{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:47:56Z","timestamp":1792140476141,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["EIA-2017-019"],"award-info":[{"award-number":["EIA-2017-019"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003840","name":"Irish Institute of Clinical Neuroscience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014257","name":"Institut pour la Recherche sur la Moelle \u00e9pini\u00e8re et l'Enc\u00e9phale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007393","name":"Association Fran\u00e7aise contre les Myopathies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.nicl.2018.101618","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T23:55:28Z","timestamp":1543362928000},"page":"101618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"special_numbering":"C","title":["The spinal and cerebral profile of adult spinal-muscular atrophy: A multimodal imaging study"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-6368","authenticated-orcid":false,"given":"Giorgia","family":"Querin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed-Mounir","family":"El Mendili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timoth\u00e9e","family":"Lenglet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Behin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Stojkovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Salachas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Devos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Le Forestier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"del Mar Amador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabab","family":"Debs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucette","family":"Lacomblez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Meininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Bruneteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Cohen-Adad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Leh\u00e9ricy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lafor\u00eat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Blancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Benali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Catala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Marchand-Pauvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Hogrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Pradat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2018.101618_bb0005","doi-asserted-by":"crossref","first-page":"8615872","DOI":"10.1155\/2016\/8615872","article-title":"Cortical reorganization following injury early in life","volume":"2016","author":"Artzi","year":"2016","journal-title":"Neural. Plast."},{"issue":"5","key":"10.1016\/j.nicl.2018.101618_bb0010","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/acn3.406","article-title":"Longitudinal characterization of biomarkers for spinal muscular atrophy","volume":"4","author":"Bonati","year":"2017","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.nicl.2018.101618_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnhum.2014.00035","article-title":"Reorganization and plastic changes of the human brain associated with skill learning and expertise","volume":"8","author":"Chang","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.nicl.2018.101618_bb0020","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.nicl.2017.01.024","article-title":"Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis","volume":"14","author":"De Albuquerque","year":"2017","journal-title":"Neuroimage. Clin."},{"key":"10.1016\/j.nicl.2018.101618_bb0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuroimage.2016.10.009","article-title":"SCT: Spinal Cord Toolbox, an open-source software for processing spinal cord MRI data","volume":"145","author":"De Leener","year":"2017","journal-title":"NeuroImage"},{"issue":"12","key":"10.1016\/j.nicl.2018.101618_bb0030","article-title":"Selective vulnerability of spinal and cortical motor neuron subpopulations in delta7 SMA mice","volume":"8","author":"D'Errico","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.nicl.2018.101618_bb0035","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labelling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"issue":"9","key":"10.1016\/j.nicl.2018.101618_bb0040","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1212\/01.wnl.0000324623.89105.c4","article-title":"Natural history of SMA IIIb: muscle strength decreases in a predictable sequence and magnitude","volume":"71","author":"Deymeer","year":"2008","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.nicl.2018.101618_bb0045","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.neuroimage.2004.12.034","article-title":"A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data","volume":"25","author":"Eickhoff","year":"2005","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.nicl.2018.101618_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095516","article-title":"Multi-parametric spinal cord MRI as potential progression marker in amyotrophic lateral sclerosis","volume":"9","author":"El Mendili","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.nicl.2018.101618_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152439","article-title":"Cervical Spinal Cord Atrophy Profile in Adult SMN1-Linked SMA","volume":"11","author":"El Mendili","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.nicl.2018.101618_bb0060","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/mus.21350","article-title":"(2009). An analysis of disease severity based on SMN2 copy number in adults with spinal muscular atrophy","volume":"40","author":"Elsheikh","year":"2009","journal-title":"Muscle Nerve"},{"issue":"6","key":"10.1016\/j.nicl.2018.101618_bb0065","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrneurol.2015.77","article-title":"Spinal muscular atrophy-recent therapeutic advances for an old challenge","volume":"11","author":"Faravelli","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.nicl.2018.101618_bb0070","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2018.101618_bb0075","doi-asserted-by":"crossref","first-page":"7582","DOI":"10.1038\/ncomms8582","article-title":"Voxel-based morphometry predicts shifts in dendritic spine density and morphology with auditory fear conditioning","volume":"6","author":"Keifer","year":"2015","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.nicl.2018.101618_bb0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.nicl.2018.101618_bb0085","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.1073\/pnas.070039597","article-title":"Navigation-related structural change in the hippocampi of taxi drivers","volume":"97","author":"Maguire","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.nicl.2018.101618_bb0090","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0022-510X(75)90207-5","article-title":"Sensory system involvement in infantile spinal muscular atrophy","volume":"26","author":"Marshall","year":"1975","journal-title":"J. Neurol. Sci."