{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:39:17Z","timestamp":1793644757510,"version":"4.5.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["G160279"],"award-info":[{"award-number":["G160279"]}]},{"name":"Australian National Health and Medical Research Council","award":["G182968"],"award-info":[{"award-number":["G182968"]}]},{"name":"NGW Macintosh Memorial Fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2018]]},"DOI":"10.1016\/j.nicl.2017.10.019","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T13:30:15Z","timestamp":1508419815000},"page":"222-231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":171,"special_numbering":"C","title":["Disruption of default mode network dynamics in acute and chronic pain states"],"prefix":"10.1016","volume":"17","author":[{"given":"Z.","family":"Alshelh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.","family":"Marciszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Akhter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Di Pietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.P.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.R.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Peck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1026-0151","authenticated-orcid":false,"given":"L.A.","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2017.10.019_bb0005","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1523\/JNEUROSCI.2768-15.2016","article-title":"Chronic neuropathic pain: It's about the rhythm","volume":"36","author":"Alshelh","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0010","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1523\/JNEUROSCI.4123-07.2008","article-title":"Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics","volume":"28","author":"Baliki","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106133","article-title":"Functional reorganization of the default mode network across chronic pain conditions","volume":"9","author":"Baliki","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2017.10.019_bb0020","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/brain\/awf022","article-title":"Imaging how attention modulates pain in humans using functional MRI","volume":"125","author":"Bantick","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2017.10.019_bb0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0166-2236(00)01683-0","article-title":"Independent component analysis at the neural cocktail party","volume":"24","author":"Brown","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain's default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0035","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hbm.1048","article-title":"A method for making group inferences from functional MRI data using independent component analysis","volume":"14","author":"Calhoun","year":"2001","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2017.10.019_bb0040","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.biopsych.2007.06.025","article-title":"Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit\/hyperactivity disorder","volume":"63","author":"Castellanos","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nicl.2017.10.019_bb0045","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2017.10.019_bb0050","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1073\/pnas.0600604103","article-title":"Neuronal metabolism governs cortical network response state","volume":"103","author":"Cunningham","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Pt 4","key":"10.1016\/j.nicl.2017.10.019_bb0055","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.2044-8260.1994.tb01150.x","article-title":"Chronic pain and attention: a cognitive approach","volume":"33","author":"Eccleston","year":"1994","journal-title":"Br J Clin Psychol"},{"key":"10.1016\/j.nicl.2017.10.019_bb0060","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1037\/0033-2909.125.3.356","article-title":"Pain demands attention: a cognitive-affective model of the interruptive function of pain","volume":"125","author":"Eccleston","year":"1999","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.nicl.2017.10.019_bb0065","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.neuroimage.2008.05.059","article-title":"The precuneus\/posterior cingulate cortex plays a pivotal role in the default mode network: evidence from a partial correlation network analysis","volume":"42","author":"Fransson","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.10.019_bb0070","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/1471-2105-7-290","article-title":"Independent component analysis reveals new and biologically significant structures in micro array data","volume":"7","author":"Frigyesi","year":"2006","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.nicl.2017.10.019_bb0075","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hbm.460020402","article-title":"Statistical parametric maps in functional imaging: a general imaging approach","volume":"2","author":"Friston","year":"1995","journal-title":"Journal of Human Brain Mapping"},{"key":"10.1016\/j.nicl.2017.10.019_bb0080","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0304-3959(01)00366-9","article-title":"Conscious and automatic uses of memory in chronic pain patients","volume":"94","author":"Grisart","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.nicl.2017.10.019_bb0085","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/35094500","article-title":"Searching for a baseline: functional imaging and the resting human brain","volume":"2","author":"Gusnard","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0090","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1523\/JNEUROSCI.5980-10.2011","article-title":"Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes","volume":"31","author":"Gustin","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0095","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1093\/cercor\/bhl075","article-title":"Cingulate activation increases dynamically with response speed under stimulus unpredictability","volume":"17","author":"Hahn","year":"2007","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2017.10.019_bb0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2217\/pmt.15.67","article-title":"How do neuroanatomical changes in individuals with chronic pain result in the constant perception of pain?","volume":"6","author":"Henderson","year":"2016","journal-title":"Pain Manag"},{"key":"10.1016\/j.nicl.2017.10.019_bb0105","doi-asserted-by":"crossref","first-page":"7574","DOI":"10.1523\/JNEUROSCI.0174-13.2013","article-title":"Chronic pain: lost inhibition?","volume":"33","author":"Henderson","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/B978-0-444-53839-0.00010-7","article-title":"Infraslow (<0.1Hz) oscillations in thalamic relay nuclei basic mechanisms and significance to health and disease states","volume":"193","author":"Hughes","year":"2011","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.nicl.2017.10.019_bb0115","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/026990597122990","article-title":"'Postconcussive' symptoms in persons with chronic pain","volume":"11","author":"Iverson","year":"1997","journal-title":"Brain Inj."},{"key":"10.1016\/j.nicl.2017.10.019_bb0120","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/j.1526-4637.2006.00212.x","article-title":"The relationship between pain and mental flexibility in older adult pain clinic patients","volume":"7","author":"Karp","year":"2006","journal-title":"Pain Med."