{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:58:17Z","timestamp":1792191497699,"version":"4.4.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":179,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","award":["SP 037.15\/432282"],"award-info":[{"award-number":["SP 037.15\/432282"]}],"id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2017]]},"DOI":"10.1016\/j.nicl.2017.06.034","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T13:46:27Z","timestamp":1498830387000},"page":"843-853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Agreement of MSmetrix with established methods for measuring cross-sectional and longitudinal brain atrophy"],"prefix":"10.1016","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8346-9044","authenticated-orcid":false,"given":"Martijn D.","family":"Steenwijk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houshang","family":"Amiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno M.","family":"Schoonheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"de Sitter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3543-3706","authenticated-orcid":false,"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra J.W.","family":"Pouwels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Vrenken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2017.06.034_bb0005","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroimage.2006.03.052","article-title":"A new improved version of the realistic digital brain phantom","volume":"32","author":"Aubert-Broche","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.06.034_bb0010","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1109\/TMI.2006.883453","article-title":"Twenty new digital brain phantoms for creation of validation image data bases","volume":"25","author":"Aubert-Broche","year":"2006","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.nicl.2017.06.034_bb0015","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S1474-4422(06)70349-0","article-title":"The measurement and clinical relevance of brain atrophy in multiple sclerosis","volume":"5","author":"Bermel","year":"2006","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2017.06.034_bb0020","series-title":"Problems with the Brainweb MRI Simulator in the Evaluation of Medical Image Segmentation Algorithms, and an Alternative Methodology","author":"Bromiley","year":"2008"},{"key":"10.1016\/j.nicl.2017.06.034_bb0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrn3900","article-title":"Exploring the origins of grey matter damage in multiple sclerosis","volume":"16","author":"Calabrese","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2017.06.034_bb0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/brain\/awv354","article-title":"What lies beneath grey matter atrophy in multiple sclerosis?","volume":"139","author":"Chard","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2017.06.034_bb0035","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jmri.22214","article-title":"Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes","volume":"32","author":"Chard","year":"2010","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.nicl.2017.06.034_bb0040","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1056\/NEJMoa0907839","article-title":"Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis","volume":"362","author":"Cohen","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2017.06.034_bb0045","first-page":"1","article-title":"Long-term (up to 4.5years) treatment with fingolimod in multiple sclerosis: results from the extension of the randomised TRANSFORMS study","author":"Cohen","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2017.06.034_bb0050","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1056\/NEJMoa1104318","article-title":"Placebo-controlled trial of oral laquinimod for multiple sclerosis","volume":"366","author":"Comi","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2017.06.034_bb0055","series-title":"NeuroImage Evaluation of Automated Techniques for the Quantification of Grey Matter Atrophy in Patients With Multiple Sclerosis","first-page":"1261","volume":"52","author":"Derakhshan","year":"2010"},{"key":"10.1016\/j.nicl.2017.06.034_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045081","article-title":"Accuracy and reliability of automated gray matter segmentation pathways on real and simulated structural magnetic resonance images of the human brain","volume":"7","author":"Eggert","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2017.06.034_bb0065","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/ana.21436","article-title":"Gray matter atrophy in multiple sclerosis: a longitudinal study","volume":"64","author":"Fisher","year":"2008","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2017.06.034_bb0070","series-title":"One-year Brain Atrophy Evident in Healthy Aging","first-page":"15223","volume":"29","author":"Fjell","year":"2009"},{"key":"10.1016\/j.nicl.2017.06.034_bb2017","series-title":"IBM SPSS Statistics for Windows, Version 20.0","author":"IBM Corp. Released","year":"2011"},{"key":"10.1016\/j.nicl.2017.06.034_bb0075","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nicl.2015.05.003","article-title":"Automatic segmentation and volumetry of multiple sclerosis brain lesions from MR images","volume":"8","author":"Jain","year":"2015","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.nicl.2017.06.034_bb0080","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0140-6736(07)61194-5","article-title":"Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study","volume":"370","author":"Kappos","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.nicl.2017.06.034_bb0085","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/hbm.20599","article-title":"Evaluation of automated brain MR image segmentation and volumetry methods","volume":"30","author":"Klauschen","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2017.06.034_bb0090","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2017.06.034_bb0095","first-page":"1","article-title":"Quantifying brain volumes for multiple sclerosis patients follow-up in clinical practice \u2013 comparison of 1.5 and 3Tesla magnetic resonance imaging","volume":"422","author":"Lysandropoulos","year":"2016","journal-title":"Brain Behav."