{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:47:49Z","timestamp":1785844069858,"version":"3.56.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":103,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["2025-2027"],"award-info":[{"award-number":["2025-2027"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.nicl.2026.103994","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:31:24Z","timestamp":1776238284000},"page":"103994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mapping the multiscale neuroanatomy of GRN-related frontotemporal dementia using mode-based morphometry"],"prefix":"10.1016","volume":"50","author":[{"given":"Enrico","family":"Premi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Bianchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Bracca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Campana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Fornito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Cantoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Corbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Magoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ghidoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Pievani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9814","authenticated-orcid":false,"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nicl.2026.103994_b0005","doi-asserted-by":"crossref","first-page":"10340","DOI":"10.1038\/ncomms10340","article-title":"Human brain networks function in connectome-specific harmonic waves","volume":"7","author":"Atasoy","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.nicl.2026.103994_b0010","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209944","article-title":"Association of Initial Side of Brain Atrophy with Clinical Features and Disease Progression in patients with GRN Frontotemporal Dementia","volume":"103","author":"Borrego-Ecija","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2026.103994_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102540","article-title":"Disease-related cortical thinning in presymptomatic granulin mutation carriers","volume":"29","author":"Borrego-\u00c9cija","year":"2021","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.nicl.2026.103994_b0020","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/rej.2007.0623","article-title":"Brain magnetic resonance imaging structural changes in a pedigree of asymptomatic progranulin mutation carriers","volume":"11","author":"Borroni","year":"2008","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.nicl.2026.103994_b0025","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.26640","article-title":"Mode-based morphometry: a multiscale approach to mapping human neuroanatomy","volume":"45","author":"Cao","year":"2024","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2026.103994_b0030","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neurobiolaging.2017.10.008","article-title":"Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study","volume":"62","author":"Cash","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2026.103994_b0035","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75056","article-title":"The individuality of shape asymmetries of the human cerebral cortex","volume":"11","author":"Chen","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.nicl.2026.103994_b0040","article-title":"A multiscale characterization of cortical shape asymmetries in early psychosis","volume":"6","author":"Chen","year":"2024","journal-title":"Brain Commun."},{"key":"10.1016\/j.nicl.2026.103994_b0045","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/1097-4679(198707)43:4<402::AID-JCLP2270430411>3.0.CO;2-E","article-title":"Relationships between parts A and B of the Trail making Test","volume":"43","author":"Corrigan","year":"1987","journal-title":"J. Clin. Psychol."},{"key":"10.1016\/j.nicl.2026.103994_b0050","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1001\/archneurol.2010.350","article-title":"Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels","volume":"68","author":"Cruchaga","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.nicl.2026.103994_b0055","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1212\/WNL.0000000000000583","article-title":"Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia","volume":"83","author":"Dopper","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2026.103994_b0060","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","volume":"62","author":"Fischl","year":"2012","journal-title":"FreeSurfer. Neuroimage"},{"key":"10.1016\/j.nicl.2026.103994_b0065","doi-asserted-by":"crossref","DOI":"10.1002\/acn3.70170","article-title":"Functional Connectivity Associations with Markers of Disease Progression in GRN Pathogenic Variant Carriers","author":"Flagan","year":"2025","journal-title":"Clin. Transl. Neurol. Ann."},{"key":"10.1016\/j.nicl.2026.103994_b0070","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.96.032413","article-title":"Cortical geometry as a determinant of brain activity eigenmodes: neural field analysis","volume":"96","author":"Gabay","year":"2017","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.nicl.2026.103994_b0075","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40035-025-00475-8","article-title":"Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells","volume":"14","author":"Gaweda-Walerych","year":"2025","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.nicl.2026.103994_b0080","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroimage.2019.01.014","article-title":"Qoala-T: a supervised-learning tool for quality control of FreeSurfer segmented MRI data","volume":"189","author":"Klapwijk","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2026.103994_b0085","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/21678421.2020.1779302","article-title":"Variability of clinical syndromes and cerebral glucose metabolism in symptomatic frontotemporal lobar degeneration associated with progranulin mutations","volume":"21","author":"Licata","year":"2020","journal-title":"Amyotroph. Lateral Scler. Front. Degener."},{"key":"10.1016\/j.nicl.2026.103994_b0090","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1007\/s11682-022-00711-z","article-title":"Pre-symptomatic radiological changes in frontotemporal dementia: propagation characteristics,predictive value andimplications for clinical trials","volume":"16","author":"McKenna","year":"2022","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.nicl.2026.103994_b0095","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1093\/brain\/awaf019","article-title":"Disease-modifying effects of TMEM106B in genetic frontotemporal dementia: a longitudinal GENFI study","volume":"148","author":"Mirza","year":"2025","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2026.103994_b0100","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/alz.12033","article-title":"Utility of the global CDR\u00ae plus NACC FTLD rating and development of scoring rules: Data from the ARTFL\/LEFFTDS Consortium","volume":"16","author":"Miyagawa","year":"2020","journal-title":"Alzheimers Dement. J. Alzheimers Assoc."