{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:47:05Z","timestamp":1790750825257,"version":"4.1.0"},"reference-count":96,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"vor","delay-in-days":120,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000654","name":"Marie Curie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014466","name":"Department of Health Services, University of Washington","doi-asserted-by":"publisher","award":["04-33516"],"award-info":[{"award-number":["04-33516"]}],"id":[{"id":"10.13039\/100014466","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG034570"],"award-info":[{"award-number":["R01-AG034570"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01-AG045611"],"award-info":[{"award-number":["R01-AG045611"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P50-AG023501"],"award-info":[{"award-number":["P50-AG023501"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.nicl.2019.101848","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T20:43:55Z","timestamp":1556829835000},"page":"101848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"C","title":["Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-7477","authenticated-orcid":false,"given":"Rik","family":"Ossenkoppele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Iaccarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Schonhaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"La Joie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"O'Neil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Janabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne L.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel H.","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Luisa","family":"Gorno-Tempini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Seeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Jagust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil D.","family":"Rabinovici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2019.101848_bb0005","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nicl.2019.101848_bb0010","first-page":"441","article-title":"Evidence for the experimental transmission of cerebral beta-amyloidosis to primates","volume":"74","author":"Baker","year":"1993","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.nicl.2019.101848_bb0015","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2967\/jnumed.116.175273","article-title":"Reference tissue-based kinetic evaluation of 18F-AV-1451 in aging and dementia","volume":"58","author":"Baker","year":"2016","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2019.101848_bb0020","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn.2801","article-title":"Neuronal activity regulates the regional vulnerability to amyloid-beta deposition","volume":"14","author":"Bero","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2019.101848_bb0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2019.101848_bb0035","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.neuron.2017.06.038","article-title":"Parallel interdigitated distributed networks within the individual estimated by intrinsic functional connectivity","volume":"95","author":"Braga","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0040","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrn3887","article-title":"Spreading of pathology in neurodegenerative diseases: a focus on human studies","volume":"16","author":"Brettschneider","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0045","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","article-title":"Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory","volume":"25","author":"Buckner","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0050","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease","volume":"29","author":"Buckner","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0055","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1152\/jn.00339.2011","article-title":"The organization of the human cerebellum estimated by intrinsic functional connectivity","volume":"106","author":"Buckner","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nicl.2019.101848_bb0060","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuroimage.2006.09.011","article-title":"Biological parametric mapping: a statistical toolbox for multimodality brain image analysis","volume":"34","author":"Casanova","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.101848_bb0070","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ana.24711","article-title":"In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum","volume":"80","author":"Cho","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101848_bb0075","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1152\/jn.00270.2012","article-title":"The organization of the human striatum estimated by intrinsic functional connectivity","volume":"108","author":"Choi","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nicl.2019.101848_bb0080","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1073\/pnas.1301175110","article-title":"Brain homogenates from human tauopathies induce tau inclusions in mouse brain","volume":"110","author":"Clavaguera","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2019.101848_bb0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/nan.12197","article-title":"Invited review: prion-like transmission and spreading of tau pathology","volume":"41","author":"Clavaguera","year":"2015","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nicl.2019.101848_bb0090","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/brain\/awx347","article-title":"Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy","volume":"141","author":"Cope","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0095","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jalz.2017.01.014","article-title":"Consensus classification of posterior cortical atrophy","volume":"13","author":"Crutch","year":"2017","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nicl.2019.101848_bb0100","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/cercor\/bhm207","article-title":"Reduced resting-state brain activity in the \"default network\" in normal aging","volume":"18","author":"Damoiseaux","year":"2008","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2019.101848_bb0105","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.neuron.2011.11.033","article-title":"Propagation of tau pathology in a model of early Alzheimer's disease","volume":"73","author":"de