{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:42:45Z","timestamp":1794328965822,"version":"4.9.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010451","name":"Health and Family Planning Commission of Hunan Province","doi-asserted-by":"publisher","award":["SBGJ202102035"],"award-info":[{"award-number":["SBGJ202102035"]}],"id":[{"id":"10.13039\/501100010451","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"publisher","award":["192102310085"],"award-info":[{"award-number":["192102310085"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.nicl.2023.103555","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T15:57:56Z","timestamp":1702655876000},"page":"103555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients"],"prefix":"10.1016","volume":"41","author":[{"given":"Xiaoxue","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghan","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2023.103555_b0005","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of parkinson disease: a review","volume":"323","author":"Armstrong","year":"2020","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.nicl.2023.103555_b0010","doi-asserted-by":"crossref","first-page":"6348","DOI":"10.1111\/jcmm.16612","article-title":"MiR-193b deregulation is associated with Parkinson's disease","volume":"25","author":"Baghi","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.nicl.2023.103555_b0015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostrom","year":"2012","journal-title":"Nature"},{"issue":"Pt 5","key":"10.1016\/j.nicl.2023.103555_b0020","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/brain\/113.5.1539","article-title":"The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson's disease, studied with PET","volume":"113","author":"Brooks","year":"1990","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2023.103555_b0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2013.02.050","article-title":"Irisin-immunoreactivity in neural and non-neural cells of the rodent","volume":"240","author":"Dun","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.nicl.2023.103555_b0030","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/mds.25870","article-title":"Cognitive impairment and dementia in Parkinson's disease: practical issues and management","volume":"29","author":"Emre","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2023.103555_b0035","first-page":"2498","article-title":"Parkinson Study, G., 2004. Levodopa and the progression of Parkinson's disease","volume":"351","author":"Fahn","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.nicl.2023.103555_b0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/mds.23939","article-title":"Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's disease","volume":"27","author":"Gallagher","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2023.103555_b0045","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/mds.26110","article-title":"Progression of gait dysfunction in incident Parkinson's disease: impact of medication and phenotype","volume":"30","author":"Galna","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2023.103555_b0050","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3389\/fneur.2018.00455","article-title":"On Cell Loss and Selective Vulnerability of Neuronal Populations in Parkinson's Disease","volume":"9","author":"Giguere","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nicl.2023.103555_b0055","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/mds.20213","article-title":"Movement disorder society task force on rating scales for parkinson's, d., 2004. movement disorder society task force report on the hoehn and yahr staging scale: status and recommendations","volume":"19","author":"Goetz","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2023.103555_b0060","first-page":"4687","article-title":"A review on irisin, a new protagonist that mediates muscle-adipose-bone-neuron connectivity","volume":"21","author":"Grygiel-Gorniak","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.nicl.2023.103555_b0065","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.metabol.2012.09.002","article-title":"FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise","volume":"61","author":"Huh","year":"2012","journal-title":"Metabolism"},{"key":"10.1016\/j.nicl.2023.103555_b0070","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.cmet.2015.08.001","article-title":"Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry","volume":"22","author":"Jedrychowski","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.nicl.2023.103555_b0075","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2967\/jnumed.108.061572","article-title":"Simple ratio analysis of 18F-fluorodopa uptake in striatal subregions separates patients with early Parkinson disease from healthy controls","volume":"50","author":"Jokinen","year":"2009","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.nicl.2023.103555_b0080","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.nicl.2023.103555_b0085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2204835119","article-title":"Amelioration of pathologic alpha-synuclein-induced Parkinson's disease by irisin","volume":"119","author":"Kam","year":"2022","journal-title":"PNAS"},{"key":"10.1016\/j.nicl.2023.103555_b0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41591-018-0275-4","article-title":"Exercise-linked FNDC5\/irisin rescues synaptic plasticity and memory defects in Alzheimer's models","volume":"25","author":"Lourenco","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.nicl.2023.103555_b0095","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.bbapap.2019.03.001","article-title":"alpha-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis","volume":"1867","author":"Mehra","year":"2019","journal-title":"Biochim Biophys Acta Proteins Proteom"},{"key":"10.1016\/j.nicl.2023.103555_b0100","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.863901","article-title":"Effects of the FNDC5\/Irisin on Elderly Dementia and Cognitive Impairment","volume":"14","author":"Peng","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nicl.2023.103555_b0105","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2023.103555_b0110","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.freeradbiomed.2016.11.045","article-title":"Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance","volume":"102","author":"Raefsky","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.nicl.2023.103555_b0115","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/jnc.15601","article-title":"Plasma alpha-synuclein and phosphorylated tau 181 as a diagnostic biomarker panel for de novo Parkinson's disease","volume":"161","author":"Ren","year":"2022","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nicl.2023.103555_b0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JPD-181306","article-title":"Progression of cognitive decline in parkinson's disease","volume":"8","author":"Roheger","year":"2018","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nicl.2023.103555_b0125","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1474-4422(16)30328-3","article-title":"Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson's disease: a cohort study","volume":"16","author":"Schrag","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2023.103555_b0130","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.pharmthera.2014.05.010","article-title":"Emerging therapies for Parkinson's disease: from bench to bedside","volume":"144","author":"Tarazi","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.nicl.2023.103555_b0135","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson's disease","volume":"25","author":"Tomlinson","year":"2010","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2023.103555_b0140","doi-asserted-by":"crossref","first-page":"29898","DOI":"10.1038\/srep29898","article-title":"FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle","volume":"6","author":"Varela-Rodriguez","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.nicl.2023.103555_b0145","first-page":"722","article-title":"Irisin protects the substantia nigra dopaminergic neurons in the rat model of Parkinson's disease","volume":"22","author":"Zarbakhsh","year":"2019","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.nicl.2023.103555_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101680","article-title":"Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process","volume":"80","author":"Zhang","year":"2022","journal-title":"Ageing Res. Rev."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158223002462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158223002462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T04:52:06Z","timestamp":1761972726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158223002462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":30,"alternative-id":["S2213158223002462"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2023.103555","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3074907\/v1","asserted-by":"object"}]},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2023.103555","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103555"}}