journal-title":"Arch Clin Neuropsychol"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib69","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/WAD.0b013e3181b76415","article-title":"The CERAD neuropsychological battery total score and the progression of Alzheimer's disease","volume":"24","author":"Rossetti","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"8","key":"10.1016\/j.neurot.2026.e01068_bib70","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/jama.2025.12923","article-title":"Structured vs self-guided multidomain lifestyle interventions for global cognitive function: the US POINTER randomized clinical trial","volume":"334","author":"Baker","year":"2025","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib71","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/jgs.17530","article-title":"\u201cReal-world\u201d eligibility for aducanumab depends on clinical setting and patients' journey","volume":"70","author":"Padovani","year":"2022","journal-title":"J Am Geriatr Soc"},{"issue":"8","key":"10.1016\/j.neurot.2026.e01068_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/gps.5789","article-title":"Potential eligibility for Aducanumab therapy in an Irish specialist cognitive service-utilising cerebrospinal fluid biomarkers and appropriate use criteria","volume":"37","author":"Togher","year":"2022","journal-title":"Int J Geriatr Psychiatr"},{"issue":"3","key":"10.1016\/j.neurot.2026.e01068_bib73","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1212\/WNL.0000000000004827","article-title":"Brain amyloid load and its associations with cognition and vascular risk factors in FINGER study","volume":"90","author":"Kemppainen","year":"2018","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neurot.2026.e01068_bib74","article-title":"The POINTER imaging baseline cohort: associations between multimodal neuroimaging biomarkers, cardiovascular health, and cognition","volume":"21","author":"Harrison","year":"2025","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"key":"10.1016\/j.neurot.2026.e01068_bib75","first-page":"21","article-title":"Poststroke cognitive impairment and dementia: prevalence, diagnosis, and treatment","volume":"4","author":"Melkas","year":"2014","journal-title":"Degener Neurol Neuromuscul Dis"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib76","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1161\/STR.0000000000000430","article-title":"Cognitive impairment after ischemic and hemorrhagic stroke: a scientific statement from the American Heart Association\/American Stroke Association","volume":"54","author":"El Husseini","year":"2023","journal-title":"Stroke"},{"issue":"24","key":"10.1016\/j.neurot.2026.e01068_bib77","doi-asserted-by":"crossref","first-page":"e2257","DOI":"10.1212\/WNL.0000000000008612","article-title":"Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups","volume":"93","author":"Lo","year":"2019","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neurot.2026.e01068_bib78","doi-asserted-by":"crossref","first-page":"221","DOI":"10.14283\/jpad.2022.34","article-title":"Aducanumab: appropriate use recommendations update","volume":"9","author":"Cummings","year":"2022","journal-title":"J Prev Alzheimers Dis"},{"issue":"3","key":"10.1016\/j.neurot.2026.e01068_bib79","doi-asserted-by":"crossref","first-page":"362","DOI":"10.14283\/jpad.2023.30","article-title":"Lecanemab: appropriate use recommendations","volume":"10","author":"Cummings","year":"2023","journal-title":"J Prev Alzheimers Dis"},{"issue":"19","key":"10.1016\/j.neurot.2026.e01068_bib80","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1212\/WNL.0000000000207757","article-title":"Antiamyloid monoclonal antibody therapy for alzheimer disease","volume":"101","author":"Ramanan","year":"2023","journal-title":"Neurology"},{"issue":"19","key":"10.1016\/j.neurot.2026.e01068_bib81","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1212\/WNL.0000000000207873","article-title":"Real-world application of Anti-\u03b2-Amyloid monoclonal antibodies: untangling eligibility","volume":"101","author":"Howe","year":"2023","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.neurot.2026.e01068_bib82","doi-asserted-by":"crossref","DOI":"10.1007\/s11910-013-0415-7","article-title":"Contemplating Alzheimer's disease and the contribution of white matter hyperintensities","volume":"13","author":"Brickman","year":"2013","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"4","key":"10.1016\/j.neurot.2026.e01068_bib83","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib84","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jalz.2014.10.008","article-title":"Vascular