{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:15:31Z","timestamp":1790144131161,"version":"4.0.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,17]],"date-time":"2018-06-17T00:00:00Z","timestamp":1529193600000},"content-version":"vor","delay-in-days":167,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["081589"],"award-info":[{"award-number":["081589"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R006504\/1"],"award-info":[{"award-number":["MR\/R006504\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2018]]},"DOI":"10.1016\/j.nicl.2018.06.023","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T05:38:51Z","timestamp":1529473131000},"page":"925-938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Identifying preclinical vascular dementia in symptomatic small vessel disease using MRI"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8281-4611","authenticated-orcid":false,"given":"Christian","family":"Lambert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Zeestraten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin G.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Mackinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Barrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh S.","family":"Markus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.nicl.2018.06.023_bb0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3988\/jcn.2016.12.2.201","article-title":"Regional MRI diffusion, white-matter Hyperintensities, and cognitive function in Alzheimer's disease and vascular dementia","volume":"12","author":"Altamura","year":"2016","journal-title":"J. Clin. Neurol."},{"key":"10.1016\/j.nicl.2018.06.023_bb0320","series-title":"Diagnostic and statistical manual of mental disorders (DSM-5\u00ae)","author":"American Psychiatric Association","year":"2013"},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0010","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.neuroimage.2010.12.049","article-title":"Diffeomorphic registration using geodesic shooting and gauss-Newton optimisation","volume":"55","author":"Ashburner","year":"2011","journal-title":"NeuroImage"},{"issue":"7","key":"10.1016\/j.nicl.2018.06.023_bb0330","first-page":"P800","article-title":"ACCURACY OF CLINICAL DIAGNOSIS OF ALZHEIMER\u2019S DISEASE IN ALZHEIMER\u2019S DISEASE CENTERS (ADCS)","volume":"13","author":"Archer","year":"2017","journal-title":"Alzheimer's & Dementia: The Journal of the Alzheimer's Association"},{"key":"10.1016\/j.nicl.2018.06.023_bb0015","first-page":"197","article-title":"Symmetric diffeomorphic modeling of longitudinal structural MRI","volume":"6","author":"Ashburner","year":"2012","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1161\/01.STR.18.3.545","article-title":"The natural history of lacunar infarction: the Oxfordshire community stroke project","volume":"18","author":"Bamford","year":"1987","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.nicl.2018.06.023_bb0025","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/j.1532-5415.1992.tb01802.x","article-title":"Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers","volume":"40","author":"Barberger-Gateau","year":"1992","journal-title":"J. Am. Geriatr. Soc."},{"issue":"11","key":"10.1016\/j.nicl.2018.06.023_bb0030","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.exger.2012.07.002","article-title":"Pharmacological prevention and treatment of vascular dementia: approaches and perspectives","volume":"47","author":"Baskys","year":"2012","journal-title":"Exp. Gerontol."},{"issue":"5","key":"10.1016\/j.nicl.2018.06.023_bb0035","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1136\/jnnp.2008.160440","article-title":"Location of lacunar infarcts correlates with cognition in a sample of non-disabled subjects with age-related white-matter changes: the LADIS study","volume":"80","author":"Benisty","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2018.06.023_bb0040","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.nicl.2014.05.009","article-title":"Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease","volume":"4","author":"Benjamin","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.06.023_bb0045","series-title":"Prediction of Impaired Performance in Trail Making Test in MCI Patients with Small Vessel Disease Using DTI Data","author":"Ciulli","year":"2016"},{"issue":"1","key":"10.1016\/j.nicl.2018.06.023_bb0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1161\/STROKEAHA.108.526996","article-title":"Improving interrater agreement about brain microbleeds development of the brain observer MicroBleed scale (BOMBS)","volume":"40","author":"Cordonnier","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2018.06.023_bb0055","series-title":"The BIRT Memory and Information Processing Battery (B-MIPB)","author":"Coughlan","year":"2007"},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0060","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuroimage.2004.12.036","article-title":"Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly","volume":"25","author":"Csernansky","year":"2005","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.nicl.2018.06.023_bb0065","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1590\/1980-57642016dn11-040005","article-title":"Mixed dementia: a review of the evidence","volume":"11","author":"Custodio","year":"2017","journal-title":"Dementia Neuropsychol."