{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:51:19Z","timestamp":1789573879792,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":31,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG037491-11"],"award-info":[{"award-number":["R01 AG037491-11"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 NS120992"],"award-info":[{"award-number":["RF1 NS120992"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG006786"],"award-info":[{"award-number":["U01 AG006786"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AG062677"],"award-info":[{"award-number":["P30 AG062677"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG041851"],"award-info":[{"award-number":["R01 AG041851"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 AG11378"],"award-info":[{"award-number":["R35 AG11378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.nicl.2022.102954","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T12:02:39Z","timestamp":1643976159000},"page":"102954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration"],"prefix":"10.1016","volume":"34","author":[{"given":"Marina","family":"Buciuc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirubol","family":"Tosakulwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa E.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Petrucelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Senjem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Spychalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley F.","family":"Boeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Ross","family":"Reichard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Whitwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Josephs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2022.102954_b0005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/ana.21154","article-title":"TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease","volume":"61","author":"Amador-Ortiz","year":"2007","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2022.102954_b0010","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","article-title":"TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"351","author":"Arai","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nicl.2022.102954_b0015","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00401-008-0480-1","article-title":"Phosphorylated TDP-43 in Alzheimer\u2019s disease and dementia with Lewy bodies","volume":"117","author":"Arai","year":"2009","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0020","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05016","article-title":"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17","volume":"442","author":"Baker","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.nicl.2022.102954_b0025","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1001\/archneur.63.10.1434","article-title":"Measurements of the amygdala and hippocampus in pathologically confirmed Alzheimer disease and frontotemporal lobar degeneration","volume":"63","author":"Barnes","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nicl.2022.102954_b0030","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1093\/brain\/awz277","article-title":"Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration","volume":"142","author":"Bejanin","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0040","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1177\/0962280218808821","article-title":"Joint longitudinal and time-to-event models for multilevel hierarchical data","volume":"28","author":"Brilleman","year":"2019","journal-title":"Stat. Methods Med. Res."},{"key":"10.1016\/j.nicl.2022.102954_b0045","first-page":"1","article-title":"TAR DNA-binding protein 43 is associated with rate of memory and functional and global cognitive decline in the decade prior to death","author":"Buciuc","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nicl.2022.102954_b0050","first-page":"1","article-title":"Effect modifiers of TDP-43 associated hippocampal atrophy rates in patients with alzheimer\u2019s disease neuropathological changes","author":"Buciuc","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nicl.2022.102954_b0055","doi-asserted-by":"crossref","DOI":"10.1111\/nan.12727","article-title":"Old age genetically confirmed frontotemporal lobar degeneration with TDP-43 has limbic predominant TDP-43 deposition","author":"Buciuc","year":"2021","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nicl.2022.102954_b0060","first-page":"1","article-title":"TDP-43 is associated with a reduced likelihood of rendering a clinical diagnosis of dementia with Lewy bodies in autopsy-confirmed cases of transitional\/diffuse Lewy body disease","author":"Buciuc","year":"2020","journal-title":"J. Neurol."},{"key":"10.1016\/j.nicl.2022.102954_b0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neurobiolaging.2020.04.001","article-title":"Association between transactive response DNA-binding protein of 43 kDa type and cognitive resilience to Alzheimer's disease: a case-control study","volume":"92","author":"Buciuc","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2022.102954_b0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-007-0237-2","article-title":"Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration","volume":"114","author":"Cairns","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2022.102954_b0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2022.102954_b0085","series-title":"Data Analysis using Regression and Multilevel\/Hierarchical Models","author":"Gelman","year":"2006"},{"key":"10.1016\/j.nicl.2022.102954_b0090","unstructured":"Goodrich, B., Gabry, J., Ali, I., Brilleman, S., 2020. rstanarm: Bayesian Applied Regression Modeling via Stan. R Package v. 2.19. 2."