{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:44:49Z","timestamp":1787161489435,"version":"build-2736575974"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.nicl.2022.103240","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T13:35:58Z","timestamp":1666704958000},"page":"103240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Neuroimaging in Leber Hereditary Optic Neuropathy: State-of-the-art and future prospects"],"prefix":"10.1016","volume":"36","author":[{"given":"Hugo T.","family":"Chow-Wing-Bom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina F.","family":"Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Yu-Wai-Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa M.","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2022.103240_b0005","doi-asserted-by":"crossref","unstructured":"Acaro\u01e7lu, G., Kansu, T., & Do\u01e7ulu, \u00c7. F. (2001). Visual recovery patterns in children with Leber\u2019s hereditary optic neuropathy. International Ophthalmology, 24(6), 349\u2013355. 10.1023\/B:INTE.0000006855.48323.f1.","DOI":"10.1023\/B:INTE.0000006855.48323.f1"},{"issue":"1\u20132","key":"10.1016\/j.nicl.2022.103240_b0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jns.2013.04.018","article-title":"Multiple sclerosis and mitochondrial gene variations: A review","volume":"330","author":"Andalib","year":"2013","journal-title":"Journal of the Neurological Sciences"},{"issue":"6","key":"10.1016\/j.nicl.2022.103240_b0015","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1172\/JCI57377","article-title":"The human visual cortex responds to gene therapy-mediated recovery of retinal function","volume":"121","author":"Ashtari","year":"2011","journal-title":"Journal of Clinical Investigation"},{"issue":"296","key":"10.1016\/j.nicl.2022.103240_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aaa8791","article-title":"Plasticity of the human visual system after retinal gene therapy in patients with Leber\u2019s congenital amaurosis","volume":"7","author":"Ashtari","year":"2015","journal-title":"Science Translational Medicine"},{"issue":"3","key":"10.1016\/j.nicl.2022.103240_b0025","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1523\/JNEUROSCI.3476-04.2005","article-title":"Reorganization of visual processing in macular degeneration","volume":"25","author":"Baker","year":"2005","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0030","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ophtha.2004.06.034","article-title":"Retinal nerve fiber layer evaluation by optical coherence tomography in Leber\u2019s hereditary optic neuropathy","volume":"112","author":"Barboni","year":"2005","journal-title":"Ophthalmology"},{"issue":"12","key":"10.1016\/j.nicl.2022.103240_b0035","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1002\/hbm.20985","article-title":"Evidence for retrochiasmatic tissue loss in Leber\u2019s hereditary optic neuropathy","volume":"31","author":"Barcella","year":"2010","journal-title":"Human Brain Mapping"},{"key":"10.1016\/j.nicl.2022.103240_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2017.06.051","article-title":"Mitochondria in neuroinflammation \u2013 Multiple sclerosis (MS), leber hereditary optic neuropathy (LHON) and LHON-MS","volume":"710","author":"Bargiela","year":"2019","journal-title":"Neuroscience Letters"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0045","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nn817","article-title":"Reorganization of human cortical maps caused by inherited photoreceptor abnormalities","volume":"5","author":"Baseler","year":"2002","journal-title":"Nature Neuroscience"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0050","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00041327-200303000-00007","article-title":"Chiasmal high signal on magnetic resonance imaging in the atrophic phase of leber hereditary optic neuropathy","volume":"23","author":"Batio\u01e7lu","year":"2003","journal-title":"Journal of Neuro-Ophthalmology"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0055","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/WNO.0000000000000621","article-title":"MRI of the Optic Nerves and Chiasm in Patients with Leber Hereditary Optic Neuropathy","volume":"38","author":"Blanc","year":"2018","journal-title":"Journal of Neuro-Ophthalmology"},{"issue":"9","key":"10.1016\/j.nicl.2022.103240_b0060","doi-asserted-by":"crossref","first-page":"096601","DOI":"10.1088\/0034-4885\/76\/9\/096601","article-title":"The physics of functional magnetic resonance imaging (fMRI)","volume":"76","author":"Buxton","year":"2013","journal-title":"Reports on Progress in Physics"},{"key":"10.1016\/j.nicl.2022.103240_b0065","first-page":"3","article-title":"Leber\u2019s Hereditary Optic Neuropathy \u2013 A Global Perspective","volume":"13(Suppl 2","author":"Carelli","year":"2019","journal-title":"European Ophthalmic Review"},{"issue":"December 2019","key":"10.1016\/j.nicl.2022.103240_b0070","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.neubiorev.2020.02.028","article-title":"Neuroplasticity in adult human visual cortex","volume":"112","author":"Castaldi","year":"2020","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1016\/j.nicl.2022.103240_b0075","doi-asserted-by":"crossref","unstructured":"Catarino, C. B., & Klopstock, T. (2017). Use of Idebenone for the Treatment of Leber\u2019s Hereditary Optic Neuropathy. Journal of Inborn Errors of Metabolism and Screening, 5, 232640981773111. 