{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:50:55Z","timestamp":1784307055145,"version":"3.55.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012456","name":"Toronto General and Western Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.nicl.2020.102212","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T12:01:02Z","timestamp":1581595262000},"page":"102212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Interaction of APOE4 alleles and PET tau imaging in former contact sport athletes"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-9620","authenticated-orcid":false,"given":"Anna","family":"Vasilevskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foad","family":"Taghdiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apameh","family":"Tarazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ali","family":"Naeimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mozghan","family":"Khodadadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruma","family":"Goswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Grinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wennberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mikulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Colella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-0090","authenticated-orcid":false,"given":"Karen D.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Rusjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Houle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Tator","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Rogaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0001","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","author":"McKee","year":"2013","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.nicl.2020.102212_bib0002","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","article-title":"Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury","volume":"68","author":"McKee","year":"2009","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"issue":"2","key":"10.1016\/j.nicl.2020.102212_bib0003","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/PAF.0b013e3181ca7f35","article-title":"Chronic traumatic encephalopathy, suicides and parasuicides in professional american athletes: the role of the forensic pathologist.","volume":"31","author":"Omalu","year":"2010","journal-title":"Am J Forensic Med Pathol"},{"key":"10.1016\/j.nicl.2020.102212_bib0004","article-title":"Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology","volume":"7","author":"Hazrati","year":"2013","journal-title":"Front Hum Neurosci [Internet]"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0005","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1227\/NEU.0b013e318212bc7b","article-title":"Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in american athletes","volume":"69","author":"Omalu","year":"2011","journal-title":"Neurosurgery"},{"issue":"15","key":"10.1016\/j.nicl.2020.102212_bib0006","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1001\/jama.1928.02700150029009","article-title":"PUNCH drunk","volume":"91","author":"Martland","year":"1928","journal-title":"JAMA"},{"key":"10.1016\/j.nicl.2020.102212_bib0007","first-page":"131","article-title":"Punch-drunk syndromes: the chronic traumatic encephalopathy of boxers","author":"Critchley","year":"1949","journal-title":"Hommage a Clovis Vincent"},{"issue":"297","key":"10.1016\/j.nicl.2020.102212_bib0008","first-page":"303","article-title":"Dementia pugilistica","volume":"35","author":"Millspaugh","year":"1937","journal-title":"US Naval Med Bull"},{"key":"10.1016\/j.nicl.2020.102212_bib0009","article-title":"Chronic traumatic encephalopathy and other neurodegenerative proteinopathies","volume":"8","author":"Tartaglia","year":"2014","journal-title":"Front Hum Neurosci [Internet]"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrneurol.2013.29","article-title":"Chronic neuropathologies of single and repetitive TBI: substrates of dementia?","volume":"9","author":"Smith","year":"2013","journal-title":"Nature Reviews Neurology"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0011","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/ana.25611","article-title":"Duration of american football play and chronic traumatic encephalopathy","volume":"87","author":"Mez","year":"2020","journal-title":"Ann. Neurol."