{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:46Z","timestamp":1787030866632,"version":"build-2736575974"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002345","name":"Eberhard Karls Universit\u00e4t T\u00fcbingen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.nicl.2024.103709","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T11:44:21Z","timestamp":1732275861000},"page":"103709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Strong connectivity to the sensorimotor cortex predicts clinical effectiveness of thalamic deep brain stimulation in essential tremor"],"prefix":"10.1016","volume":"45","author":[{"given":"F.","family":"Grimm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Walcker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Milosevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Naros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gharabaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2024.103709_b0005","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.nicl.2018.01.008","article-title":"Connectivity derived thalamic segmentation in deep brain stimulation for tremor","volume":"18","author":"Akram","year":"2018","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.nicl.2024.103709_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101758","article-title":"Connectivity derived thalamic segmentation: Separating myth from reality","volume":"22","author":"Akram","year":"2019","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.nicl.2024.103709_b0015","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1093\/brain\/awz236","article-title":"Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor","volume":"142","author":"Al-Fatly","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2024.103709_b0020","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.3174\/ajnr.A2638","article-title":"Functional connectivity targeting for deep brain stimulation in essential tremor","volume":"32","author":"Anderson","year":"2011","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.nicl.2024.103709_b0025","unstructured":"Andersson J, Jenkinson M, Smith S. Non-linear registration, aka spatial normalisation. FMRIB technical report 2010;TR07JA2."},{"key":"10.1016\/j.nicl.2024.103709_b0030","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","article-title":"An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging","volume":"125","author":"Andersson","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2024.103709_b0035","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1055\/s-0036-1597894","article-title":"Distance between active electrode contacts and dentatorubrothalamic tract in patients with habituation of stimulation effect of deep brain stimulation in essential tremor","volume":"78","author":"Anthofer","year":"2017","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"10.1016\/j.nicl.2024.103709_b0040","first-page":"664","article-title":"Relationship between neural activation and electric field distribution during deep brain stimulation","volume":"62","author":"Astrom","year":"2015","journal-title":"I.E.E.E. Trans. Biomed. Eng."},{"key":"10.1016\/j.nicl.2024.103709_b0045","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1093\/brain\/awt238","article-title":"Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains","volume":"136","author":"Babij","year":"2013","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0050","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/mrm.10609","article-title":"Characterization and propagation of uncertainty in diffusion-weighted MR imaging","volume":"50","author":"Behrens","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.nicl.2024.103709_b0055","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging","volume":"6","author":"Behrens","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.nicl.2024.103709_b0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroimage.2006.09.018","article-title":"Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?","volume":"34","author":"Behrens","year":"2007","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2024.103709_b0065","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3171\/2018.11.JNS181684","article-title":"Intraoperative localization of spatially and spectrally distinct resting-state networks in Parkinson's disease","volume":"132","author":"Belardinelli","year":"2020","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.nicl.2024.103709_b0070","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12311-015-0741-1","article-title":"Linking essential tremor to the cerebellum: clinical evidence","volume":"15","author":"Benito-Leon","year":"2016","journal-title":"Cerebellum (london, England)"},{"key":"10.1016\/j.nicl.2024.103709_b0075","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1212\/01.wnl.0000216134.88617.de","article-title":"Elderly-onset essential tremor is associated with dementia","volume":"66","author":"Benito-Leon","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2024.103709_b0080","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1212\/01.wnl.0000192393.05850.ec","article-title":"Population-based