{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:43:44Z","timestamp":1789688624771,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2024YFFK0316"],"award-info":[{"award-number":["2024YFFK0316"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101521"],"award-info":[{"award-number":["82101521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771402"],"award-info":[{"award-number":["81771402"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471482"],"award-info":[{"award-number":["82471482"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U21A20393"],"award-info":[{"award-number":["U21A20393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171443"],"award-info":[{"award-number":["82171443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYGD23032"],"award-info":[{"award-number":["ZYGD23032"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYJC21001"],"award-info":[{"award-number":["ZYJC21001"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.nicl.2025.103744","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T02:38:29Z","timestamp":1737945509000},"page":"103744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Association of valproate use and hippocampal atrophy in idiopathic generalized epilepsy"],"prefix":"10.1016","volume":"45","author":[{"given":"Xiang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuxing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-0837","authenticated-orcid":false,"given":"Dongmei","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2025.103744_b0005","doi-asserted-by":"crossref","unstructured":"Devinsky O, Elder C, Sivathamboo S, Scheffer IE, Koepp MJ. Idiopathic Generalized Epilepsy: Misunderstandings, Challenges, and Opportunities. Neurology. Feb 13 2024;102(3):e208076. doi:10.1212\/wnl.0000000000208076.","DOI":"10.1212\/WNL.0000000000208076"},{"issue":"Suppl 9","key":"10.1016\/j.nicl.2025.103744_b0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1528-1167.2005.00309.x","article-title":"Epidemiology of idiopathic generalized epilepsies","volume":"46","author":"Jallon","year":"2005","journal-title":"Epilepsia."},{"issue":"4","key":"10.1016\/j.nicl.2025.103744_b0015","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia."},{"issue":"1","key":"10.1016\/j.nicl.2025.103744_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169076","article-title":"Patterns of Gray Matter Abnormalities in Idiopathic Generalized Epilepsy: A Meta-Analysis of Voxel-Based Morphology Studies","volume":"12","author":"Bin","year":"2017","journal-title":"PLoS One."},{"issue":"20","key":"10.1016\/j.nicl.2025.103744_b0025","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1212\/WNL.0b013e318292a2e5","article-title":"Sodium valproate use is associated with reduced parietal lobe thickness and brain volume","volume":"80","author":"Pardoe","year":"2013","journal-title":"Neurology."},{"key":"10.1016\/j.nicl.2025.103744_b0030","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3389\/fneur.2020.00622","article-title":"Valproate Use Is Associated With Posterior Cortical Thinning and Ventricular Enlargement in Epilepsy Patients","volume":"11","author":"Tondelli","year":"2020","journal-title":"Front Neurol."},{"key":"10.1016\/j.nicl.2025.103744_b0035","doi-asserted-by":"crossref","unstructured":"Crespo Pimentel B, Kuchukhidze G, Xiao F, et al. Sodium valproate is associated with cortical thinning of disease-specific areas in juvenile myoclonic epilepsy. J Neurol Neurosurg Psychiatry. Jul 23 2024;doi:10.1136\/jnnp-2024-333703.","DOI":"10.1136\/jnnp-2024-333703"},{"issue":"1","key":"10.1016\/j.nicl.2025.103744_b0040","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/epi.17825","article-title":"Valproate use associated with frontal and cerebellar gray matter volume reductions: A voxel-based morphometry study","volume":"65","author":"Shin","year":"2024","journal-title":"Epilepsia."},{"issue":"13","key":"10.1016\/j.nicl.2025.103744_b0045","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1212\/WNL.0b013e318230a16c","article-title":"Chronic divalproex sodium use and brain atrophy in Alzheimer disease","volume":"77","author":"Fleisher","year":"2011","journal-title":"Neurology."},{"issue":"9","key":"10.1016\/j.nicl.2025.103744_b0050","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1093\/brain\/awz215","article-title":"Abnormal hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings","volume":"142","author":"Caciagli","year":"2019","journal-title":"Brain."