10.1177\/2326409817731112.","DOI":"10.1177\/2326409817731112"},{"key":"10.1016\/j.nicl.2022.103240_b0080","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuroimage.2013.05.032","article-title":"Long term cortical plasticity in visual retinotopic areas in humans with silent retinal ganglion cell loss","volume":"81","author":"d\u2019Almeida","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2022.103240_b0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-vision-091517-033948","article-title":"How visual cortical organization is altered by ophthalmologic and neurologic disorders","volume":"4","author":"Dumoulin","year":"2018","journal-title":"Annual Review of Vision Science"},{"key":"10.1016\/j.nicl.2022.103240_b0090","doi-asserted-by":"crossref","unstructured":"Farahbakhsh, M., Anderson, E. J., Rider, A., Greenwood, J. A., Hirji, N., Zaman, S., Jones, P. R., Schwarzkopf, D. S., Rees, G., Michaelides, M., & Dekker, T. M. (2020). A demonstration of cone function plasticity after gene therapy in achromatopsia. medRxiv. 10.1101\/2020.12.16.20246710.","DOI":"10.1101\/2020.12.16.20246710"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/WNO.0000000000000419","article-title":"Swelling of the optic nerve head: A backstage view of a staging scheme","volume":"37","author":"Fris\u00e9n","year":"2017","journal-title":"Journal of Neuro-Ophthalmology"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0100","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3390\/jcm9041112","article-title":"The Evaluation of Optic Nerves Using 7 Tesla \u201cSilent\u201d Zero Echo Time Imaging in Patients with Leber\u2019s Hereditary Optic Neuropathy with or without Idebenone Treatment","volume":"9","author":"Grochowski","year":"2020","journal-title":"Journal of Clinical Medicine"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0105","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/jcm10010014","article-title":"Alteration within the Hippocampal Volume in Patients with LHON Disease\u20147 Tesla MRI Study","volume":"10","author":"Grochowski","year":"2021","journal-title":"Journal of Clinical Medicine"},{"issue":"2","key":"10.1016\/j.nicl.2022.103240_b0110","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1148\/radiographics.14.2.8190954","article-title":"Magnetization transfer: theory and clinical applications in neuroradiology.","volume":"14","author":"Grossman","year":"1994","journal-title":"RadioGraphics"},{"issue":"6","key":"10.1016\/j.nicl.2022.103240_b0115","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/mrm.21732","article-title":"High-resolution maps of magnetization transfer with inherent correction for RF inhomogeneity and T1 relaxation obtained from 3D FLASH MRI","volume":"60","author":"Helms","year":"2008","journal-title":"Magnetic Resonance in Medicine"},{"issue":"2","key":"10.1016\/j.nicl.2022.103240_b0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/nbm.683","article-title":"Magnetization transfer in MRI: A review","volume":"14","author":"Henkelman","year":"2001","journal-title":"NMR in Biomedicine"},{"issue":"2","key":"10.1016\/j.nicl.2022.103240_b0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/WNO.0000000000000511","article-title":"Advanced MRI of the Optic Nerve","volume":"37","author":"Hoch","year":"2017","journal-title":"Journal of Neuro-Ophthalmology"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0130","first-page":"294","article-title":"Hyperintense optic nerve lesion on T2-weighted MRI imaging in the acute stage of Leber\u2019s hereditary optic neuropathy: A case report","volume":"46","author":"Honda","year":"2006","journal-title":"Clinical Neurology"},{"issue":"2","key":"10.1016\/j.nicl.2022.103240_b0135","first-page":"228","article-title":"Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA \u2013 Haplogroup","volume":"81","author":"Hudson","year":"2007","journal-title":"Background."