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Med. 5, 189ra77\u2013189ra77. https:\/\/doi.org\/10.1126\/scitranslmed.3005615.","DOI":"10.1126\/scitranslmed.3005615"},{"key":"10.1016\/j.nicl.2020.102491_b0250","series-title":"R: A Language and Environment for Statistical Computing [WWW Document]","author":"R Core Team","year":"2019"},{"key":"10.1016\/j.nicl.2020.102491_b0255","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1474-4422(06)70550-6","article-title":"Tracking atrophy progression in familial Alzheimer\u2019s disease: a serial MRI study","volume":"5","author":"Ridha","year":"2006","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.nicl.2020.102491_b0260","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/jnen\/nlv028","article-title":"Neuropathology of autosomal dominant Alzheimer disease in the national Alzheimer coordinating center database","volume":"75","author":"Ringman","year":"2016","journal-title":"J. Neuropathol. Exp. 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PLoS One 8, e73377. https:\/\/doi.org\/10.1371\/journal.pone.0073377.","DOI":"10.1371\/journal.pone.0073377"},{"key":"10.1016\/j.nicl.2020.102491_b0310","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.nicl.2018.04.022","article-title":"Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies","volume":"19","author":"Su","year":"2018","journal-title":"NeuroImage: Clin."},{"issue":"1","key":"10.1016\/j.nicl.2020.102491_b0315","first-page":"180","article-title":"Comparison of Pittsburgh compound B and florbetapir in cross\u2010sectional and longitudinal studies","volume":"11","author":"Su","year":"2019","journal-title":"Alzheimer\u2019s Dement. Diagnosis, Assess. Dis. 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