{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:29:42Z","timestamp":1786994982427,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":247,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.nicl.2020.102416","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T03:13:36Z","timestamp":1599621216000},"page":"102416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Reproducible metabolic topographies associated with multiple system atrophy: Network and regional analyses in Chinese and American patient cohorts"],"prefix":"10.1016","volume":"28","author":[{"given":"Bo","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengtao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuantao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eidelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2020.102416_b0005","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S1474-4422(17)30157-6","article-title":"Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches","volume":"16","author":"Boxer","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2020.102416_b0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12311-016-0763-3","article-title":"Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex","volume":"16","author":"Caligiore","year":"2017","journal-title":"Cerebellum"},{"key":"10.1016\/j.nicl.2020.102416_b0015","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1038\/nn.3868","article-title":"Short latency cerebellar modulation of the basal ganglia","volume":"17","author":"Chen","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nicl.2020.102416_b0020","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1093\/brain\/awr177","article-title":"The role of dopaminergic imaging in patients with symptoms of dopaminergic system neurodegeneration","volume":"134","author":"Cummings","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2020.102416_b0025","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.neuroimage.2005.03.012","article-title":"FDG PET in the differential diagnosis of parkinsonian disorders","volume":"26","author":"Eckert","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2020.102416_b0030","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/mds.21933","article-title":"Abnormal metabolic networks in atypical parkinsonism","volume":"23","author":"Eckert","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2020.102416_b0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.parkreldis.2015.11.005","article-title":"Genome-wide estimate of the heritability of Multiple System Atrophy","volume":"22","author":"Federoff","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nicl.2020.102416_b0040","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1002\/hbm.24044","article-title":"Reproducible network and regional topographies of abnormal glucose metabolism associated with progressive supranuclear palsy: Multivariate and univariate analyses in American and Chinese patient cohorts","volume":"39","author":"Ge","year":"2018","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2020.102416_b0045","doi-asserted-by":"crossref","unstructured":"Gilman, S., Wenning, G.K., Low, P. a, Brooks, D.J., Mathias, C.J., Trojanowski, J.Q., Wood, N.W., Colosimo, C., D\u00fcrr, A., Fowler, C.J., Kaufmann, H., Klockgether, T., Lees, A.J., Poewe, W.H., Quinn, N.P., Revesz, T., Robertson, D., Sandroni, P., Seppi, K., Vidailhet, M., 2008. Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71, 670\u20136.","DOI":"10.1212\/01.wnl.0000324625.00404.15"},{"key":"10.1016\/j.nicl.2020.102416_b0050","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.neuroimage.2008.01.056","article-title":"Multivariate and univariate neuroimaging biomarkers of Alzheimer\u2019s disease","volume":"40","author":"Habeck","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2020.102416_b0055","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/brain\/awf080","article-title":"The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service","volume":"125","author":"Hughes","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2020.102416_b0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2020.102416_b0065","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1097\/RLU.0000000000001474","article-title":"Additional Value of Early-Phase 18F-FP-CIT PET Image for Differential Diagnosis of Atypical Parkinsonism","volume":"42","author":"Jin","year":"2017","journal-title":"Clin. Nucl. Med."},{"key":"10.1016\/j.nicl.2020.102416_b0070","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.2967\/jnumed.119.227140","article-title":"Presynaptic striatal dopaminergic function in atypical parkinsonisms: A meta-analysis of imaging studies","volume":"60","author":"Kaasinen","year":"2019","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2020.102416_b0075","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1177\/0271678X16637880","article-title":"Metabolic network expression in parkinsonism: Clinical and dopaminergic correlations","volume":"37","author":"Ko","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nicl.2020.102416_b0080","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/mds.25975","article-title":"Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts","volume":"29","author":"Kraemmer","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2020.102416_b0085","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S1474-4422(15)00058-7","article-title":"Natural history of multiple system atrophy in the USA: A prospective cohort study","volume":"14","author":"Low","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2020.102416_b0090","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/brain\/awm328","article-title":"Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy","volume":"131","author":"Lyoo","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2020.102416_b0095","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/sj.jcbfm.9600358","article-title":"Abnormal metabolic network activity in Parkinson\u2019s disease: test-retest reproducibility","volume":"27","author":"Ma","year":"2007","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.nicl.2020.102416_b0100","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.nicl.2018.08.006","article-title":"FDG PET Parkinson's disease-related pattern as a biomarker for clinical trials in early stage disease","volume":"20","author":"Matthews","year":"2018","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.nicl.2020.102416_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101858","article-title":"A totally data-driven whole-brain multimodal pipeline for the discrimination of Parkinson's disease, multiple system atrophy and healthy control","volume":"23","author":"Nemmi","year":"2019","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.nicl.2020.102416_b0110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2147\/NDT.S146080","article-title":"Diagnostic challenges in multiple system