{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:52:55Z","timestamp":1773665575787,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.niox.2008.07.001","type":"journal-article","created":{"date-parts":[[2008,7,11]],"date-time":"2008-07-11T11:15:52Z","timestamp":1215774952000},"page":"338-344","source":"Crossref","is-referenced-by-count":8,"title":["Estimation of nitric oxide level in vivo by microdialysis with water-soluble iron-N-methyl-d-dithiocarbamate complexes as NO traps: A novel approach to nitric oxide spin trapping in animal tissues"],"prefix":"10.1016","volume":"19","author":[{"given":"Alexander A.","family":"Timoshin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Yu.","family":"Drobotova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir L.","family":"Lakomkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enno K.","family":"Ruuge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatoly F.","family":"Vanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2008.07.001_bib1","first-page":"135","article-title":"Appearance of nitric oxide in animal tissues","volume":"102","author":"Vanin","year":"1984","journal-title":"Studia Biofizika"},{"key":"10.1016\/j.niox.2008.07.001_bib2","first-page":"1974","article-title":"Iron as an inductor of nitric oxide formation in animal organisms","volume":"54","author":"Vanin","year":"1989","journal-title":"Biokhimiya (Rus)"},{"key":"10.1016\/j.niox.2008.07.001_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0003-2697(91)90282-X","article-title":"On-line detection of nitric oxide formation in liquid aqueous phase by electron paramagnetic resonance spectroscopy","volume":"199","author":"Mordvintcev","year":"1991","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.niox.2008.07.001_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0005-2728(92)90032-W","article-title":"EPR evidence for nitric oxide production from guanidine nitrogen of l-arginine in animal tissues in vivo","volume":"1099","author":"Kubrina","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2008.07.001_bib5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj2880597","article-title":"NO accounts completely for the oxygenated nitrogen species generated by enzymic l-arginine oxygenation","volume":"288","author":"Mulsch","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.niox.2008.07.001_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj2880597","article-title":"NO accounts completely for the oxygenated nitrogen species generated by enzymatic l-arginine oxygenation","volume":"288","author":"Mulsch","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.niox.2008.07.001_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0014-5793(94)00422-6","article-title":"Spin trapping of nitric oxide production in vivo in septic-shock mice","volume":"345","author":"Lai","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/j.niox.2008.07.001_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-8993(94)91402-8","article-title":"Electron paramagnetic studies of nitric oxide production during brain local ischemia and reperfusion of the rat brain","volume":"647","author":"Sato","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.niox.2008.07.001_bib9","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/jcbfm.1995.114","article-title":"Three-dimensional imaging of nitric oxide production in the rat brain subjected to ischemia\u2013reperfusion","volume":"15","author":"Kuppusamy","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.niox.2008.07.001_bib10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1246\/cl.1995.309","article-title":"In vivo electron paramagnetic resonance imaging of NO-bound iron complexes in a read head","volume":"8","author":"Yoshimura","year":"1995","journal-title":"Chem. Lett."},{"key":"10.1016\/j.niox.2008.07.001_bib11","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1073\/pnas.92.12.5312","article-title":"Local nitric oxide production in viral and autoimmune diseases of central nervous system","volume":"92","author":"Hooper","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.niox.2008.07.001_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0925-4439(95)00061-8","article-title":"Detection of nitric oxide production in mice by spin-trapping electron paramagnetic resonance spectroscopy","volume":"1272","author":"Komarov","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2008.07.001_bib13","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/(SICI)1097-0142(19960415)77:8<1598::AID-CNCR27>3.0.CO;2-U","article-title":"Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth","volume":"77","author":"Doi","year":"1996","journal-title":"Cancer Suppl."