{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:18:07Z","timestamp":1790518687404,"version":"4.1.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"NIH","award":["AG021155"],"award-info":[{"award-number":["AG021155"]}]},{"name":"NIH","award":["AG000213"],"award-info":[{"award-number":["AG000213"]}]},{"name":"NIH","award":["AG027161"],"award-info":[{"award-number":["AG027161"]}]},{"name":"NIH","award":["AG037639"],"award-info":[{"award-number":["AG037639"]}]},{"name":"NIH","award":["AG033514"],"award-info":[{"award-number":["AG033514"]}]},{"name":"Veterans Administration Merit Review Grant","award":["I01CX000165"],"award-info":[{"award-number":["I01CX000165"]}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical and Translational Science Award","award":["UL1RR025011"],"award-info":[{"award-number":["UL1RR025011"]}]},{"DOI":"10.13039\/100007015","name":"University of Wisconsin, Madison","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NSF","award":["0849122"],"award-info":[{"award-number":["0849122"]}]},{"DOI":"10.13039\/100000988","name":"Helen Bader Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000988","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001272","name":"Northwestern Mutual Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100002082","name":"Extendicare Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100002082","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Veterans Administration"},{"name":"Waisman Center, University of Wisconsin-Madison"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2014]]},"DOI":"10.1016\/j.nicl.2014.02.001","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T04:45:31Z","timestamp":1392785131000},"page":"604-614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":138,"special_numbering":"C","title":["Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3857-6163","authenticated-orcid":false,"given":"Annie M.","family":"Racine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagesh","family":"Adluru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley T.","family":"Christian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozioma C.","family":"Okonkwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin A.","family":"Cleary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Birdsill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansel T.","family":"Hillmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanabalan","family":"Murali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd E.","family":"Barnhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Rowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Maritza","family":"Dowling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Asthana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Sager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara B.","family":"Bendlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2014.02.001_bb0005","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuroimage.2011.07.029","article-title":"A diffusion tensor brain template for rhesus macaques","volume":"59","author":"Adluru","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0020","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/cviu.1999.0817","article-title":"Elastic matching of diffusion tensor images","volume":"77","author":"Alexander","year":"2000","journal-title":"Comput. Vis. Image Underst."},{"key":"10.1016\/j.nicl.2014.02.001_bb0025","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1109\/42.963816","article-title":"Spatial transformations of diffusion tensor magnetic resonance images","volume":"20","author":"Alexander","year":"2001","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0015","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","article-title":"Diffusion tensor imaging of the brain","volume":"4","author":"Alexander","year":"2007","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.nicl.2014.02.001_bb0010","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/brain.2011.0071","article-title":"Characterization of cerebral white matter properties using quantitative magnetic resonance imaging stains","volume":"1","author":"Alexander","year":"2011","journal-title":"Brain Connect."},{"key":"10.1016\/j.nicl.2014.02.001_bb0030","first-page":"129","article-title":"Trail Making Test errors in normal aging, mild cognitive impairment, and dementia","volume":"23","author":"Ashendorf","year":"2008","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0035","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0040","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system \u2014 a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.nicl.2014.02.001_bb0045","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/87565641003696775","article-title":"White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three","volume":"35","author":"Bendlin","year":"2010","journal-title":"Dev. Neuropsychol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0050","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jalz.2009.11.003","article-title":"White matter is altered with parental family history of Alzheimer's disease","volume":"6","author":"Bendlin","year":"2010","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nicl.2014.02.001_bb0055","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.mri.2007.03.017","article-title":"Diffusion tensor MRI to investigate dementias: a brief review","volume":"25","author":"Bozzali","year":"2007","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0060","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.neurobiolaging.2009.10.013","article-title":"White matter hyperintensities and cognition: testing the reserve hypothesis","volume":"32","author":"Brickman","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0065","doi-asserted-by":"crossref","first-page":"e65175","DOI":"10.1371\/journal.pone.0065175","article-title":"Associations between white matter hyperintensities and beta amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI","volume":"8","author":"Chao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2014.02.001_bb0070","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1212\/01.wnl.0000194256.15247.83","article-title":"White matter damage on diffusion tensor imaging correlates with age-related cognitive decline","volume":"66","author":"Charlton","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrneurol.2013.21","article-title":"Alzheimer disease: Abeta-independent processes-rethinking preclinical AD","volume":"9","author":"Chetelat","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0080","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/WCO.0b013e3282f4594b","article-title":"Diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease: a review","volume":"21","author":"Chua","year":"2008","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0085","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1212\/WNL.56.7.926","article-title":"Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations","volume":"56","author":"Ciccarelli","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0090","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pscychresns.2006.01.015","article-title":"The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI study","volume":"147","author":"Copenhaver","year":"2006","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.nicl.2014.02.001_bb0095","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.neuroimage.2010.12.008","article-title":"DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease","volume":"55","author":"Douaud","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0100","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.nbd.2008.08.001","article-title":"Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study","volume":"32","author":"Edison","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nicl.2014.02.001_bb0105","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.2353\/ajpath.2008.070829","article-title":"Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes","volume":"172","author":"Fein","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0110","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nrn2480","article-title":"Remyelination in the CNS: from biology to therapy","volume":"9","author":"Franklin","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2014.02.001_bb0115","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/jnnp.2008.148528","article-title":"Diffusion tensor imaging in patients with Creutzfeldt\u2013Jakob disease","volume":"79","author":"Fujita","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"Pt 6","key":"10.1016\/j.nicl.2014.02.001_bb0120","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1093\/brain\/114.6.2611","article-title":"Amnesia in man following transection of the fornix. A review","volume":"114","author":"Gaffan","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2014.02.001_bb0125","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/01688639508405143","article-title":"Construct validity in the Trail Making Test: what makes Part B harder?","volume":"17","author":"Gaudino","year":"1995","journal-title":"J. Clin. Exp. Neuropsychol."},{"issue":"Pt 1","key":"10.1016\/j.nicl.2014.02.001_bb0130","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuroimage.2013.09.014","article-title":"Activation during the Trail Making Test measured with functional near-infrared spectroscopy in healthy elderly subjects","volume":"85","author":"Hagen","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0135","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3174\/ajnr.A2983","article-title":"Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis","volume":"33","author":"Hannoun","year":"2012","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0140","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jns.2009.02.178","article-title":"White matter hyperintensities and cognitive dysfunction in Alzheimer's disease","volume":"283","author":"Heo","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nicl.2014.02.001_bb0145","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1523\/JNEUROSCI.3591-07.2007","article-title":"More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome","volume":"27","author":"Hoeft","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2014.02.001_bb0150","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/nbm.787","article-title":"Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases \u2014 a review","volume":"15","author":"Horsfield","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.nicl.2014.02.001_bb0155","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1037\/1040-3590.2.3.304","article-title":"The Auditory-Verbal Learning Test (AVLT): Norms for ages 55years and older","volume":"2","author":"Ivnik","year":"1990","journal-title":"Psychol. Assess."},{"key":"10.1016\/j.nicl.2014.02.001_bb0160","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/brain\/awp062","article-title":"Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease","volume":"132","author":"Jack","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2014.02.001_bb0165","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2174\/157339510791823790","article-title":"Responses of glial cells to stress and glucocorticoids","volume":"6","author":"Jauregui-Huerta","year":"2010","journal-title":"Curr. Immunol. Rev."},{"key":"10.1016\/j.nicl.2014.02.001_bb0170","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1212\/WNL.0b013e318289714a","article-title":"Cognitive and brain reserve and the diagnosis and treatment of preclinical Alzheimer disease","volume":"80","author":"Jicha","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0175","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neurobiolaging.2013.09.028","article-title":"Amyloid burden and neural function in people at risk for Alzheimer's disease","volume":"35","author":"Johnson","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0180","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/nbm.1543","article-title":"Twenty-five pitfalls in the analysis of diffusion MRI data","volume":"23","author":"Jones","year":"2010","journal-title":"NMR Biomed."},{"key":"10.1016\/j.nicl.2014.02.001_bb0185","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1212\/01.wnl.0000240117.55680.0a","article-title":"Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease","volume":"67","author":"Kemppainen","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2012.03.077","article-title":"Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan","volume":"62","author":"Kennedy","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0195","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neuroimage.2008.12.037","article-title":"Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration","volume":"46","author":"Klein","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0200","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.acn.2007.03.005","article-title":"Reliable Change Index scores for persons over the age of 65 tested on alternate forms of the Rey AVLT","volume":"22","author":"Knight","year":"2007","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0205","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jalz.2008.03.009","article-title":"Effect of parental family history of Alzheimer's disease on serial position profiles","volume":"4","author":"La Rue","year":"2008","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nicl.2014.02.001_bb0210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain"},{"issue":"Suppl. 