{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:26:38Z","timestamp":1781519198592,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":159,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007416","name":"Swedish Brain Power","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007435","name":"\u00c3\u0085ke Wiberg Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004200","name":"Stiftelsen Olle Engkvist Byggm\u00c3\u00a4stare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00c3\u00a5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00c3\u00a5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Stiftelsen f\u00c3\u00b6r\u00c2\u00a0Strategisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00c3\u00a4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.nicl.2020.102310","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T21:41:48Z","timestamp":1591738908000},"page":"102310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Medial temporal atrophy in preclinical dementia: Visual and automated assessment during six year follow-up"],"prefix":"10.1016","volume":"27","author":[{"given":"Gustav","family":"M\u00e5rtensson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"H\u00e5kansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana B.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Palmqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"van Westen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Westman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.nicl.2020.102310_b0005","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1258\/ar.2012.110664","article-title":"Comparison between visual assessment of MTA and hippocampal volumes in an elderly, non-demented population","volume":"53","author":"Cavallin","year":"2012","journal-title":"Acta Radiol."},{"issue":"3","key":"10.1016\/j.nicl.2020.102310_b0010","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1258\/ar.2012.110552","article-title":"Overtime reliability of medial temporal lobe atrophy rating in a clinical setting","volume":"53","author":"Cavallin","year":"2012","journal-title":"Acta Radiol."},{"issue":"2","key":"10.1016\/j.nicl.2020.102310_b0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis: I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.nicl.2020.102310_b0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/joim.12358","article-title":"Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer\u2019s disease and mild cognitive impairment","volume":"278","author":"Ferreira","year":"2015","journal-title":"J. Intern. Med."},{"issue":"April","key":"10.1016\/j.nicl.2020.102310_b0025","first-page":"1","article-title":"Distinct subtypes of Alzheimer\u2019s disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications","volume":"7","author":"Ferreira","year":"2017","journal-title":"Sci. Rep."},{"issue":"suppl. 1","key":"10.1016\/j.nicl.2020.102310_b0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuroimage.2004.07.016","article-title":"Sequence-independent segmentation of magnetic resonance images","volume":"23","author":"Fischl","year":"2004","journal-title":"NeuroImage"},{"issue":"6","key":"10.1016\/j.nicl.2020.102310_b0035","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/brain\/119.6.2001","article-title":"Presymptomatic hippocampal atrophy in Alzheimer\u2019s disease. A longitudinal MRI study","volume":"119","author":"Fox","year":"1996","journal-title":"Brain J. Neurol."},{"issue":"3","key":"10.1016\/j.nicl.2020.102310_b0040","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1007\/s00330-018-5710-x","article-title":"Repeatability and reproducibility of FreeSurfer, FSL-SIENAX and SPM brain volumetric measurements and the effect of lesion filling in multiple sclerosis","volume":"29","author":"Guo","year":"2019","journal-title":"Eur. Radiol."},{"issue":"4","key":"10.1016\/j.nicl.2020.102310_b0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00234-019-02156-6","article-title":"Structural imaging findings on non-enhanced computed tomography are severely underreported in the primary care diagnostic work-up of subjective cognitive decline","volume":"61","author":"H\u00e5kansson","year":"2019","journal-title":"Neuroradiology"},{"issue":"11","key":"10.1016\/j.nicl.2020.102310_b0050","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1212\/01.wnl.0000344568.09360.31","article-title":"Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures","volume":"72","author":"Henneman","year":"2009","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.nicl.2020.102310_b0055","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1212\/WNL.0b013e3181b879ac","article-title":"Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease","volume":"73","author":"Henneman","year":"2009","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.nicl.2020.102310_b0060","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/acn3.274","article-title":"CSF A\u03b242\/A\u03b240 and A\u03b242\/A\u03b238 ratios: Better diagnostic markers of Alzheimer disease","volume":"3","author":"Janelidze","year":"2016","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"2","key":"10.1016\/j.nicl.2020.102310_b0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1361-8415(01)00036-6","article-title":"A global optimisation method for robust affine registration of brain images","volume":"5","author":"Jenkinson","year":"2001","journal-title":"Med. Image Anal."},{"issue":"2","key":"10.1016\/j.nicl.2020.102310_b0070","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"NeuroImage"},{"issue":"12","key":"10.1016\/j.nicl.2020.102310_b0075","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1007\/s00330-011-2205-4","article-title":"Visual assessment of posterior atrophy development of a MRI rating scale","volume":"21","author":"Koedam","year":"2011","journal-title":"Eur. Radiol."},{"issue":"7","key":"10.1016\/j.nicl.2020.102310_b0080","first-page":"P1108","article-title":"Automatically computed rating scales from MRI for patients with cognitive disorders","volume":"13","author":"Koikkalainen","year":"2019","journal-title":"Eur. Radiol."},{"issue":"1","key":"10.1016\/j.nicl.2020.102310_b0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"issue":"sep","key":"10.1016\/j.nicl.2020.102310_b0090","first-page":"1","article-title":"Atrophy of the posterior subiculum is associated with memory impairment Tau- and A\u03b2 pathology in non-demented individuals","volume":"9","author":"Lindberg","year":"2017","journal-title":"Front. Aging Neurosci."