},{"issue":"6","key":"10.1016\/j.nicl.2018.101618_bb0095","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3174\/ajnr.A5162","article-title":"A Novel MRI Biomarker of Spinal Cord White Matter Injury: T2*-Weighted White Matter to Gray Matter Signal Intensity Ratio","volume":"38","author":"Martin","year":"2017","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2018.101618_bb0100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nmd.2017.11.005","article-title":"Diagnosis and management of spinal muscular atrophy: Part 1: Recommendations for diagnosis, rehabilitation, orthopaedic and nutritional care","volume":"28","author":"Mercuri","year":"2018","journal-title":"Neuromuscul. Disord."},{"issue":"8","key":"10.1016\/j.nicl.2018.101618_bb0105","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1177\/0883073809332702","article-title":"Clinical outcome measures in spinal muscular atrophy","volume":"24","author":"Montes","year":"2009","journal-title":"J. Child. Neurology"},{"key":"10.1016\/j.nicl.2018.101618_bb0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.nicl.2017.10.008","article-title":"Fast progressive lower motor neuron disease is an ALS variant: A two-centre tract of interest-based MRI data analysis","volume":"17","author":"Muller","year":"2018","journal-title":"NeuroImage Clinical."},{"issue":"1","key":"10.1016\/j.nicl.2018.101618_bb0115","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3174\/ajnr.A5427","article-title":"Spinal cord gray matter atrophy in amyotrophic Lateral sclerosis","volume":"39","author":"Paquin","year":"2018","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"9","key":"10.1016\/j.nicl.2018.101618_bb0120","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s00415-008-0929-0","article-title":"A natural history study of late onset spinal muscular atrophy types 3b and 4","volume":"255","author":"Piepers","year":"2008","journal-title":"J. Neurol."},{"issue":"3","key":"10.1016\/j.nicl.2018.101618_bb0125","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/joa.12419","article-title":"Selective loss of alpha motor neurons with sparing of gamma motor neurons and spinal cord cholinergic neurons in a mouse model of spinal muscular atrophy","volume":"228","author":"Powis","year":"2016","journal-title":"J. Anat."},{"issue":"8","key":"10.1016\/j.nicl.2018.101618_bb0130","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/ene.13329","article-title":"Spinal cord multi-parametric magnetic resonance imaging for survival prediction in amyotrophic lateral sclerosis","volume":"24","author":"Querin","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nicl.2018.101618_bb0135","doi-asserted-by":"crossref","unstructured":"Rasoanandrianina H, Grapperon AM, Taso M, Girard OM, Duhamel G, Guye, et al (2017). Region-specific impairment of the cervical spinal cord (SC) in amyotrophic lateral sclerosis: A preliminary study using SC templates and quantitative MRI (diffusion tensor imaging\/inhomogeneous magnetization transfer). NMR Biomed. 30(12). doi: https:\/\/doi.org\/10.1002\/nbm.3801.","DOI":"10.1002\/nbm.3801"},{"issue":"Suppl. 1","key":"10.1016\/j.nicl.2018.101618_bb0140","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.nicl.2018.101618_bb0145","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"NeuroImage"},{"issue":"3\u20134","key":"10.1016\/j.nicl.2018.101618_bb0150","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF00687008","article-title":"Is Werdnig-Hoffmann disease a pure lower motor neuron disorder?","volume":"65","author":"Towfighi","year":"1985","journal-title":"Acta Neuropathol."},{"issue":"2","key":"10.1016\/j.nicl.2018.101618_bb0155","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0960-8966(01)00274-7","article-title":"Intelligence and cognitive function in children and adolescents with spinal muscular atrophy","volume":"12","author":"von Gontard","year":"2002","journal-title":"Neuromuscul. Disord."},{"issue":"8","key":"10.1016\/j.nicl.2018.101618_bb0160","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.apmr.2013.01.014","article-title":"Responsiveness of the motor function measure in patients with spinal muscular atrophy","volume":"94","author":"Vuillerot","year":"2013","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"3","key":"10.1016\/j.nicl.2018.101618_bb0165","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/ene.13534","article-title":"Muscle strength and motor function throughout life in a cross- sectional cohort of 180 patients with SMA types 1c-4","volume":"25","author":"Wadman","year":"2018","journal-title":"Eur. J. Neurol."},{"issue":"8","key":"10.1016\/j.nicl.2018.101618_bb0170","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1177\/0883073807305788","article-title":"Consensus statement for standard of care in spinal muscular atrophy","volume":"22","author":"Wang","year":"2017","journal-title":"J. Child Neurol."},{"issue":"21","key":"10.1016\/j.nicl.2018.101618_bb0175","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1093\/hmg\/ddq340","article-title":"SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy","volume":"19","author":"Wishart","year":"2010","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.nicl.2018.101618_bb0180","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2008.03.031","article-title":"SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing","volume":"133","author":"Zhang","year":"2008","journal-title":"Cell"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158218303668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158218303668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:20:58Z","timestamp":1761970858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158218303668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":36,"alternative-id":["S2213158218303668"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2018.101618","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The spinal and cerebral profile of adult spinal-muscular atrophy: A multimodal imaging study","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2018.101618","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101618"}}