},{"issue":"SPEC. ISS. A","key":"10.1016\/j.nicl.2022.103240_b0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1102\/1470-7330.2010.9023","article-title":"Diffusion-weighted and diffusion tensor imaging of the brain, made easy","volume":"10","author":"Huisman","year":"2010","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.nicl.2022.103240_b0145","doi-asserted-by":"crossref","unstructured":"Inglese, M., Rovaris, M., Bianchi, S., La Mantia, L., Mancardi, G. L., Ghezzi, A., Montagna, P., Salvi, F., & Filippi, M. (2001). Magnetic resonance, magnetisation transfer, and diffusion weighted imaging correlates of optic nerve, brain, and cervical cord damage in Leber\u2019s hereditary optic neuropathy. Journal of Neurology, Neurosurgery & Psychiatry, 70(4), 431\u2013431. 10.1136\/jnnp.70.4.431.","DOI":"10.1136\/jnnp.70.4.431"},{"issue":"9","key":"10.1016\/j.nicl.2022.103240_b0150","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.3390\/jcm9092914","article-title":"Decreased Volume of Lateral and Medial Geniculate Nuclei in Patients with LHON Disease\u20147 Tesla MRI Study","volume":"9","author":"Jonak","year":"2020","journal-title":"Journal of Clinical Medicine"},{"issue":"6","key":"10.1016\/j.nicl.2022.103240_b0155","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/brainsci10060359","article-title":"Neuroanatomical Changes in Leber\u2019s Hereditary Optic Neuropathy: Clinical Application of 7T MRI Submillimeter Morphometry","volume":"10","author":"Jonak","year":"2020","journal-title":"Brain Sciences"},{"key":"10.1016\/j.nicl.2022.103240_b0160","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neuroscience.2020.12.019","article-title":"Aberrant Structural Network Architecture in Leber\u2019s Hereditary Optic Neuropathy. Minimum Spanning Tree Graph Analysis Application into Diffusion 7T MRI","volume":"455","author":"Jonak","year":"2021","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.nicl.2022.103240_b0165","doi-asserted-by":"crossref","first-page":"7739","DOI":"10.1167\/iovs.14-15388","article-title":"LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: Biodistribution and toxicology profile","volume":"55","author":"Koilkonda","year":"2014","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"5","key":"10.1016\/j.nicl.2022.103240_b0170","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/jnnp.2009.174953","article-title":"Papilloedema and MRI enhancement of the prechiasmal optic nerve at the acute stage of Leber hereditary optic neuropathy","volume":"81","author":"Lamirel","year":"2010","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"1424","key":"10.1016\/j.nicl.2022.103240_b0175","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1098\/rstb.2002.1114","article-title":"The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal","volume":"357","author":"Logothetis","year":"2002","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"issue":"6","key":"10.1016\/j.nicl.2022.103240_b0180","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1007\/s00415-019-09284-2","article-title":"Brain white matter changes in asymptomatic carriers of Leber\u2019s hereditary optic neuropathy","volume":"266","author":"Long","year":"2019","journal-title":"Journal of Neurology"},{"issue":"July","key":"10.1016\/j.nicl.2022.103240_b0185","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.mito.2017.07.006","article-title":"The pattern of retinal ganglion cell dysfunction in Leber hereditary optic neuropathy","volume":"36","author":"Majander","year":"2017","journal-title":"Mitochondrion"},{"issue":"7","key":"10.1016\/j.nicl.2022.103240_b0190","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3174\/ajnr.A4272","article-title":"Diffusion Tensor Imaging Mapping of Brain White Matter Pathology in Mitochondrial Optic Neuropathies","volume":"36","author":"Manners","year":"2015","journal-title":"American Journal of Neuroradiology"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0195","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jnnp.64.1.124","article-title":"Orbital high resolution magnetic resonance imaging with fast spin echo in the acute stage of Leber\u2019s hereditary optic neuropathy","volume":"64","author":"Mashima","year":"1998","journal-title":"Journal of Neurology Neurosurgery and Psychiatry"},{"issue":"3","key":"10.1016\/j.nicl.2022.103240_b0200","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00429-015-1002-2","article-title":"Genetically induced impairment of retinal ganglion cells at the axonal level is linked to extrastriate cortical plasticity","volume":"221","author":"Mateus","year":"2016","journal-title":"Brain Structure and Function"},{"issue":"5","key":"10.1016\/j.nicl.2022.103240_b0205","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/jnnp-2014-308186","article-title":"MRI in Leber\u2019s hereditary optic neuropathy: The relationship to multiple sclerosis","volume":"86","author":"Matthews","year":"2015","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0210","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/WNO.0000000000000524","article-title":"Vision loss and symmetric basal