{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:45:36Z","timestamp":1782337536934,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T00:00:00Z","timestamp":1484438400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FZK-01ER0816"],"award-info":[{"award-number":["FZK-01ER0816"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FZK-01ER1205"],"award-info":[{"award-number":["FZK-01ER1205"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DA1151\/5-1"],"award-info":[{"award-number":["DA1151\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2107"],"award-info":[{"award-number":["FOR2107"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2017]]},"DOI":"10.1016\/j.nicl.2017.01.013","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T02:46:24Z","timestamp":1484534784000},"page":"151-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Reduced fractional anisotropy in patients with major depressive disorder and associations with vascular stiffness"],"prefix":"10.1016","volume":"14","author":[{"given":"Marco","family":"Hermesdorf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Szentkir\u00e1lyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Schwindt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Dannlowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Wersching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2017.01.013_bb0005","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1017\/S0033291713003000","article-title":"Altered white-matter architecture in treatment-naive adolescents with clinical depression","volume":"44","author":"Aghajani","year":"2014","journal-title":"Psychol. Med."},{"key":"10.1016\/j.nicl.2017.01.013_bb0010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/ajh\/hpw026","article-title":"Higher blood pressure partially links greater adiposity to reduced brain white matter integrity","volume":"29","author":"Allen","year":"2016","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.nicl.2017.01.013_bb0015","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.HYP.30.4.817","article-title":"Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin","volume":"30","author":"Barton","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.nicl.2017.01.013_bb0020","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3389\/fnhum.2015.00408","article-title":"Depressive symptoms related to low fractional anisotropy of white matter underlying the right ventral anterior cingulate in older adults with atherosclerotic vascular disease","volume":"9","author":"Bijanki","year":"2015","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.nicl.2017.01.013_bb0025","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.atherosclerosis.2004.08.035","article-title":"Anxiety and depression are associated with unhealthy lifestyle in patients at risk of cardiovascular disease","volume":"178","author":"Bonnet","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.nicl.2017.01.013_bb0030","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1741-7015-9-90","article-title":"Cross-national epidemiology of DSM-IV major depressive episode","volume":"9","author":"Bromet","year":"2011","journal-title":"BMC Med."},{"key":"10.1016\/j.nicl.2017.01.013_bb0035","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2147\/VHRM.S7116","article-title":"Vascular health in children and adolescents: effects of obesity and diabetes","volume":"5","author":"Copeland","year":"2009","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.nicl.2017.01.013_bb0040","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1093\/brain\/awr145","article-title":"Cigarette smoking is associated with reduced microstructural integrity of cerebral white matter","volume":"134","author":"Gons","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2017.01.013_bb0045","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1212\/WNL.0b013e3182a43e33","article-title":"Physical activity is related to the structural integrity of cerebral white matter","volume":"81","author":"Gons","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2017.01.013_bb0050","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/cercor\/bhn059","article-title":"Resting-state functional connectivity reflects structural connectivity in the default mode network","volume":"19","author":"Greicius","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2017.01.013_bb0055","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neulet.2012.06.027","article-title":"Altered white matter integrity in young adults with first-episode, treatment-naive, and treatment-responsive depression","volume":"522","author":"Guo","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nicl.2017.01.013_bb0060","series-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-based Approach","author":"Hayes","year":"2013"},{"key":"10.1016\/j.nicl.2017.01.013_bb0065","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/jnnp.2007.124651","article-title":"White matter hyperintensities in late life depression: a systematic review","volume":"79","author":"Herrmann","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2017.01.013_bb0070","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/pgmj.2005.036053","article-title":"Ageing and vascular ageing","volume":"82","author":"Jani","year":"2006","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.nicl.2017.01.013_bb0075","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/mrm.20033","article-title":"The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: a Monte Carlo study","volume":"51","author":"Jones","year":"2004","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.nicl.2017.01.013_bb0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroimage.2012.06.081","article-title":"White matter integrity, fiber count, and other fallacies: the do's and don'ts of diffusion MRI","volume":"73","author":"Jones","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.01.013_bb0085","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jad.2009.04.023","article-title":"Major depressive disorder and white matter abnormalities: a diffusion tensor imaging study with tract-based spatial statistics","volume":"120","author":"Kiesepp\u00e4","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nicl.2017.01.013_bb0090","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1002\/hbm.21178","article-title":"Loss of white matter integrity in major depressive disorder: evidence using tract-based spatial statistical analysis of diffusion tensor imaging","volume":"32","author":"Korgaonkar","year":"2011","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2017.01.013_bb0095","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/HYPERTENSIONAHA.112.194746","article-title":"Blood