},{"issue":"18","key":"10.1016\/j.nicl.2020.102212_bib0012","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1056\/NEJMoa1900757","article-title":"Tau positron-emission tomography in former national football league players","volume":"380","author":"Stern","year":"2019","journal-title":"New England journal of medicine"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0013","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-015-1515-z","article-title":"The first ninds\/nibib consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy","volume":"131","author":"McKee","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0014","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.csm.2010.09.007","article-title":"Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma","volume":"30","author":"Gavett","year":"2011","journal-title":"Clin Sports Med"},{"issue":"3","key":"10.1016\/j.nicl.2020.102212_bib0015","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0033291700049588","article-title":"The aftermath of boxing1","volume":"3","author":"Corsellis","year":"1973","journal-title":"Psychol Med"},{"key":"10.1016\/j.nicl.2020.102212_bib0016","unstructured":"Review: contact sport\u2010related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates - Costanza - 2011 - Neuropathology and applied neurobiology -Wiley Online Library [Internet]. [cited 2019 Jan 17]. Available from: 10.1111\/j.1365-2990.2011.01186.x."},{"issue":"440","key":"10.1016\/j.nicl.2020.102212_bib0017","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1192\/bjp.105.440.714","article-title":"Observations on the pathology of insidious dementia following head injury","volume":"105","author":"Corsellis","year":"1959","journal-title":"Journal of Mental Science"},{"issue":"2","key":"10.1016\/j.nicl.2020.102212_bib0018","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s004010051066","article-title":"Neuronal cytoskeletal changes are an early consequence of repetitive head injury","volume":"98","author":"Geddes","year":"1999","journal-title":"Acta Neuropathol"},{"issue":"10, Supplement 2","key":"10.1016\/j.nicl.2020.102212_bib0019","first-page":"S460","article-title":"Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy","volume":"3","author":"Stern","year":"2011","journal-title":"PM&R"},{"issue":"6","key":"10.1016\/j.nicl.2020.102212_bib0020","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1089\/neu.2011.1957","article-title":"Frontal cortex neuropathology in dementia pugilistica","volume":"29","author":"Saing","year":"2011","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0021","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00304630","article-title":"Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and alzheimer's disease cases","volume":"85","author":"Hof","year":"1992","journal-title":"Acta Neuropathol"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0022","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jama.2017.8334","article-title":"Clinicopathological evaluation of chronic traumatic encephalopathy in players of american football","volume":"318","author":"Mez","year":"2017","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.nicl.2020.102212_bib0023","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00401-015-1502-4","article-title":"Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank","volume":"130","author":"Bieniek","year":"2015","journal-title":"Acta Neuropathol"},{"issue":"134","key":"10.1016\/j.nicl.2020.102212_bib0024","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003716","article-title":"Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model","volume":"4","author":"Goldstein","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.nicl.2020.102212_bib0025","unstructured":"Chronic Traumatic Encephalopathy in a National Football League Player | Neurosurgery | Oxford Academic [Internet]. [cited 2019 Jan 17]. Available from: https:\/\/academic.oup.com\/neurosurgery\/article\/57\/1\/128\/2743944."},{"issue":"7752","key":"10.1016\/j.nicl.2020.102212_bib0026","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41586-019-1026-5","article-title":"Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules","volume":"568","author":"Falcon","year":"2019","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.nicl.2020.102212_bib0027","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/ana.24517","article-title":"Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue","volume":"78","author":"Marqui\u00e9","year":"2015","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0028","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13195-017-0325-z","article-title":"Comparative binding properties of the tau pet tracers THK5117, THK5351, PBB3, and T807 in postmortem alzheimer brains","volume":"9","author":"Lemoine","year":"2017","journal-title":"Alzheimer's research & therapy"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0029","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s41181-016-0015-3","article-title":"New protein deposition tracers in the pipeline","volume":"1","author":"Jovalekic","year":"2017","journal-title":"EJNMMI radiopharmacy and chemistry"},{"issue":"6","key":"10.1016\/j.nicl.2020.102212_bib0030","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jalz.2012.11.008","article-title":"[18F]T807, a