{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:16:16Z","timestamp":1793024176091,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":262,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.nicl.2021.102835","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T21:53:11Z","timestamp":1632779591000},"page":"102835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Hyperglycemia associated with acute brain injury in neonatal encephalopathy"],"prefix":"10.1016","volume":"32","author":[{"given":"Emily W.Y.","family":"Tam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Kamino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar S.","family":"Shatil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vann","family":"Chau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aideen M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rollin","family":"Brant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elysa","family":"Widjaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2021.102835_b0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pediatrneurol.2017.04.025","article-title":"Early imaging and adverse neurodevelopmental outcome in asphyxiated newborns treated With Hypothermia","volume":"73","author":"Al Amrani","year":"2017","journal-title":"Pediatr. Neurol."},{"issue":"2","key":"10.1016\/j.nicl.2021.102835_b0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3233\/NPM-15814107","article-title":"High glucose variability is associated with poor neurodevelopmental outcomes in neonatal hypoxic ischemic encephalopathy","volume":"8","author":"Al Shafouri","year":"2015","journal-title":"J. Neonatal Perinatal Med."},{"issue":"2","key":"10.1016\/j.nicl.2021.102835_b0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.nic.2006.02.006","article-title":"Comparison of diffusion tensor imaging measurements at 3.0 T versus 1.5 T with and without parallel imaging","volume":"16","author":"Alexander","year":"2006","journal-title":"Neuroimaging Clin. N. Am."},{"key":"10.1016\/j.nicl.2021.102835_b0020","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1198\/016214508000000841","article-title":"Multiple inference and gender differences in the effects of early intervention: a reevaluation of the Abrecedarian, Perry preschool, and early training projects","volume":"103","author":"Anderson","year":"2008","journal-title":"J. Am. Stat. Assoc."},{"issue":"2","key":"10.1016\/j.nicl.2021.102835_b0025","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.jpeds.2013.01.051","article-title":"Long duration of hyperglycemia in the first 96 hours of life is associated with severe intraventricular hemorrhage in preterm infants","volume":"163","author":"Auerbach","year":"2013","journal-title":"J. Pediatr."},{"issue":"7172","key":"10.1016\/j.nicl.2021.102835_b0030","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1136\/bmj.317.7172.1549","article-title":"Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study","volume":"317","author":"Badawi","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.nicl.2021.102835_b0035","first-page":"523","article-title":"Imaging patterns of neonatal hypoglycemia","volume":"19","author":"Barkovich","year":"1998","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-3495(94)80775-1","article-title":"MR diffusion tensor spectroscopy and imaging","volume":"66","author":"Basser","year":"1994","journal-title":"Biophys. J."},{"issue":"2","key":"10.1016\/j.nicl.2021.102835_b0045","doi-asserted-by":"crossref","first-page":"F149","DOI":"10.1136\/archdischild-2015-308733","article-title":"Hypoglycaemia and hyperglycaemia are associated with unfavourable outcome in infants with hypoxic ischaemic encephalopathy: a post hoc analysis of the CoolCap Study","volume":"101","author":"Basu","year":"2016","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.nicl.2021.102835_b0050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jpeds.2018.07.041","article-title":"Early glycemic profile is associated with brain injury patterns on magnetic resonance imaging in hypoxic ischemic encephalopathy","volume":"203","author":"Basu","year":"2018","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.nicl.2021.102835_b0055","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/mrm.10609","article-title":"Characterization and propagation of uncertainty in diffusion-weighted MR imaging","volume":"50","author":"Behrens","year":"2003","journal-title":"Magn. Reson. Med."},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0060","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/jmri.26054","article-title":"Variation of T2 relaxation times in pediatric brain tumors and their effect on metabolite quantification","volume":"49","author":"Carlin","year":"2019","journal-title":"J. Magn. Reson. Imaging"},{"issue":"2","key":"10.1016\/j.nicl.2021.102835_b0065","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ana.21713","article-title":"Effect of chorioamnionitis on brain development and injury in premature newborns","volume":"66","author":"Chau","year":"2009","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.nicl.2021.102835_b0070","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3233\/NPM-15814075","article-title":"Hyperglycemia is associated with poor outcome in newborn infants undergoing therapeutic hypothermia for hypoxic ischemic encephalopathy","volume":"8","author":"Chouthai","year":"2015","journal-title":"J. Neonatal Perinatal Med."