{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:52:24Z","timestamp":1791561144964,"version":"4.3.4"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":203,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["ZIA NS003157"],"award-info":[{"award-number":["ZIA NS003157"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.nicl.2026.104041","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:49:07Z","timestamp":1785253747000},"page":"104041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Central origin of fatigability in Myalgic encephalomyelitis\/chronic fatigue syndrome revealed by multimodal neuroimaging"],"prefix":"10.1016","volume":"51","author":[{"given":"Patrick","family":"Bedard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M.","family":"Knutson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"McGurrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Vial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traian","family":"Popa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvina G.","family":"Horovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hallett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avindra","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Walitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.nicl.2026.104041_bb0005","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/nimg.2000.0599","article-title":"A method for removing imaging artifact from continuous EEG recorded during functional MRI","volume":"12","author":"Allen","year":"2000","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2026.104041_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.mri.2024.05.004","article-title":"Denoising of the gradient artifact present in simultaneous studies of muscle blood oxygen level dependent (BOLD) signal and electromyography (EMG)","volume":"111","author":"Amador-Tejada","year":"2024","journal-title":"Magn. Reson. Imaging"},{"issue":"4","key":"10.1016\/j.nicl.2026.104041_bb0015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1249\/JES.0000000000000233","article-title":"On the influence of group III\/IV muscle afferent feedback on endurance exercise performance","volume":"48","author":"Amann","year":"2020","journal-title":"Exerc. Sport Sci. Rev."},{"issue":"12","key":"10.1016\/j.nicl.2026.104041_bb0020","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1249\/MSS.0000000000002421","article-title":"Elevated perceived exertion in people with Myalgic encephalomyelitis\/chronic fatigue syndrome and fibromyalgia: A Meta-analysis","volume":"52","author":"Barhorst","year":"2020","journal-title":"Med. Sci. Sports Exerc."},{"issue":"3","key":"10.1016\/j.nicl.2026.104041_bb0025","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/hbm.20152","article-title":"Visual evoked potentials recovered from fMRI scan periods","volume":"26","author":"Becker","year":"2005","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2026.104041_bb0030","article-title":"Multimodal neuroimaging of fatigability development","volume":"3","author":"Bedard","year":"2025","journal-title":"Imaging Neurosci (Camb)"},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B. Methodol."},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00221-007-0973-5","article-title":"Changes in the functional MR signal in motor and non-motor areas during intermittent fatiguing hand exercise","volume":"182","author":"Benwell","year":"2007","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.nicl.2026.104041_bb0045","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fnhum.2013.00135","article-title":"The neurophysiology of central and peripheral fatigue during sub-maximal lower limb isometric contractions","volume":"7","author":"Berchicci","year":"2013","journal-title":"Front. Hum. Neurosci."},{"issue":"5","key":"10.1016\/j.nicl.2026.104041_bb0050","first-page":"1300","article-title":"Conduction velocity and EMG power spectrum changes in fatigue of sustained maximal efforts","volume":"51","author":"Bigland-Ritchie","year":"1981","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"10.1016\/j.nicl.2026.104041_bb0055","article-title":"Skeletal muscle properties in long COVID and ME\/CFS differ from those induced by bed rest","author":"Charlton","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.nicl.2026.104041_bb0060","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neuroimage.2013.01.047","article-title":"Linear mixed-effects modeling approach to FMRI group analysis","volume":"73","author":"Chen","year":"2013","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.nicl.2026.104041_bb0065","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance Neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput. Biomed. Res."},{"issue":"4","key":"10.1016\/j.nicl.2026.104041_bb0070","first-page":"251","article-title":"Myoelectrical manifestations of localized muscular fatigue in humans","volume":"11","author":"De Luca","year":"1984","journal-title":"Crit. Rev. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.nicl.2026.104041_bb0075","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad187","article-title":"Corticomuscular and intermuscular coherence are correlated after stroke: a simplified motor control?","volume":"5","author":"Delcamp","year":"2023","journal-title":"Brain Commun"},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"Delorme","year":"2004","journal-title":"J. Neurosci. Methods"},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0085","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuroimage.2006.05.056","article-title":"A spatially unbiased atlas template of the human cerebellum","volume":"33","author":"Diedrichsen","year":"2006","journal-title":"Neuroimage"},{"issue":"11","key":"10.1016\/j.nicl.2026.104041_bb0090","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1249\/01.mss.0000233794.31659.6d","article-title":"Muscle fatigue during dynamic contractions assessed by new spectral indices","volume":"38","author":"Dimitrov","year":"2006","journal-title":"Med. Sci. Sports Exerc."