{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:14:59Z","timestamp":1793218499898,"version":"4.5.0"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":251,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BE4045\/34-1"],"award-info":[{"award-number":["BE4045\/34-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["189136"],"award-info":[{"award-number":["189136"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030L_179450"],"award-info":[{"award-number":["320030L_179450"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.nicl.2022.103191","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T17:22:22Z","timestamp":1663089742000},"page":"103191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["White matter alterations in chronic MDMA use: Evidence from diffusion tensor imaging and neurofilament light chain blood levels"],"prefix":"10.1016","volume":"36","author":[{"given":"Josua","family":"Zimmermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Friedli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bavato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"St\u00e4mpfli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Coray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Baumgartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Grandgirard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen L.","family":"Leib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Seifritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Kathrin","family":"Stock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Beste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris B.","family":"Quednow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2022.103191_b0005","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1046\/j.1471-4159.2003.02247.x","article-title":"Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin","volume":"88","author":"Albertson","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nicl.2022.103191_b0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12035-019-01698-3","article-title":"Neurofilament Light Chain as a Biomarker, and Correlation with Magnetic Resonance Imaging in Diagnosis of CNS-Related Disorders","volume":"57","author":"Alirezaei","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.nicl.2022.103191_b0015","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","article-title":"An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging","volume":"125","author":"Andersson","year":"2016","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2022.103191_b0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40478-018-0649-3","article-title":"Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration","volume":"7","author":"Ashton","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.nicl.2022.103191_b0025","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.neuroimage.2011.02.082","article-title":"White matter cerebral blood flow is inversely correlated with structural and functional connectivity in the human brain","volume":"56","author":"Aslan","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2022.103191_b0030","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2022.103191_b0035","doi-asserted-by":"crossref","unstructured":"Bavato, F., Kexel, A.K., Kluwe-Schiavon, B., Maceski, A., Baumgartner, M.R., Seifritz, E., Kuhle, J., Quednow, B.B., 2022a. A longitudinal investigation of blood neurofilament light chain levels in chronic cocaine users.","DOI":"10.1101\/2022.02.03.22270384"},{"issue":"5-6","key":"10.1016\/j.nicl.2022.103191_b0040","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00702-022-02502-8","article-title":"Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine (\u201cEcstasy\u201d) induced cytoskeletal damage","volume":"129","author":"Bavato","year":"2022","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nicl.2022.103191_bib481","doi-asserted-by":"crossref","DOI":"10.1007\/s00702-022-02502-8","article-title":"Brain-derived neurotrophic factor protects serotonergic neurons against 3,4-methylenedioxymethamphetamine (\u201cEcstasy\u201d) induced cytoskeletal damage","author":"Bavato","year":"2022","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nicl.2022.103191_b0045","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/nbm.782","article-title":"The basis of anisotropic water diffusion in the nervous system \u2013 a technical review","volume":"15","author":"Beaulieu","year":"2002","journal-title":"NMR Biomed."},{"key":"10.1016\/j.nicl.2022.103191_b0050","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1177\/0269881116663120","article-title":"The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants?","volume":"30","author":"Bershad","year":"2016","journal-title":"J. Psychopharmacol. (Oxf.)"