{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:34:13Z","timestamp":1790699653743,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG021055"],"award-info":[{"award-number":["R01AG021055"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG053555"],"award-info":[{"award-number":["R01AG053555"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.nicl.2022.103308","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T02:28:40Z","timestamp":1672194520000},"page":"103308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Posterior white matter hyperintensities are associated with reduced medial temporal lobe subregional integrity and long-term memory in older adults"],"prefix":"10.1016","volume":"37","author":[{"given":"Batool","family":"Rizvi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithra","family":"Sathishkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddie","family":"M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myra S.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake A.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina K.","family":"Hollearn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Tustison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Greenia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Corrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia H.","family":"Kawas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Yassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.nicl.2022.103308_b0005","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000091398","article-title":"Identifying patients at high and low risk of cognitive decline using Rey Auditory Verbal Learning Test among middle-aged memory clinic outpatients","volume":"21","author":"Andersson","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"7","key":"10.1016\/j.nicl.2022.103308_b0010","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.neurobiolaging.2008.08.008","article-title":"Subregional hippocampal atrophy predicts Alzheimer\u2019s dementia in the cognitively normal","volume":"31","author":"Apostolova","year":"2010","journal-title":"Neurobiol. Aging"},{"issue":"7","key":"10.1016\/j.nicl.2022.103308_b0015","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/geronb\/gbx181","article-title":"Recognition memory dysfunction relates to hippocampal subfield volume: a study of cognitively Normal and mildly impaired older adults","volume":"74","author":"Bennett","year":"2019","journal-title":"J. Gerontol.: Ser. B."},{"issue":"4","key":"10.1016\/j.nicl.2022.103308_b0020","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.neurobiolaging.2013.10.072","article-title":"Regional white matter hyperintensities: aging, Alzheimer\u2019s disease risk, and cognitive function","volume":"35","author":"Birdsill","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"4","key":"10.1016\/j.nicl.2022.103308_b0025","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.nicl.2022.103308_b0030","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000016053","article-title":"Posterior cerebral artery territory infarcts: clinical features, infarct topography, causes and outcome1","volume":"10","author":"Brandt","year":"2000","journal-title":"Cerebrovasc. Dis."},{"issue":"12","key":"10.1016\/j.nicl.2022.103308_b0035","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11910-013-0415-7","article-title":"Contemplating Alzheimer\u2019s disease and the contribution of white matter hyperintensities","volume":"13","author":"Brickman","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"5","key":"10.1016\/j.nicl.2022.103308_b0040","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1007\/s11682-019-00151-2","article-title":"Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals","volume":"14","author":"Brugulat-Serrat","year":"2020","journal-title":"Brain Imaging Behav."},{"issue":"6","key":"10.1016\/j.nicl.2022.103308_b0045","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tins.2018.03.001","article-title":"Shared functions of perirhinal and parahippocampal cortices: implications for cognitive aging","volume":"41","author":"Burke","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nicl.2022.103308_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.750154","article-title":"Medial temporal lobe subregional atrophy in aging and Alzheimer\u2019s disease: a longitudinal study","volume":"13","author":"Chauveau","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nicl.2022.103308_b0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuroscience.2015.08.033","article-title":"Structural imaging of hippocampal subfields in healthy aging and Alzheimer\u2019s disease","volume":"309","author":"De Flores","year":"2015","journal-title":"Neuroscience"},{"issue":"3-4","key":"10.1016\/j.nicl.2022.103308_b0060","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00429-010-0283-8","article-title":"Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer\u2019s disease","volume":"215","author":"Ech\u00e1varri","year":"2011","journal-title":"Brain Struct. Funct."},{"issue":"1","key":"10.1016\/j.nicl.2022.103308_b0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35036213","article-title":"A cortical\u2013hippocampal system for declarative memory","volume":"1","author":"Eichenbaum","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.nicl.2022.103308_b0070","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/alz.12410","article-title":"White matter hyperintensity topography in Alzheimer\u2019s disease and links to cognition","volume":"18","author":"Garnier\u2010Crussard","year":"2022","journal-title":"Alzheimers Dement."