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Neurosci."},{"key":"10.1016\/j.nicl.2020.102300_b0440","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroimage.2013.02.017","article-title":"The role of the thalamic nuclei in recognition memory accompanied by recall during encoding and retrieval: an fMRI study","volume":"74","author":"Pergola","year":"2013","journal-title":"Neuroimage"},{"issue":"11","key":"10.1016\/j.nicl.2020.102300_b0445","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.tics.2018.08.006","article-title":"The regulatory role of the human mediodorsal thalamus","volume":"22","author":"Pergola","year":"2018","journal-title":"Trends Cogn. 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