},{"issue":"6","key":"10.1016\/j.nicl.2022.103191_b0055","doi-asserted-by":"crossref","first-page":"e20678","DOI":"10.1371\/journal.pone.0020678","article-title":"Diffusion MRI of Structural Brain Plasticity Induced by a Learning and Memory Task","volume":"6","author":"Blumenfeld-Katzir","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.nicl.2022.103191_b0060","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.2174\/092986712803988947","article-title":"Neuropathological Alterations in Cocaine Abuse","volume":"19","author":"B\u00fcttner","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.nicl.2022.103191_b0065","doi-asserted-by":"crossref","first-page":"17149","DOI":"10.1038\/s41598-020-74054-4","article-title":"Bundle analytics, a computational framework for investigating the shapes and profiles of brain pathways across populations","volume":"10","author":"Chandio","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nicl.2022.103191_bib482","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-4927(99)00048-7","article-title":"Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study","volume":"98","author":"Chang","year":"2000","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.nicl.2022.103191_b0070","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41592-021-01185-5","article-title":"QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data","volume":"18","author":"Cieslak","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.nicl.2022.103191_b0075","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0022-5347(25)00317-9","article-title":"Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain","volume":"241","author":"Commins","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.nicl.2022.103191_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113894","article-title":"Neurotoxicity of MDMA: Main effects and mechanisms","volume":"347","author":"Costa","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nicl.2022.103191_b0085","doi-asserted-by":"crossref","unstructured":"Cowan, R.L., Haga, E., Frederick, B. deB, Dietrich, M.S., Vimal, R.L.P., Lukas, S.E., Renshaw, P.F., 2006. MDMA use is associated with increased spatial BOLD fMRI visual cortex activation in human MDMA users. Pharmacol. Biochem. Behav. 84, 219\u2013228. Doi: 10.1016\/j.pbb.2006.04.024.","DOI":"10.1016\/j.pbb.2006.04.024"},{"key":"10.1016\/j.nicl.2022.103191_b0090","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1176\/appi.ajp.158.10.1687","article-title":"Electrophysiological Evidence of Serotonergic Impairment in Long-Term MDMA (\u201cEcstasy\u201d) Users","volume":"158","author":"Croft","year":"2001","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.nicl.2022.103191_b0095","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000026668","article-title":"Is MDMA ('Ecstasy\u2019) neurotoxic in humans? An overview of evidence and of methodological problems in research","volume":"42","author":"Curran","year":"2000","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.nicl.2022.103191_b0100","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tips.2004.08.001","article-title":"Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans","volume":"25","author":"de la Torre","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.nicl.2022.103191_b0105","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1093\/brain\/awn255","article-title":"Sustained effects of ecstasy on the human brain: a prospective neuroimaging study in novel users","volume":"131","author":"de Win","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.103191_b0110","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1192\/bjp.bp.106.035089","article-title":"Neurotoxic effects of ecstasy on the thalamus","volume":"193","author":"de Win","year":"2008","journal-title":"Br. J. Psychiatry"},{"issue":"6","key":"10.1016\/j.nicl.2022.103191_b0115","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ana.24954","article-title":"Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis","volume":"81","author":"Disanto","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2022.103191_b0120","doi-asserted-by":"crossref","unstructured":"Eaton, W.W., Smith, C., Ybarra, M., Muntaner, C., Tien, A., 2004. Center for Epidemiologic Studies Depression Scale: Review and Revision (CESD and CESD-R), in: The Use of Psychological Testing for Treatment Planning and Outcomes Assessment: Instruments for Adults, Volume 3, 3rd Ed. Lawrence Erlbaum Associates Publishers, Mahwah, NJ, US, pp. 363\u2013377.","DOI":"10.1037\/t29280-000"},{"key":"10.1016\/j.nicl.2022.103191_b0125","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/npp.2013.195","article-title":"Abnormalities in White Matter Microstructure Associated with Chronic Ketamine Use","volume":"39","author":"Edward Roberts","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nicl.2022.103191_b0130","series-title":"The Encyclopedia of Clinical Psychology","first-page":"1","article-title":"Structured Clinical Interview for the DSM (SCID)","author":"First","year":"2015"},{"key":"10.1016\/j.nicl.2022.103191_b0135","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1523\/JNEUROSCI.15-08-05476.1995","article-title":"Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+\/-)3,4-methylenedioxymethamphetamine (MDMA, \u201cecstasy\u201d)","volume":"15","author":"Fischer","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2022.103191_b0140","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuro.2015.06.001","article-title":"Chronic MDMA induces neurochemical changes in the hippocampus of adolescent and young adult rats: Down-regulation of apoptotic