novel tau positron emission tomography imaging agent for alzheimer's disease","volume":"9","author":"Xia","year":"2013","journal-title":"Alzheimer's & Dementia"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0031","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1212\/WNL.0000000000002892","article-title":"Tau pet in alzheimer disease and mild cognitive impairment","volume":"87","author":"Cho","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102212_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101651","article-title":"Positron emission tomography of tau in iraq and afghanistan veterans with blast neurotrauma","author":"Robinson","year":"2019","journal-title":"NeuroImage: Clinical"},{"key":"10.1016\/j.nicl.2020.102212_bib0033","article-title":"Tau pet and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy","volume":"24","author":"Lesman-Segev","year":"2019","journal-title":"NeuroImage: Clinical"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0034","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s40478-019-0808-1","article-title":"[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series","volume":"7","author":"Marqui\u00e9","year":"2019","journal-title":"acta neuropathol commun."},{"issue":"9","key":"10.1016\/j.nicl.2020.102212_bib0035","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1038\/tp.2014.91","article-title":"Tauopathy pet and amyloid pet in the diagnosis of chronic traumatic encephalopathies: studies of a retired nfl player and of a man with ftd and a severe head injury","volume":"4","author":"Mitsis","year":"2014","journal-title":"Transl Psychiatry"},{"issue":"9","key":"10.1016\/j.nicl.2020.102212_bib0036","doi-asserted-by":"crossref","first-page":"e900","DOI":"10.1038\/tp.2016.175","article-title":"Cerebral [18 F]T807\/AV1451 retention pattern in clinically probable cte resembles pathognomonic distribution of cte tauopathy","volume":"6","author":"Dickstein","year":"2016","journal-title":"Transl Psychiatry"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0037","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2967\/jnumed.117.195248","article-title":"Off-Target 18F-AV-1451 binding in the basal ganglia correlates with age-related iron accumulation","volume":"59","author":"Choi","year":"2018","journal-title":"J Nucl Med"},{"issue":"27","key":"10.1016\/j.nicl.2020.102212_bib0038","doi-asserted-by":"crossref","first-page":"44994","DOI":"10.18632\/oncotarget.16690","article-title":"Meta-analysis of the association between variants in mapt and neurodegenerative diseases","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"issue":"5123","key":"10.1016\/j.nicl.2020.102212_bib0039","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein e type 4 allele and the risk of alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.nicl.2020.102212_bib0040","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.2147\/NDT.S84266","article-title":"Role of apolipoprotein e in neurodegenerative diseases","volume":"11","author":"Giau","year":"2015","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"7","key":"10.1016\/j.nicl.2020.102212_bib0041","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00109-016-1427-y","article-title":"from cardiovascular disease to neurodegenerative disorders","volume":"94","author":"Mahley","year":"2016","journal-title":"J Mol Med"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0042","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and a\u03b2 in alzheimer\u2019s disease: accidental encounters or partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0043","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.molmed.2007.02.004","article-title":"A\u03b2, tau and apoe4 in alzheimer\u2019s disease: the axonal connection","volume":"13","author":"Adalbert","year":"2007","journal-title":"Trends Mol Med"},{"issue":"23","key":"10.1016\/j.nicl.2020.102212_bib0044","doi-asserted-by":"crossref","first-page":"11183","DOI":"10.1073\/pnas.91.23.11183","article-title":"Isoform-specific interactions of apolipoprotein e with microtubule-associated protein tau: implications for alzheimer disease","volume":"91","author":"Strittmatter","year":"1994","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7673","key":"10.1016\/j.nicl.2020.102212_bib0045","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nicl.2020.102212_bib0046","doi-asserted-by":"crossref","DOI":"10.1093\/arclin\/acy082","article-title":"APOE-\u03b54 genotype is associated with elevated post-concussion symptoms in military veterans with a remote history of mild traumatic brain injury","author":"Merritt","year":"2019","journal-title":"Arch Clin Neuropsychol [Internet]"},{"key":"10.1016\/j.nicl.2020.102212_bib0047","article-title":"ApoE4-associated phospholipid