{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:51:11Z","timestamp":1790844671643,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"vor","delay-in-days":307,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.nicl.2019.102078","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T11:39:59Z","timestamp":1573040399000},"page":"102078","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-320X","authenticated-orcid":false,"given":"Garazi","family":"Labayru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibai","family":"Diez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Sepulcre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Zulaica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas M.","family":"Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"L\u00f3pez de Munain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andone","family":"Sistiaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2019.102078_bib0001","doi-asserted-by":"crossref","unstructured":"Andersson, J.L.R., Jenkinson, M., Smith, S., 2007. Non-linear registration, aka spatial normalisation. FMRIB Technial Report TR07JA2. Oxford Cent. Funct. Magn. Reson. Imaging Brain, Dep. Clin. Neurol. Oxford Univ. Oxford, UK 22. https:\/\/doi.org\/10.1016\/j.neuroimage.2008.10.055.","DOI":"10.1016\/j.neuroimage.2008.10.055"},{"key":"10.1016\/j.nicl.2019.102078_bib0002","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1136\/jnnp.2003.032417","article-title":"Cerebral atrophy in myotonic dystrophy: a voxel based morphometric study","volume":"75","author":"Antonini","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2019.102078_bib0003","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nicl.2016.06.011","article-title":"Relationship between neuropsychological impairment and grey and white matter changes in adult-onset myotonic dystrophy type 1","volume":"12","author":"Baldanzi","year":"2016","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.nicl.2019.102078_bib0004","series-title":"Contributions to Neuropsychological Assessment","author":"Benton","year":"1994"},{"key":"10.1016\/j.nicl.2019.102078_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2013.00057","article-title":"Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy","volume":"6","author":"Caillet-Boudin","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.nicl.2019.102078_bib0006","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.nrl.2012.02.010","article-title":"Estudios normativos espa\u00f1oles en poblaci\u00f3n adulta joven (proyecto NEURONORMA j\u00f3venes): normas para los test de fluencia verbal","volume":"28","author":"Casals-Coll","year":"2013","journal-title":"Neurolog\u00eda"},{"key":"10.1016\/j.nicl.2019.102078_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0104697","article-title":"Cognitive impairment in myotonic dystrophy type 1 is associated with white matter damage","volume":"9","author":"Caso","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2019.102078_bib0008","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.102078_bib0009","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.102078_bib0010","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/brain\/awm184","article-title":"Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia","volume":"130","author":"Douaud","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.102078_bib0011","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2019.102078_bib0012","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/02841850510015974","article-title":"Diffusion tensor imaging of cerebral white matter in patients with myotonic dystrophy","volume":"46","author":"Fukuda","year":"2005","journal-title":"Acta Radiol."},{"key":"10.1016\/j.nicl.2019.102078_bib0013","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.nmd.2016.10.003","article-title":"Cognitive decline over time in adults with myotonic dystrophy type 1: a 9-year longitudinal study","volume":"27","author":"Gallais","year":"2017","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.nicl.2019.102078_bib0014","series-title":"STROOP. Test de Colores y Palabras","author":"Golden","year":"2001"},{"key":"10.1016\/j.nicl.2019.102078_bib0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.102078_bib0016","series-title":"Myotonic Dystrophy","author":"Harper","year":"2001"},{"key":"10.1016\/j.nicl.2019.102078_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-014-0186-5","article-title":"Comparisons of intellectual capacities between mild and classic adult-onset phenotypes of myotonic dystrophy type 1 (DM1)","volume":"9","author":"Jean","year":"2014","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.nicl.2019.102078_bib0018","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jns.2009.11.011","article-title":"Facial emotion recognition and cerebral white matter lesions in myotonic dystrophy type 1","volume":"290","author":"Kobayakawa","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nicl.2019.102078_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0204227","article-title":"Social