markers","volume":"49","author":"Garc\u00eda-Cabrerizo","year":"2015","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.nicl.2022.103191_b0145","doi-asserted-by":"crossref","DOI":"10.3389\/fninf.2014.00008","article-title":"Dipy, a library for the analysis of diffusion MRI data","volume":"8","author":"Garyfallidis","year":"2014","journal-title":"Front. Neuroinformatics"},{"issue":"3","key":"10.1016\/j.nicl.2022.103191_b0150","doi-asserted-by":"crossref","first-page":"e0150657","DOI":"10.1371\/journal.pone.0150657","article-title":"Microstructure and Cerebral Blood Flow within White Matter of the Human Brain: A TBSS Analysis","volume":"11","author":"Giezendanner","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.nicl.2022.103191_b0155","first-page":"1727","article-title":"Multivoxel 3D Proton Spectroscopy in the Brain at 1.5 Versus 3.0 T: Signal-to-Noise Ratio and Resolution Comparison","volume":"22","author":"Gonen","year":"2001","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2022.103191_b0160","first-page":"5","article-title":"Nipype: A Flexible, Lightweight and Extensible Neuroimaging Data Processing Framework in Python","author":"Gorgolewski","year":"2011","journal-title":"Front. Neuroinformatics"},{"key":"10.1016\/j.nicl.2022.103191_b0165","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/0269881106059939","article-title":"The confounding problem of polydrug use in recreational ecstasy\/MDMA users: a brief overview","volume":"20","author":"Gouzoulis-Mayfrank","year":"2006","journal-title":"J. Psychopharmacol. (Oxf.)"},{"key":"10.1016\/j.nicl.2022.103191_b0170","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/pr.55.3.3","article-title":"The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, \u201cEcstasy\u201d)","volume":"55","author":"Green","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.nicl.2022.103191_b0175","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pbb.2007.10.003","article-title":"ACTIONS OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) ON CEREBRAL DOPAMINERIC, SEROTONERGIC AND CHOLINERGIC NEURONS","volume":"90","author":"Gudelsky","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nicl.2022.103191_b0180","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.drugalcdep.2019.02.005","article-title":"Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research","volume":"197","author":"Hampton","year":"2019","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.nicl.2022.103191_b0185","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1523\/JNEUROSCI.19-12-05096.1999","article-title":"Altered Serotonin Innervation Patterns in the Forebrain of Monkeys Treated with (\u00b1)3,4-Methylenedioxymethamphetamine Seven Years Previously: Factors Influencing Abnormal Recovery","volume":"19","author":"Hatzidimitriou","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2022.103191_b0190","doi-asserted-by":"crossref","unstructured":"Hornung, J.-P., 2010. CHAPTER 1.3 - The Neuronatomy of the Serotonergic System, in: M\u00fcller, C.P., Jacobs, B.L. (Eds.), Handbook of Behavioral Neuroscience, Handbook of the Behavioral Neurobiology of Serotonin. Elsevier, pp. 51\u201364. https:\/\/doi.org\/10.1016\/S1569-7339(10)70071-0.","DOI":"10.1016\/S1569-7339(10)70071-0"},{"key":"10.1016\/j.nicl.2022.103191_b0195","doi-asserted-by":"crossref","unstructured":"Hornung, J.-P., 2003. The human raphe nuclei and the serotonergic system. J. Chem. Neuroanat., Special Issue on the Human Brain - The Structural Basis for understanding Human Brain function and dysfunction 26, 331\u2013343. Doi: 10.1016\/j.jchemneu.2003.10.002.","DOI":"10.1016\/j.jchemneu.2003.10.002"},{"key":"10.1016\/j.nicl.2022.103191_b0200","first-page":"11","article-title":"White Matter Abnormalities Based on TBSS and Its Correlation With Impulsivity Behavior of Methamphetamine Addicts","author":"Huang","year":"2020","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.nicl.2022.103191_b0205","doi-asserted-by":"crossref","first-page":"e2133","DOI":"10.1212\/WNL.0000000000008572","article-title":"Longitudinal diffusion MRI as surrogate outcome measure for myelopathy in adrenoleukodystrophy","volume":"93","author":"Huffnagel","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.103191_b0210","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/clpt.2011.78","article-title":"The Norepinephrine Transporter Inhibitor Reboxetine Reduces Stimulant Effects of MDMA (\u201cEcstasy\u201d) in Humans","volume":"90","author":"Hysek","year":"2011","journal-title":"Clin. Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.nicl.2022.103191_b0215","doi-asserted-by":"crossref","first-page":"e36476","DOI":"10.1371\/journal.pone.0036476","article-title":"Duloxetine Inhibits Effects of MDMA (\u201cEcstasy\u201c) In Vitro and in Humans in a Randomized Placebo-Controlled Laboratory Study","volume":"7","author":"Hysek","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.nicl.2022.103191_b0220","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/hbm.22099","article-title":"Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging","volume":"34","author":"Jeurissen","year":"2012","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2022.103191_b0225","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/mrm.20033","article-title":"The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: