{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:31:54Z","timestamp":1793298714434,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T00:00:00Z","timestamp":1558742400000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000377","name":"Dunhill Medical Trust","doi-asserted-by":"publisher","award":["R401\/0215"],"award-info":[{"award-number":["R401\/0215"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.nicl.2019.101880","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T20:50:52Z","timestamp":1558990252000},"page":"101880","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Diffusion tensor imaging reveals changes in microstructural integrity along compressed nerve roots that correlate with chronic pain symptoms and motor deficiencies in elderly stenosis patients"],"prefix":"10.1016","volume":"23","author":[{"given":"S.W.","family":"Hughes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Hellyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.J.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"Newbould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-099X","authenticated-orcid":false,"given":"P.H.","family":"Strutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2019.101880_bb0005","series-title":"Clinical and Radiologic Features","first-page":"1178","article-title":"Lumbar spinal stenosis","volume":"20","author":"Amundsen","year":"1995"},{"key":"10.1016\/j.nicl.2019.101880_bb0010","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00330-010-2049-3","article-title":"Tractography of lumbar nerve roots: initial results","volume":"21","author":"Balbi","year":"2011","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.nicl.2019.101880_bb0015","doi-asserted-by":"crossref","first-page":"i6748","DOI":"10.1136\/bmj.i6748","article-title":"Low back pain and sciatica: summary of NICE guidance","volume":"356","author":"Bernstein","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.nicl.2019.101880_bb0020","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00234-017-1869-0","article-title":"Relationships between the integrity and function of lumbar nerve roots as assessed by diffusion tensor imaging and neurophysiology","volume":"59","author":"Chiou","year":"2017","journal-title":"Neuroradiology"},{"key":"10.1016\/j.nicl.2019.101880_bb0025","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1007\/s00586-010-1520-9","article-title":"Clinical applications of diffusion magnetic resonance imaging of the lumbar foraminal nerve root entrapment","volume":"19","author":"Eguchi","year":"2010","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.nicl.2019.101880_bb0030","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3174\/ajnr.A2681","article-title":"Quantitative evaluation and visualization of lumbar foraminal nerve root entrapment by using diffusion tensor imaging: preliminary results","volume":"32","author":"Eguchi","year":"2011","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2019.101880_bb0035","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4184\/asj.2016.10.1.164","article-title":"Diagnosis of lumbar Foraminal stenosis using diffusion tensor imaging","volume":"10","author":"Eguchi","year":"2016","journal-title":"Asian Spine J."},{"key":"10.1016\/j.nicl.2019.101880_bb0040","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4184\/asj.2016.10.2.327","article-title":"Discrimination between lumbar Intraspinal stenosis and Foraminal stenosis using diffusion tensor imaging parameters: preliminary results","volume":"10","author":"Eguchi","year":"2016","journal-title":"Asian Spine J."},{"key":"10.1016\/j.nicl.2019.101880_bb0045","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3171\/2015.10.SPINE15858","article-title":"Prognostic value of magnetic resonance imaging findings in patients with sciatica","volume":"24","author":"El Barzouhi","year":"2016","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.nicl.2019.101880_bb0050","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/AJP.0b013e31815349bf","article-title":"Spinal canal size and clinical symptoms among persons diagnosed with lumbar spinal stenosis","volume":"23","author":"Geisser","year":"2007","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.nicl.2019.101880_bb0055","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2106\/00004623-199501000-00005","article-title":"Lumbar foraminal stenosis: critical heights of the intervertebral discs and foramina. A cryomicrotome study in cadavera","volume":"77","author":"Hasegawa","year":"1995","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.nicl.2019.101880_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130833","article-title":"Peripheral nerve diffusion tensor imaging: assessment of axon and myelin sheath integrity","volume":"10","author":"Heckel","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nicl.2019.101880_bb0065","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ana.23824","article-title":"Individual prediction of white matter injury following traumatic brain injury","volume":"73","author":"Hellyer","year":"2013","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2019.101880_bb0070","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1113\/jphysiol.1987.sp016621","article-title":"Responses in small hand muscles from magnetic stimulation of the human brain","volume":"388","author":"Hess","year":"1987","journal-title":"J. Physiol."},{"key":"10.1016\/j.nicl.2019.101880_bb0075","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1097\/00007632-199611010-00002","article-title":"Anatomic changes of the spinal canal and intervertebral foramen associated with flexion-extension movement","volume":"21","author":"Inufusa","year":"1996","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.nicl.2019.101880_bb0080","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.spinee.2009.03.005","article-title":"Spinal stenosis prevalence and association with symptoms: the Framingham study","volume":"9","author":"Kalichman","year":"2009","journal-title":"Spine J."},{"key":"10.1016\/j.nicl.2019.101880_bb0085","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.spinee.2015.11.003","article-title":"The diagnosis of double-crush lesion in the L5 lumbar nerve using diffusion tensor imaging","volume":"16","author":"Kanamoto","year":"2016","journal-title":"Spine J."},{"key":"10.1016\/j.nicl.2019.101880_bb0090","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s00415-012-6497-3","article-title":"Nerve conduction and electromyography studies","volume":"259","author":"Kane","year":"2012","journal-title":"J. Neurol."