ganglia lesions in Leber hereditary optic neuropathy","volume":"37","author":"Mercuri","year":"2017","journal-title":"Journal of Neuro-Ophthalmology"},{"issue":"9","key":"10.1016\/j.nicl.2022.103240_b0215","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1007\/s00415-011-6406-1","article-title":"Patterns of white matter diffusivity abnormalities in Leber\u2019s hereditary optic neuropathy: A tract-based spatial statistics study","volume":"259","author":"Milesi","year":"2012","journal-title":"Journal of Neurology"},{"key":"10.1016\/j.nicl.2022.103240_b0220","doi-asserted-by":"crossref","first-page":"108990","DOI":"10.1016\/j.jneumeth.2020.108990","article-title":"Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging","volume":"348","author":"Mohammadi","year":"2021","journal-title":"Journal of Neuroscience Methods"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0225","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ophtha.2020.12.032","article-title":"Mitochondrial Disorders and the Eye: A New Era for Diagnosis","volume":"128","author":"Moore","year":"2021","journal-title":"Ophthalmology"},{"issue":"15 Supplement","key":"10.1016\/j.nicl.2022.103240_b0230","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1212\/WNL.94.15_supplement.2339","article-title":"rAAV2\/2-ND4 for the Treatment of Leber Hereditary Optic Neuropathy (LHON): Final Results from the RESCUE and REVERSE Phase III Clinical Trials and Experimental Data in Nonhuman Primates to Support a Bilateral Effect (2339)","volume":"94","author":"Moster","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2022.103240_b0235","doi-asserted-by":"crossref","DOI":"10.1097\/WNO.0000000000001045","article-title":"Visual Outcomes in Leber Hereditary Optic Neuropathy Patients With the m.11778G>A (MTND4) Mitochondrial DNA Mutation","author":"Newman","year":"2020","journal-title":"Journal of Neuro-Ophthalmology, Publish Ah(C)"},{"issue":"May","key":"10.1016\/j.nicl.2022.103240_b0240","article-title":"Intravitreal Gene Therapy vs. Natural History in Patients With Leber Hereditary Optic Neuropathy Carrying the m.11778G>A ND4 Mutation: Systematic Review and Indirect Comparison","volume":"12","author":"Newman","year":"2021","journal-title":"Frontiers in Neurology"},{"issue":"10","key":"10.1016\/j.nicl.2022.103240_b0245","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1167\/iovs.14-14737","article-title":"White matter consequences of retinal receptor and ganglion cell damage","volume":"55","author":"Ogawa","year":"2014","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"17","key":"10.1016\/j.nicl.2022.103240_b0250","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.0b013e3182a95698","article-title":"Teaching NeuroImages: Chiasmal enlargement and enhancement in Leber hereditary optic neuropathy","volume":"81","author":"Ong","year":"2013","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm10010151","article-title":"Changes in visual function and correlations with inner retinal structure in acute and chronic leber\u2019s hereditary optic neuropathy patients after treatment with idebenone","volume":"10","author":"Pemp","year":"2021","journal-title":"Journal of Clinical Medicine"},{"key":"10.1016\/j.nicl.2022.103240_b0260","unstructured":"Pfeffer, G., Burke, A., Yu-Wai-Man, P., Compston, D. A. S., & Chinnery, Patrick, F. (2014). Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations. Neurology. 2013 Nov 6 (epub ahead of print). Journal of Neuro-Ophthalmology, 34(1), 90\u201391. http:\/\/www.embase.com\/search\/results?subaction=viewrecord&from=export&id=L372468170%5Cnhttp:\/\/dx.doi.org\/10.1097\/WNO.0000000000000104%5Cnhttp:\/\/sfx.aub.aau.dk\/sfxaub?sid=EMBASE&issn=10708022&id=doi:10.1097%2FWNO.0000000000000104&atitle=Clinical+features+o."},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0265","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/archopht.121.4.577","article-title":"Chiasmal Enlargement and Optic Nerve Enhancement on Magnetic Resonance Imaging in Leber Hereditary Optic Neuropathy","volume":"121","author":"Phillips","year":"2003","journal-title":"Archives of Ophthalmology"},{"issue":"10","key":"10.1016\/j.nicl.2022.103240_b0270","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/sj.ejhg.5201828","article-title":"Epidemiology and penetrance of Leber hereditary optic neuropathy in Finland","volume":"15","author":"Puomila","year":"2007","journal-title":"European Journal of Human Genetics"},{"issue":"3","key":"10.1016\/j.nicl.2022.103240_b0275","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00415-011-6230-7","article-title":"Auditory function in individuals within Leber\u2019s hereditary optic neuropathy pedigrees","volume":"259","author":"Rance","year":"2012","journal-title":"Journal of