},{"key":"10.1016\/j.nicl.2021.102835_b0075","doi-asserted-by":"crossref","first-page":"101832","DOI":"10.1016\/j.nicl.2019.101832","article-title":"White matter microstructure and cognitive outcomes in relation to neonatal inflammation in 6-year-old children born preterm","volume":"23","author":"Dubner","year":"2019","journal-title":"Neuroimage Clin."},{"issue":"4","key":"10.1016\/j.nicl.2021.102835_b0080","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jpeds.2005.11.015","article-title":"Neonatal hypoglycemia and occipital cerebral injury","volume":"148","author":"Filan","year":"2006","journal-title":"J. Pediatr."},{"issue":"7","key":"10.1016\/j.nicl.2021.102835_b0085","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2337\/db11-1286","article-title":"Effects of hyperglycemia and effects of ketosis on cerebral perfusion, cerebral water distribution, and cerebral metabolism","volume":"61","author":"Glaser","year":"2012","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.nicl.2021.102835_b0090","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s12028-010-9404-8","article-title":"Treating hyperglycemia in neurocritical patients: benefits and perils","volume":"13","author":"Godoy","year":"2010","journal-title":"Neurocrit. Care"},{"issue":"2","key":"10.1016\/j.nicl.2021.102835_b0095","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2013a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.nicl.2021.102835_b0100","doi-asserted-by":"crossref","unstructured":"Jacobs, S.E., Berg, M., Hunt, R., Tarnow-Mordi, W.O., Inder, T.E., Davis, P.G., 2013. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev, CD003311.","DOI":"10.1002\/14651858.CD003311.pub3"},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0105","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1474-4422(18)30325-9","article-title":"Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study","volume":"18","author":"Lally","year":"2019","journal-title":"Lancet Neurol."},{"issue":"10","key":"10.1016\/j.nicl.2021.102835_b0110","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1001\/jamapediatrics.2017.1579","article-title":"Association of Neonatal Glycemia With Neurodevelopmental Outcomes at 4.5 Years","volume":"171","author":"McKinlay","year":"2017","journal-title":"JAMA Pediatr."},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0002-9378(03)00908-6","article-title":"Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy","volume":"190","author":"Miller","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.nicl.2021.102835_b0120","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jpeds.2004.12.026","article-title":"Patterns of brain injury in term neonatal encephalopathy","volume":"146","author":"Miller","year":"2005","journal-title":"J. Pediatr."},{"issue":"4","key":"10.1016\/j.nicl.2021.102835_b0125","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/mrm.22501","article-title":"Correcting eddy current and motion effects by affine whole-brain registrations: evaluation of three-dimensional distortions and comparison with slicewise correction","volume":"64","author":"Mohammadi","year":"2010","journal-title":"Magn. Reson. Med."},{"issue":"2","key":"10.1016\/j.nicl.2021.102835_b0130","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41390-020-0827-4","article-title":"Continuous glucose monitoring profile during therapeutic hypothermia in encephalopathic infants with unfavorable outcome","volume":"88","author":"Montaldo","year":"2020","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0135","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/jmre.1998.1673","article-title":"A comparative study of acquisition schemes for diffusion tensor imaging using MRI","volume":"137","author":"Papadakis","year":"1999","journal-title":"J. Magn. Reson."},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0140","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.10241","article-title":"Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study","volume":"52","author":"Parsons","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2021.102835_b0145","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1469-8749.1993.tb11680.x","article-title":"Proton spectroscopy of the neonatal brain following hypoxic-ischaemic injury","volume":"35","author":"Peden","year":"1993","journal-title":"Dev. Med. Child Neurol."},{"issue":"6","key":"10.1016\/j.nicl.2021.102835_b0150","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/mrm.1910360612","article-title":"Toward a quantitative assessment of diffusion anisotropy","volume":"36","author":"Pierpaoli","year":"1996","journal-title":"Magn. Reson. Med."},{"issue":"3","key":"10.1016\/j.nicl.2021.102835_b0155","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiology.201.3.8939209","article-title":"Diffusion tensor MR imaging of the human brain","volume":"201","author":"Pierpaoli","year":"1996","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2021.102835_b0160","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jpeds.2019.02.027","article-title":"Hyperglycemia and Glucose Variability Are Associated with Worse Brain Function and Seizures in Neonatal Encephalopathy: A Prospective Cohort Study","volume":"209","author":"Pinchefsky","year":"2019","journal-title":"J. Pediatr."