dysregulation contributes to development of tau hyper-phosphorylation after traumatic brain injury","volume":"7","author":"Cao","year":"2017","journal-title":"Sci Rep [Internet]"},{"issue":"suppl_2","key":"10.1016\/j.nicl.2020.102212_bib0048","doi-asserted-by":"crossref","first-page":"R188","DOI":"10.1093\/hmg\/ddl190","article-title":"Untangling the tau gene association with neurodegenerative disorders","volume":"15","author":"Pittman","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"7","key":"10.1016\/j.nicl.2020.102212_bib0049","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1007\/s12035-015-9415-8","article-title":"The role of mapt in neurodegenerative diseases: genetics","volume":"53","author":"Zhang","year":"2016","journal-title":"Mechanisms and Therapy. Mol Neurobiol"},{"issue":"12","key":"10.1016\/j.nicl.2020.102212_bib0050","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/WNL.56.12.1702","article-title":"Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype","volume":"56","author":"Houlden","year":"2001","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.nicl.2020.102212_bib0051","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ana.20178","article-title":"Novel haplotypes in 17q21 are associated with progressive supranuclear palsy","volume":"56","author":"Pastor","year":"2004","journal-title":"Ann. Neurol."},{"issue":"12","key":"10.1016\/j.nicl.2020.102212_bib0052","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/hmg\/ddh138","article-title":"The structure of the tau haplotype in controls and in progressive supranuclear palsy","volume":"13","author":"Pittman","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0053","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/hmg\/8.4.711","article-title":"Association of an extended haplotype in the tau gene with progressive supranuclear palsy","volume":"8","author":"Baker","year":"1999","journal-title":"Hum Mol Genet"},{"issue":"11","key":"10.1016\/j.nicl.2020.102212_bib0054","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/bjsports-2017-097699","article-title":"Consensus statement on concussion in sport\u2014the 5th international conference on concussion in sport held in berlin","volume":"51","author":"McCrory","year":"2016","journal-title":"Br J Sports Med"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0055","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","article-title":"The alzheimer's disease neuroimaging initiative (ADNI): mri methods","volume":"27","author":"Jack Jr","year":"2008","journal-title":"Journal of Magnetic Resonance Imaging: An Official Journal of the International Society for Magnetic Resonance in Medicine"},{"issue":"9","key":"10.1016\/j.nicl.2020.102212_bib0056","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1001\/archneur.60.9.1202","article-title":"Biochemical diagnosis of alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to \u03b2-amyloid peptide42","volume":"60","author":"Maddalena","year":"2003","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0057","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jalz.2014.02.004","article-title":"Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early alzheimer's disease","volume":"11","author":"Blennow","year":"2015","journal-title":"Alzheimer's & Dementia"},{"issue":"8","key":"10.1016\/j.nicl.2020.102212_bib0058","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein e allele \u03f54 with late\u2010onset familial and sporadic alzheimer\u2019s disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0059","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pscychresns.2006.01.011","article-title":"An automated method for the extraction of regional data from pet images","volume":"147","author":"Rusjan","year":"2006","journal-title":"Psychiatry Research: Neuroimaging"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0060","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/jcbfm.1992.81","article-title":"Measurement of radiotracer concentration in brain gray matter using positron emission tomography: mRI-based correction for partial volume effects","volume":"12","author":"M\u00fcller-G\u00e4rtner","year":"1992","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"2","key":"10.1016\/j.nicl.2020.102212_bib0061","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1207\/S15324826AN0902_5","article-title":"The trail making test, part B: cognitive flexibility or ability to maintain set?","volume":"9","author":"Kortte","year":"2002","journal-title":"Appl Neuropsychol"},{"key":"10.1016\/j.nicl.2020.102212_bib0062","series-title":"A Compendium of Neuropsychological tests: Administration, norms, and Commentary","author":"Strauss","year":"2006"},{"key":"10.1016\/j.nicl.2020.102212_bib0063","series-title":"Rey Auditory Verbal Learning test: A