case-control study of cognitive function in essential tremor","volume":"66","author":"Benito-Leon","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2024.103709_b0085","doi-asserted-by":"crossref","first-page":"e1936","DOI":"10.1097\/MD.0000000000001936","article-title":"Altered functional connectivity in essential tremor: a resting-state fMRI study","volume":"94","author":"Benito-Leon","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.nicl.2024.103709_b0090","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.neurom.2021.11.015","article-title":"The fast gray matter acquisition T1 inversion recovery sequence in deep brain stimulation: introducing the rubral wing for dentato-rubro-thalamic tract depiction and tremor control","volume":"26","author":"Bot","year":"2023","journal-title":"Neuromodulation"},{"key":"10.1016\/j.nicl.2024.103709_b0095","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.brs.2023.02.002","article-title":"Lateral cerebellothalamic tract activation underlies DBS therapy for Essential Tremor","volume":"16","author":"Brinda","year":"2023","journal-title":"Brain Stimul."},{"key":"10.1016\/j.nicl.2024.103709_b0100","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0105","doi-asserted-by":"crossref","unstructured":"Coenen VA, Allert N, Paus S, Kronenburger M, Urbach H, Madler B. Modulation of the cerebello-thalamo-cortical network in thalamic deep brain stimulation for tremor: a diffusion tensor imaging study. Neurosurgery 2014;75:657-669; discussion 669-670.","DOI":"10.1227\/NEU.0000000000000540"},{"key":"10.1016\/j.nicl.2024.103709_b0110","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1017\/S1355617717000170","article-title":"Mild cognitive impairment subtypes in a cohort of elderly essential tremor cases","volume":"23","author":"Collins","year":"2017","journal-title":"J. Int. Neuropsychol. Soc.: JINS"},{"key":"10.1016\/j.nicl.2024.103709_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102235","article-title":"PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract","volume":"26","author":"Dembek","year":"2020","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.nicl.2024.103709_b0120","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2024.103709_b0125","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S1474-4422(10)70322-7","article-title":"Treatment of patients with essential tremor","volume":"10","author":"Deuschl","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroimage.2009.01.045","article-title":"A probabilistic MR atlas of the human cerebellum","volume":"46","author":"Diedrichsen","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2024.103709_b0135","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.neuroimage.2010.10.035","article-title":"Imaging the deep cerebellar nuclei: a probabilistic atlas and normalization procedure","volume":"54","author":"Diedrichsen","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2024.103709_b0140","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41597-019-0254-8","article-title":"7 Tesla MRI of the ex vivo human brain at 100 micron resolution","volume":"6","author":"Edlow","year":"2019","journal-title":"Sci. Data"},{"key":"10.1016\/j.nicl.2024.103709_b0145","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/mdc3.12565","article-title":"Ventral intermediate nucleus versus zona incerta region deep brain stimulation in essential tremor","volume":"5","author":"Eisinger","year":"2018","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.nicl.2024.103709_b0150","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/ana.25975","article-title":"Probabilistic mapping of deep brain stimulation: insights from 15 years of therapy","volume":"89","author":"Elias","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0155","first-page":"271","article-title":"Clinical rating scale for tremor","volume":"2","author":"Fahn","year":"1993","journal-title":"Parkinson's Dis. Movem. Disord."},{"key":"10.1016\/j.nicl.2024.103709_b0160","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41746-024-01253-y","article-title":"Machine learning explains response variability of deep brain stimulation on Parkinson's disease quality of life","volume":"7","author":"Ferrea","year":"2024","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.nicl.2024.103709_b0165","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s12311-015-0740-2","article-title":"Linking essential tremor to the cerebellum: physiological evidence","volume":"15","author":"Filip","year":"2016","journal-title":"Cerebellum (london, England)"},{"key":"10.1016\/j.nicl.2024.103709_b0170","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00429-007-0170-0","article-title":"Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery","volume":"212","author":"Gallay","year":"2008","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.nicl.2024.103709_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.891446","article-title":"Essential tremor patients experience significant burden beyond tremor: a systematic literature review","volume":"13","author":"Gerbasi","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0180","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41531-024-00812-0","article-title":"Randomized crossover trial on motor and non-motor outcome of directional deep brain stimulation in Parkinson's disease","volume":"10","author":"Gharabaghi","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.nicl.2024.103709_b0185","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/brain\/awt304","article-title":"Physiological and anatomical decomposition of subthalamic neurostimulation effects in essential tremor","volume":"137","author":"Groppa","year":"2014","journal-title":"Brain J. Neurol."