},{"issue":"4","key":"10.1016\/j.nicl.2026.104041_bb0095","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jelekin.2005.01.005","article-title":"Estimate of M-wave changes in human biceps brachii during continuous stimulation","volume":"15","author":"Dimitrova","year":"2005","journal-title":"J. Electromyogr. Kinesiol."},{"issue":"20","key":"10.1016\/j.nicl.2026.104041_bb0100","doi-asserted-by":"crossref","first-page":"6513","DOI":"10.1523\/JNEUROSCI.16-20-06513.1996","article-title":"Spinal cord terminations of the medial wall motor areas in macaque monkeys","volume":"16","author":"Dum","year":"1996","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0105","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1152\/jn.00497.2015","article-title":"Changes in cortical activity measured with EEG during a high-intensity cycling exercise","volume":"115","author":"Enders","year":"2016","journal-title":"J. Neurophysiol."},{"issue":"11","key":"10.1016\/j.nicl.2026.104041_bb0110","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1249\/MSS.0000000000000929","article-title":"Translating fatigue to human performance","volume":"48","author":"Enoka","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"issue":"8","key":"10.1016\/j.nicl.2026.104041_bb0115","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","article-title":"The human Brainnetome atlas: A new brain atlas based on connectional architecture","volume":"26","author":"Fan","year":"2016","journal-title":"Cereb. Cortex"},{"issue":"4","key":"10.1016\/j.nicl.2026.104041_bb0120","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1152\/physrev.2001.81.4.1725","article-title":"Spinal and supraspinal factors in human muscle fatigue","volume":"81","author":"Gandevia","year":"2001","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0125","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1038\/s41598-021-85851-w","article-title":"Specific modulation of corticomuscular coherence during submaximal voluntary isometric, shortening and lengthening contractions","volume":"11","author":"Glories","year":"2021","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.nicl.2026.104041_bb0130","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1097\/WNR.0000000000000242","article-title":"Movement-related cortical potentials during muscle fatigue induced by upper limb submaximal isometric contractions","volume":"25","author":"Guo","year":"2014","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.nicl.2026.104041_bb0135","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1142\/S0219635215300127","article-title":"Nonparametric directionality measures for time series and point process data","volume":"14","author":"Halliday","year":"2015","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.nicl.2026.104041_bb0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneumeth.2016.05.008","article-title":"Non-parametric directionality analysis - extension for removal of a single common predictor and application to time series","volume":"268","author":"Halliday","year":"2016","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.nicl.2026.104041_bb0145","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3389\/fneur.2017.00483","article-title":"Cortical substrate of Supraspinal fatigue following exhaustive aerobic exercise localizes to a large cluster in the anterior premotor cortex","volume":"8","author":"Herath","year":"2017","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1400121","article-title":"Distinct plasma immune signatures in ME\/CFS are present early in the course of illness","volume":"1","author":"Hornig","year":"2015","journal-title":"Sci. Adv."},{"issue":"5","key":"10.1016\/j.nicl.2026.104041_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/s23052440","article-title":"Effects of muscle fatigue and recovery on the neuromuscular network after an intermittent handgrip fatigue task: spectral analysis of electroencephalography and electromyography signals","volume":"23","author":"Hsu","year":"2023","journal-title":"Sensors (Basel)"},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/17461391.2016.1252428","article-title":"The \u2018sensory tolerance limit\u2019: A hypothetical construct determining exercise performance?","volume":"18","author":"Hureau","year":"2018","journal-title":"Eur. J. Sport Sci."},{"key":"10.1016\/j.nicl.2026.104041_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1726848","article-title":"Strengthened corticosubcortical functional connectivity during muscle fatigue","author":"Jiang","year":"2016","journal-title":"Neural Plast."},{"issue":"2","key":"10.1016\/j.nicl.2026.104041_bb0170","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neuroimage.2010.04.246","article-title":"Mapping sources of correlation in resting state FMRI, with artifact detection and removal","volume":"52","author":"Jo","year":"2010","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0175","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1388-2457(00)00452-1","article-title":"Movement-related cortical potentials associated with progressive muscle fatigue in a grasping task","volume":"112","author":"Johnston","year":"2001","journal-title":"Clin. Neurophysiol."