handbook","author":"Schmidt","year":"1996"},{"key":"10.1016\/j.nicl.2020.102212_bib0064","series-title":"Symbol Digit Modalities Test","author":"Smith","year":"1982"},{"key":"10.1016\/j.nicl.2020.102212_bib0065","series-title":"Neuropsychological Assessment","author":"Lezak","year":"2004"},{"key":"10.1016\/j.nicl.2020.102212_bib0066","article-title":"WMS-III: wechsler memory scale administration and scoring manual","author":"Wechsler","year":"1997","journal-title":"Psychological Corporation"},{"key":"10.1016\/j.nicl.2020.102212_bib0067","series-title":"Personality Assessment Inventory","author":"Morey","year":"1991"},{"key":"10.1016\/j.nicl.2020.102212_bib0068","series-title":"WAIS-III, Wechsler adult Intelligence scale: Administration and Scoring Manual","author":"Wechsler","year":"1997"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0069","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/13854049008401496","article-title":"Performance measures of 16\u2013to 86-year-old males and females on the auditory verbal learning test","volume":"4","author":"Geffen","year":"1990","journal-title":"Clinical Neuropsychologist"},{"key":"10.1016\/j.nicl.2020.102212_bib0070","series-title":"Comprehensive Norms For an Expanded Halstead-Reitan battery: A supplement For the Wechsler Adult Intelligence Scale-Revised","author":"Heaton","year":"1992"},{"issue":"3","key":"10.1016\/j.nicl.2020.102212_bib0071","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0304-3940(95)11649-H","article-title":"ApoE3 binding to tau tandem repeat i is abolished by tau serine262 phosphorylation","volume":"192","author":"Huang","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nicl.2020.102212_bib0072","unstructured":"Paglini G., Peris L., Mascotti F., Quiroga S., Caceres A. Tau protein function in axonal formation.:7."},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0073","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/JSM.0b013e31815c1d4c","article-title":"Apoe, apoe promoter, and tau genotypes and risk for concussion in college athletes","volume":"18","author":"Terrell","year":"2008","journal-title":"Clinical Journal of Sport Medicine"},{"issue":"6","key":"10.1016\/j.nicl.2020.102212_bib0074","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/JSM.0b013e3181fc0a81","article-title":"Apolipoprotein e genotype and concussion in college athletes","volume":"20","author":"Tierney","year":"2010","journal-title":"Clinical Journal of Sport Medicine"},{"issue":"17","key":"10.1016\/j.nicl.2020.102212_bib0075","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1073\/pnas.90.17.8098","article-title":"Binding of human apolipoprotein e to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.nicl.2020.102212_bib0076","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrn2967","article-title":"Amyloid-\u03b2 and tau \u2014 a toxic pas de deux in alzheimer's disease","volume":"12","author":"Ittner","year":"2011","journal-title":"Nature Reviews Neuroscience"},{"issue":"6","key":"10.1016\/j.nicl.2020.102212_bib0077","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1474-4422(13)70090-5","article-title":"Tau pathology and neurodegeneration","volume":"12","author":"Spillantini","year":"2013","journal-title":"The Lancet Neurology"},{"issue":"3","key":"10.1016\/j.nicl.2020.102212_bib0078","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1474-4422(09)70042-0","article-title":"Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges","volume":"8","author":"Williams","year":"2009","journal-title":"The Lancet Neurology"},{"issue":"2","key":"10.1016\/j.nicl.2020.102212_bib0079","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbadis.2004.09.008","article-title":"Tau pathology in alzheimer disease and other tauopathies","volume":"1739","author":"Iqbal","year":"2005","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"issue":"50","key":"10.1016\/j.nicl.2020.102212_bib0080","doi-asserted-by":"crossref","first-page":"E8187","DOI":"10.1073\/pnas.1616344113","article-title":"Tau prions from alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells","volume":"113","author":"Woerman","year":"2016","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0081","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/JSM.0b013e31817e6f3e","article-title":"Does the apolipoprotein \u03b54 allele predispose varsity athletes to concussion?","volume":"18","author":"Kristman","year":"2008","journal-title":"A prospective cohort study. Clinical Journal of Sport Medicine"},{"issue":"7","key":"10.1016\/j.nicl.2020.102212_bib0082","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1212\/WNL.58.7.1115","article-title":"APOE genotype influences acquisition and recall following traumatic brain injury","volume":"58","author":"Crawford","year":"2002","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0083","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1089\/neu.2007.0489","article-title":"Meta-Analysis