Calignon","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0110","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1001\/jamaneurol.2013.420","article-title":"Does a positive Pittsburgh compound B scan in a patient with dementia equal Alzheimer disease?","volume":"70","author":"Ducharme","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.nicl.2019.101848_bb0115","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrn2786","article-title":"Prion-like mechanisms in neurodegenerative diseases","volume":"11","author":"Frost","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0125","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2019.101848_bb0130","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/cercor\/bhn059","article-title":"Resting-state functional connectivity reflects structural connectivity in the default mode network","volume":"19","author":"Greicius","year":"2009","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2019.101848_bb0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/hbm.10022","article-title":"Detection of functional connectivity using temporal correlations in MR images","volume":"15","author":"Hampson","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2019.101848_bb0140","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fnins.2017.00167","article-title":"Tau pathology distribution in Alzheimer's disease corresponds differentially to cognition-relevant functional brain networks","volume":"11","author":"Hansson","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0145","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/brain\/awx353","article-title":"Networks of tau distribution in Alzheimer's disease","volume":"141","author":"Hoenig","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0150","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.neuron.2013.12.003","article-title":"Biomarker modeling of Alzheimer's disease","volume":"80","author":"Jack","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0155","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/brain\/awy059","article-title":"Longitudinal tau PET in ageing and Alzheimer's disease","volume":"141","author":"Jack","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0160","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/dmm.012146","article-title":"Selective vulnerability to neurodegenerative disease: the curious case of prion protein","volume":"7","author":"Jackson","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.nicl.2019.101848_bb0165","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.tics.2011.09.004","article-title":"Lifespan brain activity, beta-amyloid, and Alzheimer's disease","volume":"15","author":"Jagust","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.nicl.2019.101848_bb0170","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s007020200068","article-title":"Alzheimer disease and cerebrovascular pathology: an update","volume":"109","author":"Jellinger","year":"2002","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.nicl.2019.101848_bb0175","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ana.21164","article-title":"Imaging of amyloid burden and distribution in cerebral amyloid angiopathy","volume":"62","author":"Johnson","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101848_bb0180","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.24546","article-title":"Tau positron emission tomographic imaging in aging and early Alzheimer disease","volume":"79","author":"Johnson","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101848_bb0185","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/brain\/awv338","article-title":"Cascading network failure across the Alzheimer's disease spectrum","volume":"139","author":"Jones","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0190","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cortex.2017.09.018","article-title":"Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum","volume":"97","author":"Jones","year":"2017","journal-title":"Cortex"},{"key":"10.1016\/j.nicl.2019.101848_bb0195","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.nicl.2019.101848_bb0200","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.neuron.2016.09.055","article-title":"Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo","volume":"92","author":"Kaufman","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00401-018-1855-6","article-title":"Tau seeding activity begins in the transentorhinal\/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART","volume":"136","author":"Kaufman","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2019.101848_bb0210","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.1212\/WNL.0000000000004860","article-title":"Associations between [(18)F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample","volume":"90","author":"La Joie","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2019.101848_bb0215","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/brain\/aws327","article-title":"Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease","volume":"136","author":"Lehmann","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0220","doi-asserted-by":"crossref","first-page":"11606","DOI":"10.1073\/pnas.1221536110","article-title":"Intrinsic connectivity networks in healthy subjects explain clinical variability in Alzheimer's disease","volume":"110","author":"Lehmann","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2019.101848_bb0225","article-title":"Trans-synaptic spread of tau pathology in vivo","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2019.101848_bb0230","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1097\/00004647-199609000-00008","article-title":"Distribution volume ratios without blood sampling from graphical analysis of PET data","volume":"16","author":"Logan","year":"1996","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nicl.2019.101848_bb0235","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40478-016-0315-6","article-title":"An autoradiographic evaluation of AV-1451 tau PET in dementia","volume":"4","author":"Lowe","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.nicl.2019.101848_bb0240","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/brain\/awx320","article-title":"Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia","volume":"141","author":"Lowe","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0245","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.neuroimage.2014.09.034","article-title":"Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance","volume":"104","author":"Malone","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.101848_bb0250","doi-asserted-by":"crossref","first-page":"20069","DOI":"10.1073\/pnas.0905314106","article-title":"Precuneus