{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T23:45:14Z","timestamp":1789083914954,"version":"build-2803163510"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":114,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1U01-HL-117718-01"],"award-info":[{"award-number":["1U01-HL-117718-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS074980"],"award-info":[{"award-number":["R01 NS074980"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1 T32 MH 111360-1 A1"],"award-info":[{"award-number":["1 T32 MH 111360-1 A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 ES024936"],"award-info":[{"award-number":["R01 ES024936"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2017]]},"DOI":"10.1016\/j.nicl.2017.04.023","type":"journal-article","created":{"date-parts":[[2017,4,29]],"date-time":"2017-04-29T05:30:47Z","timestamp":1493443847000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients"],"prefix":"10.1016","volume":"15","author":[{"given":"Soyoung","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Borzage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand A.","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Coates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Leahy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2017.04.023_bb0005","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1056\/NEJM199202273260905","article-title":"The use of transcranial ultrasonography to predict stroke in sickle cell disease","volume":"326","author":"Adams","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2017.04.023_bb0010","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/ana.410420505","article-title":"Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler","volume":"42","author":"Adams","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0015","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1182\/asheducation-2001.1.31","article-title":"Sickle cell and the brain","volume":"2001","author":"Adams","year":"2001","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.nicl.2017.04.023_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0149-7634(03)00005-8","article-title":"Trajectories of brain development: point of vulnerability or window of opportunity?","volume":"27","author":"Andersen","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nicl.2017.04.023_bb0025","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1161\/01.STR.0000217258.63925.6b","article-title":"Ischemic thresholds for gray and white matter: a diffusion and perfusion magnetic resonance study","volume":"37","author":"Arakawa","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2017.04.023_bb0030","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1542\/peds.97.6.864","article-title":"Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease","volume":"97","author":"Armstrong","year":"1996","journal-title":"Pediatrics"},{"key":"10.1016\/j.nicl.2017.04.023_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.25655","article-title":"Contribution of sickle cell disease to the pediatric stroke burden among hospital discharges of African-Americans-United States, 1997\u20132012","author":"Baker","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.nicl.2017.04.023_bb0040","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2214\/AJR.11.7404","article-title":"Quantitative brain diffusion-tensor MRI findings in patients with sickle cell disease","volume":"198","author":"Balci","year":"2012","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0045","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/ana.20790","article-title":"Detecting white matter injury in sickle cell disease using voxel-based morphometry","volume":"59","author":"Baldeweg","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0050","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/01.STR.0000116105.26237.EC","article-title":"Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease","volume":"35","author":"Bath","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2017.04.023_bb0055","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1182\/blood-2010-06-293514","article-title":"Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort","volume":"117","author":"Bernaudin","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0060","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1182\/blood-2014-09-599852","article-title":"Chronic and acute anemia and extracranial internal carotid stenosis are risk factors for silent cerebral infarcts in sickle cell anemia","volume":"125","author":"Bernaudin","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0065","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1152\/japplphysiol.00994.2015","article-title":"Predictors of cerebral blood flow in patients with and without anemia","volume":"120","author":"Borzage","year":"2016","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0070","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/sj.jcbfm.9600135","article-title":"MR perfusion and diffusion in acute ischemic stroke: human gray and white matter have different thresholds for infarction","volume":"25","author":"Bristow","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nicl.2017.04.023_bb0075","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/ajh.24441","article-title":"Determinants of resting cerebral blood flow in sickle cell disease","volume":"91","author":"Bush","year":"2016","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ajh.24235","article-title":"Evolution of sickle cell disease from a life-threatening disease of children to a chronic disease of adults: the last 40years","volume":"91","author":"Chaturvedi","year":"2016","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0085","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3174\/ajnr.A4101","article-title":"A prospective longitudinal brain morphometry study of children with sickle cell disease","volume":"36","author":"Chen","year":"2014","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0090","first-page":"696","article-title":"Changes in regional cerebral blood flow during brain maturation in children and adolescents","volume":"33","author":"Chiron","year":"1992","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2017.04.023_bb0095","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1538-7836.2009.03584.x","article-title":"Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis","volume":"8","author":"Chu","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.nicl.2017.04.023_bb0100","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/pmed.1998.0274","article-title":"A critical period of brain development: studies of cerebral glucose utilization with PET","volume":"27","author":"Chugani","year":"1998","journal-title":"Prev. Med. (Baltim)."