1","key":"10.1016\/j.nicl.2014.02.001_bb0215","first-page":"25","article-title":"Neuropsychological assessment in behavioral toxicology\u2014developing techniques and interpretative issues","volume":"10","author":"Lezak","year":"1984","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1016\/j.nicl.2014.02.001_bb0220","series-title":"Neuropsychological Assessment","author":"Lezak","year":"2004"},{"key":"10.1016\/j.nicl.2014.02.001_bb0225","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.neurobiolaging.2009.10.006","article-title":"Diffusion tensor imaging and Tract-Based Spatial Statistics in Alzheimer's disease and mild cognitive impairment","volume":"32","author":"Liu","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0230","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1002\/art.24070","article-title":"White and gray matter abnormalities in the brain of patients with fibromyalgia: a diffusion-tensor and volumetric imaging study","volume":"58","author":"Lutz","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.nicl.2014.02.001_bb0235","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1162\/jocn.2009.21047","article-title":"Cerebral white matter integrity mediates adult age differences in cognitive performance","volume":"21","author":"Madden","year":"2009","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.nicl.2014.02.001_bb0240","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroimage.2009.01.054","article-title":"Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease","volume":"46","author":"Mielke","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0245","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/brain\/awn320","article-title":"Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects","volume":"132","author":"Mormino","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2014.02.001_bb0250","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1460-9568.2004.03534.x","article-title":"Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis","volume":"20","author":"Mueggler","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nicl.2014.02.001_bb0255","doi-asserted-by":"crossref","first-page":"e67630","DOI":"10.1371\/journal.pone.0067630","article-title":"Diffusion tensor magnetic resonance imaging of the brain in APP transgenic mice: a cohort study","volume":"8","author":"Muller","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2014.02.001_bb0260","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.283.12.1571","article-title":"Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline","volume":"283","author":"Naslund","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.nicl.2014.02.001_bb0265","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.nicl.2013.07.006","article-title":"Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI and, normal aging","volume":"3","author":"Nir","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0275","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1552-6569.2011.00633.x","article-title":"The fornix sign: a potential sign for Alzheimer's disease based on diffusion tensor imaging","volume":"22","author":"Oishi","year":"2012","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0280","doi-asserted-by":"crossref","DOI":"10.1017\/S1355617714000113","article-title":"Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer's disease","author":"Okonkwo","year":"2014","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.nicl.2014.02.001_bb0270","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1212\/WNL.57.4.632","article-title":"Evidence for cortical \u201cdisconnection\u201d as a mechanism of age-related cognitive decline","volume":"57","author":"O'Sullivan","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0285","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1093\/brain\/awt171","article-title":"Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology","volume":"136","author":"Perez-Nievas","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2014.02.001_bb0290","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/1522-2594(200008)44:2<259::AID-MRM13>3.0.CO;2-6","article-title":"Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging","volume":"44","author":"Pfefferbaum","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.nicl.2014.02.001_bb0295","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s00234-013-1195-0","article-title":"In vivo quantitative whole-brain diffusion tensor imaging analysis of APP\/PS1 transgenic mice using voxel-based and atlas-based methods","volume":"55","author":"Qin","year":"2013","journal-title":"Neuroradiology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.acn.2004.02.005","article-title":"Assessment practices of clinical neuropsychologists in the United States and Canada: a survey of INS, NAN, and APA Division 40 members","volume":"20","author":"Rabin","year":"2005","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0305","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neuroimage.2010.03.020","article-title":"Trajectories of brain aging in middle-aged and older adults: regional and individual differences","volume":"51","author":"Raz","year":"2010","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0310","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/brain\/awm102","article-title":"Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations","volume":"130","author":"Ringman","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2014.02.001_bb0315","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1212\/WNL.0b013e318245d295","article-title":"Amyloid burden in healthy aging: regional distribution and cognitive consequences","volume":"78","author":"Rodrigue","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0320","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1038\/cddis.2009.2","article-title":"Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease","volume":"1","author":"Rodr\u00edguez","year":"2010","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.nicl.2014.02.001_bb0325","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/(SICI)1098-1136(199910)28:1<40::AID-GLIA5>3.0.CO;2-6","article-title":"Diffusion barriers evoked in the rat cortex by reactive astrogliosis","volume":"28","author":"Roitbak","year":"1999","journal-title":"Glia"},{"key":"10.1016\/j.nicl.2014.02.001_bb0330","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/brain\/awt065","article-title":"Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease","volume":"136","author":"Ryan","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2014.02.001_bb0335","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/0891988705281882","article-title":"Middle-aged children of persons with Alzheimer's disease: APOE genotypes and cognitive function in the Wisconsin Registry for Alzheimer's Prevention","volume":"18","author":"Sager","year":"2005","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0340","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s11910-004-0084-7","article-title":"Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease","volume":"4","author":"Scarmeas","year":"2004","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.nicl.2014.02.001_bb0345","series-title":"Rey Auditory Verbal Learning Test: A Handbook","author":"Schmidt","year":"1996"},{"key":"10.1016\/j.nicl.2014.02.001_bb0350","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.neurobiolaging.2010.05.019","article-title":"A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease","volume":"32","author":"Sexton","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0355","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12035-013-8418-6","article-title":"Voxel-Based