shares intrinsic functional architecture in humans and monkeys","volume":"106","author":"Margulies","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2019.101848_bb0255","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/ana.24517","article-title":"Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue","volume":"78","author":"Marquie","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101848_bb0260","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13195-018-0403-x","article-title":"Greater tau load and reduced cortical thickness in APOE epsilon4-negative Alzheimer's disease: a cohort study","volume":"10","author":"Mattsson","year":"2018","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nicl.2019.101848_bb0265","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nicl.2019.101848_bb0270","doi-asserted-by":"crossref","first-page":"8303","DOI":"10.1523\/JNEUROSCI.0357-05.2005","article-title":"Structural covariance in the human cortex","volume":"25","author":"Mechelli","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0275","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.neuron.2015.01.025","article-title":"Pathological tau disrupts ongoing network activity","volume":"85","author":"Menkes-Caspi","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0280","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1126\/science.1131864","article-title":"Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host","volume":"313","author":"Meyer-Luehmann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.nicl.2019.101848_bb0285","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1212\/WNL.0b013e3181c0d427","article-title":"Clinical syndromes associated with posterior atrophy: early age at onset AD spectrum","volume":"73","author":"Migliaccio","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2019.101848_bb0290","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00004728-199507000-00006","article-title":"Preserved pontine glucose metabolism in Alzheimer disease: a reference region for functional brain image (PET) analysis","volume":"19","author":"Minoshima","year":"1995","journal-title":"J. Comput. Assist. Tomogr."},{"key":"10.1016\/j.nicl.2019.101848_bb0295","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/NEN.0b013e31825018f7","article-title":"Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature","volume":"71","author":"Nelson","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nicl.2019.101848_bb0300","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1093\/brain\/aws113","article-title":"Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement","volume":"135","author":"Ossenkoppele","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0305","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1002\/hbm.22927","article-title":"Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease","volume":"36","author":"Ossenkoppele","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2019.101848_bb0310","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1093\/brain\/awv191","article-title":"The behavioural\/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features","volume":"138","author":"Ossenkoppele","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0315","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/ana.24321","article-title":"Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy","volume":"77","author":"Ossenkoppele","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101848_bb0320","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1093\/brain\/aww027","article-title":"Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease","volume":"139","author":"Ossenkoppele","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0325","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/jama.2018.12917","article-title":"Discriminative accuracy of [18F]flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders","volume":"320","author":"Ossenkoppele","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.nicl.2019.101848_bb0330","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.nbd.2014.08.032","article-title":"Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice","volume":"73","author":"Peeraer","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.nicl.2019.101848_bb0335","first-page":"748","article-title":"Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition","volume":"140","author":"Pontecorvo","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0340","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1056\/NEJM198403083101021","article-title":"Some speculations about prions, amyloid, and Alzheimer's disease","volume":"310","author":"Prusiner","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2019.101848_bb0345","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/brain\/awp326","article-title":"Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden","volume":"133","author":"Rabinovici","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0350","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/brain.2011.0019","article-title":"The restless brain","volume":"1","author":"Raichle","year":"2011","journal-title":"Brain Connect"},{"key":"10.1016\/j.nicl.2019.101848_bb0355","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.celrep.2014.12.034","article-title":"Network diffusion model of progression predicts longitudinal patterns of atrophy and metabolism in Alzheimer's disease","volume":"10","author":"Raj","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.nicl.2019.101848_bb0360","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuroimage.2015.05.054","article-title":"Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities","volume":"117","author":"Reijmer","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.101848_bb0365","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1471-4159.2011.07551.x","article-title":"Exogenous seeding of cerebral beta-amyloid deposition in betaAPP-transgenic rats","volume":"120","author":"Rosen","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nicl.2019.101848_bb0370","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.jalz.2016.01.003","article-title":"Characterization