A Monte Carlo study\u2020","volume":"51","author":"Jones","year":"2004","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.nicl.2022.103191_b0230","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroimage.2012.06.081","article-title":"White matter integrity, fiber count, and other fallacies: The do\u2019s and don\u2019ts of diffusion MRI","volume":"73","author":"Jones","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2022.103191_b0235","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.neuroimage.2009.02.029","article-title":"Prior MDMA (Ecstasy) use is associated with increased basal ganglia\u2013thalamocortical circuit activation during motor task performance in humans: An fMRI study","volume":"46","author":"Karageorgiou","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2022.103191_b0240","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","article-title":"Neurofilaments as biomarkers in neurological disorders","volume":"14","author":"Khalil","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.nicl.2022.103191_b0245","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0091-3057(01)00708-0","article-title":"How strong is the evidence that brain serotonin neurons are damaged in human users of ecstasy?","volume":"71","author":"Kish","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.nicl.2022.103191_b0250","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1212\/WNL.55.2.294","article-title":"Striatal serotonin is depleted in brain of a human MDMA (Ecstasy) user","volume":"55","author":"Kish","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.103191_b0255","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.addbeh.2017.05.005","article-title":"The relationship between social desirability bias and self-reports of health, substance use, and social network factors among urban substance users in Baltimore","volume":"73","author":"Latkin","year":"2017","journal-title":"Maryland. Addict. Behav."},{"key":"10.1016\/j.nicl.2022.103191_b0260","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1600-0404.1995.tb07018.x","article-title":"Multiple choice vocabulary test MWT as a valid and short test to estimate premorbid intelligence","volume":"91","author":"Lehrl","year":"1995","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.nicl.2022.103191_b0265","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0893-133X(99)00148-7","article-title":"Acute Psychological Effects of 3,4-Methylenedioxymethamphetamine (MDMA, \u201cEcstasy\u201d) are Attenuated by the Serotonin Uptake Inhibitor Citalopram","volume":"22","author":"Liechti","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nicl.2022.103191_b0270","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/15622975.2021.1907709","article-title":"Neurofilament light chain as novel blood biomarker of disturbed neuroaxonal integrity in patients with ketamine dependence","volume":"22","author":"Liu","year":"2021","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.nicl.2022.103191_b0275","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1148\/radiol.11101918","article-title":"Potential Long-term Effects of MDMA on the Basal Ganglia-Thalamocortical Circuit: A Proton MR Spectroscopy and Diffusion-Tensor Imaging Study","volume":"260","author":"Liu","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2022.103191_b0280","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.drugalcdep.2016.12.016","article-title":"A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects","volume":"173","author":"Ma","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.nicl.2022.103191_b0285","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/npp.1994.15","article-title":"Serotonin Neurotoxicity after (\u00b1)3,4-Methylenedioxymethamphetamine (MDMA; \u201cEcstasy\u201d): A Controlled Study in Humans","volume":"10","author":"McCann","year":"1994","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nicl.2022.103191_b0290","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s002130050967","article-title":"Cognitive performance in (\u00b1) 3,4-methylenedioxymethamphetamine (MDMA, \u201cecstasy\u201d) users: a controlled study","volume":"143","author":"McCann","year":"1999","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.nicl.2022.103191_b0295","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.nicl.2018.02.006","article-title":"Alcohol intake and brain white matter in middle aged men: Microscopic and macroscopic differences","volume":"18","author":"McEvoy","year":"2018","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.nicl.2022.103191_b0300","doi-asserted-by":"crossref","first-page":"e13149","DOI":"10.1111\/adb.13149","article-title":"The impact of levamisole and alcohol on white matter microstructure in adult chronic cocaine users","volume":"27","author":"Michels","year":"2022","journal-title":"Addict. Biol."