},{"issue":"9","key":"10.1016\/j.nicl.2022.103308_b0075","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1093\/aje\/kwp256","article-title":"Association of white matter lesions and lacunar infarcts with executive functioning: the SMART-MR study","volume":"170","author":"Geerlings","year":"2009","journal-title":"Am. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.nicl.2022.103308_b0080","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1037\/0894-4105.14.2.224","article-title":"The cognitive correlates of white matter abnormalities in normal aging: a quantitative review","volume":"14","author":"Gunning-Dixon","year":"2000","journal-title":"Neuropsychology"},{"issue":"14","key":"10.1016\/j.nicl.2022.103308_b0085","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/S0028-3932(03)00129-5","article-title":"Neuroanatomical correlates of selected executive functions in middle-aged and older adults: a prospective MRI study","volume":"41","author":"Gunning-Dixon","year":"2003","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.nicl.2022.103308_b0090","article-title":"Introduction to mediation, moderation, and conditional process analysis: a regression-based approach","author":"Hayes","year":"2017","journal-title":"Guilford Publications"},{"issue":"1","key":"10.1016\/j.nicl.2022.103308_b0095","first-page":"e12068","article-title":"Anterolateral entorhinal cortex thickness as a new biomarker for early detection of Alzheimer\u2019s disease","volume":"12","author":"Holbrook","year":"2020","journal-title":"Alzheimer\u2019s & Dement.: Diagn. Assess. Dis. Monit."},{"key":"10.1016\/j.nicl.2022.103308_b0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fnins.2012.00171","article-title":"101 labeled brain images and a consistent human cortical labeling protocol","volume":"6","author":"Klein","year":"2012","journal-title":"Front. Neurosci."},{"issue":"11","key":"10.1016\/j.nicl.2022.103308_b0105","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1109\/TMI.2019.2905770","article-title":"Standardized assessment of automatic segmentation of white matter hyperintensities and results of the WMH segmentation challenge","volume":"38","author":"Kuijf","year":"2019","journal-title":"IEEE Trans. Med. Imaging"},{"issue":"2","key":"10.1016\/j.nicl.2022.103308_b0110","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcaa132","article-title":"Cerebrovascular disease promotes tau pathology in Alzheimer\u2019s disease","volume":"2","author":"Laing","year":"2020","journal-title":"Brain Commun."},{"issue":"6","key":"10.1016\/j.nicl.2022.103308_b0115","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ana.24647","article-title":"White matter hyperintensities are a core feature of Alzheimer\u2019s disease: evidence from the dominantly inherited Alzheimer network","volume":"79","author":"Lee","year":"2016","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2022.103308_b0120","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neuroimage.2018.07.005","article-title":"Fully convolutional network ensembles for white matter hyperintensities segmentation in MR images","volume":"183","author":"Li","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2022.103308_b0125","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.12659\/MSM.909188","article-title":"Correlation of brain perfusion with white matter hyperintensity, brain atrophy, and cognition in patients with posterior cerebral artery stenosis and subjective cognitive decline","volume":"24","author":"Liu","year":"2018","journal-title":"Med. Sci. Monit.: Int. Med. J. Exp. Clin. Res."},{"issue":"1","key":"10.1016\/j.nicl.2022.103308_b0130","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1747-4949.2011.00725.x","article-title":"Cerebral small vessel disease: a review of clinical, radiological, and histopathological phenotypes","volume":"7","author":"Moran","year":"2012","journal-title":"Int. J. Stroke"},{"issue":"s4","key":"10.1016\/j.nicl.2022.103308_b0135","doi-asserted-by":"crossref","first-page":"S393","DOI":"10.3233\/JAD-141473","article-title":"White matter hyperintensities as early and independent predictors of Alzheimer\u2019s disease risk","volume":"42","author":"Mortamais","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.nicl.2022.103308_b0140","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neurobiolaging.2017.04.025","article-title":"Human anterolateral entorhinal cortex volumes are associated with cognitive decline in aging prior to clinical diagnosis","volume":"57","author":"Olsen","year":"2017","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.nicl.2022.103308_b0145","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1161\/STROKEAHA.120.031743","article-title":"Distinct hippocampal subfields atrophy in older people with vascular brain injuries","volume":"52","author":"Pin","year":"2021","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.nicl.2022.103308_b0150","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000330019","article-title":"White matter disease independently predicts progression from mild cognitive impairment to Alzheimer\u2019s disease in a clinic cohort","volume":"31","author":"Prasad","year":"2011","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"9","key":"10.1016\/j.nicl.2022.103308_b0155","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1093\/brain\/awh553","article-title":"Cerebral small-vessel disease and decline in information processing speed, executive function and memory","volume":"128","author":"Prins","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2022.103308_b0160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2017.12.006","article-title":"The effect of white matter hyperintensities on cognition is mediated by cortical atrophy","volume":"64","author":"Rizvi","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2022.103308_b0165","doi-asserted-by":"crossref","first-page":"102143","DOI":"10.1016\/j.nicl.2019.102143","article-title":"Tract-defined