{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:37:02Z","timestamp":1769499422312,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.niox.2013.08.006","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T02:45:41Z","timestamp":1378262741000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness"],"prefix":"10.1016","volume":"35","author":[{"given":"R.F.","family":"Dautov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.T.M.","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Licari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L.","family":"Sverdlov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.H.","family":"Ritchie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.K.","family":"Kemp-Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.","family":"Horowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.Y.","family":"Chirkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2013.08.006_b0005","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.2741\/1621","article-title":"Tracking functions of cGMP-dependent protein kinases (cGK)","volume":"10","author":"Lohmann","year":"2005","journal-title":"Front. Biosci."},{"key":"10.1016\/j.niox.2013.08.006_b0010","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0735-1097(01)01238-4","article-title":"Stable angina and acute coronary syndromes are associated with nitric oxide resistance in platelets","volume":"37","author":"Chirkov","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.niox.2013.08.006_b0015","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.pharmthera.2007.06.012","article-title":"Impaired tissue responsiveness to organic nitrates and nitric oxide: a new therapeutic frontier?","volume":"116","author":"Chirkov","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.niox.2013.08.006_b0020","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/BF00168445","article-title":"Suppressed anti-aggregating and cGMP-elevating effects of sodium nitroprusside in platelets from patients with stable angina pectoris","volume":"354","author":"Chirkov","year":"1996","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.niox.2013.08.006_b0025","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/01.CIR.100.2.129","article-title":"Nitrate resistance in platelets from patients with stable angina pectoris","volume":"100","author":"Chirkov","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2013.08.006_b0265","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.amjcard.2004.02.052","article-title":"Effect of perindopril on platelet nitric oxide resistance in patients with chronic heart failure secondary to ischemic left ventricular dysfunction","volume":"93","author":"Chirkov","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.niox.2013.08.006_b0035","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","article-title":"Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease","volume":"101","author":"Schachinger","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2013.08.006_b0040","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1161\/01.ATV.0000193622.77294.57","article-title":"Platelet nitric oxide responsiveness: a novel prognostic marker in acute coronary syndromes","volume":"25","author":"Willoughby","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.niox.2013.08.006_b0045","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.jacc.2012.01.066","article-title":"Ramipril sensitizes platelets to nitric oxide: implications for therapy in high-risk patients","volume":"60","author":"Willoughby","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.niox.2013.08.006_b0050","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1053\/euhj.2002.3296","article-title":"Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide","volume":"23","author":"Willoughby","year":"2002","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.niox.2013.08.006_b0055","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.bjp.0703058","article-title":"Differential actions of l-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta","volume":"129","author":"Ellis","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2013.08.006_b0060","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/sj.bjp.0704269","article-title":"Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion","volume":"134","author":"Wanstall","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2013.08.006_b0065","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1160\/TH05-01-0062","article-title":"Effect of nitroxyl on human platelets function","volume":"94","author":"Bermejo","year":"2005","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.niox.2013.08.006_b0070","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1161\/01.HYP.0000072010.54901.DE","article-title":"NO-activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries","volume":"41","author":"Irvine","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.niox.2013.08.006_b0075","doi-asserted-by":"crossref","first-page":"21788","DOI":"10.1074\/jbc.M109.014282","article-title":"The effects of nitroxyl (HNO) on soluble guanylate cyclase activity: interactions at ferrous heme and cysteine thiols","volume":"284","author":"Miller","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2013.08.006_b0080","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1073\/pnas.0937302100","article-title":"Positive inotropic and lusitropic effects of HNO\/NO-in failing hearts: independence from beta-adrenergic signaling","volume":"100","author":"Paolocci","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.niox.2013.08.006_b0085","doi-asserted-by":"crossref","first-page":"10463","DOI":"10.1073\/pnas.181191198","article-title":"Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling","volume":"98","author":"Paolocci","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.niox.2013.08.006_b0090","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.pharmthera.2009.08.001","article-title":"Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO\u2217 and beyond","volume":"124","author":"Ritchie","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.niox.2013.08.006_b0095","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.RES.0000253904.53601.c9","article-title":"Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling","volume":"100","author":"Tocchetti","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.niox.2013.08.006_b0100","doi-asserted-by":"crossref","first-page":"e34892","DOI":"10.1371\/journal.pone.0034892","article-title":"Nitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2013.08.006_b0105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.freeradbiomed.2013.02.025","article-title":"Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity","volume":"60","author":"Miller","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2013.08.006_b0110","doi-asserted-by":"crossref","first-page":"H1405","DOI":"10.1152\/ajpheart.00489.2011","article-title":"Vasorelaxant and antiaggregatory actions of the nitroxyl donor isopropylamine NONOate are maintained in hypercholesterolemia","volume":"301","author":"Bullen","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2013.08.006_b0115","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.phrs.2012.07.010","article-title":"Endothelium-dependent nitroxyl-mediated relaxation is resistant to superoxide anion scavenging and preserved in diabetic rat aorta","volume":"66","author":"Leo","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.niox.2013.08.006_b0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.phrs.2011.07.002","article-title":"Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses","volume":"65","author":"Wynne","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.niox.2013.08.006_b0125","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1089\/ars.2010.3269","article-title":"Chronic administration of the HNO donor Angeli\u2019s salt does not lead to tolerance, cross-tolerance, or endothelial dysfunction: comparison with GTN and DEA\/NO","volume":"14","author":"Irvine","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.niox.2013.08.006_b0130","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1021\/bi00054a013","article-title":"Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor\/NO