{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:46:58Z","timestamp":1792673218389,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":291,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroImage: Clinical"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.nicl.2026.104082","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:20:04Z","timestamp":1792596004000},"page":"104082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Diagnostic performance and methodological heterogeneity of neuromelanin-sensitive MRI in Parkinson's disease: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"52","author":[{"given":"Rayo","family":"Akande","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kustermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160tefan","family":"Holiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Anzures-Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Pagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.nicl.2026.104082_bb0005","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jmri.29073","article-title":"Automatic Segmentation and Quantification of Nigrosome-1 Neuromelanin and Iron in MRI: A Candidate Biomarker for Parkinson\u2019s Disease","volume":"60","author":"Ariz","year":"2023","journal-title":"J. Magn. Reson. Imaging"},{"issue":"11","key":"10.1016\/j.nicl.2026.104082_bb0010","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1136\/jnnp-2012-304436","article-title":"Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of parkinsonian syndromes","volume":"84","author":"Bajaj","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"10.1016\/j.nicl.2026.104082_bb0015","article-title":"Neuromelanin and T2*-MRI for the assessment of genetically at-risk, prodromal, and symptomatic Parkinson\u2019s disease. Npj","volume":"8","author":"Ben Bashat","year":"2022","journal-title":"Parkinson\u2019s Disease"},{"issue":"10","key":"10.1016\/j.nicl.2026.104082_bb0020","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.21037\/qims-23-87","article-title":"Diagnostic value of combined magnetic resonance imaging techniques in the evaluation of Parkinson's disease","volume":"13","author":"Cao","year":"2023","journal-title":"Quantitative Imaging Med. Surgery"},{"issue":"7","key":"10.1016\/j.nicl.2026.104082_bb0025","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/mds.26201","article-title":"Automated Neuromelanin Imaging as a Diagnostic Biomarker for Parkinson\u2019s Disease","volume":"30","author":"Castellanos","year":"2015","journal-title":"Mov. Disord."},{"issue":"3","key":"10.1016\/j.nicl.2026.104082_bb0030","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1007\/s00330-020-07240-7","article-title":"Diagnostic performance of neuromelanin-sensitive magnetic resonance imaging for patients with Parkinson\u2019s disease and factor analysis for its heterogeneity: a systematic review and meta-analysis","volume":"31","author":"Cho","year":"2021","journal-title":"Eur. Radiol."},{"issue":"12","key":"10.1016\/j.nicl.2026.104082_bb0035","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.jclinepi.2006.06.011","article-title":"Bivariate meta-analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach","volume":"59","author":"Chu","year":"2006","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.nicl.2026.104082_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.parkreldis.2020.12.006","article-title":"Magnetic resonance imaging evaluation of nigrosome 1 and neuromelanin can assist Parkinson\u2019s disease diagnosis, but requires an expert neuroradiologist","volume":"83","author":"De Pietro Franco Zorzenon","year":"2021","journal-title":"Parkinsonism Relat. Disord."},{"issue":"9","key":"10.1016\/j.nicl.2026.104082_bb0050","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jclinepi.2005.01.016","article-title":"The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed","volume":"58","author":"Deeks","year":"2005","journal-title":"J. Clin. Epidemiol."},{"issue":"3","key":"10.1016\/j.nicl.2026.104082_bb0060","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3233\/JPD-171135","article-title":"Substantia Nigra Neuromelanin as an Imaging Biomarker of Disease Progression in Parkinson\u2019s Disease","volume":"7","author":"Fabbri","year":"2017","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.nicl.2026.104082_bb0065","series-title":"BEST (Biomarkers, EndpointS, and other Tools) resource","author":"FDA-NIH Biomarker Working Group","year":"2016"},{"key":"10.1016\/j.nicl.2026.104082_bb0070","article-title":"NigraNet: An automatic framework to assess nigral neuromelanin content in early Parkinson's disease using convolutional neural network","volume":"36","author":"Gaurav","year":"2022","journal-title":"NeuroImage: Clin."},{"issue":"11","key":"10.1016\/j.nicl.2026.104082_bb0075","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0895-4356(03)00177-X","article-title":"The diagnostic odds ratio: a single indicator of test performance","volume":"56","author":"Glas","year":"2003","journal-title":"J. Clin. Epidemiol."