regional white matter hyperintensities and memory","volume":"25","author":"Rizvi","year":"2020","journal-title":"NeuroImage: Clinical"},{"issue":"10","key":"10.1016\/j.nicl.2022.103308_b0170","doi-asserted-by":"crossref","first-page":"e2125166","DOI":"10.1001\/jamanetworkopen.2021.25166","article-title":"Association of regional white matter hyperintensities with longitudinal Alzheimer-like pattern of neurodegeneration in older adults","volume":"4","author":"Rizvi","year":"2021","journal-title":"JAMA Netw. Open"},{"issue":"4","key":"10.1016\/j.nicl.2022.103308_b0175","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.neuroimage.2009.04.092","article-title":"Memory performance correlates with gray matter density in the ento-\/perirhinal cortex and posterior hippocampus in patients with mild cognitive impairment and healthy controls\u2014a voxel based morphometry study","volume":"47","author":"Schmidt-Wilcke","year":"2009","journal-title":"Neuroimage"},{"issue":"18","key":"10.1016\/j.nicl.2022.103308_b0180","doi-asserted-by":"crossref","first-page":"7181","DOI":"10.1073\/pnas.0400285101","article-title":"Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging","volume":"101","author":"Small","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.nicl.2022.103308_b0185","first-page":"35","article-title":"Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer\u2019s disease: a combined positron emission tomography\/magnetic resonance imaging study","volume":"9","author":"Sone","year":"2017","journal-title":"Alzheimer\u2019s & Dement.: Diagn. Assess. Dis. Monit."},{"issue":"1","key":"10.1016\/j.nicl.2022.103308_b0190","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.neuro.27.070203.144130","article-title":"The medial temporal lobe","volume":"27","author":"Squire","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.nicl.2022.103308_b0195","doi-asserted-by":"crossref","first-page":"e673","DOI":"10.1212\/WNL.0000000000004983","article-title":"The effect of white matter hyperintensities on verbal memory: Mediation by temporal lobe atrophy","volume":"90","author":"Swardfager","year":"2018","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.nicl.2022.103308_b0200","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11682-018-9969-y","article-title":"Medial temporal lobe volumes in late-life depression: effects of age and vascular risk factors","volume":"14","author":"Taylor","year":"2020","journal-title":"Brain Imaging Behav."},{"issue":"12","key":"10.1016\/j.nicl.2022.103308_b0205","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jalz.2015.05.014","article-title":"The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment","volume":"11","author":"Tosto","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.nicl.2022.103308_b0210","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuroimage.2014.05.044","article-title":"Large-scale evaluation of ANTs and FreeSurfer cortical thickness measurements","volume":"99","author":"Tustison","year":"2014","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.nicl.2022.103308_b0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-87564-6","article-title":"The ANTsX ecosystem for quantitative biological and medical imaging","volume":"11","author":"Tustison","year":"2021","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.nicl.2022.103308_b0220","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/13854049708400464","article-title":"Rey AVLT: Developmental norms for adults and the sensitivity of different memory measures to age","volume":"11","author":"Vakil","year":"1997","journal-title":"Clin. Neuropsychol."},{"issue":"9","key":"10.1016\/j.nicl.2022.103308_b0225","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/j.neurobiolaging.2014.02.021","article-title":"Hippocampal subfield volumes at 7T in early Alzheimer\u2019s disease and normal aging","volume":"35","author":"Wisse","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"16","key":"10.1016\/j.nicl.2022.103308_b0230","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1002\/hbm.25151","article-title":"Longitudinal atrophy in early Braak regions in preclinical Alzheimer\u2019s disease","volume":"41","author":"Xie","year":"2020","journal-title":"Hum. Brain Mapp."},{"issue":"10","key":"10.1016\/j.nicl.2022.103308_b0235","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tins.2011.06.006","article-title":"Pattern separation in the hippocampus","volume":"34","author":"Yassa","year":"2011","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.nicl.2022.103308_b0240","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hbm.22627","article-title":"Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment","volume":"36","author":"Yushkevich","year":"2015","journal-title":"Hum. Brain Mapp."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158222003734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158222003734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:31:16Z","timestamp":1781105476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158222003734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":48,"alternative-id":["S2213158222003734"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2022.103308","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.19.508591","asserted-by":"object"}]},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Posterior white matter hyperintensities are associated with reduced medial temporal lobe subregional integrity and long-term memory in older adults","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2022.103308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103308"}}