contributions to cognitive impairment and dementia including Alzheimer's disease","volume":"11","author":"Snyder","year":"2015","journal-title":"Alzheimer's Dement"},{"issue":"5","key":"10.1016\/j.neurot.2026.e01068_bib88","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/alz.12470","article-title":"Expected wait times for access to a disease-modifying Alzheimer's treatment in the United States","volume":"18","author":"Mattke","year":"2022","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"issue":"11","key":"10.1016\/j.neurot.2026.e01068_bib89","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.jalz.2019.07.005","article-title":"Longitudinal analysis of dementia diagnosis and specialty care among racially diverse medicare beneficiaries","volume":"15","author":"Drabo","year":"2019","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib90","doi-asserted-by":"crossref","first-page":"e697","DOI":"10.1093\/geront\/gny067","article-title":"Primary care physicians' perceived barriers to optimal dementia care: a systematic review","volume":"59","author":"Mansfield","year":"2019","journal-title":"The Gerontologist"},{"issue":"4","key":"10.1016\/j.neurot.2026.e01068_bib91","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/WAD.0b013e3181a6bebc","article-title":"Missed and delayed diagnosis of dementia in primary care: prevalence and contributing factors","volume":"23","author":"Bradford","year":"2009","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"12A","key":"10.1016\/j.neurot.2026.e01068_bib92","doi-asserted-by":"crossref","first-page":"112i","DOI":"10.1016\/j.amjcard.2007.03.029","article-title":"The action to control cardiovascular risk in diabetes memory in diabetes study (ACCORD-MIND): rationale, design, and methods","volume":"99","author":"Williamson","year":"2007","journal-title":"Am J Cardiol"},{"issue":"13","key":"10.1016\/j.neurot.2026.e01068_bib93","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1212\/WNL.0000000000207739","article-title":"The brain health imperative in the 21st century\u2014A call to action","volume":"101","author":"Rost","year":"2023","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.neurot.2026.e01068_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanhl.2024.100665","article-title":"Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations","volume":"5","author":"Farina","year":"2024","journal-title":"Lancet Healthy Longev"},{"issue":"6","key":"10.1016\/j.neurot.2026.e01068_bib95","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1161\/STR.0000000000000367","article-title":"A primary care agenda for brain health: a scientific statement from the American heart association","volume":"52","author":"Lazar","year":"2021","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.neurot.2026.e01068_bib96","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1161\/STROKEAHA.124.044292","article-title":"Brain health","volume":"55","author":"Rundek","year":"2024","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.neurot.2026.e01068_bib98","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/STR.0000000000000480","article-title":"Vascular neurology considerations for antiamyloid immunotherapy: a science advisory from the American heart association","volume":"56","author":"Greenberg","year":"2025","journal-title":"Stroke"},{"issue":"suppl 7","key":"10.1016\/j.neurot.2026.e01068_bib99","article-title":"Safety and efficacy of concomitant intensive systolic blood pressure control with anti-amyloid monoclonal antibodies in reducing amyloid related imaging abnormalities","volume":"21","author":"Pruzin","year":"2025","journal-title":"Alzheimer's Dement"}],"container-title":["Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747926002382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1878747926002382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:53:10Z","timestamp":1792720390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1878747926002382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":93,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1878747926002382"],"URL":"https:\/\/doi.org\/10.1016\/j.neurot.2026.e01068","relation":{},"ISSN":["1878-7479"],"issn-type":[{"value":"1878-7479","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The path to treating multiple-etiology dementia: Combining vascular risk control and disease-modifying neurodegenerative therapies","name":"articletitle","label":"Article Title"},{"value":"Neurotherapeutics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neurot.2026.e01068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics.","name":"copyright","label":"Copyright"}],"article-number":"e01068"}}