},{"issue":"1","key":"10.1016\/j.nicl.2025.103744_b0055","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yebeh.2013.06.034","article-title":"Hippocampal atrophy and memory dysfunction in patients with juvenile myoclonic epilepsy","volume":"29","author":"Lin","year":"2013","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nicl.2025.103744_b0060","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yebeh.2017.08.031","article-title":"Microstructural white matter changes and their relation to neuropsychological deficits in patients with juvenile myoclonic epilepsy","volume":"76","author":"Knake","year":"2017","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.nicl.2025.103744_b0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.eplepsyres.2014.11.014","article-title":"Selective medial temporal volume reduction in the hippocampus of patients with idiopathic generalized tonic-clonic seizures","volume":"110","author":"Zhou","year":"2015","journal-title":"Epilepsy Res."},{"issue":"4","key":"10.1016\/j.nicl.2025.103744_b0070","first-page":"143","article-title":"Volume changes of medial temporal lobe structures in patients with genetic generalized and temporal lobe epilepsy in relation to neuropsychological functions","volume":"31","author":"Bochy\u0144ska","year":"2022","journal-title":"Postep Psychiatr Neurol."},{"key":"10.1016\/j.nicl.2025.103744_b0075","doi-asserted-by":"crossref","unstructured":"DeKraker J, Haast RAM, Yousif MD, et al. Automated hippocampal unfolding for morphometry and subfield segmentation with HippUnfold. Elife. Dec 15 2022;11doi:10.7554\/eLife.77945.","DOI":"10.7554\/eLife.77945"},{"issue":"6","key":"10.1016\/j.nicl.2025.103744_b0080","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1111\/epi.17236","article-title":"ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions","volume":"63","author":"Hirsch","year":"2022","journal-title":"Epilepsia."},{"issue":"1","key":"10.1016\/j.nicl.2025.103744_b0085","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-0327(88)90072-9","article-title":"The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders","volume":"14","author":"Maier","year":"1988","journal-title":"J Affect Disord. Jan-Feb"},{"issue":"1\u20133","key":"10.1016\/j.nicl.2025.103744_b0090","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jad.2006.12.015","article-title":"Sensitivity to change, discriminative performance, and cutoff criteria to define remission for embedded short scales of the Hamilton depression rating scale (HAMD)","volume":"102","author":"Ballesteros","year":"2007","journal-title":"J Affect Disord."},{"issue":"3","key":"10.1016\/j.nicl.2025.103744_b0095","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage."},{"issue":"1","key":"10.1016\/j.nicl.2025.103744_b0100","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/hbm.25326","article-title":"FreeSurfer-based segmentation of hippocampal subfields: A review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts","volume":"43","author":"S\u00e4mann","year":"2022","journal-title":"Hum Brain Mapp."},{"issue":"12","key":"10.1016\/j.nicl.2025.103744_b0105","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1002\/hbm.24607","article-title":"Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease","volume":"40","author":"Xie","year":"2019","journal-title":"Hum Brain Mapp."},{"issue":"3","key":"10.1016\/j.nicl.2025.103744_b0110","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3348\/kjr.2006.7.3.162","article-title":"Structural brain abnormalities in juvenile myoclonic epilepsy patients: volumetry and voxel-based morphometry","volume":"7","author":"Tae","year":"2006","journal-title":"Korean J Radiol. Jul-Sep"},{"key":"10.1016\/j.nicl.2025.103744_b0115","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.seizure.2015.06.009","article-title":"Extrafrontal structural changes in juvenile myoclonic epilepsy: a topographic analysis of combined structural and microstructural brain imaging","volume":"30","author":"Kim","year":"2015","journal-title":"Seizure."},{"issue":"42","key":"10.1016\/j.nicl.2025.103744_b0120","doi-asserted-by":"crossref","first-page":"10908","DOI":"10.1523\/JNEUROSCI.0229-16.2016","article-title":"In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation\/Differentiation","volume":"36","author":"Fujimura","year":"2016","journal-title":"J Neurosci."