{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:54:06Z","timestamp":1791924846906,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Swiss Neuromatrix Foundation","award":["ER2-2014"],"award-info":[{"award-number":["ER2-2014"]}]},{"DOI":"10.13039\/100013057","name":"Heffter Research Institute","doi-asserted-by":"crossref","award":["2-190414"],"award-info":[{"award-number":["2-190414"]}],"id":[{"id":"10.13039\/100013057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"the Swiss National Science Foundation","doi-asserted-by":"publisher","award":["155184"],"award-info":[{"award-number":["155184"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["088130\/Z\/09\/Z"],"award-info":[{"award-number":["088130\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/j.nicl.2015.08.009","type":"journal-article","created":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T02:15:52Z","timestamp":1440209752000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["The mixed serotonin receptor agonist psilocybin reduces threat-induced modulation of amygdala connectivity"],"prefix":"10.1016","volume":"11","author":[{"given":"Rainer","family":"Kraehenmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Friston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin H.","family":"Preller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Seifritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz X.","family":"Vollenweider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.nicl.2015.08.009_bb0028","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.nicl.2015.08.009_bb006","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s12035-013-8472-0","article-title":"Regulating prefrontal cortex activation: an emerging role for the 5-HT2A serotonin receptor in the modulation of emotion-based actions?","volume":"48","author":"Aznar","year":"2013","journal-title":"Mol. Neurobiol."},{"issue":"40","key":"10.1016\/j.nicl.2015.08.009_bb0037","doi-asserted-by":"crossref","first-page":"14378","DOI":"10.1523\/JNEUROSCI.2400-11.2011","article-title":"Effective connectivity during processing of facial affect: evidence for multiple parallel pathways","volume":"31","author":"Dima","year":"2011","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.nicl.2015.08.009_bb0050","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrn3027","article-title":"Neural mechanisms of the cognitive model of depression","volume":"12","author":"Disner","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2015.08.009_bb0021","article-title":"Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II)","author":"First","year":"1997"},{"issue":"11","key":"10.1016\/j.nicl.2015.08.009_bb008","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1093\/cercor\/bhp022","article-title":"Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling","volume":"19","author":"Fisher","year":"2009","journal-title":"Cereb. Cortex"},{"issue":"4","key":"10.1016\/j.nicl.2015.08.009_bb0034","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/cne.20520","article-title":"The organization of projections from the amygdala to visual cortical areas TE and V1 in the macaque monkey","volume":"486","author":"Freese","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nicl.2015.08.009_bb0056","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1038\/tp.2013.85","article-title":"Altered fusiform connectivity during processing of fearful faces in social anxiety disorder","volume":"3","author":"Frick","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.nicl.2015.08.009_bb0013","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1053-8119(03)00202-7","article-title":"Dynamic causal modelling","volume":"19","author":"Friston","year":"2003","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.nicl.2015.08.009_bb0029","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general linear approach","volume":"2","author":"Friston","year":"1994","journal-title":"Hum. Brain Mapp."},{"issue":"44","key":"10.1016\/j.nicl.2015.08.009_bb003","doi-asserted-by":"crossref","first-page":"17435","DOI":"10.1523\/JNEUROSCI.2992-13.2013","article-title":"Top-down control of visual responses to fear by the amygdala","volume":"33","author":"Furl","year":"2013","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.nicl.2015.08.009_bb0042","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.biopsych.2012.04.031","article-title":"Reversed frontotemporal connectivity during emotional face processing in remitted depression","volume":"72","author":"Goulden","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.nicl.2015.08.009_bb0015","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/cercor\/bhp144","article-title":"Noradrenergic modulation of cortical networks engaged in visuomotor processing","volume":"20","author":"Grefkes","year":"2010","journal-title":"Cereb. Cortex"},{"issue":"3","key":"10.1016\/j.nicl.2015.08.009_bb005","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.neuroimage.2011.02.064","article-title":"Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder","volume":"56","author":"Hahn","year":"2011","journal-title":"Neuroimage"},{"issue":"5580","key":"10.1016\/j.nicl.2015.08.009_bb0063","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.1071829","article-title":"Serotonin transporter genetic variation and the response of the human amygdala","volume":"297","author":"Hariri","year":"2002","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.nicl.2015.08.009_bb0026","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00213-003-1640-6","article-title":"Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose\u2013effect study","volume":"172","author":"Hasler","year":"2004","journal-title":"Psychopharmacology (Berl.)"