},{"key":"10.1016\/j.nicl.2017.06.034_bb0100","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1474-4422(08)70200-X","article-title":"Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial","volume":"7","author":"Mikol","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2017.06.034_bb0105","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1056\/NEJMoa1014656","article-title":"Randomized trial of oral teriflunomide for relapsing multiple sclerosis","volume":"365","author":"O'Connor","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2017.06.034_bb0110","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/jnnp-2013-307282","article-title":"Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial","volume":"85","author":"Olsson","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2017.06.034_bb0115","first-page":"S53","article-title":"The amount of peripheral CSF affects brain tissue type segmentation in MS","volume":"17","author":"Popescu","year":"2011","journal-title":"Mult. Scler. J."},{"key":"10.1016\/j.nicl.2017.06.034_bb0120","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.neuroimage.2012.03.074","article-title":"Optimizing parameter choice for FSL-Brain Extraction Tool (BET) on 3D T1 images in multiple sclerosis","volume":"61","author":"Popescu","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.06.034_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143942","article-title":"Grey matter atrophy in multiple sclerosis: clinical interpretation depends on choice of analysis method","volume":"11","author":"Popescu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2017.06.034_bb0130","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhi044","article-title":"Regional brain changes in aging healthy adults: general trends, individual differences and modifiers","author":"Raz","year":"2005","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2017.06.034_bb0135","series-title":"Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain","first-page":"3295","volume":"23","author":"Resnick","year":"2003"},{"key":"10.1016\/j.nicl.2017.06.034_bb0140","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1212\/WNL.0b013e3182703f46","article-title":"Subcortical atrophy and cognition: sex effects in multiple sclerosis","volume":"79","author":"Schoonheim","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2017.06.034_bb0145","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.compmedimag.2013.07.002","article-title":"On the estimation and correction of bias in local atrophy estimations using example atrophy simulations","volume":"37","author":"Sharma","year":"2013","journal-title":"Comput. Med. Imaging Graph."},{"key":"10.1016\/j.nicl.2017.06.034_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.518","article-title":"Reliable measurements of brain atrophy in individual patients with multiple sclerosis","volume":"6","author":"Smeets","year":"2016","journal-title":"Brain Behav."},{"key":"10.1016\/j.nicl.2017.06.034_bb0155","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nimg.2002.1040","article-title":"Accurate, robust, and automated longitudinal and cross-sectional brain change analysis","volume":"17","author":"Smith","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.06.034_bb0160","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.nicl.2013.10.003","article-title":"Accurate white matter lesion segmentation by k nearest neighbor classification with tissue type priors (kNN-TTPs)","volume":"3","author":"Steenwijk","year":"2013","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.nicl.2017.06.034_bb0165","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1148\/radiol.14132708","article-title":"What explains gray matter atrophy in long-standing multiple sclerosis?","volume":"272","author":"Steenwijk","year":"2014","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2017.06.034_bb0170","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1007\/s00415-012-6762-5","article-title":"Recommendations to improve imaging and analysis of brain lesion load and atrophy in longitudinal studies of multiple sclerosis","volume":"260","author":"Vrenken","year":"2013","journal-title":"J. Neurol."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158217301651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158217301651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:18:04Z","timestamp":1761970684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158217301651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":35,"alternative-id":["S2213158217301651"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2017.06.034","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Agreement of MSmetrix with established methods for measuring cross-sectional and longitudinal brain atrophy","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2017.06.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}