},{"issue":"56","key":"10.1016\/j.nicl.2024.103709_b0190","first-page":"482","article-title":"Changes in regional brain glucose metabolism measured with F-18-FDG-PET in essential tremor","volume":"2015","author":"Ha","year":"1987","journal-title":"Acta Radiol. (stockholm, Sweden"},{"key":"10.1016\/j.nicl.2024.103709_b0195","doi-asserted-by":"crossref","first-page":"fcae093","DOI":"10.1093\/braincomms\/fcae093","article-title":"Insertional effect following electrode implantation: an underreported but important phenomenon","volume":"6","author":"Hamani","year":"2024","journal-title":"Brain Commun."},{"key":"10.1016\/j.nicl.2024.103709_b0200","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3389\/fneur.2018.00495","article-title":"A voxel-wise meta-analysis of gray matter abnormalities in essential tremor","volume":"9","author":"Han","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0205","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.nicl.2018.11.001","article-title":"Distinct cortical responses evoked by electrical stimulation of the thalamic ventral intermediate nucleus and of the subthalamic nucleus","volume":"20","author":"Hartmann","year":"2018","journal-title":"NeuroImage Clinical"},{"key":"10.1016\/j.nicl.2024.103709_b0210","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.clinph.2011.08.033","article-title":"Continuous theta-burst stimulation of the primary motor cortex in essential tremor","volume":"123","author":"Hellriegel","year":"2012","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.nicl.2024.103709_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0173(89)90007-6","article-title":"A new parcellation of the human thalamus on the basis of histochemical staining","volume":"14","author":"Hirai","year":"1989","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.nicl.2024.103709_b0220","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.24974","article-title":"Connectivity Predicts deep brain stimulation outcome in Parkinson disease","volume":"82","author":"Horn","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0225","doi-asserted-by":"crossref","DOI":"10.1227\/NEU.0b013e3182262c9a","article-title":"Contrasting connectivity of the ventralis intermedius and ventralis oralis posterior nuclei of the motor thalamus demonstrated by probabilistic tractography","volume":"70","author":"Hyam","year":"2012","journal-title":"Neurosurgery"},{"issue":"Suppl 3","key":"10.1016\/j.nicl.2024.103709_b0230","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1002\/mds.10137","article-title":"Motor thalamic circuits in primates with emphasis on the area targeted in treatment of movement disorders","volume":"17","author":"Ilinsky","year":"2002","journal-title":"Movement Disorders : Official J. Movement Disorder Soc."},{"key":"10.1016\/j.nicl.2024.103709_b0235","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2024.103709_b0240","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Fsl. Neuroimage"},{"key":"10.1016\/j.nicl.2024.103709_b0245","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3171\/2016.10.JNS161603","article-title":"Diffusion tractography imaging-guided frameless linear accelerator stereotactic radiosurgical thalamotomy for tremor: case report","volume":"128","author":"Kim","year":"2018","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.nicl.2024.103709_b0250","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1212\/WNL.0b013e318249f702","article-title":"The tremor network targeted by successful VIM deep brain stimulation in humans","volume":"78","author":"Klein","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2024.103709_b0255","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.parkreldis.2021.06.019","article-title":"Determining an efficient deep brain stimulation target in essential tremor - Cohort study and review of the literature","volume":"89","author":"Kubler","year":"2021","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nicl.2024.103709_b0260","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/jnnp.2010.213330","article-title":"Increased number of heterotopic Purkinje cells in essential tremor","volume":"82","author":"Kuo","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2024.103709_b0265","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1460-9568.2010.07481.x","article-title":"Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei","volume":"33","author":"Kuramoto","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.nicl.2024.103709_b0270","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00234-011-0878-7","article-title":"Dentatorubrothalamic