},{"key":"10.1016\/j.nicl.2026.103994_b0105","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S1474-4422(19)30394-1","article-title":"Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study","volume":"19","author":"Moore","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2026.103994_b0110","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41586-023-06098-1","article-title":"Geometric constraints on human brain function","volume":"618","author":"Pang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.nicl.2026.103994_b0115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neurobiolaging.2018.12.017","article-title":"Gray and white matter changes in presymptomatic genetic frontotemporal dementia: a longitudinal MRI study","volume":"76","author":"Panman","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2026.103994_b0120","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/jnnp-2020-323541","article-title":"Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia","volume":"92","author":"Panman","year":"2021","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.nicl.2026.103994_b0125","article-title":"Pattern of structural and functional brain abnormalities in asymptomatic granulin mutation carriers","volume":"10","author":"Pievani","year":"2014","journal-title":"Alzheimers Dement. J. Alzheimers Assoc."},{"key":"10.1016\/j.nicl.2026.103994_b0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13195-022-00958-0","article-title":"Cognitive composites for genetic frontotemporal dementia: GENFI-Cog","volume":"14","author":"Poos","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.nicl.2026.103994_b0135","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.nicl.2018.02.017","article-title":"Gray matter changes in asymptomatic C9orf72 and GRN mutation carriers","volume":"18","author":"Popuri","year":"2018","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.nicl.2026.103994_b0140","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuroimage.2019.01.080","article-title":"The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: the chronnectome fingerprint","volume":"189","author":"Premi","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2026.103994_b0145","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/jamaneurol.2013.4835","article-title":"Effect of TMEM106B polymorphism on functional network connectivity in asymptomatic GRN mutation carriers","volume":"71","author":"Premi","year":"2014","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.nicl.2026.103994_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074762","article-title":"Cognitive reserve in granulin-related frontotemporal dementia: from preclinical to clinical stages","volume":"8","author":"Premi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2026.103994_b0155","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neurobiolaging.2021.09.001","article-title":"Dissemination in time and space in presymptomatic granulin mutation carriers: a GENFI spatial chronnectome study","volume":"108","author":"Premi","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nicl.2026.103994_b0160","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/brain\/awx103","article-title":"Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study","volume":"140","author":"Premi","year":"2017","journal-title":"Brain J. Neurol."},{"key":"10.1016\/j.nicl.2026.103994_b0165","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuroimage.2016.04.050","article-title":"Eigenmodes of brain activity: Neural field theory predictions and comparison with experiment","volume":"142","author":"Robinson","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2026.103994_b0170","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","article-title":"Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis","volume":"14","author":"Rohrer","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2026.103994_b0175","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.neuroimage.2009.12.088","article-title":"Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations","volume":"53","author":"Rohrer","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2026.103994_b0180","doi-asserted-by":"crossref","unstructured":"Samra, K., MacDougall, A.M., Bouzigues, A., Bocchetta, M., Cash, D.M., Greaves, C.V., Convery, R.S., Hardy, C., van Swieten, J.C., Seelaar, H., Jiskoot, L.C., Moreno, F., Sanchez-Valle, R., Laforce, R., Graff, C., Masellis, M., Tartaglia, M.C., Rowe, J.B., Borroni, B., Finger, E., Synofzik, M., Galimberti, D., Vandenberghe, R., de Mendon\u00e7a, A., Butler, C.R., Gerhard, A., Ducharme, S., Le Ber, I., Santana, I., Pasquier, F., Levin, J., Otto, M., Sorbi, S., Warren, J.D., Rohrer, J.D., Russell, L.L., GENetic Frontotemporal dementia Initiative (GENFI), 2023. Genetic forms of primary progressive aphasia within the GENetic Frontotemporal dementia Initiative (GENFI) cohort: comparison with sporadic primary progressive aphasia. Brain Commun. 5, fcad036. https:\/\/doi.org\/10.1093\/braincomms\/fcad036.","DOI":"10.1093\/braincomms\/fcad036"},{"key":"10.1016\/j.nicl.2026.103994_b0185","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.22847","article-title":"Rates of brain atrophy across disease stages in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants","volume":"3","author":"Staffaroni","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.nicl.2026.103994_b0190","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1038\/s41591-022-01942-9","article-title":"Temporal order of clinical and biomarker changes in familial frontotemporal dementia","volume":"28","author":"Staffaroni","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.nicl.2026.103994_b0195","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S1474-4422(08)70194-7","article-title":"Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia","volume":"7","author":"van Swieten","year":"2008","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.nicl.2026.103994_b0200","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.f4827","article-title":"Clinical review. Frontotemporal dementia","volume":"347","author":"Warren","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.nicl.2026.103994_b0205","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.tins.2013.06.007","article-title":"Molecular nexopathies: a new paradigm of neurodegenerative disease","volume":"36","author":"Warren","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.nicl.2026.103994_b0210","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1212\/01.wnl.0000343851.46573.67","article-title":"Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN","volume":"72","author":"Whitwell","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2026.103994_b0215","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/brain\/aws001","article-title":"Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics","volume":"135","author":"Whitwell","year":"2012","journal-title":"Brain J. Neurol."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158226000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158226000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:34:53Z","timestamp":1785843293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158226000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":43,"alternative-id":["S2213158226000537"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2026.103994","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping the multiscale neuroanatomy of GRN-related frontotemporal dementia using mode-based morphometry","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2026.103994","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103994"}}