},{"key":"10.1016\/j.nicl.2025.103744_b0125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41378-020-0165-z","article-title":"Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model","volume":"6","author":"Cui","year":"2020","journal-title":"Microsyst Nanoeng."},{"issue":"6","key":"10.1016\/j.nicl.2025.103744_b0130","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1528-1167.2008.01943.x","article-title":"Dose-dependent memory effects and cerebral volume changes after in utero exposure to valproate in the rat","volume":"50","author":"Frisch","year":"2009","journal-title":"Epilepsia."},{"issue":"4","key":"10.1016\/j.nicl.2025.103744_b0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0250262","article-title":"Neonatal valproic acid exposure produces altered gyrification related to increased parvalbumin-immunopositive neuron density with thickened sulcal floors","volume":"16","author":"Sawada","year":"2021","journal-title":"PLoS One."},{"issue":"5","key":"10.1016\/j.nicl.2025.103744_b0140","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/ana.24240","article-title":"Neurodevelopment in new-onset juvenile myoclonic epilepsy over the first 2 years","volume":"76","author":"Lin","year":"2014","journal-title":"Ann Neurol."},{"issue":"3","key":"10.1016\/j.nicl.2025.103744_b0145","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.seizure.2013.01.001","article-title":"Subcortical structural abnormalities in juvenile myoclonic epilepsy (JME): MR volumetry and vertex based analysis","volume":"22","author":"Saini","year":"2013","journal-title":"Seizure."},{"key":"10.1016\/j.nicl.2025.103744_b0150","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3389\/fpsyt.2019.00513","article-title":"Possible Implication of the CA2 Hippocampal Circuit in Social Cognition Deficits Observed in the Neuroligin 3 Knock-Out Mouse, a Non-Syndromic Animal Model of Autism","volume":"10","author":"Modi","year":"2019","journal-title":"Front Psychiatry."},{"issue":"2","key":"10.1016\/j.nicl.2025.103744_b0155","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0006-3223(98)00138-3","article-title":"A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives","volume":"44","author":"Benes","year":"1998","journal-title":"Biol Psychiatry."},{"issue":"19","key":"10.1016\/j.nicl.2025.103744_b0160","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1016\/j.neuron.2022.07.020","article-title":"Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy","volume":"110","author":"Whitebirch","year":"2022","journal-title":"Neuron."},{"issue":"5","key":"10.1016\/j.nicl.2025.103744_b0165","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/hipo.1065","article-title":"GluR5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic depressives","volume":"11","author":"Benes","year":"2001","journal-title":"Hippocampus."},{"key":"10.1016\/j.nicl.2025.103744_b0170","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.msard.2018.12.009","article-title":"Altered volume and microstructural integrity of hippocampus in NMOSD","volume":"28","author":"Chen","year":"2019","journal-title":"Mult Scler Relat Disord."},{"issue":"2","key":"10.1016\/j.nicl.2025.103744_b0175","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1192\/bjp.2023.143","article-title":"Association of hippocampal subfield volumes with prevalence, course and incidence of depressive symptoms: The Maastricht Study","volume":"224","author":"Monereo-S\u00e1nchez","year":"2024","journal-title":"Br J Psychiatry."},{"issue":"6","key":"10.1016\/j.nicl.2025.103744_b0180","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.biopsych.2018.08.021","article-title":"The Hippocampus in Depression: More Than the Sum of Its Parts? Advanced Hippocampal Substructure Segmentation in Depression","volume":"85","author":"Roddy","year":"2019","journal-title":"Biol Psychiatry."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158225000142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158225000142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:16:33Z","timestamp":1762607793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158225000142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":36,"alternative-id":["S2213158225000142"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2025.103744","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of valproate use and hippocampal atrophy in idiopathic generalized epilepsy","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2025.103744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103744"}}