{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:11:32Z","timestamp":1784761892612,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301284"],"award-info":[{"award-number":["81301284"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471732,81571631"],"award-info":[{"award-number":["81471732,81571631"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30930029"],"award-info":[{"award-number":["30930029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671761"],"award-info":[{"award-number":["81671761"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2013YB28"],"award-info":[{"award-number":["2013YB28"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["xx2013045"],"award-info":[{"award-number":["xx2013045"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2013CB837300"],"award-info":[{"award-number":["2013CB837300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008659","name":"European Committee for Treatment and Research in Multiple Sclerosis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2018]]},"DOI":"10.1016\/j.nicl.2018.03.034","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T08:06:11Z","timestamp":1522224371000},"page":"232-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Progressive brain rich-club network disruption from clinically isolated syndrome towards multiple sclerosis"],"prefix":"10.1016","volume":"19","author":[{"given":"Ni","family":"Shu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoqiong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuncheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2018.03.034_bb0005","doi-asserted-by":"crossref","first-page":"4307","DOI":"10.1523\/JNEUROSCI.5061-11.2012","article-title":"Topologically convergent and divergent structural connectivity patterns between patients with remitted geriatric depression and amnestic mild cognitive impairment","volume":"32","author":"Bai","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2018.03.034_bb0010","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jmrb.1996.0086","article-title":"Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI","volume":"111","author":"Basser","year":"1996","journal-title":"J. Magn. Reson. B"},{"key":"10.1016\/j.nicl.2018.03.034_bb0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-3495(94)80775-1","article-title":"MR diffusion tensor spectroscopy and imaging","volume":"66","author":"Basser","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.nicl.2018.03.034_bb0020","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2018.03.034_bb0025","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrn3900","article-title":"Exploring the origins of grey matter damage in multiple sclerosis","volume":"16","author":"Calabrese","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2018.03.034_bb0030","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(14)70101-2","article-title":"Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging","volume":"13","author":"Ciccarelli","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2018.03.034_bb0035","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","article-title":"Multiple sclerosis","volume":"372","author":"Compston","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.nicl.2018.03.034_bb0040","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/brain\/awu132","article-title":"The hubs of the human connectome are generally implicated in the anatomy of brain disorders","volume":"137","author":"Crossley","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2018.03.034_bb0045","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/brain\/awv075","article-title":"Disconnection of network hubs and cognitive impairment after traumatic brain injury","volume":"138","author":"Fagerholm","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2018.03.034_bb0050","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S1474-4422(13)70144-3","article-title":"Assessment of system dysfunction in the brain through MRI-based connectomics","volume":"12","author":"Filippi","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2018.03.034_bb0055","article-title":"Brain mapping in multiple sclerosis: lessons learned about the human brain","author":"Filippi","year":"2017","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.03.034_bb0060","article-title":"Graph theoretical framework of brain networks in multiple sclerosis: a review of concepts","author":"Fleischer","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.nicl.2018.03.034_bb0065","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/cercor\/bhn102","article-title":"Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography","volume":"19","author":"Gong","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2018.03.034_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000597","article-title":"Mapping human whole-brain structural networks with diffusion MRI","volume":"2","author":"Hagmann","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2018.03.034_bb0075","doi-asserted-by":"crossref","first-page":"19066","DOI":"10.1073\/pnas.1110024108","article-title":"Increased functional connectivity indicates the severity of cognitive impairment in multiple sclerosis","volume":"108","author":"Hawellek","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2018.03.034_bb0080","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1093\/brain\/awp089","article-title":"Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load","volume":"132","author":"He","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2018.03.034_bb0085","doi-asserted-by":"crossref","first-page":"15775","DOI":"10.1523\/JNEUROSCI.3539-11.2011","article-title":"Rich-club organization of the human connectome","volume":"31","author":"van den Heuvel","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2018.03.034_bb0090","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.tics.2013.09.012","article-title":"Network hubs in the human brain","volume":"17","author":"van den Heuvel","year":"2013","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.nicl.2018.03.034_bb0095","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/jamapsychiatry.2013.1328","article-title":"Abnormal rich