tract in human brain: diffusion tensor tractography study","volume":"53","author":"Kwon","year":"2011","journal-title":"Neuroradiology"},{"key":"10.1016\/j.nicl.2024.103709_b0275","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0280","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00234-016-1771-1","article-title":"Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor","volume":"59","author":"Lenka","year":"2017","journal-title":"Neuroradiology"},{"key":"10.1016\/j.nicl.2024.103709_b0285","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3171\/jns.1988.68.4.0630","article-title":"Methods for microstimulation and recording of single neurons and evoked potentials in the human central nervous system","volume":"68","author":"Lenz","year":"1988","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.nicl.2024.103709_b0290","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF00236557","article-title":"The olivo-cerebellar system: functional properties as revealed by harmaline-induced tremor","volume":"18","author":"Llinas","year":"1973","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nicl.2024.103709_b0295","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s12311-013-0545-0","article-title":"From neurons to neuron neighborhoods: the rewiring of the cerebellar cortex in essential tremor","volume":"13","author":"Louis","year":"2014","journal-title":"Cerebellum (london, England)"},{"issue":"Suppl 1","key":"10.1016\/j.nicl.2024.103709_b0300","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.parkreldis.2015.08.034","article-title":"Non-motor symptoms in essential tremor: a review of the current data and state of the field","volume":"22","author":"Louis","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"issue":"Suppl 1","key":"10.1016\/j.nicl.2024.103709_b0305","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/j.parkreldis.2017.07.010","article-title":"Essential tremor then and now: How views of the most common tremor diathesis have changed over time","volume":"46","author":"Louis","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nicl.2024.103709_b0310","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/B978-0-323-98817-9.00012-0","article-title":"Essential tremor","volume":"196","author":"Louis","year":"2023","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0315","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/brain\/awm266","article-title":"Neuropathological changes in essential tremor: 33 cases compared with 21 controls","volume":"130","author":"Louis","year":"2007","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0320","doi-asserted-by":"crossref","first-page":"473","DOI":"10.5334\/tohm.380","article-title":"The olivary hypothesis of essential tremor: time to lay this model to rest?","volume":"7","author":"Louis","year":"2017","journal-title":"Tremor and Other Hyperkinetic Movements (new York, NY)"},{"key":"10.1016\/j.nicl.2024.103709_b0325","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/j.1468-1331.2007.01923.x","article-title":"Self-reported depression and anti-depressant medication use in essential tremor: cross-sectional and prospective analyses in a population-based study","volume":"14","author":"Louis","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0330","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5334\/tohm.632","article-title":"How common is essential tremor? update on the worldwide prevalence of essential tremor","volume":"11","author":"Louis","year":"2021","journal-title":"Tremor Other Hyperkinet. Mov. (n y)"},{"key":"10.1016\/j.nicl.2024.103709_b0335","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12311-015-0735-z","article-title":"Linking essential tremor to the cerebellum: neurochemical evidence","volume":"15","author":"Marin-Lahoz","year":"2016","journal-title":"Cerebellum (london, England)"},{"key":"10.1016\/j.nicl.2024.103709_b0340","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/B978-0-444-53497-2.00005-X","article-title":"Computational modeling of deep brain stimulation","volume":"116","author":"McIntyre","year":"2013","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0345","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.3171\/2015.4.JNS142741","article-title":"The nondecussating pathway of the dentatorubrothalamic tract in humans: human connectome-based tractographic study and microdissection validation","volume":"124","author":"Meola","year":"2016","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.nicl.2024.103709_b0350","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.nicl.2018.10.009","article-title":"Structural connectivity-based segmentation of the thalamus and prediction of tremor improvement following thalamic deep brain stimulation of the ventral intermediate nucleus","volume":"20","author":"Middlebrooks","year":"2018","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.nicl.2024.103709_b0355","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00234-017-1972-2","article-title":"A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation","volume":"60","author":"Middlebrooks","year":"2018","journal-title":"Neuroradiology"},{"key":"10.1016\/j.nicl.2024.103709_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101761","article-title":"Complexities