{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:35:35Z","timestamp":1792139735225,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":196,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2021YFS0240"],"award-info":[{"award-number":["2021YFS0240"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018925","name":"Health Commission of Henan Province","doi-asserted-by":"publisher","award":["SBGJ202003048"],"award-info":[{"award-number":["SBGJ202003048"]}],"id":[{"id":"10.13039\/100018925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["142102310512"],"award-info":[{"award-number":["142102310512"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.nicl.2022.103122","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T18:33:25Z","timestamp":1658255605000},"page":"103122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Association between gray\/white matter contrast and white matter microstructural alterations in medication-na\u00efve obsessive\u2013compulsive disorder"],"prefix":"10.1016","volume":"35","author":[{"given":"Qihui","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingmin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2022.103122_b0005","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.biopsych.2013.10.021","article-title":"Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder","volume":"75","author":"Anticevic","year":"2014","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jad.2010.03.027","article-title":"The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive-compulsive disorder","volume":"124","author":"Atmaca","year":"2010","journal-title":"J Affect Disord"},{"key":"10.1016\/j.nicl.2022.103122_b0015","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1038\/s41467-020-18984-7","article-title":"Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits","volume":"11","author":"Benamer","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.nicl.2022.103122_b0020","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1001\/jamapsychiatry.2013.173","article-title":"Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder","volume":"70","author":"Beucke","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0025","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1154433","article-title":"Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives","volume":"321","author":"Chamberlain","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.nicl.2022.103122_b0030","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/0004867418806370","article-title":"The right thalamic glutamate level correlates with functional connectivity with right dorsal anterior cingulate cortex\/middle occipital gyrus in unmedicated obsessive-compulsive disorder: A combined fMRI and (1)H-MRS study","volume":"53","author":"Chen","year":"2019","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0035","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s11065-020-09432-w","article-title":"Cerebellar Contributions to proactive and reactive control in the stop signal task: a systematic review and meta-analysis of functional magnetic resonance imaging studies","volume":"30","author":"Clark","year":"2020","journal-title":"Neuropsychol Rev"},{"key":"10.1016\/j.nicl.2022.103122_b0040","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1176\/appi.ajp.2012.12010073","article-title":"Presupplementary motor area hyperactivity during response inhibition: a candidate endophenotype of obsessive-compulsive disorder","volume":"169","author":"de Wit","year":"2012","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0045","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/acps.13241","article-title":"White matter microstructure and connectivity in patients with obsessive-compulsive disorder and their unaffected siblings","volume":"143","author":"Dikmeer","year":"2021","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.nicl.2022.103122_b0050","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/hbm.20082","article-title":"High-resolution MRI reflects myeloarchitecture and cytoarchitecture of human cerebral cortex","volume":"24","author":"Eickhoff","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.nicl.2022.103122_b0055","doi-asserted-by":"crossref","first-page":"895","DOI":"10.4329\/wjr.v6.i12.895","article-title":"Functional topography of the corpus callosum investigated by DTI and fMRI","volume":"6","author":"Fabri","year":"2014","journal-title":"World J Radiol"},{"key":"10.1016\/j.nicl.2022.103122_b0060","doi-asserted-by":"crossref","first-page":"e1062","DOI":"10.1038\/tp.2017.22","article-title":"Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder","volume":"7","author":"Gan","year":"2017","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12888-015-0535-5","article-title":"Obsessive-compulsive disorder is a heterogeneous disorder: evidence from diffusion tensor imaging and magnetization transfer imaging","volume":"15","author":"Glahn","year":"2015","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0070","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pbj.2016.07.005","article-title":"Cognitive and emotional impairments in obsessive-compulsive disorder: Evidence from functional brain alterations","volume":"1","author":"Goncalves","year":"2016","journal-title":"Porto