},{"issue":"1","key":"10.1016\/j.nicl.2018.06.023_bb0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/jnnp.70.1.9","article-title":"Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study, The Rotterdam Scan Study","volume":"70","author":"De Leeuw","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.nicl.2018.06.023_bb0075","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/2396987316650780","article-title":"Topographic distribution of white matter changes and lacunar infarcts in neurodegenerative and vascular dementia syndromes: a post-mortem 7.0-tesla magnetic resonance imaging study","volume":"1","author":"De Reuck","year":"2016","journal-title":"Eur. Stroke J."},{"key":"10.1016\/j.nicl.2018.06.023_bb0080","series-title":"Delis-Kaplan Executive Function Scale","author":"Delis","year":"2001"},{"issue":"4","key":"10.1016\/j.nicl.2018.06.023_bb0085","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.neuroimage.2011.01.052","article-title":"Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)","volume":"55","author":"Draganski","year":"2011","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0090","first-page":"421","article-title":"MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging","volume":"8","author":"Fazekas","year":"1987","journal-title":"Am. J. Neuroradiol."},{"issue":"1","key":"10.1016\/j.nicl.2018.06.023_bb0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jns.2010.08.039","article-title":"Cognitive impairment of vascular origin: neuropathology of cognitive impairment of vascular origin","volume":"299","author":"Ferrer","year":"2010","journal-title":"J. Neurol. Sci."},{"issue":"12","key":"10.1016\/j.nicl.2018.06.023_bb0100","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1093\/brain\/awn280","article-title":"Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 tesla","volume":"131","author":"Frisoni","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2018.06.023_bb0105","series-title":"NIPS Workshop on Kernel Learning: Automatic Selection of Optimal Kernels","author":"Gehler","year":"2008"},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0110","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1212\/WNL.49.3.690","article-title":"Sensitivity and specificity of newly proposed clinical criteria for possible vascular dementia","volume":"49","author":"Gold","year":"1997","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.nicl.2018.06.023_bb0115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/jnnp.2009.204685","article-title":"Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations","volume":"82","author":"Gouw","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"2","key":"10.1016\/j.nicl.2018.06.023_bb0120","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/brain\/awg040","article-title":"Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis","volume":"126","author":"Hassan","year":"2003","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.nicl.2018.06.023_bb0125","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.neuroimage.2008.01.027","article-title":"Voxel-based cortical thickness measurements in MRI","volume":"40","author":"Hutton","year":"2008","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.nicl.2018.06.023_bb0130","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neuroimage.2009.06.043","article-title":"A comparison between voxel-based cortical thickness and voxel-based morphometry in normal aging","volume":"48","author":"Hutton","year":"2009","journal-title":"NeuroImage"},{"issue":"1\u20132","key":"10.1016\/j.nicl.2018.06.023_bb0135","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jns.2010.08.038","article-title":"Is there pure vascular dementia in old age?","volume":"299","author":"Jellinger","year":"2010","journal-title":"J. Neurol. Sci."},{"issue":"5","key":"10.1016\/j.nicl.2018.06.023_bb0140","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00401-016-1571-z","article-title":"Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease","volume":"131","author":"Kalaria","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"9","key":"10.1016\/j.nicl.2018.06.023_bb0145","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S1474-4422(07)70195-3","article-title":"Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials","volume":"6","author":"Kavirajan","year":"2007","journal-title":"Lancet Neurol."