cognition in Myotonic Dystrophy Type 1\u202f: specific or secondary impairment?","volume":"13","author":"Labayru","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2019.102078_bib0020","series-title":"Neuropsychological Assessment","author":"Lezak","year":"2004"},{"key":"10.1016\/j.nicl.2019.102078_bib0021","first-page":"53","article-title":"Utilidad de las formas cortas de la Escala de Inteligencia de Wechsler para Adultos (WAIS)","volume":"19","author":"L\u00f3pez","year":"2003","journal-title":"An. Psicol"},{"key":"10.1016\/j.nicl.2019.102078_bib0022","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1212\/WNL.43.8.1573","article-title":"Prevalence of myotonic dystrophy in Guip\u00fazcoa (Basque Country, Spain)","volume":"43","author":"L\u00f3pez de Munain","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2019.102078_bib0023","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/hmg\/7.2.307","article-title":"Progression of somatic CTG repeat length heterogeneity in the blood cells of myotonic dystrophy patients","volume":"7","author":"Martorell","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nicl.2019.102078_bib0024","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1212\/WNL.56.3.336","article-title":"Assessment of a disease-specific muscular impairment rating scale in myotonic dystrophy","volume":"56","author":"Mathieu","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2019.102078_bib0025","doi-asserted-by":"crossref","unstructured":"Miller, E.N., 1990. CalCAP: California Computerized Assessment Package.","DOI":"10.1037\/t05191-000"},{"key":"10.1016\/j.nicl.2019.102078_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2018.00646","article-title":"Current progress in CNS imaging of myotonic dystrophy","volume":"9","author":"Minnerop","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nicl.2019.102078_bib0027","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1093\/brain\/awr299","article-title":"The brain in myotonic dystrophy 1 and 2: evidence for a predominant white matter disease","volume":"134","author":"Minnerop","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2019.102078_bib0028","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00415-008-0017-5","article-title":"Cognitive impairment in myotonic dystrophy type 1 (DM1): a longitudinal follow-up study","volume":"255","author":"Modoni","year":"2008","journal-title":"J. Neurol."},{"key":"10.1016\/j.nicl.2019.102078_bib0029","first-page":"960","article-title":"Brain imaging in myotonic dystrophy type 1. A systematic review","volume":"89","author":"Okkersen","year":"2017","journal-title":"Am. Acad. Neurol."},{"key":"10.1016\/j.nicl.2019.102078_bib0030","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neulet.2006.08.077","article-title":"Relationship between diffusion tensor imaging and brain morphology in patients with myotonic dystrophy","volume":"407","author":"Ota","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nicl.2019.102078_bib0031","first-page":"1","article-title":"Diffusion tensor imaging and voxel-based morphometry reveal corticospinal tract involvement in the motor dysfunction of adult-onset myotonic dystrophy type 1","volume":"8","author":"Park","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nicl.2019.102078_bib0032","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/arclin\/acp042","article-title":"Spanish multicenter normative studies (NEURONORMA Project): norms for verbal fluency tests","volume":"24","author":"Pe\u00f1a-Casanova","year":"2009","journal-title":"Arch. Clin. Neuropsychol."},{"key":"10.1016\/j.nicl.2019.102078_bib0033","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00415-014-7545-y","article-title":"Frontostriatal dysexecutive syndrome: a core cognitive feature of myotonic dystrophy type 2","volume":"262","author":"Peric","year":"2014","journal-title":"J. Neurol."},{"key":"10.1016\/j.nicl.2019.102078_bib0034","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10072-016-2778-4","article-title":"Clusters of cognitive impairment among different phenotypes of myotonic dystrophy type 1 and type 2","volume":"38","author":"Peric","year":"2017","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.nicl.2019.102078_bib0035","series-title":"Raven: Standard Progressive Matrices","author":"Raven","year":"2001"},{"key":"10.1016\/j.nicl.2019.102078_bib0036","series-title":"Test de copia y de reproducci\u00f3n de memoria de figuras geom\u00e9tricas complejas","author":"Rey","year":"2009"},{"key":"10.1016\/j.nicl.2019.102078_bib0037","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/jmg.34.3.229","article-title":"Mild myotonic dystrophy is associated with memory impairment in the context of normal general intelligence","volume":"34","author":"Rubinsztein","year":"1997","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.nicl.2019.102078_bib0038","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10072-007-0742-z","article-title":"Cognitive impairment in adult myotonic dystrophies: a longitudinal study","volume":"28","author":"Sansone","year":"2007","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.nicl.2019.102078_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0130352","article-title":"Cortical and subcortical grey and white matter atrophy in myotonic dystrophies type 1 and 2 is associated with cognitive impairment, depression and daytime sleepiness","volume":"10","author":"Schneider-Gold","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2019.102078_bib0040","first-page":"21","article-title":"How genetics affects the brain to produce higher-level dysfunctions in myotonic dystrophy type 1","volume":"30","author":"Serra","year":"2015","journal-title":"Funct. Neurol."