},{"key":"10.1016\/j.nicl.2019.101880_bb0095","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00330-008-0971-4","article-title":"Diffusion tensor imaging and tractography of the median nerve in carpal tunnel syndrome: preliminary results","volume":"18","author":"Khalil","year":"2008","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.nicl.2019.101880_bb0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00003086-198209000-00026","article-title":"Lumbar spinal nerve lateral entrapment","author":"Kirkaldy-Willis","year":"1982","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.nicl.2019.101880_bb0105","doi-asserted-by":"crossref","first-page":"E854","DOI":"10.1097\/BRS.0b013e318249537f","article-title":"A case of symptomatic extra-foraminal lumbosacral stenosis (\"far-out syndrome\") diagnosed by diffusion tensor imaging","volume":"37","author":"Kitamura","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.nicl.2019.101880_bb0110","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0736-0266(03)00131-1","article-title":"Pathology of lumbar nerve root compression. Part 1: Intraradicular inflammatory changes induced by mechanical compression","volume":"22","author":"Kobayashi","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.nicl.2019.101880_bb0115","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1054\/jhsb.2001.0616","article-title":"Carpal tunnel syndrome: the correlation between outcome, symptoms and nerve conduction study findings","volume":"26","author":"Longstaff","year":"2001","journal-title":"J. Hand Surg. (Br.)"},{"key":"10.1016\/j.nicl.2019.101880_bb0120","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/B978-0-7020-4086-3.00035-7","article-title":"Spinal stenosis","volume":"119","author":"Melancia","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.nicl.2019.101880_bb0125","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1054\/jhsb.2000.0361","article-title":"Relationship between the self-administered Boston questionnaire and electrophysiological findings in follow-up of surgically-treated carpal tunnel syndrome","volume":"25","author":"Mondelli","year":"2000","journal-title":"J. Hand Surg. (Br.)"},{"key":"10.1016\/j.nicl.2019.101880_bb0130","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/mrm.21746","article-title":"Efficient fat suppression by slice-selection gradient reversal in twice-refocused diffusion encoding","volume":"60","author":"Nagy","year":"2008","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.nicl.2019.101880_bb0135","series-title":"Spinal Injury: Assessment and Initial Management","author":"NICE","year":"2016"},{"key":"10.1016\/j.nicl.2019.101880_bb0140","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00586-012-2554-y","article-title":"Evaluation of corticospinal excitability in cervical myelopathy, before and after surgery, with transcranial magnetic stimulation: a pilot study","volume":"22","author":"Nicotra","year":"2013","journal-title":"Eur. Spine J."},{"key":"10.1016\/j.nicl.2019.101880_bb0145","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.mri.2015.05.002","article-title":"Diffusion tensor imaging of lumbar spinal nerve in subjects with degenerative lumbar disorders","volume":"33","author":"Oikawa","year":"2015","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.nicl.2019.101880_bb0150","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00590-016-1806-7","article-title":"Lumbar foraminal stenosis, the hidden stenosis including at L5\/S1","volume":"26","author":"Orita","year":"2016","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.nicl.2019.101880_bb0155","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.math.2005.07.001","article-title":"Diagnosis and classification of chronic low back pain disorders: maladaptive movement and motor control impairments as underlying mechanism","volume":"10","author":"O'sullivan","year":"2005","journal-title":"Man. Ther."},{"key":"10.1016\/j.nicl.2019.101880_bb0160","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.clinph.2010.12.037","article-title":"Screening questionnaire before TMS: an update","volume":"122","author":"Rossi","year":"2011","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.nicl.2019.101880_bb0165","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00007632-198401000-00004","article-title":"Pathoanatomy and pathophysiology of nerve root compression","volume":"9","author":"Rydevik","year":"1984","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.nicl.2019.101880_bb0170","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00007632-199105000-00001","article-title":"Effects of acute, graded compression on spinal nerve root function and structure. An experimental study of the pig cauda equina","volume":"16","author":"Rydevik","year":"1991","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.nicl.2019.101880_bb0175","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrneurol.2014.15","article-title":"Network dysfunction after traumatic brain injury","volume":"10","author":"Sharp","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nicl.2019.101880_bb0180","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1006\/nimg.2002.1267","article-title":"Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water","volume":"17","author":"Song","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.101880_bb0185","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.neuroimage.2003.07.005","article-title":"Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia","volume":"20","author":"Song","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.101880_bb0190","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/01.BRS.0000048645.33118.02","article-title":"Pathomechanisms of nerve root injury caused by disc herniation: an experimental study of mechanical compression and chemical irritation","volume":"28","author":"Takahashi","year":"2003","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.nicl.2019.101880_bb0195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00007632-198401000-00006","article-title":"Subarticular entrapment of the dorsal root ganglion as a cause of sciatic pain","volume":"9","author":"Vanderlinden","year":"1984","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.nicl.2019.101880_bb0200","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/j.1532-2149.2013.00301.x","article-title":"Systematic review of prognostic factors predicting outcome in non-surgically treated patients with sciatica","volume":"17","author":"Verwoerd","year":"2013","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.nicl.2019.101880_bb0205","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/j.pain.0000000000000433","article-title":"Quantitative sensory testing using DFNS protocol in Europe: an evaluation of heterogeneity across multiple centers in patients with peripheral neuropathic pain and healthy subjects","volume":"157","author":"Vollert","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.nicl.2019.101880_bb0210","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/practneurol-2011-000198","article-title":"The fundamentals of electromyography","volume":"12","author":"Whittaker","year":"2012","journal-title":"Pract. Neurol."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221315821930230X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221315821930230X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:37:14Z","timestamp":1761971834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221315821930230X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":42,"alternative-id":["S221315821930230X"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2019.101880","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diffusion tensor imaging reveals changes in microstructural integrity along compressed nerve roots that correlate with chronic pain symptoms and motor deficiencies in elderly stenosis patients","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2019.101880","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101880"}}