},{"issue":"March","key":"10.1016\/j.nicl.2020.102310_b0095","doi-asserted-by":"crossref","first-page":"101872","DOI":"10.1016\/j.nicl.2019.101872","article-title":"AVRA: automatic visual ratings of atrophy from MRI images using recurrent convolutional neural networks","volume":"23","author":"M\u00e5rtensson","year":"2019","journal-title":"NeuroImage: Clinical"},{"key":"10.1016\/j.nicl.2020.102310_b0100","doi-asserted-by":"crossref","unstructured":"M\u00e5rtensson, G., Ferreira, D., Granberg, T., Cavallin, L., Oppedal, K., Padovani, A., Rektorova, I., Bonanni, L., Pardini, M., Kramberger, M., Taylor, J.-P., Hort, J., Sn\u00e6dal, J., Kulisevsky, J., Blanc, F., Antonini, A., Mecocci, P., Vellas, B., Tsolaki, M., K\u0142oszewska, I., Soininen, H., Lovestone, S., Simmons, A., Aarsland, D., Westman, E., 2019. The reliability of a deep learning model in clinical out-of-distribution MRI data: a multicohort study. arXiv preprint, pp. 1\u201318.http:\/\/arxiv.org\/abs\/1911.00515.","DOI":"10.1016\/j.media.2020.101714"},{"issue":"5","key":"10.1016\/j.nicl.2020.102310_b0105","doi-asserted-by":"crossref","first-page":"e388","DOI":"10.1212\/WNL.0000000000004887","article-title":"Comparing 18 F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease","volume":"90","author":"Mattsson","year":"2018","journal-title":"Neurology"},{"issue":"January","key":"10.1016\/j.nicl.2020.102310_b0110","first-page":"49","article-title":"TheHiveDB image data management and analysis framework","volume":"7","author":"Muehlboeck","year":"2014","journal-title":"Front. Neuroinf."},{"issue":"3","key":"10.1016\/j.nicl.2020.102310_b0115","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild cognitive impairment as a diagnostic entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J. Intern. Med."},{"issue":"August","key":"10.1016\/j.nicl.2020.102310_b0120","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.nicl.2017.08.022","article-title":"Progressive medial temporal lobe atrophy during preclinical Alzheimer\u2019s disease","volume":"16","author":"Pettigrew","year":"2017","journal-title":"NeuroImage: Clinical"},{"issue":"4","key":"10.1016\/j.nicl.2020.102310_b0125","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"Reuter","year":"2012","journal-title":"NeuroImage"},{"issue":"10","key":"10.1016\/j.nicl.2020.102310_b0130","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1474-4422(06)70550-6","article-title":"Tracking atrophy progression in familial Alzheimer\u2019s disease: a serial MRI study","volume":"5","author":"Ridha","year":"2006","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.nicl.2020.102310_b0135","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1148\/radiol.2293021299","article-title":"Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging","volume":"229","author":"Rusinek","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2020.102310_b0140","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/jnnp.55.10.967","article-title":"Atrophy of medial temporal lobes on MRI in probable Alzheimer\u2019s disease and normal ageing: diagnostic value and neuropsychological correlates","volume":"55","author":"Scheltens","year":"1992","journal-title":"J. Neurol. Neurosurgery Psychiatry"},{"issue":"9","key":"10.1016\/j.nicl.2020.102310_b0145","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00868807","article-title":"Visual assessment of medial temporal lobe atrophy on magnetic resonance imaging: Interobserver reliability","volume":"242","author":"Scheltens","year":"1995","journal-title":"J. Neurol."},{"issue":"1","key":"10.1016\/j.nicl.2020.102310_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12877-015-0066-4","article-title":"Medial temporal lobe atrophy is underreported and may have important clinical correlates in medical inpatients","volume":"15","author":"Torisson","year":"2015","journal-title":"BMC Geriatrics"},{"key":"10.1016\/j.nicl.2020.102310_b0155","first-page":"1","article-title":"Medial temporal lobe atrophy ratings in a large 75-year-old population-based cohort: gender-corrected and education-corrected normative data","author":"Velickaite","year":"2017","journal-title":"Eur. Radiol."},{"issue":"6","key":"10.1016\/j.nicl.2020.102310_b0160","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00234-019-02188-y","article-title":"Dementia imaging in clinical practice: a European-wide survey of 193 centres and conclusions by the ESNR working group","volume":"61","author":"Vernooij","year":"2019","journal-title":"Neuroradiology"},{"issue":"3","key":"10.1016\/j.nicl.2020.102310_b0165","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0925-4927(99)00016-5","article-title":"Visual assessment of medial temporal lobe atrophy in demented and healthy control subjects: correlation with volumetry","volume":"90","author":"Wahlund","year":"1999","journal-title":"Psychiatry Res.: Neuroimaging"},{"issue":"1","key":"10.1016\/j.nicl.2020.102310_b0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s13244-016-0521-6","article-title":"Imaging biomarkers of dementia: recommended visual rating scales with teaching cases","volume":"8","author":"Wahlund","year":"2017","journal-title":"Insights Imaging"},{"issue":"1","key":"10.1016\/j.nicl.2020.102310_b0175","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1148\/radiol.2531082262","article-title":"Diagnostic imaging of patients in a memory clinic: comparison of MR imaging and 64-detector row CT","volume":"253","author":"Wattjes","year":"2009","journal-title":"Radiology"},{"issue":"7","key":"10.1016\/j.nicl.2020.102310_b0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022506","article-title":"Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer\u2019s disease","volume":"6","author":"Westman","year":"2011","journal-title":"PLoS ONE"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158220301479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158220301479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:30:04Z","timestamp":1761971404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158220301479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":36,"alternative-id":["S2213158220301479"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2020.102310","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.05.979229","asserted-by":"object"}]},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Medial temporal atrophy in preclinical dementia: Visual and automated assessment during six year follow-up","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2020.102310","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102310"}}