},{"key":"10.1016\/j.nicl.2017.04.023_bb0105","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2015-09-618579","article-title":"Central nervous system complications and management in sickle cell disease","author":"Debaun","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0110","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1182\/blood-2011-02-272682","article-title":"Silent cerebral infarcts: a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia","volume":"119","author":"DeBaun","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0115","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1182\/blood-2011-05-349621","article-title":"Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure","volume":"119","author":"DeBaun","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0120","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1401731","article-title":"Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia","volume":"371","author":"DeBaun","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2017.04.023_bb0125","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.c3666","article-title":"The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis","volume":"341","author":"Debette","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.nicl.2017.04.023_bb0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0014-2999(99)00280-0","article-title":"Drug development for stroke: importance of protecting cerebral white matter","volume":"375","author":"Dewar","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0135","article-title":"A common brain network links development, aging, and vulnerability to disease","volume":"201410378","author":"Douaud","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nicl.2017.04.023_bb0140","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1056\/NEJM199709113371107","article-title":"Pathogenesis and treatment of sickle cell disease","volume":"337","author":"Epstein","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2017.04.023_bb0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ajh.21569","article-title":"Cardiopulmonary complications leading to premature deaths in adult patients with sickle cell disease","volume":"85","author":"Fitzhugh","year":"2010","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0150","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1467-8624.2009.01380.x","article-title":"How the timing and quality of early experiences influence the development of brain architecture","volume":"81","author":"Fox","year":"2010","journal-title":"Child Dev."},{"key":"10.1016\/j.nicl.2017.04.023_bb0155","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.1073\/pnas.0402680101","article-title":"Dynamic mapping of human cortical development during childhood through early adulthood","volume":"101","author":"Gogtay","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2017.04.023_bb0160","doi-asserted-by":"crossref","first-page":"S512","DOI":"10.1016\/j.amepre.2009.12.022","article-title":"Population estimates of sickle cell disease in the U.S","volume":"38","author":"Hassell","year":"2010","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.nicl.2017.04.023_bb0165","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2013-12-545186","article-title":"Magnetic resonance imaging\/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial","author":"Helton","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0170","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nrn1787","article-title":"Critical period plasticity in local cortical circuits","volume":"6","author":"Hensch","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2017.04.023_bb0175","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1182\/blood-2010-01-261123","article-title":"Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease","volume":"117","author":"Hulbert","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0180","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1161\/01.STR.0000135226.53499.85","article-title":"Stroke risk profile predicts white matter hyperintensity volume: the Framingham study","volume":"35","author":"Jeerakathil","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2017.04.023_bb0185","series-title":"Biomedical Image Registration","first-page":"180","article-title":"A method for automated cortical surface registration and labeling","author":"Joshi","year":"2012"},{"key":"10.1016\/j.nicl.2017.04.023_bb0190","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/bjh.12496","article-title":"Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia","volume":"163","author":"Kawadler","year":"2013","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0195","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1161\/STROKEAHA.115.008721","article-title":"White matter damage relates to oxygen saturation in children with sickle cell anemia without silent cerebral infarcts","volume":"46","author":"Kawadler","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2017.04.023_bb0200","doi-asserted-by":"crossref","first-page":"1549-56","DOI":"10.1093\/cercor\/bhn193","article-title":"Regionally specific cortical thinning in children with sickle cell disease","volume":"19","author":"Kirk","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2017.04.023_bb0205","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/bjh.13179","article-title":"Volume