},{"key":"10.1016\/j.niox.2008.07.001_bib14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1246\/cl.1996.785","article-title":"Nitric oxide trapping of water-soluble iron(III) complexes with dithiocarbamate derivatives","volume":"9","author":"Fujii","year":"1996","journal-title":"Chem. Lett."},{"key":"10.1016\/j.niox.2008.07.001_bib15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1006\/bbrc.1996.1214","article-title":"EPR and laser flash photolysis studies of the reaction of nitric oxide with water soluble NO trap Fe(II)\u2013proline\u2013dithiocarbamate complex","volume":"225","author":"Paschenko","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.niox.2008.07.001_bib16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0076-6879(96)68019-7","article-title":"Detection of nitric oxide by electron spin resonance in chemical, photochemical, cellular, physiological and pathophysiological systems","volume":"268","author":"Kalynaraman","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.niox.2008.07.001_bib17","series-title":"Nitric Oxide Research from Chemistry to Biology: EPR Spectroscopy of Nitrosylated Compounds","author":"Henry","year":"1997"},{"key":"10.1016\/j.niox.2008.07.001_bib18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0304-4165(97)00032-9","article-title":"Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-d-glucamine dithiocarbamate as traps of nitric oxide in animal tissues","volume":"1336","author":"Mikoyan","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2008.07.001_bib19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0925-4439(97)84636-4","article-title":"Iron potentiates nitric oxide scavenging by dithiocarbamates in tissue of septic shock mice","volume":"1361","author":"Komarov","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2008.07.001_bib20","series-title":"Nitric Oxide in Transplant Rejection and Anti-Tumor Defense","first-page":"49","article-title":"EPR studies and biological implications of nitrosyl nonheme iron complexes","author":"Vanin","year":"1998"},{"key":"10.1016\/j.niox.2008.07.001_bib21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0076-6879(99)01091-5","article-title":"Iron dithiocarbamates as a spin trap for nitric oxide detection","volume":"301","author":"Vanin","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.niox.2008.07.001_bib22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0304-4165(00)00033-7","article-title":"Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems","volume":"1474","author":"Vanin","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2008.07.001_bib23","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1039\/b003942j","article-title":"Reaction of nitric oxide with Fe(III) complex of N-dithiocarboxy)sarcosine: a new type of reductive nitrosylation involving iron (IY) as an intermediate","author":"Fujii","year":"2000","journal-title":"J. Chem. Soc. Dalton Trans."},{"key":"10.1016\/j.niox.2008.07.001_bib24","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0891-5849(01)00466-X","article-title":"Antioxidant capacity of mononitrosyl-iron-dithiocarbamate: implication for nitric oxide trapping","volume":"30","author":"Vanin","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2008.07.001_bib25","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1021\/cr010152s","article-title":"Bioimaging of nitric oxide","volume":"102","author":"Nagano","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.niox.2008.07.001_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0076-6879(02)59169-2","article-title":"Iron dithiocarbamates as spin traps for nitric oxide: pitfalls and successes","volume":"359","author":"Vanin","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.niox.2008.07.001_bib27","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1080\/10715760412331273449","article-title":"Spinnokinetics analysis of blood deposition and billiary excretion of nitric oxide (NO)-Fe(II)-N-(dithiocarboxy)sarcosine complex in rats: BBCM-ESR and BEM-ESR studies","volume":"38","author":"Yasui","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2008.07.001_bib28","first-page":"537","article-title":"Determination of nitric oxide level in mammals using water-soluble iron(III)-dithiocarbamate complex","volume":"50","author":"Timoshin","year":"2005","journal-title":"Biofizika (Rus)"},{"key":"10.1016\/j.niox.2008.07.001_bib29","first-page":"295","article-title":"Why iron-dithiocarbamates ensure detection of nitric oxide in cells and tissues, Nitric Oxide","volume":"15","author":"Vanin","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.niox.2008.07.001_bib30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/mrm.20746","article-title":"Evaluation of lipid-based carriers system and inclusion complexes of diethylthiocarbamate-iron to trap nitric oxide in biological systems","volume":"55","author":"Charlier","year":"2006","journal-title":"Magn. Res. Med. Sci."