Diffusion Tensor Imaging of an APP\/PS1 Mouse Model of Alzheimer's Disease","volume":"48","author":"Shu","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0360","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.nbd.2003.12.003","article-title":"Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition","volume":"15","author":"Song","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nicl.2014.02.001_bb0365","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1212\/WNL.53.9.1942","article-title":"Rate of memory decline in AD is related to education and occupation: cognitive reserve?","volume":"53","author":"Stern","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0370","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.neuroimage.2010.08.068","article-title":"Bound pool fractions complement diffusion measures to describe white matter micro and macrostructure","volume":"54","author":"Stikov","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0375","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neurobiolaging.2008.04.007","article-title":"Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: relations to timed performance","volume":"31","author":"Sullivan","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0380","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.expneurol.2004.09.006","article-title":"Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging","volume":"191","author":"Sun","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0385","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.neuroimage.2006.07.047","article-title":"Multivariate network analysis of fiber tract integrity in Alzheimer's disease","volume":"34","author":"Teipel","year":"2007","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0390","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00429-010-0271-z","article-title":"Histochemical visualization and diffusion MRI at 7Tesla in the TgCRND8 transgenic model of Alzheimer's disease","volume":"215","author":"Thiessen","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.nicl.2014.02.001_bb0395","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuroimage.2008.05.002","article-title":"Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion-weighted imaging phantom data","volume":"42","author":"Tournier","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0400","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3174\/ajnr.A1564","article-title":"Thalamic Involvement and Its Impact on Clinical Disability in Patients with Multiple Sclerosis: a diffusion tensor imaging study at 3T","volume":"30","author":"Tovar-Moll","year":"2009","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0405","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/mrm.10268","article-title":"High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity","volume":"48","author":"Tuch","year":"2002","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.nicl.2014.02.001_bb0410","doi-asserted-by":"crossref","first-page":"6174","DOI":"10.1523\/JNEUROSCI.1392-08.2008","article-title":"Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer's disease","volume":"28","author":"Villain","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2014.02.001_bb0415","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2014.02.001_bb0420","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1148\/radiol.2301021640","article-title":"Fiber tract-based atlas of human white matter anatomy","volume":"230","author":"Wakana","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0425","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.neuroimage.2011.01.038","article-title":"DTI registration in atlas based fiber analysis of infantile Krabbe disease","volume":"55","author":"Wang","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2014.02.001_bb0430","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1212\/01.wnl.0000271087.67782.cb","article-title":"Relation of cognitive activity to risk of developing Alzheimer disease","volume":"69","author":"Wilson","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2014.02.001_bb0435","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O","article-title":"A unified statistical approach for determining significant signals in images of cerebral activation","volume":"4","author":"Worsley","year":"1996","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2014.02.001_bb0440","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/neu.2009.1110","article-title":"Evaluating the relationship between memory functioning and cingulum bundles in acute mild traumatic brain injury using diffusion tensor imaging","volume":"27","author":"Wu","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nicl.2014.02.001_bb0445","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1399-5618.2007.00395.x","article-title":"White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study","volume":"9","author":"Yurgelun-Todd","year":"2007","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.nicl.2014.02.001_bb0450","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.neurobiolaging.2012.11.017","article-title":"Gray and white matter degeneration revealed by diffusion in an Alzheimer mouse model","volume":"34","author":"Zerbi","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0460","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.media.2006.06.004","article-title":"Deformable registration of diffusion tensor MR images with explicit orientation optimization","volume":"10","author":"Zhang","year":"2006","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.nicl.2014.02.001_bb0455","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1109\/TMI.2007.906784","article-title":"High-dimensional spatial normalization of diffusion tensor images improves the detection of white matter differences: an example study using amyotrophic lateral sclerosis","volume":"26","author":"Zhang","year":"2007","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.nicl.2014.02.001_bb0465","series-title":"Medical Image Computing and Computer-assisted Intervention: MICCAI","first-page":"211","article-title":"Unbiased white matter atlas construction using diffusion tensor images","volume":"10","author":"Zhang","year":"2007"},{"key":"10.1016\/j.nicl.2014.02.001_bb0470","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neuroimage.2006.05.063","article-title":"Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease","volume":"33","author":"Ziolko","year":"2006","journal-title":"NeuroImage"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158214000199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158214000199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:02:23Z","timestamp":1761969743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158214000199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":94,"alternative-id":["S2213158214000199"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2014.02.001","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2014.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}