},{"issue":"17","key":"10.1016\/j.nicl.2018.06.023_bb0150","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1212\/WNL.0000000000000360","article-title":"Seoul criteria for PiB (\u2212) subcortical vascular dementia based on clinical and MRI variables","volume":"82","author":"Kim","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2018.06.023_bb0155","series-title":"The Medical Clinics of North America","article-title":"Clinical Neuropsychology","author":"Klove","year":"1963"},{"issue":"2","key":"10.1016\/j.nicl.2018.06.023_bb0165","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1080\/13854049308401524","article-title":"Hemispheric bias of the mini-mental state examination in elderly males","volume":"7","author":"Kupke","year":"1993","journal-title":"Clin. Neuropsychol."},{"key":"10.1016\/j.nicl.2018.06.023_bb0170","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nicl.2015.07.002","article-title":"Characterising the grey matter correlates of leukoaraiosis in cerebral small vessel disease","volume":"9","author":"Lambert","year":"2015","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.nicl.2018.06.023_bb0175","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/brain\/aww009","article-title":"Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease","volume":"139","author":"Lambert","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2018.06.023_bb0180","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.neuroimage.2016.08.028","article-title":"Defining thalamic nuclei and topographic connectivity gradients in vivo","volume":"158","author":"Lambert","year":"2016","journal-title":"NeuroImage"},{"issue":"7","key":"10.1016\/j.nicl.2018.06.023_bb0185","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nrneurol.2013.107","article-title":"Ushering in the study and treatment of preclinical Alzheimer disease","volume":"9","author":"Langbaum","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.nicl.2018.06.023_bb0190","doi-asserted-by":"crossref","first-page":"e61014","DOI":"10.1371\/journal.pone.0061014","article-title":"Mechanisms of cognitive impairment in cerebral small vessel disease: multimodal MRI results from the St George's cognition and neuroimaging in stroke (SCANS) study","volume":"8","author":"Lawrence","year":"2013","journal-title":"PloS One"},{"issue":"4","key":"10.1016\/j.nicl.2018.06.023_bb0195","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1212\/WNL.0000000000000612","article-title":"Structural network efficiency is associated with cognitive impairment in small-vessel disease","volume":"83","author":"Lawrence","year":"2014","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nicl.2018.06.023_bb0200","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1212\/WNL.0b013e318221acee","article-title":"Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B","volume":"77","author":"Lee","year":"2011","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.nicl.2018.06.023_bb0205","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1161\/STROKEAHA.110.609768","article-title":"White matter hyperintensity penumbra","volume":"42","author":"Maillard","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.nicl.2018.06.023_bb0210","series-title":"Handbook of Normative Data for Neuropsychological Assessment","author":"Mitrushina","year":"2005"},{"issue":"2","key":"10.1016\/j.nicl.2018.06.023_bb0215","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000070683","article-title":"Factor structure of a modified version of the Wisconsin card sorting test: an analysis of executive deficit in Alzheimer's disease and mild cognitive impairment","volume":"16","author":"Nagahama","year":"2003","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.nicl.2018.06.023_bb0220","series-title":"National Adult Reading Test (NART): Test Manual","author":"Nelson","year":"1991"},{"issue":"2","key":"10.1016\/j.nicl.2018.06.023_bb0225","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00005053-198602000-00002","article-title":"Bedside cognitive screening instruments: a critical assessment","volume":"174","author":"Nelson","year":"1986","journal-title":"J. Nerv. Ment. Dis."},{"issue":"7","key":"10.1016\/j.nicl.2018.06.023_bb0230","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jalz.2016.12.007","article-title":"Small vessel disease is linked to disrupted structural network covariance in Alzheimer's disease","volume":"13","author":"Nestor","year":"2017","journal-title":"Alzheimer's Dementia"},{"issue":"7","key":"10.1016\/j.nicl.2018.06.023_bb0235","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.nicl.2018.06.023_bb0240","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1747-4949.2010.00552.x","article-title":"Magnetic resonance imaging in cerebral small vessel disease and its use as a surrogate disease