},{"key":"10.1016\/j.niox.2008.07.001_bib31","series-title":"Radicals for Life: The Various Forms of Nitric Oxide","first-page":"383","article-title":"Mononitrosyl iron complexes with dithiocarbamate ligands: physico-chemical properties","author":"Vanin","year":"2007"},{"key":"10.1016\/j.niox.2008.07.001_bib32","first-page":"195","article-title":"Decomposition of water-soluble mononitrosyl iron-complexes with dithiocarbamates and of dinitrosyl iron complexes with thiol ligands in animal organisms, Nitric oxide","volume":"18","author":"Serezhenkov","year":"2008","journal-title":"Biol. Chem."},{"key":"10.1016\/j.niox.2008.07.001_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.freeradbiomed.2005.03.019","article-title":"A new method for monitoring nitric oxide production using Teflon membrane microdialysis","volume":"39","author":"Stefansson","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2008.07.001_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1600-0773.1984.tb01916.x","article-title":"Sodium N-methyl-d-glucamine dithiocarbamate and cadmium intoxication","volume":"54","author":"Shinobu","year":"1984","journal-title":"Acta Pharmacol. Toxicol."},{"key":"10.1016\/j.niox.2008.07.001_bib35","first-page":"194","article-title":"Evidence that intrinsic iron but not intrinsic copper determined S-nitrosocysteine decomposition in buffer solution, Nitric Oxide","volume":"7","author":"Vanin","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.niox.2008.07.001_bib36","doi-asserted-by":"crossref","first-page":"H2163","DOI":"10.1152\/ajpheart.00525.2004","article-title":"Nitrite as an alternative source of NO in vivo","volume":"288","author":"Tsuchiya","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2008.07.001_bib37","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1039\/b105460k","article-title":"Direct NO group transfer from S-nitrosothiols to iron centers","author":"Butler","year":"2001","journal-title":"Chem. Commun."},{"key":"10.1016\/j.niox.2008.07.001_bib38","first-page":"60","article-title":"The mechanism of S-nitrosothiol decomposition catalyzed by iron, Nitric Oxide","volume":"10","author":"Vanin","year":"2004","journal-title":"Biol. Chem."},{"key":"10.1016\/j.niox.2008.07.001_bib39","first-page":"295","article-title":"Why iron-dithiocarbamates ensure detection of nitric oxide in cells and tissues, Nitric Oxide","volume":"15","author":"Vanin","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/j.niox.2008.07.001_bib40","first-page":"968","article-title":"Nitrite protonation as a necessary stage in the generation of nitric oxide from nitrite in biological systems","volume":"51","author":"Mikoyan","year":"2006","journal-title":"Biofizika (Rus)"},{"key":"10.1016\/j.niox.2008.07.001_bib41","first-page":"224","article-title":"The 2.03 signal as an indicator of dinitrosyl-iron complexes with thiol-containing ligands, Nitric Oxide","volume":"2","author":"Vanin","year":"1998","journal-title":"Biol. Chem."},{"key":"10.1016\/j.niox.2008.07.001_bib42","first-page":"413","article-title":"Long-lasting hypotension action of stable preparations of dinitrosyl-iron complexes with thiol-containing ligands in conscious normotensive and hypertensive rats, Nitric Oxide","volume":"16","author":"Lakomkin","year":"2007","journal-title":"Biol. Chem."},{"key":"10.1016\/j.niox.2008.07.001_bib43","doi-asserted-by":"crossref","unstructured":"G.Rosen, B.E. Britigan, H.J. Halpern, S. Pou, in: Free Radicals: Biology and Detection\u2018 by Spin Trapping, Oxford University Press, 1999, pp. 26\u201327 and 86\u201387.","DOI":"10.1093\/oso\/9780195095050.001.0001"},{"key":"10.1016\/j.niox.2008.07.001_bib44","first-page":"243","article-title":"Organ sites of lipopolysaccharide-induced nitric oxide production in the anesthetized rat, Nitric Oxide","volume":"5","author":"Mailman","year":"2001","journal-title":"Biol. Chem."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860308003376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860308003376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T07:10:28Z","timestamp":1709104228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860308003376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S1089860308003376"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2008.07.001","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}