Biomed J"},{"key":"10.1016\/j.nicl.2022.103122_b0075","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The yale-brown obsessive compulsive scale. I. development, use, and reliability","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0080","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neubiorev.2018.01.016","article-title":"Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity","volume":"87","author":"Gursel","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.nicl.2022.103122_b0085","first-page":"222","article-title":"Inhibition-related cortical hypoconnectivity as a candidate vulnerability marker for obsessive-compulsive disorder","volume":"5","author":"Hampshire","year":"2020","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"10.1016\/j.nicl.2022.103122_b0090","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/glia.22716","article-title":"Myelination, oligodendrocytes, and serious mental illness","volume":"62","author":"Haroutunian","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.nicl.2022.103122_b0095","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1001\/jama.2017.2200","article-title":"Obsessive-compulsive disorder: advances in diagnosis and treatment","volume":"317","author":"Hirschtritt","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.nicl.2022.103122_b0100","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/cercor\/bhx030","article-title":"A systematic relationship between functional connectivity and intracortical myelin in the human cerebral cortex","volume":"27","author":"Huntenburg","year":"2017","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.nicl.2022.103122_b0105","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1017\/S0033291716000593","article-title":"Increased MRI-based cortical grey\/white-matter contrast in sensory and motor regions in schizophrenia and bipolar disorder","volume":"46","author":"Jorgensen","year":"2016","journal-title":"Psychol Med"},{"key":"10.1016\/j.nicl.2022.103122_b0110","first-page":"99","article-title":"Correlations between gray-white matter contrast in prefrontal lobe regions and cognitive set-shifting in healthy adults","volume":"33","author":"Kim","year":"2017","journal-title":"Journal of Young Investigators"},{"key":"10.1016\/j.nicl.2022.103122_b0115","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/mrm.1910200210","article-title":"Cholesterol of myelin is the determinant of gray-white contrast in MRI of brain","volume":"20","author":"Koenig","year":"1991","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.nicl.2022.103122_b0120","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/mrm.1910140306","article-title":"Relaxometry of brain: why white matter appears bright in MRI","volume":"14","author":"Koenig","year":"1990","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.nicl.2022.103122_b0125","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1002\/hbm.25465","article-title":"Temporal variability of regional intrinsic neural activity in drug-naive patients with obsessive-compulsive disorder","volume":"42","author":"Liu","year":"2021","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.nicl.2022.103122_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2020.111046","article-title":"Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging","volume":"298","author":"Maleki","year":"2020","journal-title":"Psychiatry Res Neuroimaging"},{"key":"10.1016\/j.nicl.2022.103122_b0135","first-page":"5","article-title":"A large fraction of neocortical myelin ensheathes axons of local inhibitory neurons","author":"Micheva","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.nicl.2022.103122_b0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tics.2011.11.003","article-title":"Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways","volume":"16","author":"Milad","year":"2012","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.nicl.2022.103122_b0145","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fnbeh.2019.00099","article-title":"A working hypothesis for the role of the cerebellum in impulsivity and compulsivity","volume":"13","author":"Miquel","year":"2019","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.nicl.2022.103122_b0150","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.biopsych.2018.09.027","article-title":"Probing brain developmental patterns of myelination and associations with psychopathology in youths using gray\/white matter contrast","volume":"85","author":"Norbom","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0155","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.biopsych.2018.11.010","article-title":"Error processing and inhibitory control in obsessive-compulsive disorder: a meta-analysis using statistical parametric