{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:35:07Z","timestamp":1789799707497,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016839","name":"Center for Behavioral Brain Sciences","doi-asserted-by":"publisher","award":["ZS\/2016\/04\/78113"],"award-info":[{"award-number":["ZS\/2016\/04\/78113"]}],"id":[{"id":"10.13039\/100016839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005224","name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.nicl.2020.102545","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T05:22:43Z","timestamp":1608873763000},"page":"102545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Longitudinal clinical and neuroanatomical correlates of memory impairment in motor neuron disease"],"prefix":"10.1016","volume":"29","author":[{"given":"Judith","family":"Machts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Keute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joern","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Petri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Prudlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Vielhaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea Ariel","family":"Schoenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.nicl.2020.102545_b0005","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1016\/j.neurobiolaging.2014.05.035","article-title":"Hippocampal degeneration in patients with amyotrophic lateral sclerosis","volume":"35","author":"Abdulla","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.nicl.2020.102545_b0010","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0028-3932(99)00146-3","article-title":"Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS)","volume":"38","author":"Abrahams","year":"2000","journal-title":"Neuropsychologia"},{"issue":"8","key":"10.1016\/j.nicl.2020.102545_b0015","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.tics.2013.06.009","article-title":"The role of the parahippocampal cortex in cognition","volume":"17","author":"Aminoff","year":"2013","journal-title":"Trends in Cognitive Sciences"},{"issue":"3-4","key":"10.1016\/j.nicl.2020.102545_b0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/21678421.2014.897357","article-title":"Estimating clinical stage of amyotrophic lateral sclerosis from the ALS Functional Rating Scale","volume":"15","author":"Balendra","year":"2014","journal-title":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"},{"issue":"7","key":"10.1016\/j.nicl.2020.102545_b0025","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1136\/jnnp-2020-322992","article-title":"Progression of cognitive and behavioural impairment in early amyotrophic lateral sclerosis","volume":"91","author":"Beeldman","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"10.1016\/j.nicl.2020.102545_b0030","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/jnnp-2015-310734","article-title":"The cognitive profile of ALS: a systematic review and meta-analysis update","volume":"87","author":"Beeldman","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5-6","key":"10.1016\/j.nicl.2020.102545_b0035","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/21678421.2020.1771732","article-title":"Decline of cognitive and behavioral functions in amyotrophic lateral sclerosis: a longitudinal study","volume":"21","author":"Bersano","year":"2020","journal-title":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"},{"issue":"1","key":"10.1016\/j.nicl.2020.102545_b0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis: ALS Stages","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann Neurol."},{"issue":"5","key":"10.1016\/j.nicl.2020.102545_b0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders"},{"issue":"3-4","key":"10.1016\/j.nicl.2020.102545_b0050","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/21678421.2017.1283418","article-title":"Longitudinal assessment of the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS): lack of practice effect in ALS patients?","volume":"18","author":"Burkhardt","year":"2017","journal-title":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration"},{"key":"10.1016\/j.nicl.2020.102545_b0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III)","volume":"169","author":"Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.nicl.2020.102545_b0060","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/jnnp.2010.235952","article-title":"Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study","volume":"82","author":"Chio","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nicl.2020.102545_b0065","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neurobiolaging.2019.07.019","article-title":"Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections","volume":"84","author":"Christidi","year":"2019","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.nicl.2020.102545_b0070","doi-asserted-by":"crossref","first-page":"e1370","DOI":"10.1212\/WNL.0000000000006317","article-title":"ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS","volume":"91","author":"Crockford","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102545_b0075","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/jnnp-2018-318788","article-title":"Cognitive and behavioural changes in PLS and PMA:challenging the concept of restricted phenotypes","volume":"90","author":"de Vries","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nicl.2020.102545_b0080","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2020.102545_b0085","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1136\/jnnp-2013-307135","article-title":"Amyotrophic lateral sclerosis: a long preclinical period?","volume":"85","author":"Eisen","year":"2014","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nicl.2020.102545_b0090","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1212\/WNL.0b013e31828f18ac","article-title":"Cognitive changes predict functional decline in ALS: a population-based longitudinal study","volume":"80","author":"Elamin","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102545_b0095","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1212\/WNL.0b013e318214359f","article-title":"Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia","volume":"76","author":"Elamin","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102545_b0100","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102545_b0105","doi-asserted-by":"crossref","unstructured":"Iglesias, J.E., Van Leemput, K., Augustinack, J., Insausti, R., Fischl, B., Reuter, M., Alzheimer's Disease Neuroimaging, I., 2016. Bayesian longitudinal segmentation of hippocampal substructures in brain MRI using subject-specific atlases. Neuroimage 141, 542-555.","DOI":"10.1016\/j.neuroimage.2016.07.020"},{"key":"10.1016\/j.nicl.2020.102545_b0110","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1148\/radiology.172.2.2748838","article-title":"Anterior temporal lobes and hippocampal formations: normative volumetric measurements from MR images in young adults","volume":"172","author":"Jack","year":"1989","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2020.102545_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101356","article-title":"The