},{"issue":"4","key":"10.1016\/j.nicl.2026.104041_bb0180","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1212\/WNL.0b013e31827f07be","article-title":"Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy","volume":"80","author":"Kluger","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.nicl.2026.104041_bb0185","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.neuroscience.2015.01.065","article-title":"Group III and IV muscle afferents: role on central motor drive and clinical implications","volume":"290","author":"Laurin","year":"2015","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0190","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12967-020-02269-0","article-title":"Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome\/myalgic encephalomyelitis (CFS\/ME)","volume":"18","author":"Lim","year":"2020","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0195","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1152\/jn.00821.2002","article-title":"Human brain activation during sustained and intermittent submaximal fatigue muscle contractions: an FMRI study","volume":"90","author":"Liu","year":"2003","journal-title":"J. Neurophysiol."},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0200","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuroimage.2006.09.050","article-title":"Shifting of activation center in the brain during muscle fatigue: an explanation of minimal central fatigue?","volume":"35","author":"Liu","year":"2007","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.nicl.2026.104041_bb0205","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00221-012-3087-7","article-title":"Modulation of corticomuscular coherence by peripheral stimuli","volume":"219","author":"McClelland","year":"2012","journal-title":"Exp. Brain Res."},{"issue":"3","key":"10.1016\/j.nicl.2026.104041_bb0210","article-title":"Pathological mechanisms underlying Myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"9","author":"Missailidis","year":"2019","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.nicl.2026.104041_bb0215","series-title":"Fatigue. Allen &UnwinLtd","author":"Mosso","year":"1915"},{"issue":"43","key":"10.1016\/j.nicl.2026.104041_bb0220","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017600","article-title":"Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis\/chronic fatigue syndrome: A systematic review and meta-analysis","volume":"98","author":"Nelson","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"10.1016\/j.nicl.2026.104041_bb0225","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/jn.00792.2009","article-title":"Rectification of the EMG signal impairs the identification of oscillatory input to the muscle","volume":"103","author":"Neto","year":"2010","journal-title":"J. Neurophysiol."},{"issue":"3","key":"10.1016\/j.nicl.2026.104041_bb0230","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.neuroimage.2005.06.067","article-title":"Removal of FMRI environment artifacts from EEG data using optimal basis sets","volume":"28","author":"Niazy","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.nicl.2026.104041_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2012.00082","article-title":"Fatigue is a brain-derived emotion that regulates the exercise behavior to ensure the protection of whole body homeostasis","volume":"3","author":"Noakes","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.nicl.2026.104041_bb0240","series-title":"Electric Fields of the Brain: The Neurophysics of EEG. Oxford University Press","author":"Nunez","year":"2006"},{"issue":"34","key":"10.1016\/j.nicl.2026.104041_bb0245","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2024358118","article-title":"Redox imbalance links COVID-19 and myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"118","author":"Paul","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nicl.2026.104041_bb0250","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuroimage.2019.05.026","article-title":"ICLabel: an automated electroencephalographic independent component classifier, dataset, and website","volume":"198","author":"Pion-Tonachini","year":"2019","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.nicl.2026.104041_bb0255","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/hbm.20562","article-title":"Voluntary activation and cortical activity during a sustained maximal contraction: an fMRI study","volume":"30","author":"Post","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2026.104041_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fspor.2021.644765","article-title":"Surface electromyography spectral parameters for the study of muscle fatigue in swimming","volume":"3","author":"Puce","year":"2021","journal-title":"Front. Sports Act. Living"},{"issue":"6","key":"10.1016\/j.nicl.2026.104041_bb0265","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.mri.2007.03.005","article-title":"Evaluating gradient artifact correction of EEG data acquired simultaneously with fMRI","volume":"25","author":"Ritter","year":"2007","journal-title":"Magn. Reson. Imaging"},{"key":"10.1016\/j.nicl.2026.104041_bb0270","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2497348","article-title":"Understanding muscle dysfunction in chronic fatigue syndrome","author":"Rutherford","year":"2016","journal-title":"J. Aging Res."},{"issue":"11","key":"10.1016\/j.nicl.2026.104041_bb0275","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/S1388-2457(99)00144-3","article-title":"Corticomotor excitability and perception of effort during sustained exercise in the chronic fatigue syndrome","volume":"110","author":"Sacco","year":"1999","journal-title":"Clin. Neurophysiol."