of apoe 4 allele and outcome after traumatic brain injury","volume":"25","author":"Zhou","year":"2008","journal-title":"J. Neurotrauma"},{"issue":"12","key":"10.1016\/j.nicl.2020.102212_bib0084","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1093\/brain\/awh296","article-title":"Six-month recovery from mild to moderate traumatic brain injury: the role of APOE-\u03b54 allele","volume":"127","author":"Chamelian","year":"2004","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.nicl.2020.102212_bib0085","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/jama.1997.03550020068040","article-title":"Apolipoprotein e \u22084 associated with chronic traumatic brain injury in boxing","volume":"278","author":"Jordan","year":"1997","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.nicl.2020.102212_bib0086","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1399-0004.1986.tb01901.x","article-title":"A racial difference in apolipoprotein e allele frequencies between the japanese and caucasian populations","volume":"30","author":"Eto","year":"1986","journal-title":"Clin. Genet."},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0087","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.cccn.2003.11.001","article-title":"Apolipoprotein e genotyping in the malay, chinese and indian ethnic groups in malaysia\u2014a study on the distribution of the different apoE alleles and genotypes","volume":"340","author":"Seet","year":"2004","journal-title":"Clinica Chimica Acta"},{"issue":"10","key":"10.1016\/j.nicl.2020.102212_bib0088","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/jama.279.10.751","article-title":"The APOE-\u220a4 allele and the risk of alzheimer disease among african americans, whites, and hispanics","volume":"279","author":"Tang","year":"1998","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.nicl.2020.102212_bib0089","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/jgs.15727","article-title":"Apolipoprotein e genotypes, age, race, and cognitive decline in a population sample","volume":"67","author":"Rajan","year":"2019","journal-title":"J Am Geriatr Soc"},{"issue":"12","key":"10.1016\/j.nicl.2020.102212_bib0090","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.jalz.2019.07.016","article-title":"Local ancestry at apoe modifies alzheimer's disease risk in caribbean hispanics","volume":"15","author":"Blue","year":"2019","journal-title":"Alzheimer's & Dementia"},{"issue":"12","key":"10.1016\/j.nicl.2020.102212_bib0091","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007791","article-title":"Ancestral origin of apoe \u03b54 alzheimer disease risk in puerto rican and african american populations","volume":"14","author":"Rajabli","year":"2018","journal-title":"PLoS Genet."},{"issue":"7","key":"10.1016\/j.nicl.2020.102212_bib0092","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180356","article-title":"APOE \u03b54-TOMM40 \u2018523 haplotypes and the risk of alzheimer\u2019s disease in older caucasian and african americans","volume":"12","author":"Yu","year":"2017","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.nicl.2020.102212_bib0093","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-190538","article-title":"Race, apoe \u03b54, and long-term cognitive trajectories in a biracial population sample","volume":"72","author":"Rajan","year":"2019","journal-title":"Journal of Alzheimer's disease: JAD"},{"issue":"3","key":"10.1016\/j.nicl.2020.102212_bib0094","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2004.05.119","article-title":"The tau H2 haplotype is almost exclusively caucasian in origin","volume":"369","author":"Evans","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nicl.2020.102212_bib0095","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.nicl.2018.05.014","article-title":"The relationship between brain atrophy and cognitive-behavioural symptoms in retired canadian football players with multiple concussions","volume":"19","author":"Misquitta","year":"2018","journal-title":"NeuroImage: Clinical"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158220300498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158220300498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:27:07Z","timestamp":1761971227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158220300498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":95,"alternative-id":["S2213158220300498"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2020.102212","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction of APOE4 alleles and PET tau imaging in former contact sport athletes","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2020.102212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102212"}}