{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:54:22Z","timestamp":1784163262952,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.niox.2006.09.002","type":"journal-article","created":{"date-parts":[[2006,9,13]],"date-time":"2006-09-13T11:16:41Z","timestamp":1158146201000},"page":"258-265","source":"Crossref","is-referenced-by-count":25,"title":["Exogenous nitric oxide stimulated collagen type I expression and TGF-\u03b21 production in keloid fibroblasts by a cGMP-dependent manner"],"prefix":"10.1016","volume":"16","author":[{"given":"Yi-Chiang","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yie W.","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woan-Ruoh","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2006.09.002_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1067-1927.2004.012111.x","article-title":"Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways","volume":"12","author":"Satish","year":"2004","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.niox.2006.09.002_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1524-4725.2001.99315.x","article-title":"Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures","volume":"27","author":"Espana","year":"2001","journal-title":"Dermatol. Surg."},{"key":"10.1016\/j.niox.2006.09.002_bib3","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1046\/j.1523-1747.2000.00950.x","article-title":"Reduced hyaluronan in keloid tissue and cultured keloid fibroblasts","volume":"114","author":"Meyer","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.niox.2006.09.002_bib4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1524-475X.1998.60106.x","article-title":"p53 and apoptosis alterations in keloids and keloid fibroblasts","volume":"6","author":"Ladin","year":"1998","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.niox.2006.09.002_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0022-4804(02)96494-2","article-title":"Differential expression of inflammatory mediators in radiation-impaired wound healing","volume":"107","author":"Schaffer","year":"2002","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.niox.2006.09.002_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1006\/bbrc.2000.2602","volume":"271","author":"Hwang","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.niox.2006.09.002_bib7","first-page":"511","article-title":"Hypertrophic scar formation is associated with an increased number of epidermal Langerhans cells","volume":"54","author":"Niessen","year":"2001","journal-title":"J. Pathol."},{"key":"10.1016\/j.niox.2006.09.002_bib8","first-page":"121","article-title":"Inflammatory cell subpopulations in keloid scars","volume":"202","author":"Boyce","year":"2004","journal-title":"Br. J. Plast. Surg."},{"key":"10.1016\/j.niox.2006.09.002_bib9","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1242\/jcs.00474","article-title":"Epidermal tissue regeneration and stromal interaction in HaCaT cells is initiated by TGF-alpha","volume":"116","author":"Maas","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.niox.2006.09.002_bib10","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/110241599750007153","article-title":"Inhibition of nitric oxide synthesis in wounds: pharmacology and effect on accumulation of collagen in wounds in mice","volume":"165","author":"Schaffer","year":"1999","journal-title":"Eur. J. Surg."},{"key":"10.1016\/j.niox.2006.09.002_bib11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1006\/bbrc.1998.8681","article-title":"Enhanced collagen accumulation following direct transfection of the inducible nitric oxide synthase gene in cutaneous wounds","volume":"246","author":"Thornton","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.niox.2006.09.002_bib12","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1053\/meta.2002.35185","article-title":"L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathways","volume":"51","author":"Witte","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.niox.2006.09.002_bib13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1006\/niox.2000.0307","article-title":"Enhancement of fibroblast collagen synthesis by nitric oxide","volume":"4","author":"Witte","year":"2000","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2006.09.002_bib14","doi-asserted-by":"crossref","first-page":"13141","DOI":"10.1073\/pnas.0502977102","article-title":"Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner","volume":"102","author":"Isenberg","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.niox.2006.09.002_bib15","doi-asserted-by":"crossref","first-page":"R501","DOI":"10.1152\/ajpregu.00472.2005","article-title":"P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts","volume":"290","author":"Xia","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.niox.2006.09.002_bib16","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/sj.jid.5700200","article-title":"Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring","volume":"126","author":"Campaner","year":"2006","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.niox.2006.09.002_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00403-005-0596-2","article-title":"Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor in cultured keloid fibroblasts: relevance to angiogenic activity","volume":"297","author":"Fujiwara","year":"2005","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.niox.2006.09.002_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.niox.2006.01.006","article-title":"Nitric oxide produced by iNOS is associated with collagen synthesis in keloid scar formation","volume":"14","author":"Hsu","year":"2006","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2006.09.002_bib19","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1096\/fasebj.13.14.2002","article-title":"Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair","volume":"13","author":"Frank","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.niox.2006.09.002_bib20","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/110241599750007153","article-title":"Inhibition of nitric oxide synthesis in wounds: Pharmacology and effect on accumulation of collagen in wound in mice","volume":"165","author":"Micheal","year":"1999","journal-title":"Eur. J. Surg."