},{"issue":"1","key":"10.1016\/j.nicl.2026.104082_bb0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology"},{"key":"10.1016\/j.nicl.2026.104082_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1287917","article-title":"Quantitative iron\u2013neuromelanin MRI associates with motor severity in Parkinson\u2019s disease and matches radiological disease classification","volume":"15","author":"Hartono","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.nicl.2026.104082_bb0090","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00702-017-1688-9","article-title":"Neuromelanin MRI is useful for monitoring motor complications in Parkinson's and PARK2 disease","volume":"124","author":"Hatano","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nicl.2026.104082_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117810","article-title":"Imaging iron and neuromelanin simultaneously using a single 3D gradient echo magnetization transfer sequence: Combining neuromelanin, iron and the nigrosome-1 sign as complementary imaging biomarkers in early stage Parkinson\u2019s disease","volume":"230","author":"He","year":"2021","journal-title":"NeuroImage"},{"issue":"5","key":"10.1016\/j.nicl.2026.104082_bb0100","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1002\/hbm.23547","article-title":"In vivo detection of lateral\u2013ventral tier nigral degeneration in Parkinson\u2019s disease","volume":"38","author":"Huddleston","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.nicl.2026.104082_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/frdem.2023.1215505","article-title":"Neuromelanin-sensitive MRI correlates of cognitive and motor function in Parkinson\u2019s disease with freezing of gait","volume":"2","author":"Huddleston","year":"2023","journal-title":"Front. Dementia"},{"issue":"3","key":"10.1016\/j.nicl.2026.104082_bb0110","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases","volume":"55","author":"Hughes","year":"1992","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"4","key":"10.1016\/j.nicl.2026.104082_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0282684","article-title":"In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson\u2019s disease using neuromelanin-sensitive MRI: Replication in two cohorts","volume":"18","author":"Hwang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2026.104082_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2016.00196","article-title":"Neuromelanin imaging and dopaminergic loss in Parkinson\u2019s disease","volume":"8","author":"Isaias","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nicl.2026.104082_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119814","article-title":"Diagnosing Parkinson\u2019s disease by combining neuromelanin and iron imaging features using an automated midbrain template approach","volume":"266","author":"Jokar","year":"2023","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.nicl.2026.104082_bb0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/jnnp.2008.157370","article-title":"The role of DAT-SPECT in movement disorders","volume":"81","author":"K\u00e4gi","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"3","key":"10.1016\/j.nicl.2026.104082_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151191","article-title":"Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density","volume":"11","author":"Kawaguchi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nicl.2026.104082_bb0140","series-title":"Parkinson\u2019s Disease: Pathogenesis and Clinical Aspects","first-page":"3","article-title":"Parkinson\u2019s Disease: Etiology, Neuropathology, and Pathogenesis","author":"Kouli","year":"2018"},{"issue":"1","key":"10.1016\/j.nicl.2026.104082_bb0145","article-title":"Diagnostic utility of 7\u00a0T neuromelanin imaging of the substantia nigra in Parkinson\u2019s disease. Npj","volume":"10","author":"Lakhani","year":"2024","journal-title":"Parkinson\u2019s Disease"},{"issue":"12","key":"10.1016\/j.nicl.2026.104082_bb0150","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s00234-019-02279-w","article-title":"Convolutional neural network-based segmentation can help in assessing the substantia nigra in neuromelanin MRI","volume":"61","author":"Le Berre","year":"2019","journal-title":"Neuroradiology"},{"issue":"1","key":"10.1016\/j.nicl.2026.104082_bb0160","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-020-01828-8","article-title":"Short-echo-time magnitude image derived from quantitative susceptibility mapping could resemble neuromelanin-sensitive MRI image in substantia nigra","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Neurol."