club organization and functional brain dynamics in schizophrenia","volume":"70","author":"van den Heuvel","year":"2013","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.nicl.2018.03.034_bb0100","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2018.03.034_bb0105","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1148\/radiol.2015142786","article-title":"Multimodal quantitative MR imaging of the thalamus in multiple sclerosis and neuromyelitis optica","volume":"277","author":"Liu","year":"2015","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2018.03.034_bb0110","first-page":"152843","article-title":"Functional brain network alterations in clinically isolated syndrome and multiple sclerosis: a graph-based connectome study","author":"Liu","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2018.03.034_bb0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(11)70274-5","article-title":"Clinically isolated syndromes","volume":"11","author":"Miller","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2018.03.034_bb0120","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/nbm.781","article-title":"Fiber tracking: principles and strategies - a technical review","volume":"15","author":"Mori","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.nicl.2018.03.034_bb0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/1531-8249(199902)45:2<265::AID-ANA21>3.0.CO;2-3","article-title":"Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging","volume":"45","author":"Mori","year":"1999","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2018.03.034_bb0130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.nicl.2018.03.034_bb0135","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1212\/WNL.0000000000001970","article-title":"Motor network efficiency and disability in multiple sclerosis","volume":"85","author":"Pardini","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2018.03.034_bb0140","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2018.03.034_bb0145","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple Sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2018.03.034_bb0155","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00429-014-0896-4","article-title":"Impaired functional integration in multiple sclerosis: a graph theory study","volume":"221","author":"Rocca","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.nicl.2018.03.034_bb0160","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.03.034_bb0165","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.nic.2017.01.002","article-title":"Brain atrophy in multiple sclerosis: clinical relevance and technical aspects","volume":"27","author":"Sastre-Garriga","year":"2017","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.nicl.2018.03.034_bb0170","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/hbm.21424","article-title":"Functional connectivity changes in multiple sclerosis patients: a graph analytical study of MEG resting state data","volume":"34","author":"Schoonheim","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2018.03.034_bb0175","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1093\/cercor\/bhr039","article-title":"Diffusion tensor tractography reveals disrupted topological efficiency in white matter structural networks in multiple sclerosis","volume":"21","author":"Shu","year":"2011","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2018.03.034_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/srep29383","article-title":"Disrupted topological organization of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis","volume":"6","author":"Shu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nicl.2018.03.034_bb0185","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrn3801","article-title":"Modern network science of neurological disorders","volume":"15","author":"Stam","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2018.03.034_bb0190","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/hbm.22650","article-title":"Functional brain networks: linking thalamic atrophy to clinical disability in multiple sclerosis, a multimodal fMRI and MEG study","volume":"36","author":"Tewarie","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2018.03.034_bb0195","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.03.034_bb0200","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.nicl.2014.01.012","article-title":"Graph theoretical analysis indicates cognitive impairment in MS stems from neural disconnection","volume":"4","author":"Van Schependom","year":"2014","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.nicl.2018.03.034_bb0205","first-page":"386","article-title":"GRETNA: a graph theoretical network analysis toolbox for imaging connectomics","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.nicl.2018.03.034_bb0210","article-title":"BrainNet viewer: a network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2018.03.034_bb0215","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroimage.2010.06.041","article-title":"Network-based statistic: identifying differences in brain networks","volume":"53","author":"Zalesky","year":"2010","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.03.034_bb0220","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1002\/hbm.22877","article-title":"Age-related changes in the topological organization of the white matter structural connectome across the human lifespan","volume":"36","author":"Zhao","year":"2015","journal-title":"Hum. Brain Mapp."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158218301049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158218301049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:17:10Z","timestamp":1761970630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158218301049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":43,"alternative-id":["S2213158218301049"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2018.03.034","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progressive brain rich-club network disruption from clinically isolated syndrome towards multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2018.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}