maps","volume":"85","author":"Norman","year":"2019","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0160","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1016\/j.neubiorev.2013.10.008","article-title":"Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies","volume":"37","author":"Piras","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.nicl.2022.103122_b0165","doi-asserted-by":"crossref","unstructured":"Piras, F., Piras, F., Abe, Y., Agarwal, S.M., Anticevic, A., Ameis, S., Arnold, P., Banaj, N., Bargallo, N., Batistuzzo, M.C., Benedetti, F., Beucke, J.C., Boedhoe, P.S.W., Bollettini, I., Brem, S., Calvo, A., Cho, K.I.K., Ciullo, V., Dallaspezia, S., Dickie, E., Ely, B.A., Fan, S., Fouche, J.P., Gruner, P., Gursel, D.A., Hauser, T., Hirano, Y., Hoexter, M.Q., Iorio, M., James, A., Reddy, Y.C.J., Kaufmann, C., Koch, K., Kochunov, P., Kwon, J.S., Lazaro, L., Lochner, C., Marsh, R., Nakagawa, A., Nakamae, T., Narayanaswamy, J.C., Sakai, Y., Shimizu, E., Simon, D., Simpson, H.B., Soreni, N., Stampfli, P., Stern, E.R., Szeszko, P., Takahashi, J., Venkatasubramanian, G., Wang, Z., Yun, J.Y., Group, E.O.W., Stein, D.J., Jahanshad, N., Thompson, P.M., van den Heuvel, O.A., Spalletta, G., 2021. White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group. Transl Psychiatry 11, 173.","DOI":"10.1038\/s41398-021-01276-z"},{"key":"10.1016\/j.nicl.2022.103122_b0170","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1148\/radiol.2462061469","article-title":"Corpus callosum in patients with obsessive-compulsive disorder: diffusion-tensor imaging study","volume":"246","author":"Saito","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2022.103122_b0175","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/ana.20202","article-title":"Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain","volume":"56","author":"Schmierer","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.nicl.2022.103122_b0180","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/mrm.21487","article-title":"Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation","volume":"59","author":"Schmierer","year":"2008","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.nicl.2022.103122_b0185","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuroimage.2018.10.023","article-title":"Depth-dependent intracortical myelin organization in the living human brain determined by in vivo ultra-high field magnetic resonance imaging","volume":"185","author":"Sprooten","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2022.103122_b0190","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-019-0102-3","article-title":"Obsessive-compulsive disorder","volume":"5","author":"Stein","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.nicl.2022.103122_b0195","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/archpsyc.64.2.209","article-title":"A genetic family-based association study of OLIG2 in obsessive-compulsive disorder","volume":"64","author":"Stewart","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.nicl.2022.103122_b0200","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/brain\/awn267","article-title":"The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems","volume":"132","author":"van den Heuvel","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.103122_b0205","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnana.2016.00088","article-title":"Subcomponents and connectivity of the inferior fronto-occipital fasciculus revealed by diffusion spectrum imaging fiber tracking","volume":"10","author":"Wu","year":"2016","journal-title":"Front Neuroanat"},{"key":"10.1016\/j.nicl.2022.103122_b0210","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fnana.2016.00084","article-title":"Segmentation of the cingulum bundle in the human brain: A new perspective based on DSI tractography and fiber dissection study","volume":"10","author":"Wu","year":"2016","journal-title":"Front Neuroanat"},{"key":"10.1016\/j.nicl.2022.103122_b0215","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1017\/S0033291718001915","article-title":"Altered resting-state cerebellar-cerebral functional connectivity in obsessive-compulsive disorder","volume":"49","author":"Xu","year":"2019","journal-title":"Psychol Med"},{"key":"10.1016\/j.nicl.2022.103122_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.pscychresns.2020.111231","article-title":"An association of myelin oligodendrocyte glycoprotein (MOG) gene variants with white matter volume in pediatric obsessive-compulsive disorder","volume":"307","author":"Zai","year":"2021","journal-title":"Psychiatry Res Neuroimaging"},{"key":"10.1016\/j.nicl.2022.103122_b0225","doi-asserted-by":"crossref","unstructured":"Ziegler, G., Hauser, T.U., Moutoussis, M., Bullmore, E.T., Goodyer, I.M., Fonagy, P., Jones, P.B., Consortium, N., Lindenberger, U., Dolan, R.J., 2019. Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories. Nat Neurosci 22, 992-999.","DOI":"10.1038\/s41593-019-0394-3"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158222001875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158222001875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:39:04Z","timestamp":1761971944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158222001875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":45,"alternative-id":["S2213158222001875"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2022.103122","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between gray\/white matter contrast and white matter microstructural alterations in medication-na\u00efve obsessive\u2013compulsive disorder","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2022.103122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103122"}}