},{"issue":"6","key":"10.1016\/j.nicl.2026.104041_bb0280","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1212\/WNL.47.6.1410","article-title":"Decreased postexercise facilitation of motor evoked potentials in patients with chronic fatigue syndrome or depression","volume":"47","author":"Samii","year":"1996","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.nicl.2026.104041_bb0285","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00421-006-0211-z","article-title":"Central adaptations during repetitive contractions assessed by the readiness potential","volume":"97","author":"Schillings","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.nicl.2026.104041_bb0290","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.nicl.2018.04.025","article-title":"Brain function characteristics of chronic fatigue syndrome: A task fMRI study","volume":"19","author":"Shan","year":"2018","journal-title":"Neuroimage Clin"},{"issue":"10","key":"10.1016\/j.nicl.2026.104041_bb0295","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/j.clinph.2004.05.012","article-title":"Altered central nervous system signal during motor performance in chronic fatigue syndrome","volume":"115","author":"Siemionow","year":"2004","journal-title":"Clin. Neurophysiol."},{"issue":"2","key":"10.1016\/j.nicl.2026.104041_bb0300","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1109\/TNSRE.2010.2047173","article-title":"Single-trial EEG-EMG coherence analysis reveals muscle fatigue-related progressive alterations in corticomuscular coupling","volume":"18","author":"Siemionow","year":"2010","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"issue":"11","key":"10.1016\/j.nicl.2026.104041_bb0305","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/S1388-2457(00)00444-2","article-title":"Motor cortex excitability in chronic fatigue syndrome","volume":"111","author":"Starr","year":"2000","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.nicl.2026.104041_bb0310","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.01025","article-title":"Characterization of post-exertional malaise in patients with myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"11","author":"Stussman","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.nicl.2026.104041_bb0315","article-title":"EEG-based spectral analysis showing brainwave changes related to modulating progressive fatigue during a prolonged intermittent motor task","volume":"16","author":"Suviseshamuthu","year":"2022","journal-title":"Front. Hum. Neurosci."},{"issue":"4","key":"10.1016\/j.nicl.2026.104041_bb0320","first-page":"0","article-title":"Mitochondrial dysfunction in Myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"40","author":"Syed","year":"2025","journal-title":"Physiology (Bethesda)"},{"issue":"5","key":"10.1016\/j.nicl.2026.104041_bb0325","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1152\/japplphysiol.01194.2010","article-title":"Muscle fatigue-induced enhancement of corticomuscular coherence following sustained submaximal isometric contraction of the tibialis anterior muscle","volume":"110","author":"Ushiyama","year":"2011","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"1","key":"10.1016\/j.nicl.2026.104041_bb0330","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-45107-3","article-title":"Deep phenotyping of post-infectious myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"15","author":"Walitt","year":"2024","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.nicl.2026.104041_bb0335","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.194","article-title":"Muscle fatigue: general understanding and treatment","volume":"49","author":"Wan","year":"2017","journal-title":"Exp. Mol. Med."},{"issue":"34","key":"10.1016\/j.nicl.2026.104041_bb0340","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302738120","article-title":"WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"120","author":"Wang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.nicl.2026.104041_bb0345","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1088\/1361-6579\/aa6b4b","article-title":"Effects of force load, muscle fatigue and extremely low frequency magnetic stimulation on EEG signals during side arm lateral raise task","volume":"38","author":"Wang","year":"2017","journal-title":"Physiol. Meas."},{"key":"10.1016\/j.nicl.2026.104041_bb0350","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2008.10.074","article-title":"Weakening of functional corticomuscular coupling during muscle fatigue","volume":"1250","author":"Yang","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.nicl.2026.104041_bb0355","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jsr.2023.04.014","article-title":"Impact of physical and mental fatigue on construction workers' unsafe behavior based on physiological measurement","volume":"85","author":"Zhang","year":"2023","journal-title":"J. Safety Res."},{"key":"10.1016\/j.nicl.2026.104041_bb0360","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.13019","article-title":"Validity of using perceived exertion to assess muscle fatigue during resistance exercises","volume":"10","author":"Zhao","year":"2022","journal-title":"Peerj"}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158226001002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158226001002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:16:08Z","timestamp":1791558968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158226001002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":72,"alternative-id":["S2213158226001002"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2026.104041","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Central origin of fatigability in Myalgic encephalomyelitis\/chronic fatigue syndrome revealed by multimodal neuroimaging","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2026.104041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104041"}}