{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:17:22Z","timestamp":1772558242296,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Indivior Inc"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.nicl.2019.101679","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T04:46:36Z","timestamp":1548132396000},"page":"101679","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6889-4686","authenticated-orcid":false,"given":"Chemin","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmet T.","family":"Karim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Pecina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard J.","family":"Aizenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Lenze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Blumberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit H.","family":"Mulsant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan D.","family":"Kharasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles F.","family":"Reynolds III","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9286-0694","authenticated-orcid":false,"given":"Jordan F.","family":"Karp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2019.101679_bb0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jad.2013.02.027","article-title":"Transcranial direct current stimulation (tDCS) for depression: analysis of response using a three-factor structure of the Montgomery\u2013\u00c5sberg depression rating scale","volume":"150","author":"Alonzo","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.nicl.2019.101679_bb0010","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1176\/appi.ajp.2008.07081340","article-title":"Empirically derived decision trees for the treatment of late-life depression","volume":"165","author":"Andreescu","year":"2008","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0015","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/02699930143000239","article-title":"Knowing what you're feeling and knowing what to do about it: mapping the relation between emotion differentiation and emotion regulation","volume":"15","author":"Barrett","year":"2001","journal-title":"Cognit. Emot."},{"key":"10.1016\/j.nicl.2019.101679_bb0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pain.2005.08.027","article-title":"Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network","volume":"120","author":"Bingel","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.nicl.2019.101679_bb0025","doi-asserted-by":"crossref","first-page":"M249","DOI":"10.1093\/gerona\/58.3.M249","article-title":"Depression in late life: review and commentary","volume":"58","author":"Blazer","year":"2003","journal-title":"J. Gerontol. Ser. A Biol. Med. Sci."},{"key":"10.1016\/j.nicl.2019.101679_bb0030","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00004714-199502000-00008","article-title":"Buprenorphine treatment of refractory depression","volume":"15","author":"Bodkin","year":"1995","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.nicl.2019.101679_bb0035","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1097\/ALN.0b013e318238fea0","article-title":"Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active","volume":"115","author":"Brown","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.nicl.2019.101679_bb0040","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrn894","article-title":"How do you feel? Interoception: the sense of the physiological condition of the body","volume":"3","author":"Craig","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2019.101679_bb0045","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1038\/nn1105-1431","article-title":"Neurobiology of addiction: treatment and public policy ramifications","volume":"8","author":"Dackis","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nicl.2019.101679_bb0050","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1176\/appi.ajp.160.1.64","article-title":"The neural substrates of affective processing in depressed patients treated with venlafaxine","volume":"160","author":"Davidson","year":"2003","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.nicl.2019.101679_bb0055","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1196\/annals.1390.002","article-title":"Reward-related responses in the human striatum","volume":"1104","author":"Delgado","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.nicl.2019.101679_bb0060","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1152\/jn.2000.84.6.3072","article-title":"Tracking the hemodynamic responses to reward and punishment in the striatum","volume":"84","author":"Delgado","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nicl.2019.101679_bb0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3758\/CABN.3.1.27","article-title":"Dorsal striatum responses to reward and punishment: effects of valence and magnitude manipulations","volume":"3","author":"Delgado","year":"2003","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.nicl.2019.101679_bb0070","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrn3027","article-title":"Neural mechanisms of the cognitive model of depression","volume":"12","author":"Disner","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2019.101679_bb0075","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2006.07.029","article-title":"Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala","volume":"51","author":"Etkin","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101679_bb0080","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00213-014-3723-y","article-title":"Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice","volume":"232","author":"Falcon","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nicl.2019.101679_bb0085","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1176\/appi.ajp.2015.15070921","article-title":"Opioid modulation with buprenorphine\/samidorphan as adjunctive treatment for inadequate response to antidepressants: a randomized double-blind placebo-controlled trial","volume":"173","author":"Fava","year":"2016","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.nicl.2019.101679_bb0090","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/hbm.20426","article-title":"A meta-analytic study of changes in brain activation in depression","volume":"29","author":"Fitzgerald","year":"2008","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2019.101679_bb0095","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1139\/jpn.0953","article-title":"Functional atlas of emotional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies","volume":"34","author":"Fusar-Poli","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.nicl.2019.101679_bb0100","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/02699931.2010.544160","article-title":"Explicit and implicit emotion regulation: a dual-process framework","volume":"25","author":"Gyurak","year":"2011","journal-title":"Cognit. Emot."