{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:21:51Z","timestamp":1793186511560,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T00:00:00Z","timestamp":1538697600000},"content-version":"vor","delay-in-days":277,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GM1103A"],"award-info":[{"award-number":["01GM1103A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010764","name":"German Network for Motor Neuron Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LU 336\/15-1"],"award-info":[{"award-number":["LU 336\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007801","name":"Agenzia di Ricerca per la Sclerosi Laterale Amiotrofica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2018]]},"DOI":"10.1016\/j.nicl.2018.10.005","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:42:07Z","timestamp":1539045727000},"page":"1062-1069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A two-centre tract of interest-based DTI analysis"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-9381","authenticated-orcid":false,"given":"Hans-Peter","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Agosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gorges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Kassubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo Gioele","family":"Spinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilo","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-0479","authenticated-orcid":false,"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2018.10.005_bb0005","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/hbm.22286","article-title":"Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS","volume":"35","author":"Agosta","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2018.10.005_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/21678421.2014.964258","article-title":"The El Escorial criteria: strengths and weaknesses","volume":"16","author":"Agosta","year":"2015","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.nicl.2018.10.005_bb0015","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/cns.12410","article-title":"Propagation of pathology through brain networks in neurodegenerative diseases: from molecules to clinical phenotypes","volume":"21","author":"Agosta","year":"2015","journal-title":"CNS Neurosci. Ther."},{"issue":"567","key":"10.1016\/j.nicl.2018.10.005_bb0020","article-title":"Longitudinal Diffusion Tensor Imaging-based assessment of tract alterations: an application to amyotrophic lateral sclerosis","volume":"11","author":"Baldaranov","year":"2017","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.nicl.2018.10.005_bb0025","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrneurol.2013.221","article-title":"Amyotrophic lateral sclerosis - a model of corticofugal axonal spread","volume":"9","author":"Braak","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nicl.2018.10.005_bb0030","first-page":"E136","article-title":"Does sporadic amyotrophic lateral sclerosis spread via axonal connectivities? Neurol","volume":"1","author":"Braak","year":"2017","journal-title":"Int. Open"},{"key":"10.1016\/j.nicl.2018.10.005_bb0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2018.10.005_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (phase III)","volume":"169","author":"Cedarbaum","year":"1999","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nicl.2018.10.005_bb0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00401-007-0234-5","article-title":"TDP-43 in differential diagnosis of motor neuron disorders","volume":"114","author":"Dickson","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2018.10.005_bb0060","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S1474-4422(15)00134-9","article-title":"Progress towards a neuroimaging biomarker for amyotrophic lateral sclerosis","volume":"14","author":"Filippi","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2018.10.005_bb0065","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1006\/nimg.2001.1037","article-title":"Thresholding of statistical maps in functional neuroimaging using the false discovery rate","volume":"15","author":"Genovese","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.10.005_bb0070","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1586\/14737175.2016.1146590","article-title":"Computer-based magnetic resonance imaging as a tool in clinical diagnosis in neurodegenerative diseases","volume":"16","author":"Kassubek","year":"2016","journal-title":"Expert. Rev. Neurother."},{"key":"10.1016\/j.nicl.2018.10.005_bb0075","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/brain\/awu090","article-title":"Diffusion tensor imaging analysis of sequential spreading of disease in amyotrophic lateral sclerosis confirms patterns of TDP-43 pathology","volume":"137","author":"Kassubek","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2018.10.005_bb0080","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/jnnp-2017-316365","article-title":"Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker","volume":"89","author":"Kassubek","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2018.10.005_bb0085","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3109\/21678421.2013.794843","article-title":"Myelin imaging in amyotrophic and primary lateral sclerosis","volume":"14","author":"Kolind","year":"2013","journal-title":"Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration"},{"key":"10.1016\/j.nicl.2018.10.005_bb0090","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1440-1789.2011.01271.x","article-title":"Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration--immunohistochemical and biochemical analyses of TDP-43","volume":"32","author":"Kosaka","year":"2012","journal-title":"Neuropathology"},{"key":"10.1016\/j.nicl.2018.10.005_bb0095","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jmri.1076","article-title":"Diffusion tensor imaging: concepts and applications","volume":"13","author":"Le Bihan","year":"2001","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.nicl.2018.10.005_bb0100","first-page":"1","article-title":"A revision of the El Escorial criteria - 2015","volume":"29","author":"Ludolph","year":"2015","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"issue":"77","key":"10.1016\/j.nicl.2018.10.005_bb0105","doi-asserted-by":"crossref","DOI":"10.3791\/50427-v","article-title":"Diffusion tensor magnetic resonance imaging in the analysis of neurodegenerative diseases","author":"M\u00fcller","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nicl.2018.10.005_bb0110","doi-asserted-by":"crossref","first-page":"N99","DOI":"10.1088\/0031-9155\/52\/6\/N01","article-title":"Preservation of diffusion tensor properties during spatial normalisation by use of tensor imaging and fibre tracking on a normal brain database","volume":"52","author":"M\u00fcller","year":"2007","journal-title":"Phys. Med. Biol."},{"key":"10.1016\/j.nicl.2018.10.005_bb0115","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1475-925X-6-42","article-title":"Diffusion tensor imaging and tractwise fractional anisotropy statistics: quantitative analysis in white matter pathology","volume":"6","author":"M\u00fcller","year":"2007","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.nicl.2018.10.005_bb0120","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/jnnp-2015-311952","article-title":"A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis","volume":"87","author":"M\u00fcller","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2018.10.005_bb0125","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.nicl.2018.03.018","article-title":"Identical patterns of cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: a tract of interest-based MRI study","volume":"18","author":"M\u00fcller","year":"2018","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.nicl.2018.10.005_bb0130","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/brain\/115.2.495","article-title":"Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria","volume":"115","author":"Pringle","year":"1992","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2018.10.005_bb0135","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1007\/s00415-016-8281-2","article-title":"Corticoefferent pathways in pure lower motor neuron disease: a diffusion tensor imaging study","volume":"263","author":"Rosenbohm","year":"2016","journal-title":"J. Neurol."},{"key":"10.1016\/j.nicl.2018.10.005_bb0140","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/21678421.2014.977297","article-title":"Ex post facto assessment of diffusion tensor imaging metrics from different MRI protocols: preparing for multicentre studies in ALS","volume":"16","author":"Rosskopf","year":"2015","journal-title":"Amyotroph. Lateral Scler. Frontotemporal Degener."},{"key":"10.1016\/j.nicl.2018.10.005_bb0145","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/mus.20728","article-title":"Primary lateral sclerosis","volume":"35","author":"Singer","year":"2007","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.nicl.2018.10.005_bb0150","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1006\/nimg.2002.1267","article-title":"Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water","volume":"17","author":"Song","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.10.005_bb0155","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/hbm.20971","article-title":"Whole brain-based analysis of regional white matter tract alterations in rare motor neuron diseases by diffusion tensor imaging","volume":"31","author":"Unrath","year":"2010","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2018.10.005_bb0165","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/ane.12713","article-title":"The concept and diagnostic criteria of primary lateral sclerosis","volume":"136","author":"Wais","year":"2017","journal-title":"Acta Neurol. Scand."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158218303152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158218303152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:12:13Z","timestamp":1761970333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158218303152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":30,"alternative-id":["S2213158218303152"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2018.10.005","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A two-centre tract of interest-based DTI analysis","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2018.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}