},{"key":"10.1016\/j.nicl.2026.104082_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2024.120588","article-title":"PENCIL imaging: A novel approach for neuromelanin sensitive MRI in Parkinson\u2019s disease","volume":"291","author":"Liu","year":"2024","journal-title":"NeuroImage"},{"issue":"8","key":"10.1016\/j.nicl.2026.104082_bb0170","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/jnnp-2015-311890","article-title":"The prediagnostic phase of Parkinson\u2019s disease","volume":"87","author":"Noyce","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"6","key":"10.1016\/j.nicl.2026.104082_bb0175","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00234-013-1171-8","article-title":"3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease","volume":"55","author":"Ogisu","year":"2013","journal-title":"Neuroradiology"},{"key":"10.1016\/j.nicl.2026.104082_bb0180","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neulet.2013.02.012","article-title":"Changes in substantia nigra and locus coeruleus in patients with early-stage Parkinson's disease using neuromelanin-sensitive MR imaging","volume":"541","author":"Ohtsuka","year":"2013","journal-title":"Neurosci. Lett."},{"issue":"7","key":"10.1016\/j.nicl.2026.104082_bb0185","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.parkreldis.2014.04.005","article-title":"Differentiation of early-stage parkinsonisms using neuromelanin-sensitive magnetic resonance imaging","volume":"20","author":"Ohtsuka","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"issue":"11","key":"10.1016\/j.nicl.2026.104082_bb0190","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1007\/s11604-023-01452-9","article-title":"Denoising approach with deep learning-based reconstruction for neuromelanin-sensitive MRI: image quality and diagnostic performance","volume":"41","author":"Oshima","year":"2023","journal-title":"Jpn. J. Radiol."},{"issue":"4","key":"10.1016\/j.nicl.2026.104082_bb0195","doi-asserted-by":"crossref","first-page":"371","DOI":"10.7861\/clinmedicine.16-4-371","article-title":"Imaging in Parkinson's disease","volume":"16","author":"Pagano","year":"2016","journal-title":"Clin. Med."},{"key":"10.1016\/j.nicl.2026.104082_bb0200","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"n71","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.nicl.2026.104082_bb0205","series-title":"Statistics","author":"Parkinson's Foundation","year":"2023"},{"issue":"12","key":"10.1016\/j.nicl.2026.104082_bb0210","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.nicl.2026.104082_bb0215","doi-asserted-by":"crossref","DOI":"10.3174\/ajnr.A5702","article-title":"Comparative study of MRI biomarkers in the substantia nigra to discriminate idiopathic Parkinson's disease","author":"Pyatigorskaya","year":"2018","journal-title":"Am. J. Neuroradiol."},{"issue":"3","key":"10.1016\/j.nicl.2026.104082_bb0220","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3233\/JPD-150551","article-title":"Quantitative analysis versus visual assessment of neuromelanin MR imaging for the diagnosis of Parkinson\u2019s disease","volume":"5","author":"Reim\u00e3o","year":"2015","journal-title":"J. Parkinsons Dis."},{"issue":"10","key":"10.1016\/j.nicl.2026.104082_bb0225","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jclinepi.2005.02.022","article-title":"Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews","volume":"58","author":"Reitsma","year":"2005","journal-title":"J. Clin. Epidemiol."},{"issue":"3","key":"10.1016\/j.nicl.2026.104082_bb0230","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1148\/radiol.2016160662","article-title":"In vivo assessment of brainstem depigmentation in parkinson\u2019s disease: potential as a severity marker for multicenter studies","volume":"283","author":"Schwarz","year":"2017","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.nicl.2026.104082_bb0235","doi-asserted-by":"crossref","DOI":"10.1186\/s12880-023-01018-1","article-title":"Diagnostic performance of a high-spatial-resolution voxelwise analysis of neuromelanin-sensitive imaging in early-stage idiopathic Parkinson\u2019s disease","volume":"23","author":"Seong","year":"2023","journal-title":"BMC Med. Imaging"},{"key":"10.1016\/j.nicl.2026.104082_bb0240","article-title":"Predictive markers for Parkinson\u2019s disease using deep neural nets on neuromelanin sensitive MRI","volume":"22","author":"Shinde","year":"2019","journal-title":"NeuroImage: Clin."},{"issue":"1","key":"10.1016\/j.nicl.2026.104082_bb0245","article-title":"Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson\u2019s disease. Npj","volume":"4","author":"Sulzer","year":"2018","journal-title":"Parkinson\u2019s Disease"},{"issue":"1086","key":"10.1016\/j.nicl.2026.104082_bb0250","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20180037","article-title":"Quantifying changes in nigrosomes using quantitative susceptibility mapping and neuromelanin imaging for the diagnosis of early-stage Parkinson's disease","volume":"91","author":"Takahashi","year":"2018","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.nicl.2026.104082_bb0255","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejrad.2018.06.024","article-title":"Comprehensive MRI quantification of the substantia nigra pars compacta in Parkinson's disease","volume":"109","author":"Takahashi","year":"2018","journal-title":"Eur. J. Radiol."},{"issue":"1130","key":"10.1016\/j.nicl.2026.104082_bb0260","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20210837","article-title":"Imaging of the nigrostriatal system for evaluating the preclinical phase of Parkinson's disease development: the utility of neuromelanin, diffusion MRI, and DAT-SPECT","volume":"95","author":"Takahashi","year":"2022","journal-title":"Br. J. Radiol."