atrophy","volume":"14","author":"Obelieniene","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.nicl.2020.102416_b0115","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2967\/jnumed.111.095224","article-title":"Subregional Patterns of Preferential Striatal Dopamine Transporter Loss Differ in Parkinson Disease, Progressive Supranuclear Palsy, and Multiple-System Atrophy","volume":"53","author":"Oh","year":"2012","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2020.102416_b0120","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1002\/hbm.22295","article-title":"Characterization of disease-related covariance topographies with SSMPCA toolbox: effects of spatial normalization and PET scanners","volume":"35","author":"Peng","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.nicl.2020.102416_b0125","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1212\/WNL.0b013e318250d7fd","article-title":"Network correlates of disease severity in multiple system atrophy","volume":"78","author":"Poston","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102416_b0130","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/mds.25327","article-title":"Accuracy of the national institute for neurological disorders and stroke\/society for progressive supranuclear palsy and neuroprotection and natural history in Parkinson plus syndromes criteria for the diagnosis of progressive supranuclear palsy","volume":"28","author":"Respondek","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2020.102416_b0135","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1212\/WNL.0000000000002350","article-title":"Accuracy of clinical diagnosis of Parkinson disease","volume":"86","author":"Rizzo","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102416_b0140","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1474-4422(18)30169-8","article-title":"Network imaging biomarkers: insights and clinical applications in Parkinson\u2019s disease","volume":"17","author":"Schindlbeck","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2020.102416_b0145","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.neuroimage.2008.12.063","article-title":"Differential diagnosis of parkinsonian syndromes using PCA-based functional imaging features","volume":"45","author":"Spetsieris","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2020.102416_b0150","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/WCO.0000000000000355","article-title":"Atypical parkinsonism - New advances","volume":"29","author":"Stamelou","year":"2016","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.nicl.2020.102416_b0155","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0140-6736(14)60041-6","article-title":"Imaging insights into basal ganglia function, Parkinson\u2019s disease, and dystonia","volume":"384","author":"Stoessl","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.nicl.2020.102416_b0160","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2967\/jnumed.110.086959","article-title":"Diagnostic accuracy of combined FP-CIT, IBZM, and MIBG scintigraphy in the differential diagnosis of degenerative parkinsonism: A multidimensional statistical approach","volume":"52","author":"S\u00fcdmeyer","year":"2011","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2020.102416_b0165","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1474-4422(10)70002-8","article-title":"Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis","volume":"9","author":"Tang","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2020.102416_b0170","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.2967\/jnumed.112.105379","article-title":"Nigrostriatal Dopamine Terminal Imaging with Dopamine Transporter SPECT: An Update","volume":"54","author":"Tatsch","year":"2013","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2020.102416_b0175","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1002\/mds.23291","article-title":"Typical cerebral metabolic patterns in neurodegenerative brain diseases","volume":"25","author":"Teune","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2020.102416_b0180","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/mds.25361","article-title":"Validation of parkinsonian disease-related metabolic brain patterns","volume":"28","author":"Teune","year":"2013","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2020.102416_b0185","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/brain\/awp282","article-title":"Brain \u03b1-synuclein accumulation in multiple system atrophy, Parkinson\u2019s disease and progressive supranuclear palsy: A comparative investigation","volume":"133","author":"Tong","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2020.102416_b0190","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2967\/jnumed.115.161992","article-title":"Automated Differential Diagnosis of Early Parkinsonism Using Metabolic Brain Networks: A Validation Study","volume":"57","author":"Tripathi","year":"2016","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2020.102416_b0195","first-page":"933","article-title":"Statistical parametric mapping of 99mTc-ECD SPECT in idiopathic Parkinson\u2019s disease and multiple system atrophy with predominant parkinsonian features: Correlation with clinical parameters","volume":"45","author":"Van Laere","year":"2004","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2020.102416_b0200","doi-asserted-by":"crossref","first-page":"588","DOI":"10.2967\/jnumed.109.070144","article-title":"Combined Striatal Binding and Cerebral Influx Analysis of Dynamic 11C-Raclopride PET Improves Early Differentiation Between Multiple-System Atrophy and Parkinson Disease","volume":"51","author":"Van Laere","year":"2010","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2020.102416_b0205","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.parkreldis.2013.02.013","article-title":"Metabolic brain network in the Chinese patients with Parkinson\u2019s disease based on18F-FDG PET imaging","volume":"19","author":"Wu","year":"2013","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.nicl.2020.102416_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101891","article-title":"Cerebellar atrophy and its contribution to motor and cognitive performance in multiple system atrophy","volume":"23","author":"Yang","year":"2019","journal-title":"Neuroimage Clin."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158220302539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158220302539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:41:08Z","timestamp":1761972068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158220302539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":42,"alternative-id":["S2213158220302539"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2020.102416","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reproducible metabolic topographies associated with multiple system atrophy: Network and regional analyses in Chinese and American patient cohorts","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2020.102416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102416"}}