of tau positron emission tomography tracer [(18)F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias","volume":"12","author":"Sander","year":"2016","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nicl.2019.101848_bb0375","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.neuron.2014.04.047","article-title":"Distinct tau prion strains propagate in cells and mice and define different tauopathies","volume":"82","author":"Sanders","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0380","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","article-title":"PET imaging of tau deposition in the aging human brain","volume":"89","author":"Scholl","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0385","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/brain\/awx171","article-title":"Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer's disease","volume":"140","author":"Scholl","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0390","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.neuroimage.2009.05.037","article-title":"Neural correlates of Alzheimer's disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients","volume":"47","author":"Schroeter","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.101848_bb0395","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/brain\/aww023","article-title":"Regional profiles of the candidate tau PET ligand 18F-AV-1451 recapitulate key features of Braak histopathological stages","volume":"139","author":"Schwarz","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0400","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","article-title":"Neurodegenerative diseases target large-scale human brain networks","volume":"62","author":"Seeley","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0405","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/brain\/awt146","article-title":"In vivo characterization of the early states of the amyloid-beta network","volume":"136","author":"Sepulcre","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0410","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/cercor\/bhr099","article-title":"Decoding subject-driven cognitive states with whole-brain connectivity patterns","volume":"22","author":"Shirer","year":"2012","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nicl.2019.101848_bb0415","doi-asserted-by":"crossref","first-page":"13040","DOI":"10.1073\/pnas.0905267106","article-title":"Correspondence of the brain's functional architecture during activation and rest","volume":"106","author":"Smith","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2019.101848_bb0420","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.neuron.2014.05.004","article-title":"The intersection of amyloid beta and tau at synapses in Alzheimer's disease","volume":"82","author":"Spires-Jones","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.101848_bb0425","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.3233\/JAD-170740","article-title":"Regional distribution, asymmetry, and clinical correlates of tau uptake on [18F]AV-1451 PET in atypical Alzheimer's disease","volume":"62","author":"Tetzloff","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nicl.2019.101848_bb0430","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.jalz.2015.05.018","article-title":"[(18)F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: specific detection of advanced phases of amyloid-beta pathology","volume":"11","author":"Thal","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nicl.2019.101848_bb0435","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/brain\/awv112","article-title":"Existing Pittsburgh compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation","volume":"138","author":"Villeneuve","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.101848_bb0440","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.1073\/pnas.1010461107","article-title":"Spatial correlation between brain aerobic glycolysis and amyloid-beta (Abeta) deposition","volume":"107","author":"Vlassenko","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2019.101848_bb0445","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hbm.24401","article-title":"Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease","volume":"40","author":"Vogel","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2019.101848_bb0450","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrn.2016.13","article-title":"A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration","volume":"17","author":"Walsh","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.nicl.2019.101848_bb0455","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1073858414537560","article-title":"Understanding structural-functional relationships in the human brain: a large-scale network perspective","volume":"21","author":"Wang","year":"2015","journal-title":"Neuroscientist"},{"key":"10.1016\/j.nicl.2019.101848_bb0460","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/ana.25142","article-title":"[(18) F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease","volume":"83","author":"Whitwell","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101848_bb0465","article-title":"BrainNet viewer: a network visualization tool for human brain connectomics","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2019.101848_bb0470","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.neuroimage.2011.04.046","article-title":"Biological parametric mapping with robust and non-parametric statistics","volume":"57","author":"Yang","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.101848_bb0475","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nicl.2019.101848_bb0480","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.neuron.2012.03.004","article-title":"Predicting regional neurodegeneration from the healthy brain functional connectome","volume":"73","author":"Zhou","year":"2012","journal-title":"Neuron"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158219301986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158219301986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:36:33Z","timestamp":1761971793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158219301986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":96,"alternative-id":["S2213158219301986"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2019.101848","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2019.101848","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101848"}}