},{"key":"10.1016\/j.nicl.2019.101679_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00001756-200001170-00009","article-title":"Modulating emotional responses: effects of a neocortical network on the limbic system","volume":"11","author":"Hariri","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.nicl.2019.101679_bb0110","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.1071829","article-title":"Serotonin transporter genetic variation and the response of the human amygdala","volume":"297","author":"Hariri","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.nicl.2019.101679_bb0115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/nimg.2002.1179","article-title":"The amygdala response to emotional stimuli: a comparison of faces and scenes","volume":"17","author":"Hariri","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2019.101679_bb0120","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/brain\/awm255","article-title":"Imaging of opioid receptors in the central nervous system","volume":"131","author":"Henriksen","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101679_bb0125","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jagp.2012.07.002","article-title":"Dynamic prediction of treatment response in late-life depression","volume":"22","author":"Joel","year":"2014","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0130","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1001\/jamapsychiatry.2015.3447","article-title":"Predictors and moderators of remission with aripiprazole augmentation in treatment-resistant late-life depression: an analysis of the irl-grey randomized clinical trial","volume":"73","author":"Kaneriya","year":"2016","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"10.1016\/j.nicl.2019.101679_bb0135","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mp.2016.55","article-title":"Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters","volume":"22","author":"Karim","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0140","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.nicl.2018.06.006","article-title":"Acute trajectories of neural activation predict remission to pharmacotherapy in late-life depression","volume":"19","author":"Karim","year":"2018","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.nicl.2019.101679_bb0145","doi-asserted-by":"crossref","first-page":"785","DOI":"10.4088\/JCP.13m08725","article-title":"Safety, tolerability, and clinical effect of low-dose buprenorphine for treatment-resistant depression in midlife and older adults","volume":"75","author":"Karp","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0150","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.5665\/sleep.6154","article-title":"Sleep-wake differences in relative regional cerebral metabolic rate for glucose among patients with insomnia compared with good sleepers","volume":"39","author":"Kay","year":"2016","journal-title":"Sleep"},{"key":"10.1016\/j.nicl.2019.101679_bb0155","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-pharmtox-010715-103143","article-title":"Existing and future drugs for the treatment of the dark side of addiction","volume":"56","author":"Koob","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.nicl.2019.101679_bb0160","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1001\/archpsyc.62.9.985","article-title":"Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function","volume":"62","author":"Krystal","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0165","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0140-6736(11)60602-8","article-title":"Major depressive disorder: new clinical, neurobiological, and treatment perspectives","volume":"379","author":"Kupfer","year":"2012","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.nicl.2019.101679_bb0170","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1523\/JNEUROSCI.4458-07.2008","article-title":"The dysphoric component of stress is encoded by activation of the dynorphin \u03ba-opioid system","volume":"28","author":"Land","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2019.101679_bb0175","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.biopsych.2007.02.019","article-title":"Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder","volume":"62","author":"Langenecker","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0180","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/S0140-6736(15)00308-6","article-title":"Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial","volume":"386","author":"Lenze","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.nicl.2019.101679_bb0185","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/1570159043359477","article-title":"Buprenorphine: a unique drug with complex pharmacology","volume":"2","author":"Lutfy","year":"2004","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.nicl.2019.101679_bb0190","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tins.2012.11.002","article-title":"Opioid receptors: distinct roles in mood disorders","volume":"36","author":"Lutz","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nicl.2019.101679_bb0195","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1176\/appi.ajp.159.5.728","article-title":"The functional neuroanatomy of the placebo effect","volume":"159","author":"Mayberg","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0200","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/jamapsychiatry.2013.143","article-title":"Toward a neuroimaging treatment selection biomarker for major depressive disorder","volume":"70","author":"McGrath","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0205","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0210","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/mp.2011.88","article-title":"Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders","volume":"17","author":"Myers-Schulz","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: a primer with examples","volume":"15","author":"Nichols","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2019.101679_bb0220","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.tics.2005.03.010","article-title":"The cognitive control of emotion","volume":"9","author":"Ochsner","year":"2005","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.nicl.2019.101679_bb0225","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/gps.776","article-title":"A three-factor analytic model of the MADRS in geriatric depression","volume":"18","author":"Parker","year":"2003","journal-title":"Int. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.nicl.2019.101679_bb0230","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1001\/jamapsychiatry.2015.1335","article-title":"Association between placebo-activated neural systems and antidepressant responses: neurochemistry of placebo effects in major depression","volume":"72","author":"Peci\u00f1a","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0235","article-title":"Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches","author":"Peci\u00f1a","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0240","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1126\/science.1067176","article-title":"Placebo and opioid analgesia--imaging a shared neuronal network","volume":"295","author":"Petrovic","year":"2002","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.nicl.2019.101679_bb0245","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/mp.2008.65","article-title":"Neural systems underlying voluntary and automatic emotion regulation: toward a neural model of bipolar disorder","volume":"13","author":"Phillips","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0250","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1001\/jamapsychiatry.2014.1221","article-title":"Association of in vivo \u03ba-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology","volume":"71","author":"Pietrzak","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0255","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jchromb.2013.09.004","article-title":"High-sensitivity analysis of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in plasma and urine by liquid chromatography-mass spectrometry","volume":"939","author":"Regina","year":"2013","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.nicl.2019.101679_bb0260","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbr.2016.10.050","article-title":"A role for the mu opioid receptor in the antidepressant effects of buprenorphine","volume":"319","author":"Robinson","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.nicl.2019.101679_bb0265","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1037\/0021-843X.114.4.627","article-title":"Emotion context insensitivity in major depressive disorder","volume":"114","author":"Rottenberg","year":"2005","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.nicl.2019.101679_bb0270","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR* D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.nicl.2019.101679_bb0275","first-page":"68","article-title":"Salience network functional connectivity predicts placebo effects in major depression","volume":"1","author":"Sikora","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0280","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1001\/jamapsychiatry.2015.1324","article-title":"Antidepressant response trajectories and associated clinical prognostic factors among older adults","volume":"72","author":"Smagula","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0285","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.4088\/JCP.10r06531","article-title":"Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials","volume":"72","author":"Tedeschini","year":"2011","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0290","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2147\/IJGM.S21029","article-title":"Symptom predictors of response to electroconvulsive therapy in older patients with treatment-resistant depression","volume":"4","author":"Tominaga","year":"2011","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.nicl.2019.101679_bb0295","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.7455683","article-title":"The framing of decisions and the psychology of choice","volume":"211","author":"Tversky","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.nicl.2019.101679_bb0300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-002-1003-8","article-title":"Behavioral pharmacology of buprenorphine, with a focus on preclinical models of reward and addiction","volume":"161","author":"Tzschentke","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.nicl.2019.101679_bb0305","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1192\/bjp.bp.108.061960","article-title":"Adverse reactions to antidepressants","volume":"195","author":"Uher","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.nicl.2019.101679_bb0310","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1185\/030079906X148319","article-title":"The onset of effect for escitalopram and its relevance for the clinical management of depression","volume":"22","author":"Wade","year":"2006","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.nicl.2019.101679_bb0315","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1176\/appi.ajp.2007.07040575","article-title":"Altered reward processing in women recovered from anorexia nervosa","volume":"164","author":"Wagner","year":"2007","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.nicl.2019.101679_bb0320","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1523\/JNEUROSCI.0439-05.2005","article-title":"Placebo effects mediated by endogenous opioid activity on \u03bc-opioid receptors","volume":"25","author":"Zubieta","year":"2005","journal-title":"J. Neurosci."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158219300294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158219300294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:19:54Z","timestamp":1761970794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158219300294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":64,"alternative-id":["S2213158219300294"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2019.101679","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2019.101679","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101679"}}