},{"issue":"9","key":"10.1016\/j.nicl.2026.104082_bb0265","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/mds.27365","article-title":"Neuromelanin imaging and midbrain volumetry in progressive supranuclear palsy and Parkinson's disease","volume":"33","author":"Taniguchi","year":"2018","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.nicl.2026.104082_bb0270","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/brain\/awad300","article-title":"Neuromelanin-sensitive MRI as a promising biomarker of catecholamine function","volume":"147","author":"Trujillo","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.nicl.2026.104082_bb0275","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.parkreldis.2018.07.007","article-title":"Neuromelanin-sensitive MRI of the substantia nigra: An imaging biomarker to differentiate essential tremor from tremor-dominant Parkinson's disease","volume":"58","author":"Wang","year":"2019","journal-title":"Parkinsonism Relat. Disord."},{"issue":"12","key":"10.1016\/j.nicl.2026.104082_bb0280","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s10072-019-04014-y","article-title":"The diagnostic value of SNpc using NM-MRI in Parkinson's disease: meta-analysis","volume":"40","author":"Wang","year":"2019","journal-title":"Neurol. Sci."},{"issue":"2","key":"10.1016\/j.nicl.2026.104082_bb0285","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00702-020-02295-8","article-title":"Substantia nigra neuromelanin magnetic resonance imaging in patients with different subtypes of Parkinson's disease","volume":"128","author":"Wang","year":"2021","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.nicl.2026.104082_bb0290","article-title":"Neuromelanin magnetic resonance imaging of substantia nigra and locus coeruleus in Parkinson's disease with freezing of gait","volume":"15","author":"Wang","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.nicl.2026.104082_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116457","article-title":"Reproducibility assessment of neuromelanin-sensitive magnetic resonance imaging protocols for region-of-interest and voxelwise analyses","volume":"208","author":"Wengler","year":"2020","journal-title":"NeuroImage"},{"key":"10.1016\/j.nicl.2026.104082_bb0300","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neulet.2016.12.036","article-title":"Subtypes evaluation of motor dysfunction in Parkinson's disease using neuromelanin-sensitive magnetic resonance imaging","volume":"638","author":"Xiang","year":"2017","journal-title":"Neurosci. Lett."},{"issue":"11","key":"10.1016\/j.nicl.2026.104082_bb0305","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/mds.27502","article-title":"Life span pigmentation changes of the substantia nigra detected by neuromelanin-sensitive MRI","volume":"33","author":"Xing","year":"2018","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.nicl.2026.104082_bb0310","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/mds.28934","article-title":"Neuromelanin-MRI to quantify and track nigral depigmentation in Parkinson\u2019s disease: A multicenter longitudinal study using template-based standardized analysis","volume":"37","author":"Xing","year":"2022","journal-title":"Mov. Disord."},{"issue":"4","key":"10.1016\/j.nicl.2026.104082_bb0315","doi-asserted-by":"crossref","first-page":"716","DOI":"10.4103\/0028-3886.383826","article-title":"Neuromelanin-sensitive magnetic resonance imaging as a measure for differential diagnosis of essential tremor and Parkinson's disease","volume":"71","author":"Xuan","year":"2023","journal-title":"Neurol. India"},{"issue":"3","key":"10.1016\/j.nicl.2026.104082_bb0320","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0014-5793(01)03269-0","article-title":"The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease","volume":"510","author":"Zecca","year":"2002","journal-title":"FEBS Lett."},{"issue":"12","key":"10.1016\/j.nicl.2026.104082_bb0325","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3390\/brainsci9120335","article-title":"Semi-automatic signature-based segmentation method for quantification of neuromelanin in substantia nigra","volume":"9","author":"Zupan","year":"2019","journal-title":"Brain Sci."}],"container-title":["NeuroImage: Clinical"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158226001427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213158226001427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:12:47Z","timestamp":1792671167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213158226001427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":62,"alternative-id":["S2213158226001427"],"URL":"https:\/\/doi.org\/10.1016\/j.nicl.2026.104082","relation":{},"ISSN":["2213-1582"],"issn-type":[{"value":"2213-1582","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic performance and methodological heterogeneity of neuromelanin-sensitive MRI in Parkinson's disease: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"NeuroImage: Clinical","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nicl.2026.104082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104082"}}