marker","volume":"6","author":"Patel","year":"2011","journal-title":"Int. J. Stroke"},{"issue":"1","key":"10.1016\/j.nicl.2018.06.023_bb0245","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuroimage.2009.11.046","article-title":"Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease","volume":"50","author":"Plant","year":"2010","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.06.023_bb0250","series-title":"MLwiN Version 2.1","author":"Rasbash","year":"2009"},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0255","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/brain\/awl385","article-title":"Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease","volume":"130","author":"Reed","year":"2007","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2018.06.023_bb0260","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2466\/pms.1958.8.3.271","article-title":"The validity of the trail making test as an indicator of organic brain damage","volume":"8","author":"Reitan","year":"1958","journal-title":"Percept. Mot. Skills"},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0265","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12021-013-9178-1","article-title":"PRoNTo: pattern recognition for neuroimaging toolbox","volume":"11","author":"Schrouff","year":"2013","journal-title":"Neuroinformatics"},{"issue":"1\u20132","key":"10.1016\/j.nicl.2018.06.023_bb0270","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jns.2012.02.013","article-title":"Neuroprotection in vascular dementia: a future path","volume":"322","author":"Skoog","year":"2012","journal-title":"J. Neurol. Sci."},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0275","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.438","article-title":"Peripheral (deep) but not periventricular MRI white matter hyperintensities are increased in clinical vascular dementia compared to Alzheimer's disease","volume":"6","author":"Smith","year":"2016","journal-title":"Brain Behav."},{"issue":"11","key":"10.1016\/j.nicl.2018.06.023_bb0280","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.exger.2012.05.023","article-title":"Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain","volume":"47","author":"Thal","year":"2012","journal-title":"Exp. Gerontol."},{"issue":"9","key":"10.1016\/j.nicl.2018.06.023_bb0325","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1532-5415.1992.tb01992.x","article-title":"The mini\u2010mental state examination: a comprehensive review","volume":"40","author":"Tombaugh","year":"1992","journal-title":"Journal of the American Geriatrics Society"},{"issue":"4","key":"10.1016\/j.nicl.2018.06.023_bb0285","doi-asserted-by":"crossref","first-page":"825-e25","DOI":"10.1016\/j.neurobiolaging.2011.05.018","article-title":"Structural MRI changes detectable up to ten years before clinical Alzheimer's disease","volume":"33","author":"Tondelli","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.nicl.2018.06.023_bb0290","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neurobiolaging.2013.06.018","article-title":"Comparison of neuroimaging modalities for the prediction of conversion from mild cognitive impairment to Alzheimer's dementia","volume":"35","author":"Trzepacz","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"12","key":"10.1016\/j.nicl.2018.06.023_bb0295","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1212\/WNL.0000000000002502","article-title":"Structural network efficiency predicts conversion to dementia","volume":"86","author":"Tuladhar","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2018.06.023_bb0300","series-title":"Wechsler Adult Intelligence Scale-III","author":"Wechsler","year":"1997"},{"issue":"3","key":"10.1016\/j.nicl.2018.06.023_bb0310","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.neuroimage.2006.01.015","article-title":"User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability","volume":"31","author":"Yushkevich","year":"2006","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.nicl.2018.06.023_bb0315","doi-asserted-by":"crossref","first-page":"e0147836","DOI":"10.1371\/journal.pone.0147836","article-title":"Application of diffusion tensor imaging parameters to detect change in longitudinal studies in cerebral small vessel disease","volume":"11","author":"Zeestraten","year":"2016","journal-title":"PloS One"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158218302067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158218302067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:09:54Z","timestamp":1761970194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158218302067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":64,"alternative-id":["S2213158218302067"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2018.06.023","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identifying preclinical vascular dementia in symptomatic small vessel disease using MRI","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2018.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}