of connectivity-based DBS targeting: Rebirth of the debate on thalamic and subthalamic treatment of tremor","volume":"22","author":"Middlebrooks","year":"2019","journal-title":"NeuroImage Clinical"},{"key":"10.1016\/j.nicl.2024.103709_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102846","article-title":"Connectivity correlates to predict essential tremor deep brain stimulation outcome: Evidence for a common treatment pathway","volume":"32","author":"Middlebrooks","year":"2021","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.nicl.2024.103709_b0370","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/19714009211036689","article-title":"Directed stimulation of the dentato-rubro-thalamic tract for deep brain stimulation in essential tremor: a blinded clinical trial","volume":"35","author":"Middlebrooks","year":"2022","journal-title":"Neuroradiol. J."},{"key":"10.1016\/j.nicl.2024.103709_b0375","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1093\/brain\/awy139","article-title":"Physiological mechanisms of thalamic ventral intermediate nucleus stimulation for tremor suppression","volume":"141","author":"Milosevic","year":"2018","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0380","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/mds.28093","article-title":"Online mapping with the deep brain stimulation lead: a novel targeting tool in Parkinson's Disease","volume":"35","author":"Milosevic","year":"2020","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2024.103709_b0385","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1007\/s00429-015-1115-7","article-title":"Dentatorubrothalamic tract localization with postmortem MR diffusion tractography compared to histological 3D reconstruction","volume":"221","author":"Mollink","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.nicl.2024.103709_b0390","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/(SICI)1096-9861(19971103)387:4<588::AID-CNE8>3.0.CO;2-Z","article-title":"Multiarchitectonic and stereotactic atlas of the human thalamus","volume":"387","author":"Morel","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0395","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3171\/2017.9.JNS171321","article-title":"Validation of diffusion tensor imaging tractography to visualize the dentatorubrothalamic tract for surgical planning","volume":"130","author":"Nowacki","year":"2018","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.nicl.2024.103709_b0400","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ana.26324","article-title":"Probabilistic mapping reveals optimal stimulation site in essential tremor","volume":"91","author":"Nowacki","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0405","doi-asserted-by":"crossref","DOI":"10.1007\/s00701-007-1419-3","article-title":"Quantification and visualization of three-dimensional inconsistency of the ventrointermediate nucleus of the thalamus in the Schaltenbrand-Wahren brain atlas","volume":"150","author":"Nowinski","year":"2008","journal-title":"Acta Neurochir."},{"key":"10.1016\/j.nicl.2024.103709_b0410","doi-asserted-by":"crossref","DOI":"10.1227\/01.NEU.0000119329.66931.9E","article-title":"Thalamic deep brain stimulation for essential tremor: relation of lead location to outcome","volume":"54","author":"Papavassiliou","year":"2004","journal-title":"Neurosurgery"},{"key":"10.1016\/j.nicl.2024.103709_b0415","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1093\/brain\/awr164","article-title":"Altered cortical-cerebellar circuits during verbal working memory in essential tremor","volume":"134","author":"Passamonti","year":"2011","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0420","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuroimage.2018.04.074","article-title":"Structural and functional connectivity of the nondecussating dentato-rubro-thalamic tract","volume":"176","author":"Petersen","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2024.103709_b0425","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3171\/2011.7.JNS11250","article-title":"Multi-institutional evaluation of deep brain stimulation targeting using probabilistic connectivity-based thalamic segmentation","volume":"115","author":"Pouratian","year":"2011","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.nicl.2024.103709_b0430","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clinph.2011.09.024","article-title":"The oscillating central network of Essential tremor","volume":"123","author":"Raethjen","year":"2012","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.nicl.2024.103709_b0435","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/cne.903450204","article-title":"Cerebellothalamocortical and pallidothalamocortical projections to the primary and supplementary motor cortical areas: a multiple tracing study in macaque monkeys","volume":"345","author":"Rouiller","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0440","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.2196\/resprot.6885","article-title":"Deep Brain Stimulation for Tremor Tractographic Versus Traditional (DISTINCT): study protocol of a randomized controlled feasibility trial","volume":"5","author":"Sajonz","year":"2016","journal-title":"JMIR Res. Protoc."