{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:11:32Z","timestamp":1793394692973,"version":"4.5.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":134,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TRANSACT","award":["FP7-PEOPLE-2012-ITN-316679"],"award-info":[{"award-number":["FP7-PEOPLE-2012-ITN-316679"]}]},{"name":"CENTER-TBI","award":["FP7-COOPERATION-2013-602150"],"award-info":[{"award-number":["FP7-COOPERATION-2013-602150"]}]},{"name":"BRAINPATH","award":["FP7-PEOPLE-2013-IAPP-612360"],"award-info":[{"award-number":["FP7-PEOPLE-2013-IAPP-612360"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1016\/j.nicl.2015.05.003","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T12:19:03Z","timestamp":1431778743000},"page":"367-375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":214,"special_numbering":"C","title":["Automatic segmentation and volumetry of multiple sclerosis brain lesions from MR images"],"prefix":"10.1016","volume":"8","author":[{"given":"Saurabh","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M.","family":"Sima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemie","family":"Ribbens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6884-2496","authenticated-orcid":false,"given":"Melissa","family":"Cambron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Maertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Van Hecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"De Mey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn D.","family":"Steenwijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marita","family":"Daams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-1479","authenticated-orcid":false,"given":"Frederik","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Van Huffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Vrenken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Smeets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2015.05.003_bb009","series-title":"NiftySeg: Statistical Segmentation and Label Fusion Software Package","author":"Cardoso","year":"2012"},{"issue":"1","key":"10.1016\/j.nicl.2015.05.003_bb0011","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jmri.22214","article-title":"Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes","volume":"32","author":"Chard","year":"2010","journal-title":"J. Magn. Reson. Imaging"},{"issue":"9648","key":"10.1016\/j.nicl.2015.05.003_bb001","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.nicl.2015.05.003_bb0014","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2307\/1932409","article-title":"Measures of the amount of ecologic association between species","volume":"26","author":"Dice","year":"1945","journal-title":"Ecology"},{"issue":"2","key":"10.1016\/j.nicl.2015.05.003_bb0018","first-page":"239","article-title":"Intraobserver and interobserver variability in schemes for estimating volume of brain lesions on MR images in multiple sclerosis","volume":"19","author":"Filippi","year":"1998","journal-title":"A.J.N.R. Am. J. Neuroradiol."},{"issue":"1","key":"10.1016\/j.nicl.2015.05.003_bb0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.media.2012.09.004","article-title":"Review of automatic segmentation methods of multiple sclerosis white matter lesions on conventional magnetic resonance imaging","volume":"17","author":"Garc\u00eda-Lorenzo","year":"2013","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.nicl.2015.05.003_bb0015","series-title":"Encyclopedia of Statistical Sciences","first-page":"213","article-title":"Intraclass correlation coefficient","author":"Koch","year":"1982"},{"key":"10.1016\/j.nicl.2015.05.003_bb0077","series-title":"NiftyReg","author":"Modat","year":"2010"},{"issue":"3","key":"10.1016\/j.nicl.2015.05.003_bb007","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.cmpb.2009.09.002","article-title":"Fast free-form deformation using graphics processing units","volume":"98","author":"Modat","year":"2010","journal-title":"Comput. Methods Programs Biomed."},{"issue":"4","key":"10.1016\/j.nicl.2015.05.003_bb0017","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00234-011-0886-7","article-title":"Segmentation of multiple sclerosis lesions in MR images: a review","volume":"54","author":"Mortazavi","year":"2012","journal-title":"Neuroradiology"},{"key":"10.1016\/j.nicl.2015.05.003_bb006","first-page":"140","article-title":"Robust registration of multimodal images: towards real-time clinical applications","volume":"2489","author":"Ourselin","year":"2002","journal-title":"Medical Image Computing and Computer-Assisted Intervention"},{"issue":"2","key":"10.1016\/j.nicl.2015.05.003_bb002","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.nicl.2015.05.003_bb004","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1016\/j.neuroimage.2011.11.032","article-title":"An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis","volume":"59","author":"Schmidt","year":"2012","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.nicl.2015.05.003_bb005","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.neuroimage.2009.09.005","article-title":"A topology-preserving approach to the segmentation of brain images with multiple sclerosis lesions","volume":"49","author":"Shiee","year":"2010","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.nicl.2015.05.003_bb0013","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.nicl.2013.10.003","article-title":"Accurate white matter lesion segmentation by k nearest neighbor classification with tissue type priors (kNN-TTPs)","volume":"3","author":"Steenwijk","year":"2013","journal-title":"Neuroimage Clin."},{"issue":"11","key":"10.1016\/j.nicl.2015.05.003_bb003","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1001\/archneurol.2011.241","article-title":"Interferon beta-1b for the treatment of primary progressive multiple sclerosis: five-year clinical trial follow-up","volume":"68","author":"Tur","year":"2011","journal-title":"Arch. Neurol."},{"issue":"8","key":"10.1016\/j.nicl.2015.05.003_bb0010","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1109\/42.938237","article-title":"Automated segmentation of multiple sclerosis lesions by model outlier detection","volume":"20","author":"Van Leemput","year":"2001","journal-title":"I.E.E.E. Transactions Med. Imaging"},{"issue":"10","key":"10.1016\/j.nicl.2015.05.003_bb008","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1109\/42.811270","article-title":"Automated model-based tissue classification of MR images of the brain","volume":"18","author":"Van Leemput","year":"1999","journal-title":"I.E.E.E. Transactions Med. Imaging"},{"issue":"10","key":"10.1016\/j.nicl.2015.05.003_bb0019","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1007\/s00415-012-6762-5","article-title":"Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis","volume":"260","author":"Vrenken","year":"2013","journal-title":"J. Neurol."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158215000959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158215000959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T03:59:10Z","timestamp":1761969550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158215000959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":19,"alternative-id":["S2213158215000959"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2015.05.003","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Automatic segmentation and volumetry of multiple sclerosis brain lesions from MR images","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2015.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}