},{"key":"10.1016\/j.niox.2006.09.002_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1067\/msy.2000.107372","article-title":"Supplemental dietary arginine enhances wound healing in normal but not inducible nitric oxide synthase knockout mice","volume":"128","author":"Shi","year":"2000","journal-title":"Surgery"},{"key":"10.1016\/j.niox.2006.09.002_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/jmcc.1998.0887","article-title":"Regulation of cardiac fibroblast extracellular matrix production by bradykinin and nitric oxide","volume":"31","author":"Kim","year":"1999","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.niox.2006.09.002_bib23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/jtbi.2000.2012","article-title":"Mathematical modeling of nitric oxide activity in wound healing can explain keloid and hypertrophic scarring","volume":"204","author":"Cobbold","year":"2000","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.niox.2006.09.002_bib24","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1054\/mehy.2001.1373","article-title":"The role of nitric oxide in the formation of keloid and hypertrophic lesions","volume":"57","author":"A Cobbold","year":"2001","journal-title":"Med. Hypoth."},{"key":"10.1016\/j.niox.2006.09.002_bib25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1139\/y81-025","article-title":"Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite","volume":"59","author":"Gruetter","year":"1981","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.niox.2006.09.002_bib26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.RES.0000082524.34487.31","article-title":"Regulation of nitric oxide-sensitive guanylyl cyclase","volume":"93","author":"Friebe","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2006.09.002_bib27","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.bbrc.2005.06.183","article-title":"High lung PDE5: A strong basis for treating pulmonary hypertension with PDE5 inhibitors","volume":"334","author":"Corbin","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.niox.2006.09.002_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1158\/1541-7786.MCR-05-0140","article-title":"Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells","volume":"4","author":"Kwak","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.niox.2006.09.002_bib29","doi-asserted-by":"crossref","first-page":"28315","DOI":"10.1074\/jbc.C400115200","article-title":"Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis","volume":"279","author":"Zhang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2006.09.002_bib30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/01.prs.0000195073.73580.46","article-title":"Keloid pathogenesis and treatment","volume":"117","author":"Al-Attar","year":"2006","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.niox.2006.09.002_bib31","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1097\/01.prs.0000182343.99694.28","article-title":"Hypertrophic scar fibroblasts have increased connective tissue growth factor expression after transforming growth factor-beta stimulation","volume":"116","author":"Colwell","year":"2005","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.niox.2006.09.002_bib32","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0891-5849(03)00211-9","article-title":"Nitric oxide-mediated upregulation of the TGF-beta-inducible early response gene-1 (TIEG1) in human fibroblasts by mRNA stabilization independent of TGF-beta","volume":"34","author":"Mitsumoto","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2006.09.002_bib33","doi-asserted-by":"crossref","first-page":"39403","DOI":"10.1074\/jbc.M504140200","article-title":"Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway","volume":"280","author":"Akool","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2006.09.002_bib34","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1072-7515(98)00303-2","article-title":"Up-regulation by human recombinant transforming growth factor beta-1 of collagen production in cultured dermal fibroblasts is mediated by the inhibition of nitric oxide signaling","volume":"188","author":"Chu","year":"1999","journal-title":"J. Am. Coll. Surg."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108986030600396X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108986030600396X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T04:18:51Z","timestamp":1555820331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108986030600396X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S108986030600396X"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2006.09.002","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}