},{"key":"10.1016\/j.nicl.2021.102835_b0165","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuroimage.2013.02.052","article-title":"Structural connectivity asymmetry in the neonatal brain","volume":"75","author":"Ratnarajah","year":"2013","journal-title":"Neuroimage"},{"issue":"06","key":"10.1016\/j.nicl.2021.102835_b0170","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1055\/s-2001-20403","article-title":"Neonatal diffusion-weighted MR imaging: relation with histopathology or follow-up MR examination","volume":"32","author":"Roelants-van Rijn","year":"2001","journal-title":"Neuropediatrics"},{"issue":"13","key":"10.1016\/j.nicl.2021.102835_b0175","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1177\/0883073817726681","article-title":"Prognostic value of brain magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: a meta-analysis","volume":"32","author":"S\u00e1nchez Fern\u00e1ndez","year":"2017","journal-title":"J. Child Neurol."},{"issue":"7","key":"10.1016\/j.nicl.2021.102835_b0180","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/ijs.12517","article-title":"The correlation between admission blood glucose and intravenous rt-PA-induced arterial recanalization in acute ischemic stroke: a multi-centre TCD study","volume":"10","author":"Saqqur","year":"2015","journal-title":"Int. J. Stroke"},{"issue":"3","key":"10.1016\/j.nicl.2021.102835_b0185","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/jmri.25380","article-title":"Comparison of diffusion metrics obtained at 1.5T and 3T in human brain with diffusional kurtosis imaging","volume":"45","author":"Shaw","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"issue":"4","key":"10.1016\/j.nicl.2021.102835_b0190","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1203\/00006450-199210000-00022","article-title":"Postischemic hyperglycemia is not protective to the neonatal rat brain","volume":"32","author":"Sheldon","year":"1992","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0195","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/bjophthalmol-2016-309187","article-title":"Early postnatal hyperglycaemia is a risk factor for treatment-demanding retinopathy of prematurity","volume":"102","author":"Slidsborg","year":"2018","journal-title":"Br. J. Ophthalmol."},{"issue":"4","key":"10.1016\/j.nicl.2021.102835_b0200","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"issue":"10","key":"10.1016\/j.nicl.2021.102835_b0205","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00234-016-1721-y","article-title":"Tensor and non-tensor tractography for the assessment of the corticospinal tract of children with motor disorders: a comparative study","volume":"58","author":"Stefanou","year":"2016","journal-title":"Neuroradiology"},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0210","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1203\/PDR.0b013e3181a1fb3d","article-title":"Cerebellar development in the preterm neonate: effect of supratentorial brain injury","volume":"66","author":"Tam","year":"2009","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0215","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jpeds.2011.12.047","article-title":"Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy","volume":"161","author":"Tam","year":"2012","journal-title":"J. Pediatr."},{"issue":"3","key":"10.1016\/j.nicl.2021.102835_b0220","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1542\/peds.2007-2002","article-title":"Occipital lobe injury and cortical visual outcomes after neonatal hypoglycemia","volume":"122","author":"Tam","year":"2008","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.nicl.2021.102835_b0225","doi-asserted-by":"crossref","first-page":"e0247678","DOI":"10.1371\/journal.pone.0247678","article-title":"Transient changes in white matter microstructure during general anesthesia","volume":"16","author":"Tang","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2021.102835_b0230","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nicl.2014.08.003","article-title":"Cellular correlates of longitudinal diffusion tensor imaging of axonal degeneration following hypoxic-ischemic cerebral infarction in neonatal rats","volume":"6","author":"Tuor","year":"2014","journal-title":"Neuroimage Clin."},{"issue":"1","key":"10.1016\/j.nicl.2021.102835_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/mrm.22579","article-title":"A constrained least-squares approach to the automated quantitation of in vivo (1)H magnetic resonance spectroscopy data","volume":"65","author":"Wilson","year":"2011","journal-title":"Magn. Reson. Med."},{"issue":"7","key":"10.1016\/j.nicl.2021.102835_b0240","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3174\/ajnr.A3423","article-title":"Brain injury patterns in hypoglycemia in neonatal encephalopathy","volume":"34","author":"Wong","year":"2013","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"5","key":"10.1016\/j.nicl.2021.102835_b0245","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s00429-018-1614-4","article-title":"Altered white matter development in children born very preterm","volume":"223","author":"Young","year":"2018","journal-title":"Brain Struct. Funct."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158221002795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158221002795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:39:14Z","timestamp":1761971954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158221002795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":49,"alternative-id":["S2213158221002795"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2021.102835","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperglycemia associated with acute brain injury in neonatal encephalopathy","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2021.102835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102835"}}