of white matter hyperintensities is an independent predictor of intelligence quotient and processing speed in children with sickle cell disease","volume":"168","author":"van der Land","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0210","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.neubiorev.2006.06.001","article-title":"Brain development in children and adolescents: insights from anatomical magnetic resonance imaging","volume":"30","author":"Lenroot","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nicl.2017.04.023_bb0215","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1371\/journal.pone.0084802","article-title":"White matter injury due to experimental chronic cerebral hypoperfusion is associated with C5 deposition","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2017.04.023_bb0220","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1212\/WNL.0000000000000188","article-title":"Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition","volume":"82","author":"Mackin","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2017.04.023_bb0225","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1067\/mpd.2001.117580","article-title":"Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease","volume":"139","author":"Miller","year":"2001","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nicl.2017.04.023_bb0230","first-page":"965","article-title":"The spectrum of brain MR abnormalities in sickle-cell disease: a report from the Cooperative Study of Sickle Cell Disease","volume":"17","author":"Moser","year":"1996","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0235","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1203\/01.PDR.0000084083.71422.16","article-title":"Preterm children have disturbances of white matter at 11years of age as shown by diffusion tensor imaging","volume":"54","author":"Nagy","year":"2003","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.nicl.2017.04.023_bb0240","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s002470000290","article-title":"Incidence of focal white matter lesions in a population of hemophiliac children and their normal siblings. Hemophilia Growth and Development Study","volume":"30","author":"Nelson","year":"2000","journal-title":"Pediatr. Radiol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0245","doi-asserted-by":"crossref","first-page":"E2745","DOI":"10.1073\/pnas.1502170112","article-title":"Interpreting the neurodevelopmental hypothesis of schizophrenia in the context of normal brain development and ageing","volume":"112","author":"Nour","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.nicl.2017.04.023_bb0250","first-page":"288","article-title":"Cerebrovascular accidents in sickle cell disease: rates and risk factors","volume":"91","author":"Ohene-Frempong","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0255","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1161\/01.STR.27.9.1641","article-title":"Cerebral white matter is highly vulnerable to ischemia","volume":"27","author":"Pantoni","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2017.04.023_bb0260","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1182\/blood.V99.8.3014","article-title":"Longitudinal changes in brain magnetic resonance imaging findings in children with sickle cell disease","volume":"99","author":"Pegelow","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2014.02.031","article-title":"Cerebral white matter lesions and perceived cognitive dysfunction: the role of pregnancy","volume":"211","author":"Postma","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0270","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0002-9343(78)90772-6","article-title":"The natural history of stroke in sickle cell disease","volume":"65","author":"Powars","year":"1978","journal-title":"Am. J. Med."},{"key":"10.1016\/j.nicl.2017.04.023_bb0275","first-page":"71","article-title":"Cerebral vasculopathy in sickle cell anemia: diagnostic contribution of positron emission tomography","volume":"93","author":"Powars","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0280","series-title":"Hemodynamic Etiology of Elevated Flow Velocity and Stroke in Sickle-Cell Disease","first-page":"803","author":"Prohovnik","year":"2009"},{"key":"10.1016\/j.nicl.2017.04.023_bb0285","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1182\/blood-2009-07-233700","article-title":"Improved survival of children and adolescents with sickle cell disease","volume":"115","author":"Quinn","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.nicl.2017.04.023_bb0290","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jamaneurol.2013.576","article-title":"Acute silent cerebral ischemic events in children with sickle cell anemia","volume":"70","author":"Quinn","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0295","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrn700","article-title":"Neurogenesis in adult primate neocortex: an evaluation of the evidence","volume":"3","author":"Rakic","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2017.04.023_bb0300","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.nicl.2017.04.023_bb0305","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/03630269.2015.1040493","article-title":"Aging in sickle cell disease: co-morbidities and new issues in management","volume":"39","author":"Sandhu","year":"2015","journal-title":"Hemoglobin"},{"key":"10.1016\/j.nicl.2017.04.023_bb0310","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1017\/S1355617706060085","article-title":"Decreased corpus callosum size in sickle cell disease: relationship with cerebral infarcts and cognitive functioning","volume":"12","author":"Schatz","year":"2006","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.nicl.2017.04.023_bb0315","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/mrdd.20115","article-title":"Sickle cell disease as a neurodevelopmental