},{"key":"10.1016\/j.nicl.2019.102078_bib0041","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1017\/S0033291709990602","article-title":"Cognitive\/personality pattern and triplet expansion size in adult myotonic dystrophy type 1 (DM1): CTG repeats, cognition and personality in DM1","volume":"40","author":"Sistiaga","year":"2010","journal-title":"Psychol. Med."},{"key":"10.1016\/j.nicl.2019.102078_bib0042","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.102078_bib0043","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nimg.2002.1040","article-title":"Accurate, robust, and automated longitudinal and cross-sectional brain change analysis","volume":"17","author":"Smith","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2019.102078_bib0044","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ncl.2014.04.011","article-title":"Myotonic dystrophy","volume":"32","author":"Thornton","year":"2014","journal-title":"Neurol. Clin"},{"key":"10.1016\/j.nicl.2019.102078_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2018.101615","article-title":"Structural white matter networks in myotonic dystrophy type 1","volume":"21","author":"van Dorst","year":"2019","journal-title":"NeuroImage Clin"},{"key":"10.1016\/j.nicl.2019.102078_bib0046","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1212\/WNL.0b013e3181d8c35f","article-title":"Comparative analysis of brain structure, metabolism, and cognition in myotonic dystrophy 1 and 2","volume":"74","author":"Weber","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2019.102078_bib0047","series-title":"WAIS-III: Escala de Inteligencia de Wechsler para Adultos III","author":"Wechsler","year":"1999"},{"key":"10.1016\/j.nicl.2019.102078_bib0048","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/jnnp.2005.070763","article-title":"Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion","volume":"77","author":"Winblad","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2019.102078_bib0049","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1744-9081-2-16","article-title":"Cognitive deficits and CTG repeat expansion size in classical myotonic dystrophy type 1 (DM1)","volume":"2","author":"Winblad","year":"2006","journal-title":"Behav. brain Funct."},{"key":"10.1016\/j.nicl.2019.102078_bib0050","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/ene.13062","article-title":"Cognition in myotonic dystrophy type 1: a 5-year follow-up study","volume":"23","author":"Winblad","year":"2016","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nicl.2019.102078_bib0051","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jns.2014.04.005","article-title":"Tractography reveals diffuse white matter abnormalities in Myotonic Dystrophy Type 1","volume":"341","author":"Wozniak","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.nicl.2019.102078_bib0052","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.nmd.2010.11.013","article-title":"White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1: A diffusion tensor imaging study","volume":"21","author":"Wozniak","year":"2011","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.nicl.2019.102078_bib0053","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1007\/s00415-012-6771-4","article-title":"Diffusion tensor imaging reveals widespread white matter abnormalities in children and adolescents with myotonic dystrophy type 1","volume":"260","author":"Wozniak","year":"2013","journal-title":"J. Neurol."},{"key":"10.1016\/j.nicl.2019.102078_bib0054","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.nicl.2016.04.012","article-title":"Relationship of white and gray matter abnormalities to clinical and genetic features in myotonic dystrophy type 1","volume":"11","author":"Zanigni","year":"2016","journal-title":"NeuroImage Clin."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158219304255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158219304255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:25:40Z","timestamp":1761971140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158219304255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":54,"alternative-id":["S2213158219304255"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2019.102078","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2019.102078","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102078"}}