pressure and obesity exert independent influences on pulse wave velocity in youth","volume":"60","author":"Lurbe","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.nicl.2017.01.013_bb0100","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1161\/STROKEAHA.116.012949","article-title":"Effects of arterial stiffness on brain integrity in young adults from the Framingham heart study","volume":"47","author":"Maillard","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2017.01.013_bb0105","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/cercor\/bht358","article-title":"Human thalamus regulates cortical activity via spatially specific and structurally constrained phase-amplitude coupling","volume":"25","author":"Malekmohammadi","year":"2015","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2017.01.013_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MNH.0000000000000092","article-title":"Arterial stiffness","volume":"24","author":"Mitchell","year":"2015","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.nicl.2017.01.013_bb0115","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1093\/brain\/awr253","article-title":"Arterial stiffness, pressure and flow pulsatility and brain structure and function: the age, gene\/environment susceptibility - Reykjavik study","volume":"134","author":"Mitchell","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2017.01.013_bb0120","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neuroimage.2007.12.035","article-title":"Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template","volume":"40","author":"Mori","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.01.013_bb0125","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/desc.12077","article-title":"Higher education is an age-independent predictor of white matter integrity and cognitive control in late adolescence","volume":"16","author":"Noble","year":"2013","journal-title":"Dev. Sci."},{"key":"10.1016\/j.nicl.2017.01.013_bb0130","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/pcn.12255","article-title":"White matter abnormalities in major depressive disorder with melancholic and atypical features: a diffusion tensor imaging study","volume":"69","author":"Ota","year":"2015","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.nicl.2017.01.013_bb0135","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12872-016-0224-4","article-title":"Measurement of pulse wave velocity in normal ageing: comparison of Vicorder and magnetic resonance phase contrast imaging","volume":"16","author":"Parikh","year":"2016","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.nicl.2017.01.013_bb0140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/1522-2594(200008)44:2<259::AID-MRM13>3.0.CO;2-6","article-title":"Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging","volume":"44","author":"Pfefferbaum","year":"2000","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.nicl.2017.01.013_bb0145","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl. Psychol. Meas."},{"key":"10.1016\/j.nicl.2017.01.013_bb0150","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.01.013_bb0155","first-page":"1295","article-title":"Vascular depression: a distinct diagnostic subtype? Biol","volume":"60","author":"Sneed","year":"2006","journal-title":"Psychiatry"},{"key":"10.1016\/j.nicl.2017.01.013_bb0160","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/sj.jhh.1001838","article-title":"Brachial\u2013ankle pulse wave velocity: an index of central arterial stiffness?","volume":"19","author":"Sugawara","year":"2005","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.nicl.2017.01.013_bb0165","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuroimage.2015.01.041","article-title":"Central artery stiffness, baroreflex sensitivity, and brain white matter neuronal fiber integrity in older adults","volume":"110","author":"Tarumi","year":"2015","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.01.013_bb0170","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/1471-244X-14-174","article-title":"Establishing the bidirectional relationship between depression and subclinical arteriosclerosis \u2013 rationale, design, and characteristics of the BiDirect study","volume":"14","author":"Teismann","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.nicl.2017.01.013_bb0175","article-title":"MR imaging of the brain in large cohort studies: feasibility report of the population- and patient-based BiDirect study","volume":"1\u20138","author":"Teuber","year":"2016","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.nicl.2017.01.013_bb0180","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1113\/JP270597","article-title":"Arterial structure and function in vascular ageing: are you as old as your arteries?","volume":"594","author":"Thijssen","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.nicl.2017.01.013_bb0185","doi-asserted-by":"crossref","first-page":"20121004","DOI":"10.1098\/rsif.2012.1004","article-title":"Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review","volume":"10","author":"Tsamis","year":"2013","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.nicl.2017.01.013_bb0190","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.01.013_bb0195","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1291\/hypres.26.615","article-title":"Brachial-ankle pulse wave velocity as a marker of atherosclerotic vascular damage and cardiovascular risk","volume":"26","author":"Yamashina","year":"2003","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.nicl.2017.01.013_bb0200","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.brainres.2010.10.104","article-title":"Altered white matter integrity in first-episode, treatment-naive young adults with major depressive disorder: a tract-based spatial statistics study","volume":"1369","author":"Zhu","year":"2011","journal-title":"Brain Res."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221315821730013X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221315821730013X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:08:45Z","timestamp":1761970125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221315821730013X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":40,"alternative-id":["S221315821730013X"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2017.01.013","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced fractional anisotropy in patients with major depressive disorder and associations with vascular stiffness","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2017.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}