{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:39:59Z","timestamp":1789983599269,"version":"4.0.1"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,2]],"date-time":"2017-07-02T00:00:00Z","timestamp":1498953600000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Novartis Pharmaceuticals","award":["CFTY20DUSNC15T"],"award-info":[{"award-number":["CFTY20DUSNC15T"]}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["NMSS RG 5120A3\/1"],"award-info":[{"award-number":["NMSS RG 5120A3\/1"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Noto Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2017]]},"DOI":"10.1016\/j.nicl.2017.07.001","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T03:17:08Z","timestamp":1499138228000},"page":"111-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["The relationship between cortical lesions and periventricular NAWM abnormalities suggests a shared mechanism of injury in primary-progressive MS"],"prefix":"10.1016","volume":"16","author":[{"given":"Matteo","family":"Pardini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Petracca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaff","family":"Harel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazar","family":"Fleysher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Oesingmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bommarito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Fabian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"Chard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Lublin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Inglese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.nicl.2017.07.001_bb0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1365-2990.1987.tb00177.x","article-title":"Periventricular lesions in multiple sclerosis: their perivenous origin and relationship to granular ependymitis","volume":"13","author":"Adams","year":"1987","journal-title":"Neuropathol. Appl. Neurobiol."},{"issue":"7","key":"10.1016\/j.nicl.2017.07.001_bb0010","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/jnen\/62.7.723","article-title":"Subpial demyelination in the cerebral cortex of multiple sclerosis patients","volume":"62","author":"Bo","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"Pt 2","key":"10.1016\/j.nicl.2017.07.001_bb0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/brain\/aww296","article-title":"An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis","volume":"140","author":"Brown","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2017.07.001_bb0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/jnnp.25.4.315","article-title":"The distribution of plaques in the cerebrum in multiple sclerosis","volume":"25","author":"Brownell","year":"1962","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.nicl.2017.07.001_bb0025","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/ana.21906","article-title":"A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis","volume":"67","author":"Calabrese","year":"2010","journal-title":"Ann. Neurol."},{"issue":"Pt 10","key":"10.1016\/j.nicl.2017.07.001_bb0030","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1093\/brain\/aws189","article-title":"Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis","volume":"135","author":"Choi","year":"2012","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.nicl.2017.07.001_bb0035","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/ana.24461","article-title":"Periventricular lesions correlate with cortical thinning in multiple sclerosis","volume":"78","author":"Jehna","year":"2015","journal-title":"Ann. Neurol."},{"issue":"Pt 5","key":"10.1016\/j.nicl.2017.07.001_bb0040","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/brain\/awv065","article-title":"Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis","volume":"138","author":"Liu","year":"2015","journal-title":"Brain"},{"issue":"11","key":"10.1016\/j.nicl.2017.07.001_bb0045","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1136\/jnnp-2016-313979","article-title":"Relationship of grey and white matter abnormalities with distance from the surface of the brain in multiple sclerosis","volume":"87","author":"Pardini","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.nicl.2017.07.001_bb0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/1352458516637679","article-title":"Retinal degeneration in primary-progressive multiple sclerosis: a role for cortical lesions?","volume":"23","author":"Petracca","year":"2017","journal-title":"Mult. Scler."},{"issue":"11","key":"10.1016\/j.nicl.2017.07.001_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078879","article-title":"MS cortical lesions on DIR: not quite what they seem?","volume":"8","author":"Sethi","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.nicl.2017.07.001_bb0060","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nimg.2002.1040","article-title":"Accurate, robust, and automated longitudinal and cross-sectional brain change analysis","volume":"17","author":"Smith","year":"2002","journal-title":"NeuroImage"},{"issue":"Suppl. 1","key":"10.1016\/j.nicl.2017.07.001_bb0065","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.nicl.2017.07.001_bb0070","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"NeuroImage"},{"issue":"Pt 8","key":"10.1016\/j.nicl.2017.07.001_bb0075","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1093\/brain\/awu139","article-title":"Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics","volume":"137","author":"Vidaurre","year":"2014","journal-title":"Brain"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158217301663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158217301663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:15:42Z","timestamp":1761970542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158217301663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":15,"alternative-id":["S2213158217301663"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2017.07.001","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between cortical lesions and periventricular NAWM abnormalities suggests a shared mechanism of injury in primary-progressive MS","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2017.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}