},{"key":"10.1016\/j.nicl.2024.103709_b0445","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/(SICI)1096-9861(20000207)417:2<164::AID-CNE3>3.0.CO;2-6","article-title":"Pallidal and cerebellar afferents to pre-supplementary motor area thalamocortical neurons in the owl monkey: a multiple labeling study","volume":"417","author":"Sakai","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0450","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s13760-014-0396-6","article-title":"Cognitive functions, fatigue, depression, anxiety, and sleep disturbances: assessment of nonmotor features in young patients with essential tremor","volume":"115","author":"Sengul","year":"2015","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.nicl.2024.103709_b0455","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.nicl.2014.05.003","article-title":"Neuroimaging essentials in essential tremor: a systematic review","volume":"5","author":"Sharifi","year":"2014","journal-title":"NeuroImage Clinical"},{"key":"10.1016\/j.nicl.2024.103709_b0460","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1212\/01.wnl.0000310425.76205.02","article-title":"Pathologic findings in prospectively ascertained essential tremor subjects","volume":"70","author":"Shill","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2024.103709_b0465","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.parkreldis.2015.11.025","article-title":"Lewy bodies in essential tremor are no different than in controls","volume":"23","author":"Shill","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.nicl.2024.103709_b0470","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.clineuro.2009.10.004","article-title":"A pilot study: Microlesion effects and tremor outcome in the ventrointermediate deep brain stimulation (VIM-DBS)","volume":"112","author":"Sitburana","year":"2010","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.nicl.2024.103709_b0475","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3348\/kjr.2015.16.5.967","article-title":"Differences in regional glucose metabolism of the brain measured with F-18-FDG-PET in patients with essential tremor according to their response to beta-blockers","volume":"16","author":"Song","year":"2015","journal-title":"Korean J. Radiol."},{"key":"10.1016\/j.nicl.2024.103709_b0480","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1152\/jn.1976.39.5.1020","article-title":"Anatomical analysis of ventrolateral thalamic input to primate motor cortex","volume":"39","author":"Strick","year":"1976","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.nicl.2024.103709_b0485","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ana.25475","article-title":"Deep brain stimulation: Connectivity profile for bradykinesia alleviation","volume":"85","author":"Strotzer","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0490","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/brain\/awab074","article-title":"Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation","volume":"144","author":"Tsuboi","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2024.103709_b0495","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neubiorev.2015.01.014","article-title":"Limbic circuitry of the midline thalamus","volume":"54","author":"Vertes","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.nicl.2024.103709_b0500","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/mds.28045","article-title":"A comprehensive review of brain connectomics and imaging to improve deep brain stimulation outcomes","volume":"35","author":"Wong","year":"2020","journal-title":"Movement Disorders: Off. J. Movement Disorder Soc."},{"key":"10.1016\/j.nicl.2024.103709_b0505","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1468-1331.2011.03598.x","article-title":"Increased number of Purkinje cell dendritic swellings in essential tremor","volume":"19","author":"Yu","year":"2012","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.nicl.2024.103709_b0510","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans. Med. Imaging"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158224001505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158224001505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:16:28Z","timestamp":1762607788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158224001505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":102,"alternative-id":["S2213158224001505"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2024.103709","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Strong connectivity to the sensorimotor cortex predicts clinical effectiveness of thalamic deep brain stimulation in essential tremor","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2024.103709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103709"}}