},{"issue":"4","key":"10.1016\/j.nicl.2015.08.009_bb0041","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1016\/j.neuroimage.2011.03.072","article-title":"Bidirectional communication between amygdala and fusiform gyrus during facial recognition","volume":"56","author":"Herrington","year":"2011","journal-title":"Neuroimage"},{"issue":"5386","key":"10.1016\/j.nicl.2015.08.009_bb0067","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1126\/science.282.5386.108","article-title":"Mechanisms of directed attention in the human extrastriate cortex as revealed by functional MRI","volume":"282","author":"Kastner","year":"1998","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.nicl.2015.08.009_bb0054","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.biopsych.2012.04.005","article-title":"Psilocybine biases facial recognition, goal-directed behavior, and mood state toward positive relative to negative emotions through different serotonergic subreceptors","volume":"72","author":"Kometer","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nicl.2015.08.009_bb001","article-title":"Psilocybin-induced decrease in amygdala reactivity correlates with enhanced positive mood in healthy volunteers. Biol","author":"Kraehenmann","year":"2014","journal-title":"Psychiatry"},{"key":"10.1016\/j.nicl.2015.08.009_bb0027","series-title":"Affective Ratings of Pictures and Instruction Manual","article-title":"International affective picture system (IAPS)","author":"Lang","year":"2005"},{"key":"10.1016\/j.nicl.2015.08.009_bb0051","article-title":"Halluzinogene. Psychische Grenzzust\u00e4nde in Forschung und Psychotherapie","author":"Leuner","year":"1981"},{"issue":"2","key":"10.1016\/j.nicl.2015.08.009_bb0046","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neulet.2012.06.058","article-title":"Impaired prefrontal\u2013amygdala effective connectivity is responsible for the dysfunction of emotion process in major depressive disorder: a dynamic causal modeling study on MEG","volume":"523","author":"Lu","year":"2012","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.nicl.2015.08.009_bb004","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/brain\/121.1.47","article-title":"A neuromodulatory role for the human amygdala in processing emotional facial expressions","volume":"121","author":"Morris","year":"1998","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.nicl.2015.08.009_bb0066","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.neubiorev.2013.07.010","article-title":"Acute neural effects of selective serotonin reuptake inhibitors versus noradrenaline reuptake inhibitors on emotion processing: implications for differential treatment efficacy","volume":"37","author":"Outhred","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.nicl.2015.08.009_bb0038","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.neuroimage.2004.03.026","article-title":"Comparing dynamic causal models","volume":"22","author":"Penny","year":"2004","journal-title":"Neuroimage"},{"issue":"11","key":"10.1016\/j.nicl.2015.08.009_bb0010","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nrn2920","article-title":"Emotion processing and the amygdala: from a \u2018low road\u2019 to \u2018many roads\u2019 of evaluating biological significance","volume":"11","author":"Pessoa","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.nicl.2015.08.009_bb0059","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/jn.1999.82.1.69","article-title":"Serotonergic modulation of neurotransmission in the rat basolateral amygdala","volume":"82","author":"Rainnie","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nicl.2015.08.009_bb0061","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.neuroimage.2013.03.075","article-title":"The role of serotonin in the neurocircuitry of negative affective bias: serotonergic modulation of the dorsal medial prefrontal\u2013amygdala \u2018aversive amplification\u2019 circuit","volume":"78","author":"Robinson","year":"2013","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.nicl.2015.08.009_bb0019","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00213-012-2811-0","article-title":"The NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on structural encoding of emotional face expressions","volume":"225","author":"Schmidt","year":"2013","journal-title":"Psychopharmacology (Berl.)"},{"issue":"9","key":"10.1016\/j.nicl.2015.08.009_bb0016","first-page":"903","article-title":"Brain connectivity abnormalities predating the onset of psychosis: correlation with the effect of medication","volume":"70","author":"Schmidt","year":"2013","journal-title":"J.A.M.A. Psychiatry"},{"issue":"Suppl. 20","key":"10.1016\/j.nicl.2015.08.009_bb0020","first-page":"22","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.nicl.2015.08.009_bb007","first-page":"243","volume":"108","author":"Sladky","year":"2015"},{"key":"10.1016\/j.nicl.2015.08.009_bb0025","first-page":"36","volume":"iv","author":"Spielberger","year":"1983"},{"issue":"4","key":"10.1016\/j.nicl.2015.08.009_bb0014","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.neuroimage.2009.03.025","article-title":"Bayesian model selection for group studies","volume":"46","author":"Stephan","year":"2009","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.nicl.2015.08.009_bb0032","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.neuroimage.2007.07.040","article-title":"Comparing hemodynamic models with DCM","volume":"38","author":"Stephan","year":"2007","journal-title":"Neuroimage"},{"issue":"11","key":"10.1016\/j.nicl.2015.08.009_bb0023","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1177\/0269881110382466","article-title":"Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies","volume":"25","author":"Studerus","year":"2011","journal-title":"J. Psychopharmacol. (Oxford)"},{"issue":"9","key":"10.1016\/j.nicl.2015.08.009_bb0052","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nrn2884","article-title":"The neurobiology of psychedelic drugs: implications for the treatment of mood disorders","volume":"11","author":"Vollenweider","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"issue":"21","key":"10.1016\/j.nicl.2015.08.009_bb0011","doi-asserted-by":"crossref","first-page":"8974","DOI":"10.1523\/JNEUROSCI.5518-12.2013","article-title":"Reduced serotonin transporter availability decreases prefrontal control of the amygdala","volume":"33","author":"Volman","year":"2013","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nicl.2015.08.009_bb0049","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/WCO.0000000000000159","article-title":"Affective and motivational control of vision","volume":"28","author":"Vuilleumier","year":"2015","journal-title":"Curr. Opin. Neurol."},{"issue":"6","key":"10.1016\/j.nicl.2015.08.009_bb0024","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","article-title":"Development and validation of brief measures of positive and negative affect: the PANAS scales","volume":"54","author":"Watson","year":"1988","journal-title":"J. Pers. Soc. Psychol."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158215001473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158215001473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:09:05Z","timestamp":1761970145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158215001473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":41,"alternative-id":["S2213158215001473"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2015.08.009","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mixed serotonin receptor agonist psilocybin reduces threat-induced modulation of amygdala connectivity","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2015.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}