through a radical reaction","volume":"32","author":"Akaike","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.niox.2013.08.006_b0135","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/bbrc.1994.1668","article-title":"Bioassay discrimination between nitric oxide (NO) and nitroxyl (NO\u2212) using l-cysteine","volume":"201","author":"Pino","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.niox.2013.08.006_b0140","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0026-895X(25)10233-2","article-title":"Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one","volume":"48","author":"Garthwaite","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.niox.2013.08.006_b0145","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1006\/bbrc.2000.3976","article-title":"Inhibition of human platelet aggregation by nitric oxide donor drugs: relative contribution of cGMP-independent mechanisms","volume":"279","author":"Sogo","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.niox.2013.08.006_b0270","series-title":"Measurements of Platelet Function","first-page":"64","article-title":"Platelet aggregation","author":"Kinlough-Rathbone","year":"1983"},{"key":"10.1016\/j.niox.2013.08.006_b0155","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/jm00115a013","article-title":"Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects","volume":"34","author":"Maragos","year":"1991","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.niox.2013.08.006_b0160","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.freeradbiomed.2008.10.049","article-title":"TNF-induced mitochondrial damage: a link between mitochondrial complex I activity and left ventricular dysfunction","volume":"46","author":"Mariappan","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2013.08.006_b0165","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1021\/jm050151i","article-title":"Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in vivo","volume":"48","author":"Miranda","year":"2005","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.niox.2013.08.006_b0170","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1021\/ic101736e","article-title":"HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH","volume":"50","author":"Salmon","year":"2011","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.niox.2013.08.006_b0175","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1089\/ars.2010.3327","article-title":"Nitroxyl (HNO) as a vasoprotective signaling molecule","volume":"14","author":"Bullen","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.niox.2013.08.006_b0275","first-page":"A15855","article-title":"Nitric oxide-independent stimulators of soluble guanylyl cyclase circumvent platelet nitric oxide resistance in hypercholesterolemic mice","author":"Bullen","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2013.08.006_b0185","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1161\/01.CIR.62.1.160","article-title":"Pharmacokinetic-hemodynamic studies of intravenous nitroglycerin in congestive cardiac failure","volume":"62","author":"Armstrong","year":"1980","journal-title":"Circulation"},{"key":"10.1016\/j.niox.2013.08.006_b0190","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/bph.12152","article-title":"Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite","volume":"169","author":"Maher","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2013.08.006_b0195","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jacc.2006.08.053","article-title":"The deleterious effects of hyperglycemia on platelet function in diabetic patients with acute coronary syndromes mediation by superoxide production, resolution with intensive insulin administration","volume":"49","author":"Worthley","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.niox.2013.08.006_b0200","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1046\/j.1440-1681.2003.03859.x","article-title":"Pilot study examining the effect of cholesterol lowering on platelet nitric oxide responsiveness and arterial stiffness in subjects with isolated mild hypercholesterolaemia","volume":"30","author":"Stepien","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.niox.2013.08.006_b0205","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1073\/pnas.1430507100","article-title":"A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system","volume":"100","author":"Miranda","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.niox.2013.08.006_b0210","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jinorgbio.2012.08.027","article-title":"A comparison of the chemistry associated with the biological signaling and actions of nitroxyl (HNO) and nitric oxide (NO)","volume":"118","author":"Fukuto","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.niox.2013.08.006_b0215","doi-asserted-by":"crossref","first-page":"21602","DOI":"10.1073\/pnas.0911083106","article-title":"A nitric oxide\/cysteine interaction mediates the activation of soluble guanylate cyclase","volume":"106","author":"Fernhoff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.niox.2013.08.006_b0220","doi-asserted-by":"crossref","first-page":"43053","DOI":"10.1074\/jbc.M112.393892","article-title":"Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide","volume":"287","author":"Fernhoff","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.niox.2013.08.006_b0225","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1124\/mol.109.059915","article-title":"Mechanisms underlying activation of soluble guanylate cyclase by the nitroxyl donor Angeli\u2019s salt","volume":"76","author":"Zeller","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.niox.2013.08.006_b0230","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0162-0134(02)00498-1","article-title":"Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS","volume":"93","author":"Miranda","year":"2003","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.niox.2013.08.006_b0235","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1089\/ars.2010.3855","article-title":"HNO signaling mechanisms","volume":"14","author":"Fukuto","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.niox.2013.08.006_b0240","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.freeradbiomed.2006.11.015","article-title":"Antioxidant actions of nitroxyl (HNO)","volume":"42","author":"Lopez","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.niox.2013.08.006_b0245","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-3-540-68964-5_14","article-title":"NO- and haem-independent soluble guanylate cyclase activators","author":"Schmidt","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.niox.2013.08.006_b0250","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1089\/ars.2010.3859","article-title":"Playing with cardiac \u201credox switches\u201d: the \u201cHNO way\u201d to modulate cardiac function","volume":"14","author":"Tocchetti","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.niox.2013.08.006_b0255","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jinorgbio.2012.07.023","article-title":"Water soluble acyloxy nitroso compounds: HNO release and reactions with heme and thiol containing proteins","volume":"118","author":"DuMond","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.niox.2013.08.006_b0260","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1021\/jm101432z","article-title":"Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties","volume":"54","author":"Shoman","year":"2011","journal-title":"J. Med. Chem."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860313003133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860313003133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T14:23:42Z","timestamp":1746023022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860313003133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":52,"alternative-id":["S1089860313003133"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2013.08.006","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2013.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2013 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}