Neurology"},{"issue":"2","key":"10.1016\/j.nicl.2022.103240_b0280","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/bjophthalmol-2017-311443","article-title":"Correspondence between retinotopic cortical mapping and conventional functional and morphological assessment of retinal disease","volume":"103","author":"Ritter","year":"2019","journal-title":"British Journal of Ophthalmology"},{"issue":"11","key":"10.1016\/j.nicl.2022.103240_b0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0050230","article-title":"Secondary Post-Geniculate Involvement in Leber\u2019s Hereditary Optic Neuropathy","volume":"7","author":"Rizzo","year":"2012","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.nicl.2022.103240_b0290","doi-asserted-by":"crossref","first-page":"e17081","DOI":"10.1371\/journal.pone.0017081","article-title":"Extra-visual functional and structural connection abnormalities in Leber\u2019s hereditary optic neuropathy","volume":"6","author":"Rocca","year":"2011","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.nicl.2022.103240_b0295","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10072-011-0636-y","article-title":"Resting-state brain networks: Literature review and clinical applications","volume":"32","author":"Rosazza","year":"2011","journal-title":"Neurological Sciences"},{"issue":"February","key":"10.1016\/j.nicl.2022.103240_b0300","article-title":"Optic nerve atrophy and whole and regional brain atrophy in Leber\u2019s hereditary optic neuropathy with multiple sclerosis-like disease with m.11778G>A mutation","volume":"42","author":"Ro\u015bciszewska-\u017bukowska","year":"2020","journal-title":"Multiple Sclerosis and Related Disorders"},{"key":"10.1016\/j.nicl.2022.103240_b0305","first-page":"1085","article-title":"First Application of Extremely High- resolution Magnetic Resonance Imaging to","author":"Sadun","year":"2002","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0310","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ophtha.2004.09.033","article-title":"Retinal nerve fiber layer evaluation by optical coherence tomography in unaffected carriers with Leber\u2019s hereditary optic neuropathy mutations","volume":"112","author":"Savini","year":"2005","journal-title":"Ophthalmology"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0315","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/RMR.0000000000000214","article-title":"The State of Resting State Networks","volume":"28","author":"Seitzman","year":"2019","journal-title":"Topics in Magnetic Resonance Imaging"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0320","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10633-012-9328-z","article-title":"Clinical and electrophysiological recovery in Leber hereditary optic neuropathy with G3460A mutation","volume":"125","author":"Sharkawi","year":"2012","journal-title":"Documenta Ophthalmologica"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0325","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/1971400917697342","article-title":"Resting state fMRI: A review on methods in resting state connectivity analysis and resting state networks","volume":"30","author":"Smitha","year":"2017","journal-title":"Neuroradiology Journal"},{"key":"10.1016\/j.nicl.2022.103240_b0330","doi-asserted-by":"crossref","unstructured":"Stenton, S. L., Sheremet, N. L., Catarino, C. B., Andreeva, N. A., Assouline, Z., Barboni, P., Barel, O., Berutti, R., Bychkov, I., Caporali, L., Capristo, M., Carbonelli, M., Cascavilla, M. L., Charbel Issa, P., Freisinger, P., Gerber, S., Ghezzi, D., Graf, E., Heidler, J., \u2026 Prokisch, H. (2021). Impaired complex I repair causes recessive Leber\u2019s hereditary optic neuropathy. Journal of Clinical Investigation, 131(6). 10.1172\/JCI138267.","DOI":"10.1172\/JCI138267"},{"issue":"9","key":"10.1016\/j.nicl.2022.103240_b0335","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1136\/jnnp.2003.032714","article-title":"A review of structural magnetic resonance neuroimaging","volume":"75","author":"Symms","year":"2004","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"December 2018","key":"10.1016\/j.nicl.2022.103240_b0340","article-title":"Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage","volume":"23","author":"Takemura","year":"2019","journal-title":"NeuroImage: Clinical"},{"issue":"5","key":"10.1016\/j.nicl.2022.103240_b0345","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1371\/journal.pone.0063446","article-title":"Raised Intraocular Pressure as a Potential Risk Factor for Visual Loss in Leber Hereditary Optic Neuropathy","volume":"8","author":"Thouin","year":"2013","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.nicl.2022.103240_b0350","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00041327-200303000-00057","article-title":"Optic nerve and chiasmal enhancement in leber hereditary optic neuropathy [1]","volume":"23","author":"Vaphiades","year":"2003","journal-title":"Journal of Neuro-Ophthalmology"},{"issue":"January","key":"10.1016\/j.nicl.2022.103240_b0355","first-page":"2","article-title":"Efficacy and Safety of rAAV2-ND4 Treatment for Leber\u00e2 (tm) s Hereditary Optic Neuropathy","volume":"6","author":"Wan","year":"2016","journal-title":"Scientific Reports"},{"issue":"May","key":"10.1016\/j.nicl.2022.103240_b0360","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejrad.2017.05.025","article-title":"Quantitative assessment of optic nerve in patients with Leber\u2019s hereditary optic neuropathy using reduced field-of-view diffusion tensor imaging","volume":"93","author":"Wang","year":"2017","journal-title":"European Journal of Radiology"},{"issue":"4","key":"10.1016\/j.nicl.2022.103240_b0365","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/WCO.0000000000000222","article-title":"Advances in MRI-based computational neuroanatomy: From morphometry to in-vivo histology","volume":"28","author":"Weiskopf","year":"2015","journal-title":"Current Opinion in Neurology"},{"issue":"8","key":"10.1016\/j.nicl.2022.103240_b0370","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s42254-021-00326-1","article-title":"Quantitative magnetic resonance imaging of brain anatomy and in vivo histology","volume":"3","author":"Weiskopf","year":"2021","journal-title":"Nature Reviews Physics"},{"issue":"5","key":"10.1016\/j.nicl.2022.103240_b0375","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/mrm.21965","article-title":"About \u201caxial\u201d and \u201cradial\u201d diffusivities","volume":"61","author":"Wheeler-Kingshott","year":"2009","journal-title":"Magnetic Resonance in Medicine"},{"issue":"FEB","key":"10.1016\/j.nicl.2022.103240_b0380","article-title":"Understanding the physiopathology behind axial and radial diffusivity changes-what do we Know?","volume":"9","author":"Winklewski","year":"2018","journal-title":"Frontiers in Neurology"},{"key":"10.1016\/j.nicl.2022.103240_b0385","unstructured":"Yu-Wai-Man, P., & Chinnery, Patrick, F. (2000). Leber Hereditary Optic Neuropathy. In editors. Adam MP, Ardinger HH, Pagon RA, et al. (Ed.), Gene Reviews (pp. 1\u201319). https:\/\/www.ncbi.nlm.nih.gov\/books\/."},{"issue":"2","key":"10.1016\/j.nicl.2022.103240_b0390","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1086\/346066","article-title":"The epidemiology of leber hereditary optic neuropathy in the North East of England","volume":"72","author":"Yu-Wai-Man","year":"2003","journal-title":"American Journal of Human Genetics"},{"issue":"6","key":"10.1016\/j.nicl.2022.103240_b0395","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00401-016-1625-2","article-title":"A neurodegenerative perspective on mitochondrial optic neuropathies","volume":"132","author":"Yu-Wai-Man","year":"2016","journal-title":"Acta Neuropathologica"},{"issue":"573","key":"10.1016\/j.nicl.2022.103240_b0400","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaz7423","article-title":"Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy","volume":"12","author":"Yu-Wai-Man","year":"2020","journal-title":"Science Translational Medicine"},{"issue":"2","key":"10.1016\/j.nicl.2022.103240_b0405","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3892\/etm.2013.1430","article-title":"Characterization of retinal nerve fiber layer thickness changes associated with leber\u2019s hereditary optic neuropathy by optical coherence tomography","volume":"7","author":"Zhang","year":"2014","journal-title":"Experimental and Therapeutic Medicine"},{"key":"10.1016\/j.nicl.2022.103240_b0410","article-title":"Abnormal large-scale structural rich club organization in Leber \u2019 s hereditary optic neuropathy","volume":"30","author":"Zhang","year":"2021","journal-title":"NeuroImage: Clinical"},{"issue":"6","key":"10.1016\/j.nicl.2022.103240_b0415","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1177\/1120672120936592","article-title":"Treatment of Leber\u2019s hereditary optic neuropathy: An overview of recent developments","volume":"30","author":"Zuccarelli","year":"2020","journal-title":"European Journal of Ophthalmology"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158222003059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158222003059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T02:01:04Z","timestamp":1741572064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158222003059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":83,"alternative-id":["S2213158222003059"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2022.103240","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroimaging in Leber Hereditary Optic Neuropathy: State-of-the-art and future prospects","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2022.103240","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103240"}}