},{"key":"10.1016\/j.nicl.2017.10.019_bb0125","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1523\/JNEUROSCI.5055-13.2014","article-title":"Enhanced medial prefrontal-default mode network functional connectivity in chronic pain and its association with pain rumination","volume":"34","author":"Kucyi","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0130","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.jpain.2013.04.003","article-title":"Functional connectivity of the default mode network and its association with pain networks in irritable bowel patients assessed via lidocaine treatment","volume":"14","author":"Letzen","year":"2013","journal-title":"J. Pain"},{"key":"10.1016\/j.nicl.2017.10.019_bb0135","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1073\/pnas.0709259105","article-title":"Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons","volume":"105","author":"Liang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2017.10.019_bb0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pain.2012.07.029","article-title":"Default mode network connectivity encodes clinical pain: an arterial spin labeling study","volume":"154","author":"Loggia","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.nicl.2017.10.019_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004447","article-title":"ATP-dependent infra-slow (<0.1Hz) oscillations in thalamic networks","volume":"4","author":"Lorincz","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2017.10.019_bb0150","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.neuroimage.2003.12.042","article-title":"A method for removal of global effects from fMRI time series","volume":"22","author":"Macey","year":"2004","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.10.019_bb0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/ana.410420114","article-title":"Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease","volume":"42","author":"Minoshima","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2017.10.019_bb0160","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1002\/art.34412","article-title":"Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia","volume":"64","author":"Napadow","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.nicl.2017.10.019_bb0165","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/bja\/87.1.117","article-title":"Trigeminal neuralgia\u2013pathophysiology, diagnosis and current treatment","volume":"87","author":"Nurmikko","year":"2001","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.nicl.2017.10.019_bb0170","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1097\/00001756-200112210-00008","article-title":"Pacemaker calcium oscillations in thalamic astrocytes in situ","volume":"12","author":"Parri","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.nicl.2017.10.019_bb0175","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0304-3959(99)00232-8","article-title":"Pain-related cerebral activation is altered by a distracting cognitive task","volume":"85","author":"Petrovic","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.nicl.2017.10.019_bb0180","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2017.10.019_bb0185","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S1053-8119(03)00146-0","article-title":"Pain modulates cerebral activity during cognitive performance","volume":"19","author":"Remy","year":"2003","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.10.019_bb0190","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1176\/appi.ajp.162.6.1067","article-title":"Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD","volume":"162","author":"Rubia","year":"2005","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.nicl.2017.10.019_bb0195","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1093\/cercor\/bhl052","article-title":"Interactions of pain intensity and cognitive load: the brain stays on task","volume":"17","author":"Seminowicz","year":"2007","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2017.10.019_bb0200","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1152\/jn.01210.2006","article-title":"Pain enhances functional connectivity of a brain network evoked by performance of a cognitive task","volume":"97","author":"Seminowicz","year":"2007","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nicl.2017.10.019_bb0205","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1162\/jocn.1997.9.5.624","article-title":"Common blood flow changes across visual tasks: I. Increases in subcortical structures and cerebellum but not in nonvisual cortex","volume":"9","author":"Shulman","year":"1997","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0210","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0885-3924(99)00143-8","article-title":"Impaired neuropsychological performance in chronic nonmalignant pain patients receiving long-term oral opioid therapy","volume":"19","author":"Sjogren","year":"2000","journal-title":"J. Pain Symptom Manag."},{"key":"10.1016\/j.nicl.2017.10.019_bb0215","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1053-8119(02)00012-5","article-title":"The posterior cingulate and medial prefrontal cortex mediate the anticipatory allocation of spatial attention","volume":"18","author":"Small","year":"2003","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2017.10.019_bb0220","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/0269905021000030823","article-title":"Presence of post-concussion syndrome symptoms in patients with chronic pain vs mild traumatic brain injury","volume":"17","author":"Smith-Seemiller","year":"2003","journal-title":"Brain Inj."},{"key":"10.1016\/j.nicl.2017.10.019_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025031","article-title":"REST: a toolkit for resting-state functional magnetic resonance imaging data processing","volume":"6","author":"Song","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2017.10.019_bb0230","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1162\/jocn.2009.21282","article-title":"Patterns of brain activity supporting autobiographical memory, prospection, and theory of mind, and their relationship to the default mode network","volume":"22","author":"Spreng","year":"2010","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0235","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neulet.2010.08.053","article-title":"Brain resting state is disrupted in chronic back pain patients","volume":"485","author":"Tagliazucchi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nicl.2017.10.019_bb0240","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jneumeth.2007.11.031","article-title":"Network homogeneity reveals decreased integrity of default-mode network in ADHD","volume":"169","author":"Uddin","year":"2008","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nicl.2017.10.019_bb0245","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.pain.2004.02.033","article-title":"Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain\u2013an fMRI analysis","volume":"109","author":"Valet","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.nicl.2017.10.019_bb0250","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1523\/JNEUROSCI.21-13-04923.2001","article-title":"Energy Hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration","volume":"21","author":"Valla","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0255","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.neubiorev.2009.01.005","article-title":"Keeping pain in mind: a motivational account of attention to pain","volume":"34","author":"Van Damme","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nicl.2017.10.019_bb0260","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/arclin\/acp014","article-title":"Executive function and decision-making in women with fibromyalgia","volume":"24","author":"Verdejo-Garcia","year":"2009","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.nicl.2017.10.019_bb0265","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1523\/JNEUROSCI.3756-14.2015","article-title":"Anatomical changes at the level of the primary synapse in neuropathic pain: evidence from the spinal trigeminal nucleus","volume":"35","author":"Wilcox","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2017.10.019_bb0270","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.pain.2013.11.008","article-title":"Differential brain activity in subjects with painful trigeminal neuropathy and painful temporomandibular disorder","volume":"155","author":"Youssef","year":"2014","journal-title":"Pain"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158217302589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158217302589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:23:05Z","timestamp":1761970985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158217302589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":54,"alternative-id":["S2213158217302589"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2017.10.019","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disruption of default mode network dynamics in acute and chronic pain states","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2017.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}