disorder","volume":"12","author":"Schatz","year":"2006","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.nicl.2017.04.023_bb0320","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1177\/08830738020170122401","article-title":"Lesion burden and cognitive morbidity in children with sickle cell disease","volume":"17","author":"Schatz","year":"2002","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0325","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1067\/mpd.2002.122498","article-title":"Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial stroke","volume":"140","author":"Scothorn","year":"2002","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nicl.2017.04.023_bb0330","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1523\/JNEUROSCI.5309-07.2008","article-title":"Neurodevelopmental trajectories of the human cerebral cortex","volume":"28","author":"Shaw","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.04.023_bb0335","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1161\/01.STR.0000143725.19053.60","article-title":"White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion","volume":"35","author":"Shibata","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2017.04.023_bb0340","doi-asserted-by":"crossref","first-page":"8223","DOI":"10.1523\/JNEUROSCI.1798-04.2004","article-title":"Longitudinal mapping of cortical thickness and brain growth in normal children","volume":"24","author":"Sowell","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.04.023_bb0345","first-page":"455","article-title":"Brain volume in pediatric patients with sickle cell disease: evidence of volumetric growth delay?","volume":"26","author":"Steen","year":"2005","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0350","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ajh.21476","article-title":"The excess burden of stroke in hospitalized adults with sickle cell disease","volume":"84","author":"Strouse","year":"2009","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0355","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.3174\/ajnr.A3135","article-title":"White matter damage in asymptomatic patients with sickle cell anemia: screening with diffusion tensor imaging","volume":"33","author":"Sun","year":"2012","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2017.04.023_bb0360","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1212\/WNL.50.6.1699","article-title":"Arterial territories of the human brain: cerebral hemispheres","volume":"50","author":"Tatu","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2017.04.023_bb0365","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/nrn2598","article-title":"Prenatal exposure to drugs: effects on brain development and implications for policy and education","volume":"10","author":"Thompson","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2017.04.023_bb0370","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tins.2006.01.007","article-title":"Mapping brain maturation","volume":"29","author":"Toga","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nicl.2017.04.023_bb0375","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.thromres.2013.10.006","article-title":"Markers of endothelial dysfunction differ between subphenotypes in children with sickle cell disease","volume":"132","author":"Van Der Land","year":"2013","journal-title":"Thromb. Res."},{"key":"10.1016\/j.nicl.2017.04.023_bb0380","first-page":"5117","article-title":"Review article sickle cell disease and stroke","volume":"114","author":"Verduzco","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2017.04.023_bb0385","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1001\/jama.2010.562","article-title":"Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia","volume":"303","author":"Vichinsky","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.nicl.2017.04.023_bb0390","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1111\/j.1742-1241.2009.02070.x","article-title":"The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases","volume":"63","author":"Vizioli","year":"2009","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.nicl.2017.04.023_bb0395","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3324\/haematol.11136","article-title":"Pulmonary hypertension in patients with sickle cell\/thalassemia: incidence and correlation with serum N-terminal pro-brain natriuretic peptide concentrations","volume":"92","author":"Voskaridou","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.nicl.2017.04.023_bb0400","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0022-3476(98)70397-X","article-title":"Abnormalities of the central nervous system in very young children with sickle cell anemia","volume":"132","author":"Wang","year":"1998","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nicl.2017.04.023_bb0405","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neuroimage.2013.11.010","article-title":"Unique developmental trajectories of cortical thickness and surface area","volume":"87","author":"Wierenga","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.04.023_bb0410","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1056\/NEJMoa043104","article-title":"Obstructive sleep apnea as a risk factor for stroke and death","volume":"353","author":"Yaggi","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2017.04.023_bb0415","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1001\/jama.2014.10517","article-title":"Management of sickle cell disease","volume":"312","author":"Yawn","year":"2014","journal-title":"JAMA"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158217301006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158217301006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:40:20Z","timestamp":1778852420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158217301006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":83,"alternative-id":["S2213158217301006"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2017.04.023","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2017.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}