},{"key":"10.1016\/j.nicl.2022.102954_b0095","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/ije\/29.1.158","article-title":"Principles of multilevel modelling","volume":"29","author":"Greenland","year":"2000","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.nicl.2022.102954_b0100","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/brain\/awm065","article-title":"TDP-43 is deposited in the Guam parkinsonism\u2013dementia complex brains","volume":"130","author":"Hasegawa","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0105","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.brainres.2007.09.048","article-title":"Concurrence of TDP-43, tau and \u03b1-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies","volume":"1184","author":"Higashi","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.nicl.2022.102954_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging\u2013Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimer's & Dementia"},{"key":"10.1016\/j.nicl.2022.102954_b0115","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005072-199710000-00002","article-title":"Editorial on consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease","volume":"56","author":"Hyman","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nicl.2022.102954_b0120","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/awm336","article-title":"11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment","volume":"131","author":"Jack","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0125","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1093\/brain\/aww224","article-title":"TDP-43 stage, mixed pathologies, and clinical Alzheimer\u2019s-type dementia","volume":"139","author":"James","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0130","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S1474-4422(17)30284-3","article-title":"Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study","volume":"16","author":"Josephs","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2022.102954_b0135","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/brain\/awz224","article-title":"LATE to the PART-y","volume":"142","author":"Josephs","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0140","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awaa299","article-title":"Protein contributions to brain atrophy acceleration in Alzheimer\u2019s disease and primary age-related tauopathy","author":"Josephs","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0145","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00401-018-1951-7","article-title":"Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains","volume":"137","author":"Josephs","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0150","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00401-013-1211-9","article-title":"Staging TDP-43 pathology in Alzheimer\u2019s disease","volume":"127","author":"Josephs","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0155","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00401-016-1537-1","article-title":"Updated TDP-43 in Alzheimer\u2019s disease staging scheme","volume":"131","author":"Josephs","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0160","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1212\/01.wnl.0000304041.09418.b1","article-title":"Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype","volume":"70","author":"Josephs","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.102954_b0165","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00401-014-1269-z","article-title":"TDP-43 is a key player in the clinical features associated with Alzheimer\u2019s disease","volume":"127","author":"Josephs","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0170","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00401-006-0138-9","article-title":"Heterogeneity of ubiquitin pathology in frontotemporal lobar degeneration: classification and relation to clinical phenotype","volume":"112","author":"Mackenzie","year":"2006","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0175","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00401-011-0845-8","article-title":"A harmonized classification system for FTLD-TDP pathology","volume":"122","author":"Mackenzie","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0180","series-title":"Nomenclature for Neuropathologic Subtypes of Frontotemporal Lobar Degeneration: Consensus Recommendations","author":"Mackenzie","year":"2009"},{"key":"10.1016\/j.nicl.2022.102954_b0185","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.102954_b0190","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41593-018-0293-z","article-title":"Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration","volume":"22","author":"Melamed","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nicl.2022.102954_b0195","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.102954_b0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging\u2013Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nicl.2022.102954_b0205","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1474-4422(11)70156-9","article-title":"Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study","volume":"10","author":"Murray","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2022.102954_b0210","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1212\/WNL.0000000000003610","article-title":"TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD","volume":"88","author":"Nag","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.102954_b0215","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0220","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/brain\/awr053","article-title":"Hippocampal sclerosis in advanced age: clinical and pathological features","volume":"134","author":"Nelson","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0225","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.nicl.2022.102954_b0230","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.nicl.2015.08.002","article-title":"Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration","volume":"12","author":"Pankov","year":"2016","journal-title":"NeuroImage: Clinical"},{"key":"10.1016\/j.nicl.2022.102954_b0235","doi-asserted-by":"crossref","unstructured":"Prudencio, M., Humphrey, J., Pickles, S., Brown, A.L., Hill, S.E., Kachergus, J.M., Shi, J., Heckman, M.G., Spiegel, M.R., Cook, C., Song, Y., Yue, M., Daughrity, L.M., Carlomagno, Y., Jansen-West, K., de Castro, C.F., DeTure, M., Koga, S., Wang, Y.C., Sivakumar, P., Bodo, C., Candalija, A., Talbot, K., Selvaraj, B.T., Burr, K., Chandran, S., Newcombe, J., Lashley, T., Hubbard, I., Catalano, D., Kim, D., Propp, N., Fennessey, S., Consortium, N.A., Fagegaltier, D., Phatnani, H., Secrier, M., Fisher, E.M., Oskarsson, B., van Blitterswijk, M., Rademakers, R., Graff-Radford, N.R., Boeve, B.F., Knopman, D.S., Petersen, R.C., Josephs, K.A., Thompson, E.A., Raj, T., Ward, M., Dickson, D.W., Gendron, T.F., Fratta, P., Petrucelli, L., 2020. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. J. Clin. Invest. 130, 6080\u20136092.","DOI":"10.1172\/JCI139741"},{"key":"10.1016\/j.nicl.2022.102954_b0240","doi-asserted-by":"crossref","unstructured":"Renton, A.E., Majounie, E., Waite, A., Simon-Sanchez, J., Rollinson, S., Gibbs, J.R., Schymick, J.C., Laaksovirta, H., van Swieten, J.C., Myllykangas, L., Kalimo, H., Paetau, A., Abramzon, Y., Remes, A.M., Kaganovich, A., Scholz, S.W., Duckworth, J., Ding, J., Harmer, D.W., Hernandez, D.G., Johnson, J.O., Mok, K., Ryten, M., Trabzuni, D., Guerreiro, R.J., Orrell, R.W., Neal, J., Murray, A., Pearson, J., Jansen, I.E., Sondervan, D., Seelaar, H., Blake, D., Young, K., Halliwell, N., Callister, J.B., Toulson, G., Richardson, A., Gerhard, A., Snowden, J., Mann, D., Neary, D., Nalls, M.A., Peuralinna, T., Jansson, L., Isoviita, V.M., Kaivorinne, A.L., Holtta-Vuori, M., Ikonen, E., Sulkava, R., Benatar, M., Wuu, J., Chio, A., Restagno, G., Borghero, G., Sabatelli, M., Consortium, I., Heckerman, D., Rogaeva, E., Zinman, L., Rothstein, J.D., Sendtner, M., Drepper, C., Eichler, E.E., Alkan, C., Abdullaev, Z., Pack, S.D., Dutra, A., Pak, E., Hardy, J., Singleton, A., Williams, N.M., Heutink, P., Pickering-Brown, S., Morris, H.R., Tienari, P.J., Traynor, B.J., 2011. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron 72, 257\u2013268.","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"10.1016\/j.nicl.2022.102954_b0245","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000115751","article-title":"The Mayo Clinic Study of Aging: design and sampling, participation, baseline measures and sample characteristics","volume":"30","author":"Roberts","year":"2008","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.nicl.2022.102954_b0250","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/brain\/awy146","article-title":"Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated","volume":"141","author":"Robinson","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0255","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1093\/brain\/awaa219","article-title":"Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration","volume":"143","author":"Robinson","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0260","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1212\/WNL.0b013e318202038c","article-title":"TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia","volume":"75","author":"Rohrer","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.102954_b0265","doi-asserted-by":"crossref","first-page":"e1047","DOI":"10.1212\/WNL.0000000000005163","article-title":"Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration","volume":"90","author":"Seo","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.102954_b0270","unstructured":"Team, R.C., 2019. R: A language and environment for statistical computing (version 3.1. 2). Vienna, Austria. R Foundation for Statistical Computing; 2014."},{"key":"10.1016\/j.nicl.2022.102954_b0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-020-00934-5","article-title":"Distinct molecular patterns of TDP-43 pathology in Alzheimer\u2019s disease: relationship with clinical phenotypes","volume":"8","author":"Tom\u00e9","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nicl.2022.102954_b0280","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/ene.12675","article-title":"Brain atrophy over time in genetic and sporadic frontotemporal dementia: a study of 198 serial magnetic resonance images","volume":"22","author":"Whitwell","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nicl.2022.102954_b0285","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1474-4422(12)70200-4","article-title":"Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study","volume":"11","author":"Whitwell","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2022.102954_b0290","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1212\/WNL.0b013e31820203c2","article-title":"Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration?","volume":"75","author":"Whitwell","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.102954_b0295","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/brain\/aws001","article-title":"Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics","volume":"135","author":"Whitwell","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.102954_b0300","doi-asserted-by":"crossref","first-page":"7607","DOI":"10.1073\/pnas.0900688106","article-title":"Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158222000195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158222000195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:43:20Z","timestamp":1778852600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158222000195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":60,"alternative-id":["S2213158222000195"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2022.102954","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TDP-43-associated atrophy in brains with and without frontotemporal lobar degeneration","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2022.102954","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102954"}}