},{"key":"10.1016\/j.nicl.2022.103191_b0305","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1080\/00952990701651564","article-title":"Diffusion Tensor Imaging in MDMA Users and Controls: Association with Decision Making","volume":"33","author":"Moeller","year":"2007","journal-title":"Am. J. Drug Alcohol Abuse"},{"key":"10.1016\/j.nicl.2022.103191_b0310","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/jnnp.2006.100248","article-title":"Dynamic changes in corticospinal tracts after stroke detected by fibretracking","volume":"78","author":"M\u00f8ller","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2022.103191_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113888","article-title":"Neurological and cognitive alterations induced by MDMA in humans","volume":"347","author":"Montgomery","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nicl.2022.103191_b0320","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neubiorev.2018.11.004","article-title":"Neuroimaging of chronic MDMA (\u201cecstasy\u201d) effects: A meta-analysis","volume":"96","author":"M\u00fcller","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nicl.2022.103191_b0325","first-page":"381","article-title":"MDMA and the Brain: A Short Review on the Role of Neurotransmitters in Neurotoxicity","volume":"11","author":"Mustafa","year":"2020","journal-title":"Basic Clin. Neurosci."},{"key":"10.1016\/j.nicl.2022.103191_b0330","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pscychresns.2014.01.005","article-title":"Chronic cocaine administration causes extensive white matter damage in brain: Diffusion tensor imaging and immunohistochemistry studies","volume":"221","author":"Narayana","year":"2014","journal-title":"Psychiatry Res. Neuroimaging"},{"key":"10.1016\/j.nicl.2022.103191_b0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: A primer with examples","volume":"15","author":"Nichols","year":"2002","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2022.103191_b0340","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1523\/JNEUROSCI.08-08-02788.1988","article-title":"Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity","volume":"8","author":"O\u2019Hearn","year":"1988","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nicl.2022.103191_b0345","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3174\/ajnr.A0488","article-title":"Diffusion Anisotropy Measurement of Brain White Matter Is Affected by Voxel Size: Underestimation Occurs in Areas with Crossing Fibers","volume":"28","author":"Oouchi","year":"2007","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2022.103191_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2021.109185","article-title":"White matter microstructure differences in individuals with dependence on cocaine, methamphetamine, and nicotine: Findings from the ENIGMA-Addiction working group","volume":"230","author":"Ottino-Gonz\u00e1lez","year":"2022","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.nicl.2022.103191_b0355","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/hup.351","article-title":"Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research","volume":"16","author":"Parrott","year":"2001","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"10.1016\/j.nicl.2022.103191_b0360","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/sj.npp.1300396","article-title":"Prepulse Inhibition and Habituation of Acoustic Startle Response in Male MDMA (\u2018Ecstasy\u2019) Users, Cannabis Users, and Healthy Controls","volume":"29","author":"Quednow","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nicl.2022.103191_b0365","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/0269881106061200","article-title":"Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction","volume":"20","author":"Quednow","year":"2006","journal-title":"J. Psychopharmacol. (Oxf.)"},{"key":"10.1016\/j.nicl.2022.103191_b0370","unstructured":"R Core Team, 2021. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria."},{"key":"10.1016\/j.nicl.2022.103191_b0375","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1126\/science.4023719","article-title":"Hallucinogenic amphetamine selectively destroys brain serotonin nerve terminals","volume":"229","author":"Ricaurte","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.nicl.2022.103191_b0380","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jama.1988.03410010059035","article-title":"(\u00b13,4-Methylenedioxymethamphetamine Selectively Damages Central Serotonergic Neurons in Nonhuman Primates","volume":"260","author":"Ricaurte","year":"1988","journal-title":"JAMA"},{"key":"10.1016\/j.nicl.2022.103191_b0385","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.neubiorev.2016.02.003","article-title":"Meta-analysis of molecular imaging of serotonin transporters in ecstasy\/polydrug users","volume":"63","author":"Roberts","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nicl.2022.103191_b0390","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neubiorev.2017.07.015","article-title":"MDMA and brain activity during neurocognitive performance: An overview of neuroimaging studies with abstinent \u2018Ecstasy\u2019 users","volume":"84","author":"Roberts","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nicl.2022.103191_b0395","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s00115-003-1622-2","article-title":"Instrumente zur Diagnostik der Aufmerksamkeitsdefizit-\/Hyperaktivit\u00e4tsst\u00f6rung (ADHS) im Erwachsenenalter","volume":"75","author":"R\u00f6sler","year":"2004","journal-title":"Nervenarzt"},{"key":"10.1016\/j.nicl.2022.103191_b0400","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.neuron.2017.11.026","article-title":"White Matter Plasticity in the Adult Brain","volume":"96","author":"Sampaio-Baptista","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.nicl.2022.103191_b0405","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/jat\/bkaa131","article-title":"A Comprehensive Multi-Analyte Method for Hair Analysis: Substance-Specific Quantification Ranges and Tool for Task-Oriented Data Evaluation","volume":"45","author":"Scholz","year":"2021","journal-title":"J. Anal. Toxicol."