{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:19:37Z","timestamp":1787242777721,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001336","name":"University of the Witwatersrand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.nicl.2019.101666","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T23:30:25Z","timestamp":1546990225000},"page":"101666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Emerging differences between Huntington's disease-like 2 and Huntington's disease: A comparison using MRI brain volumetry"],"prefix":"10.1016","volume":"21","author":[{"given":"David G.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Haagensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Ferreira-Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Pierson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Carr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell L.","family":"Margolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2019.101666_bb0005","doi-asserted-by":"crossref","first-page":"512","DOI":"10.5334\/tohm.349","article-title":"Absence of acanthocytosis in Huntington's disease-like 2: a prospective comparison with Huntington's disease","volume":"7","author":"Anderson","year":"2017","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"key":"10.1016\/j.nicl.2019.101666_bb0010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3233\/JHD-160232","article-title":"a systematic review of the Huntington disease-like 2 phenotype","volume":"6","author":"Anderson","year":"2017","journal-title":"J. Huntingtons Dis."},{"key":"10.1016\/j.nicl.2019.101666_bb0015","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000444020","article-title":"The frequency of Huntington disease and Huntington disease-like 2 in the South African population","volume":"46","author":"Baine","year":"2016","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.nicl.2019.101666_bb0020","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/mds.21672","article-title":"A South African mixed ancestry family with Huntington disease-like 2: clinical and genetic features","volume":"22","author":"Bardien","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2019.101666_bb0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.parkreldis.2017.11.001","article-title":"Grey matter volume loss is associated with specific clinical motor signs in Huntington's disease","volume":"46","author":"Coppen","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nicl.2019.101666_bb0030","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00415-010-5768-0","article-title":"Early atrophy of pallidum and accumbens nucleus in Huntington's disease","volume":"258","author":"van den Bogaard","year":"2011","journal-title":"J. Neurol."},{"key":"10.1016\/j.nicl.2019.101666_bb0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00004728-199901000-00030","article-title":"Improving tissue classification in MRI: a three-dimensional multispectral discriminant analysis method with automated training class selection","volume":"23","author":"Harris","year":"1999","journal-title":"J. Comput. Assist. Tomogr."},{"key":"10.1016\/j.nicl.2019.101666_bb0040","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/ng760","article-title":"A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2","volume":"29","author":"Holmes","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.nicl.2019.101666_bb0045","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/cercor\/bhh185","article-title":"Thalamic atrophy in Huntington's disease co-varies with cognitive performance: a morphometric MRI analysis","volume":"15","author":"Kassubek","year":"2004","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2019.101666_bb0050","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/ajmg.b.32332","article-title":"Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype","volume":"168","author":"Krause","year":"2015","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.nicl.2019.101666_bb0055","first-page":"2238","article-title":"Hyperintense putaminal rim sign is not a hallmark of multiple system atrophy at 3T","volume":"26","author":"Lee","year":"2005","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2019.101666_bb0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ana.1312","article-title":"A disorder similar to Huntington's disease is associated with a novel CAG repeat expansion","volume":"50","author":"Margolis","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101666_bb0065","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/ana.20248","article-title":"Huntington's disease-like 2 (HDL2) in North America and Japan","volume":"56","author":"Margolis","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101666_bb0070","first-page":"1","article-title":"Expanding the spectrum of genes involved in Huntington disease using a combined clinical and genetic approach","author":"Mariani","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nicl.2019.101666_bb0075","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","article-title":"Detection of Huntington's disease decades before diagnosis: the Predict-HD study","volume":"79","author":"Paulsen","year":"2008","journal-title":"J. Neurol. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101666_bb0080","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuroimage.2010.06.047","article-title":"Fully automated analysis using BRAINS: autoworkup","volume":"54","author":"Pierson","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2019.101666_bb0085","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuroimage.2007.05.063","article-title":"Registration and machine learning-based automated segmentation of subcortical and cerebellar brain structures","volume":"39","author":"Powell","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2019.101666_bb0090","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1002\/mds.22223","article-title":"Huntington's disease-like 2 in Brazil-report of 4 patients","volume":"23","author":"Rodrigues","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2019.101666_bb0095","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1212\/01.WNL.0000065888.88988.6E","article-title":"Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis","volume":"60","author":"Rosas","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2019.101666_bb0100","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ana.21081","article-title":"Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci","volume":"61","author":"Rudnicki","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101666_bb0105","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/NEN.0b013e31816b4aee","article-title":"A comparison of Huntington disease and Huntington disease-like 2 neuropathology","volume":"67","author":"Rudnicki","year":"2008","journal-title":"J. Neuropath Neuro."},{"key":"10.1016\/j.nicl.2019.101666_bb0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10048-012-0318-9","article-title":"JPH3 repeat expansions cause a progressive akinetic-rigid syndrome with severe dementia and putaminal rim in a five-generation African-American family","volume":"13","author":"Schneider","year":"2012","journal-title":"Neurogenetics"},{"key":"10.1016\/j.nicl.2019.101666_bb0115","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/ana.22598","article-title":"Loss of junctophilin-3 contributes to Huntington disease-like 2 pathogenesis","volume":"71","author":"Seixas","year":"2012","journal-title":"Ann. Neurol."},{"issue":"9","key":"10.1016\/j.nicl.2019.101666_bb0120","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2019.101666_bb0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2377-12-39","article-title":"Hyperintense putaminal rim at 1.5 T: prevalence in normal subjects and distinguishing features from multiple system atrophy","volume":"12","author":"Tha","year":"2012","journal-title":"BMC Neurol."},{"key":"10.1016\/j.nicl.2019.101666_bb0130","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/mds.10587","article-title":"Phenotypic features of Huntington's disease-like 2","volume":"18","author":"Walker","year":"2003","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2019.101666_bb0135","first-page":"1","article-title":"Huntington's disease-like disorders in Latin America and the Caribbean","author":"Walker","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nicl.2019.101666_bb0140","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neuron.2011.03.021","article-title":"An antisense CAG repeat transcript at JPH3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice","volume":"70","author":"Wilburn","year":"2011","journal-title":"Neuron"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158219300166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158219300166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:17:40Z","timestamp":1761970660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158219300166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":28,"alternative-id":["S2213158219300166"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2019.101666","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging differences between Huntington's disease-like 2 and Huntington's disease: A comparison using MRI brain volumetry","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2019.101666","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101666"}}