relationship between Stroop and stop-signal measures of inhibition in adolescents: influences from variations in context and measure estimation","volume":"9","author":"Khng","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nicl.2020.102545_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2018.05.035","article-title":"The hippocampal longitudinal axis-relevance for underlying tau and TDP-43 pathology","volume":"70","author":"Llado","year":"2018","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.nicl.2020.102545_b0125","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1212\/WNL.59.7.1077","article-title":"The overlap of amyotrophic lateral sclerosis and frontotemporal dementia","volume":"59","author":"Lomen-Hoerth","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102545_b0130","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11862","article-title":"Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval","volume":"5","author":"Lux","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.nicl.2020.102545_b0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1471-2202-15-83","article-title":"Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: a comparative neuropsychological study of amnestic mild cognitive impairment","volume":"15","author":"Machts","year":"2014","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.nicl.2020.102545_b0140","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.nicl.2018.03.002","article-title":"Prefrontal cortical thickness in motor neuron disease","volume":"18","author":"Machts","year":"2018","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.nicl.2020.102545_b0145","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1212\/WNL.0000000000002017","article-title":"Basal ganglia pathology in ALS is associated with neuropsychological deficits","volume":"85","author":"Machts","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102545_b0150","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3389\/fneur.2018.00565","article-title":"Global Hippocampal Volume Reductions and Local CA1 Shape Deformations in Amyotrophic Lateral Sclerosis","volume":"9","author":"Machts","year":"2018","journal-title":"Front Neurol"},{"key":"10.1016\/j.nicl.2020.102545_b0155","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1468-1331.2003.00607.x","article-title":"Memory deficits and retrieval processes in ALS","volume":"10","author":"Mantovan","year":"2003","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.nicl.2020.102545_b0160","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.nicl.2020.102545_b0165","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.nicl.2020.102545_b0170","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/jnnp-2011-300188","article-title":"The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study","volume":"83","author":"Phukan","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nicl.2020.102545_b0175","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/21678421.2018.1473443","article-title":"Cognitive-behavioral longitudinal assessment in ALS: the Italian Edinburgh Cognitive and Behavioral ALS screen (ECAS)","volume":"19","author":"Poletti","year":"2018","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.nicl.2020.102545_b0180","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/jnnp.2009.204446","article-title":"Cognitive dysfunction in lower motor neuron disease: executive and memory deficits in progressive muscular atrophy","volume":"82","author":"Raaphorst","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nicl.2020.102545_b0185","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2020.102545_b0190","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2020.102545_b0195","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.neuroimage.2012.02.084","article-title":"Within-subject template estimation for unbiased longitudinal image analysis","volume":"61","author":"Reuter","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2020.102545_b0200","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/brain\/awr351","article-title":"A proposed staging system for amyotrophic lateral sclerosis","volume":"135","author":"Roche","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2020.102545_b0205","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1007\/s00415-018-9043-0","article-title":"Significance of CSF NfL and tau in ALS","volume":"265","author":"Schreiber","year":"2018","journal-title":"J Neurol"},{"key":"10.1016\/j.nicl.2020.102545_b0210","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/21678421.2016.1267768","article-title":"Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria","volume":"18","author":"Strong","year":"2017","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"10.1016\/j.nicl.2020.102545_b0215","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrneurol.2014.184","article-title":"The phenotypic variability of amyotrophic lateral sclerosis","volume":"10","author":"Swinnen","year":"2014","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.nicl.2020.102545_b0220","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/jnnp-2012-303526","article-title":"Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?","volume":"84","author":"Taylor","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.nicl.2020.102545_b0225","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000009498","article-title":"Multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis","author":"van der Burgh","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2020.102545_b0230","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S1474-4422(18)30241-2","article-title":"The life expectancy of Stephen Hawking, according to the ENCALS model","volume":"17","author":"Westeneng","year":"2018","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nicl.2020.102545_b0235","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/23279095.2015.1004574","article-title":"Verbal Fluency: Language or Executive Function Measure?","volume":"23","author":"Whiteside","year":"2016","journal-title":"Appl Neuropsychol Adult"},{"key":"10.1016\/j.nicl.2020.102545_b0240","doi-asserted-by":"crossref","first-page":"5969137","DOI":"10.1155\/2018\/5969137","article-title":"Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients","volume":"2018","author":"Woolley","year":"2018","journal-title":"Behav Neurol"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221315822030382X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221315822030382X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:15:25Z","timestamp":1762607725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221315822030382X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":48,"alternative-id":["S221315822030382X"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2020.102545","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal clinical and neuroanatomical correlates of memory impairment in motor neuron disease","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2020.102545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102545"}}