},{"key":"10.1016\/j.nicl.2022.103191_b0410","doi-asserted-by":"crossref","first-page":"2322.e5","DOI":"10.1016\/j.neurobiolaging.2010.05.019","article-title":"A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer\u2019s disease","volume":"32","author":"Sexton","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2022.103191_b0415","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.nicl.2022.103191_b0420","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2022.103191_b0425","doi-asserted-by":"crossref","unstructured":"Strous, J.F.M., Weeland, C.J., van der Draai, F.A., Daams, J.G., Denys, D., Lok, A., Schoevers, R.A., Figee, M., 2022. Brain Changes Associated With Long-Term Ketamine Abuse, A Systematic Review. Front. Neuroanat. 16.","DOI":"10.3389\/fnana.2022.795231"},{"key":"10.1016\/j.nicl.2022.103191_b0430","unstructured":"United Nations Office on Drugs and Crime, 2022. World Drug Report 2021, 2021st ed. United Nations."},{"key":"10.1016\/j.nicl.2022.103191_b0435","series-title":"Python 3 Reference Manual","author":"Van Rossum","year":"2009"},{"key":"10.1016\/j.nicl.2022.103191_b0440","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.drugalcdep.2016.09.023","article-title":"White matter disruptions in male cocaine polysubstance users: Associations with severity of drug use and duration of abstinence","volume":"168","author":"van Son","year":"2016","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.nicl.2022.103191_b0445","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.neuroimage.2018.07.070","article-title":"TractSeg - Fast and accurate white matter tract segmentation","volume":"183","author":"Wasserthal","year":"2018","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2022.103191_b0450","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1038\/s41386-020-0691-2","article-title":"Multiparametric mapping of white matter microstructure in catatonia","volume":"45","author":"Wasserthal","year":"2020","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.nicl.2022.103191_b0455","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.euroneuro.2021.04.007","article-title":"White matter microstructure alterations in cortico-striatal networks are associated with parkinsonism in schizophrenia spectrum disorders","volume":"50","author":"Wasserthal","year":"2021","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.nicl.2022.103191_b0460","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1148\/radiol.14140925","article-title":"Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis","volume":"275","author":"Welton","year":"2015","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2022.103191_b0465","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.euroneuro.2017.08.425","article-title":"Discrete memory impairments in largely pure chronic users of MDMA","volume":"27","author":"Wunderli","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"11","key":"10.1016\/j.nicl.2022.103191_b0470","doi-asserted-by":"crossref","first-page":"e49790","DOI":"10.1371\/journal.pone.0049790","article-title":"Tract Profiles of White Matter Properties: Automating Fiber-Tract Quantification","volume":"7","author":"Yeatman","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.nicl.2022.103191_b0475","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mri.2010.06.027","article-title":"Moderating registration misalignment in voxelwise comparisons of DTI data: a performance evaluation of skeleton projection","volume":"29","author":"Zalesky","year":"2011","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.nicl.2022.103191_b0480","unstructured":"Zimmermann, J., Friedli, N., Coray, C., Bavato, F., Baumgartner, M.R., Opitz, A., Seifritz, E., Stock, A., Beste, C., Cole, D.M., Quednow, B.B., under review, Short- and long-term neuroplasticity in the human serotonin system assessed via raphe nuclei functional connectivity."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221315822200256X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221315822200256X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T05:58:34Z","timestamp":1741586314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221315822200256X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":98,"alternative-id":["S221315822200256X"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2022.103191","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White matter alterations in chronic MDMA use: Evidence from diffusion tensor imaging and neurofilament light chain blood levels","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2022.103191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103191"}}