{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:44:37Z","timestamp":1791902677740,"version":"4.3.4"},"reference-count":145,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"a National Institutes of Health grant","doi-asserted-by":"crossref","award":["R01-GM076247 to KMM"],"award-info":[{"award-number":["R01-GM076247 to KMM"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.niox.2014.08.003","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T05:45:22Z","timestamp":1408427122000},"page":"17-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways"],"prefix":"10.1016","volume":"43","author":[{"given":"Robert Y.S.","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashree","family":"Basudhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Ridnour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie L.","family":"Heinecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna H.","family":"Kesarwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Glynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Switzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Ambs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina M.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2014.08.003_bib0010","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/08820139.2012.695417","article-title":"PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells","volume":"41","author":"Obermajer","year":"2012","journal-title":"Immunol. Invest"},{"key":"10.1016\/j.niox.2014.08.003_bib0015","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.0105-2896.2009.00876.x","article-title":"Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation","volume":"234","author":"Dominguez","year":"2010","journal-title":"Immunol. Rev"},{"key":"10.1016\/j.niox.2014.08.003_bib0020","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/biof.1024","article-title":"Inflammatory markers in coronary artery disease","volume":"38","author":"Ikonomidis","year":"2012","journal-title":"Biofactors"},{"key":"10.1016\/j.niox.2014.08.003_bib0025","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1158\/1078-0432.CCR-12-0408","article-title":"Molecular pathways: toll-like receptors in the tumor microenvironment\u2013poor prognosis or new therapeutic opportunity","volume":"19","author":"Ridnour","year":"2013","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00281-012-0340-x","article-title":"Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents","volume":"35","author":"Takahashi","year":"2013","journal-title":"Semin. Immunopathol"},{"key":"10.1016\/j.niox.2014.08.003_bib0035","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.niox.2011.03.079","article-title":"Nitrative stress in inflammatory lung diseases","volume":"25","author":"Sugiura","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2014.08.003_bib0040","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1401799111","article-title":"Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression","author":"Heinecke","year":"2014","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/A:1005940202801","article-title":"Molecular biology of nitric oxide synthases","volume":"17","author":"Geller","year":"1998","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.niox.2014.08.003_bib0050","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.freeradbiomed.2008.03.020","article-title":"The chemical biology of nitric oxide: implications in cellular signaling","volume":"45","author":"Thomas","year":"2008","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0055","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1189\/jlb.1010550","article-title":"Nitric oxide and redox mechanisms in the immune response","volume":"89","author":"Wink","year":"2011","journal-title":"J. Leukoc. Biol"},{"key":"10.1016\/j.niox.2014.08.003_bib0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2249.1993.tb05895.x","article-title":"Differential mechanisms of intracellular killing of Mycobacterium avium and Listeria monocytogenes by activated human and murine macrophages. The role of nitric oxide","volume":"91","author":"Bermudez","year":"1993","journal-title":"Clin. Exp. Immunol"},{"key":"10.1016\/j.niox.2014.08.003_bib0065","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1172\/JCI42059","article-title":"Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients","volume":"120","author":"Glynn","year":"2010","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.niox.2014.08.003_bib0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1126\/science.2432665","article-title":"Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite","volume":"235","author":"Hibbs","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.niox.2014.08.003_bib0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0006-291X(88)80015-9","article-title":"Nitric oxide: a cytotoxic activated macrophage effector molecule","volume":"157","author":"Hibbs","year":"1988","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.niox.2014.08.003_bib0080","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1084\/jem.169.3.1011","article-title":"Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide","volume":"169","author":"Stuehr","year":"1989","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0085","first-page":"866","article-title":"Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to gamma-interferon and tumor necrosis factor-alpha","volume":"56","author":"Geng","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0090","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1084\/jem.181.4.1333","article-title":"Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells","volume":"181","author":"Xie","year":"1995","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0095","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1073\/pnas.84.18.6369","article-title":"Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst","volume":"84","author":"Iyengar","year":"1987","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.niox.2014.08.003_bib0105","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/jsre.1993.1164","article-title":"Nitric oxide synthase expression is induced in hepatocytes in vivo during hepatic inflammation","volume":"55","author":"Geller","year":"1993","journal-title":"J. Surg. Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0110","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1073\/pnas.90.8.3491","article-title":"Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes","volume":"90","author":"Geller","year":"1993","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0115","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1006\/bbrc.1993.1896","article-title":"Induction of nitric oxide synthesis and its reactions in cultured human and rat hepatocytes stimulated with cytokines plus LPS","volume":"194","author":"Nussler","year":"1993","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.niox.2014.08.003_bib0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/bjc.1995.274","article-title":"Nitric oxide synthase activity in human breast cancer","volume":"72","author":"Thomsen","year":"1995","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0125","first-page":"1352","article-title":"Nitric oxide synthase activity in human gynecological cancer","volume":"54","author":"Thomsen","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0130","doi-asserted-by":"crossref","first-page":"4392","DOI":"10.1073\/pnas.92.10.4392","article-title":"Roles of nitric oxide in tumor growth","volume":"92","author":"Jenkins","year":"1995","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0135","first-page":"334","article-title":"Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression","volume":"58","author":"Ambs","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0140","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/bjc.1998.470","article-title":"Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53","volume":"78","author":"Ambs","year":"1998","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0145","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/jnci\/91.1.86","article-title":"Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer","volume":"91","author":"Ambs","year":"1999","journal-title":"J. Natl Cancer Inst"},{"key":"10.1016\/j.niox.2014.08.003_bib0150","doi-asserted-by":"crossref","first-page":"8823","DOI":"10.1073\/pnas.95.15.8823","article-title":"Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice","volume":"95","author":"Ambs","year":"1998","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0155","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1073\/pnas.93.6.2442","article-title":"Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53","volume":"93","author":"Forrester","year":"1996","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0160","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1073\/pnas.0237083100","article-title":"Nitric oxide-induced cellular stress and p53 activation in chronic inflammation","volume":"100","author":"Hofseth","year":"2003","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0165","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1093\/carcin\/bgh158","article-title":"Tumour-derived and host-derived nitric oxide differentially regulate breast carcinoma metastasis to the lungs","volume":"25","author":"Gauthier","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.niox.2014.08.003_bib0170","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/gyno.1999.5374","article-title":"Nitric oxide sensitizes ovarian tumor cells to Fas-induced apoptosis","volume":"73","author":"Garban","year":"1999","journal-title":"Gynecol. Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0175","first-page":"909","article-title":"Nitric oxide donors: novel cancer therapeutics (review)","volume":"33","author":"Huerta","year":"2008","journal-title":"Int. J. Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0180","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.niox.2008.08.001","article-title":"Nitric oxide sensitizes tumor cells to TRAIL-induced apoptosis via inhibition of the DR5 transcription repressor Yin Yang 1","volume":"20","author":"Huerta-Yepez","year":"2009","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2014.08.003_bib0185","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1038\/sj.onc.1207655","article-title":"Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa B and inhibition of Bcl-xl expression","volume":"23","author":"Huerta-Yepez","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.niox.2014.08.003_bib0190","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.niox.2013.01.002","article-title":"Nitric oxide-mediated activity in anti-cancer photodynamic therapy","volume":"30","author":"Rapozzi","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2014.08.003_bib0195","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1158\/0008-5472.CAN-11-3115","article-title":"Dithiolethiones inhibit NF-kappaB activity via covalent modification in human estrogen receptor-negative breast cancer","volume":"72","author":"Switzer","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2010.10.001","article-title":"Dual role of NO donors in the reversal of tumor cell resistance and EMT: downregulation of the NF-kappaB\/Snail\/YY1\/RKIP circuitry","volume":"24","author":"Bonavida","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2014.08.003_bib0205","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrfmmm.2004.05.022","article-title":"Nitric oxide signaling in colon cancer chemoprevention","volume":"555","author":"Rao","year":"2004","journal-title":"Mutat. Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0210","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1470-2045(00)00256-4","article-title":"Role of nitric oxide in carcinogenesis and tumour progression","volume":"2","author":"Lala","year":"2001","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0215","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2174\/1566524011313080002","article-title":"iNOS: a potential therapeutic target for malignant glioma","volume":"13","author":"Jahani-Asl","year":"2013","journal-title":"Curr. Mol. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0220","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.oraloncology.2003.08.008","article-title":"Interaction between the immune system and tongue squamous cell carcinoma induced by 4-nitroquinoline N-oxide in mice","volume":"40","author":"Gannot","year":"2004","journal-title":"Oral Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0225","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1601-0825.2011.01846.x","article-title":"Myeloid-derived suppressor cells contribute to oral cancer progression in 4NQO-treated mice","volume":"18","author":"Chu","year":"2012","journal-title":"Oral Dis"},{"key":"10.1016\/j.niox.2014.08.003_bib0230","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3892\/or_00001005","article-title":"Cross-talk between NO and HMGB1 in lymphocytic thyroiditis and papillary thyroid cancer","volume":"24","author":"Mardente","year":"2010","journal-title":"Oncol. Rep"},{"key":"10.1016\/j.niox.2014.08.003_bib0235","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0076-6879(02)59174-6","article-title":"Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems","volume":"359","author":"Thomas","year":"2002","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.niox.2014.08.003_bib0240","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1021\/cb200274r","article-title":"Fifty years of diazeniumdiolate research. From laboratory curiosity to broad-spectrum biomedical advances","volume":"6","author":"Keefer","year":"2011","journal-title":"ACS Chem. Biol"},{"key":"10.1016\/j.niox.2014.08.003_bib0245","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2174\/1566524043359926","article-title":"HIF-1alpha and p53 as targets of NO in affecting cell proliferation, death and adaptation","volume":"4","author":"Zhou","year":"2004","journal-title":"Curr. Mol. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0250","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/sj.cdd.4400582","article-title":"Nitric oxide (NO): an effector of apoptosis","volume":"6","author":"Brune","year":"1999","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.niox.2014.08.003_bib0255","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/sj.cdd.4401099","article-title":"Superoxide and nitric oxide\u2013participation in cell communication","volume":"9","author":"Sarti","year":"2002","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.niox.2014.08.003_bib0260","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.1073\/pnas.0400453101","article-title":"Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide","volume":"101","author":"Thomas","year":"2004","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0265","doi-asserted-by":"crossref","first-page":"25984","DOI":"10.1074\/jbc.M602242200","article-title":"Superoxide fluxes limit nitric oxide-induced signaling","volume":"281","author":"Thomas","year":"2006","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0270","doi-asserted-by":"crossref","first-page":"13147","DOI":"10.1073\/pnas.0502979102","article-title":"Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1","volume":"102","author":"Ridnour","year":"2005","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0275","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11010-009-0318-8","article-title":"New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications","volume":"334","author":"Garthwaite","year":"2010","journal-title":"Mol. Cell. Biochem"},{"key":"10.1016\/j.niox.2014.08.003_bib0280","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1089\/ars.2006.8.1329","article-title":"The biphasic nature of nitric oxide responses in tumor biology","volume":"8","author":"Ridnour","year":"2006","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.niox.2014.08.003_bib0285","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.niox.2008.04.022","article-title":"NO-donating NSAIDs and cancer: an overview with a note on whether NO is required for their action","volume":"19","author":"Rigas","year":"2008","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2014.08.003_bib0290","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/PL00005231","article-title":"The use of nitric oxide donors in pharmacological studies","volume":"358","author":"Feelisch","year":"1998","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol"},{"key":"10.1016\/j.niox.2014.08.003_bib0295","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1039\/c3bm00153a","article-title":"Protected diazeniumdiolate-modified silica nanoparticles for extended nitric oxide release from dental composites","volume":"1","author":"Carpenter","year":"2013","journal-title":"Biomater. Sci"},{"key":"10.1016\/j.niox.2014.08.003_bib0300","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1021\/ac991370c","article-title":"Improving the thromboresistivity of chemical sensors via nitric oxide release: fabrication and in vivo evaluation of NO-releasing oxygen-sensing catheters","volume":"72","author":"Schoenfisch","year":"2000","journal-title":"Anal. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0305","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/0264-6021:3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.niox.2014.08.003_bib0310","first-page":"37","article-title":"A new nitric oxide scavenger, imidazolineoxyl N-oxide derivative, and its effects in pathophysiology and microbiology","volume":"196","author":"Maeda","year":"1995","journal-title":"Curr. Top. Microbiol. Immunol"},{"key":"10.1016\/j.niox.2014.08.003_bib0315","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2174\/092986712803414321","article-title":"Nitric oxide: state of the art in drug design","volume":"19","author":"Serafim","year":"2012","journal-title":"Curr. Med. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0320","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbrc.2013.01.041","article-title":"Applications for nitric oxide in halting proliferation of tumor cells","volume":"431","author":"Reynolds","year":"2013","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.niox.2014.08.003_bib0325","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1021\/jm2004128","article-title":"Activation of the c-Jun N-terminal kinase\/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs","volume":"54","author":"Maciag","year":"2011","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0330","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0076-6879(96)68030-6","article-title":"\u201cNONOates\u201d (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms","volume":"268","author":"Keefer","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.niox.2014.08.003_bib0335","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.urology.2009.03.004","article-title":"Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer","volume":"74","author":"Siemens","year":"2009","journal-title":"Urology"},{"key":"10.1016\/j.niox.2014.08.003_bib0340","doi-asserted-by":"crossref","first-page":"6748","DOI":"10.1158\/1078-0432.CCR-06-1124","article-title":"Nitroglycerin treatment may enhance chemosensitivity to docetaxel and carboplatin in patients with lung adenocarcinoma","volume":"12","author":"Yasuda","year":"2006","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0345","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1200\/JCO.2005.04.0436","article-title":"Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB\/IV non-small-cell lung cancer","volume":"24","author":"Yasuda","year":"2006","journal-title":"J. Clin. Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0350","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1021\/ol701419a","article-title":"V-PROLI\/NO, a prodrug of the nitric oxide donor, PROLI\/NO","volume":"9","author":"Chakrapani","year":"2007","journal-title":"Org. Lett"},{"key":"10.1016\/j.niox.2014.08.003_bib0360","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cardiores.2006.11.018","article-title":"The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature","volume":"73","author":"Favaloro","year":"2007","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0365","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.freeradbiomed.2008.04.036","article-title":"Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine","volume":"45","author":"Donzelli","year":"2008","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0370","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1006\/bbrc.1993.2307","article-title":"Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO","volume":"196","author":"Fukuto","year":"1993","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.niox.2014.08.003_bib0375","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0022-3565(25)10384-4","article-title":"The pharmacological activity of nitroxyl: a potent vasodilator with activity similar to nitric oxide and\/or endothelium-derived relaxing factor","volume":"263","author":"Fukuto","year":"1992","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1016\/j.niox.2014.08.003_bib0380","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0891-5849(02)01179-6","article-title":"Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning","volume":"34","author":"Pagliaro","year":"2003","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0385","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1073\/pnas.0937302100","article-title":"Positive inotropic and lusitropic effects of HNO\/NO- in failing hearts: independence from beta-adrenergic signaling","volume":"100","author":"Paolocci","year":"2003","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0390","doi-asserted-by":"crossref","first-page":"10463","DOI":"10.1073\/pnas.181191198","article-title":"Nitroxyl anion exerts redox-sensitive positive cardiac inotropy in vivo by calcitonin gene-related peptide signaling","volume":"98","author":"Paolocci","year":"2001","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0395","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1073\/pnas.1430507100","article-title":"A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system","volume":"100","author":"Miranda","year":"2003","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0400","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/ijc.23305","article-title":"Nitroxyl inhibits breast tumor growth and angiogenesis","volume":"122","author":"Norris","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0405","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2174\/1568026054679380","article-title":"Nitric oxide (NO)- and nitroxyl (HNO)-generating diazeniumdiolates (NONOates): emerging commercial opportunities","volume":"5","author":"Keefer","year":"2005","journal-title":"Curr. Top. Med. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0410","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S0891-5849(00)00251-3","article-title":"Diazeniumdiolates: pro- and antioxidant applications of the \u201cNONOates\u201d","volume":"28","author":"Fitzhugh","year":"2000","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0415","doi-asserted-by":"crossref","first-page":"16526","DOI":"10.1021\/ja106552p","article-title":"Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class","volume":"132","author":"Andrei","year":"2010","journal-title":"J. Am. Chem. Soc"},{"key":"10.1016\/j.niox.2014.08.003_bib0420","doi-asserted-by":"crossref","first-page":"8220","DOI":"10.1021\/jm050151i","article-title":"Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in vivo","volume":"48","author":"Miranda","year":"2005","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0425","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/jm00115a013","article-title":"Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects","volume":"34","author":"Maragos","year":"1991","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0430","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1021\/ic101736e","article-title":"HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH","volume":"50","author":"Salmon","year":"2011","journal-title":"Inorg. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0435","doi-asserted-by":"crossref","first-page":"7804","DOI":"10.1021\/jm400196q","article-title":"Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives","volume":"56","author":"Basudhar","year":"2013","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0440","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/ijc.24008","article-title":"Novel genetic variants in microRNA genes and familial breast cancer","volume":"124","author":"Shen","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0445","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1743-7563.2012.01548.x","article-title":"Differential expression of miR-21, miR-125b and miR-191 in breast cancer tissue","volume":"9","author":"Mar-Aguilar","year":"2013","journal-title":"Asia Pac J Clin Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0450","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1007\/s13277-013-0753-8","article-title":"Serum miR-21 and miR-92a as biomarkers in the diagnosis and prognosis of colorectal cancer","volume":"34","author":"Liu","year":"2013","journal-title":"Tumour Biol"},{"key":"10.1016\/j.niox.2014.08.003_bib0455","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/hmg\/dds496","article-title":"MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in glioblastoma","volume":"22","author":"Costa","year":"2013","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.niox.2014.08.003_bib0460","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.bbrc.2013.12.047","article-title":"MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K\/Akt signaling by targeting PTEN","volume":"443","author":"Yan-nan","year":"2014","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.niox.2014.08.003_bib0465","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ijc.27644","article-title":"NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression","volume":"132","author":"Okayama","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0470","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.arr.2013.05.001","article-title":"MicroRNAs linking inflamm-aging, cellular senescence and cancer","volume":"12","author":"Olivieri","year":"2013","journal-title":"Ageing Res. Rev"},{"key":"10.1016\/j.niox.2014.08.003_bib0475","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.4161\/cbt.10.12.14252","article-title":"MicroRNA-21: a novel therapeutic target in human cancer","volume":"10","author":"Pan","year":"2010","journal-title":"Cancer Biol. Ther"},{"key":"10.1016\/j.niox.2014.08.003_bib0480","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/jnci\/djt101","article-title":"Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer","volume":"105","author":"Toiyama","year":"2013","journal-title":"J. Natl Cancer Inst"},{"key":"10.1016\/j.niox.2014.08.003_bib0485","doi-asserted-by":"crossref","first-page":"617868","DOI":"10.1155\/2014\/617868","article-title":"Silencing miR-21 sensitizes non-small cell lung cancer A549 cells to ionizing radiation through inhibition of PI3K\/Akt","volume":"2014","author":"Ma","year":"2014","journal-title":"Biomed. Res. Int"},{"key":"10.1016\/j.niox.2014.08.003_bib0490","doi-asserted-by":"crossref","first-page":"e47449","DOI":"10.1371\/journal.pone.0047449","article-title":"Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K\/AKT pathway and enhancing autophagy in malignant glioma cell lines","volume":"7","author":"Gwak","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.niox.2014.08.003_bib0495","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1373\/clinchem.2010.150730","article-title":"Intracellular and extracellular microRNAs in breast cancer","volume":"57","author":"Corcoran","year":"2011","journal-title":"Clin. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0500","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.freeradbiomed.2011.08.007","article-title":"Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells","volume":"51","author":"Pupo","year":"2011","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.niox.2014.08.003_bib0505","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3892\/mmr.2014.2161","article-title":"Inhibition of invasion and epithelial-mesenchymal transition of human breast cancer cells by hydrogen sulfide through decreased phospho-p38 expression","volume":"10","author":"Lv","year":"2014","journal-title":"Mol. Med. Rep"},{"key":"10.1016\/j.niox.2014.08.003_bib0510","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00418-011-0791-5","article-title":"Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study","volume":"135","author":"Scieglinska","year":"2011","journal-title":"Histochem. Cell Biol"},{"key":"10.1016\/j.niox.2014.08.003_bib0515","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1471-2407-12-120","article-title":"A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human disease","volume":"12","author":"Kaur","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0520","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12192-008-0085-6","article-title":"HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness","volume":"14","author":"Souza","year":"2009","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.niox.2014.08.003_bib0525","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1158\/0008-5472.CAN-13-1080","article-title":"ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer","volume":"73","author":"Chen","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0530","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/02656730802140777","article-title":"Genes and genetic networks responsive to mild hyperthermia in human lymphoma U937 cells","volume":"24","author":"Tabuchi","year":"2008","journal-title":"Int. J. Hyperthermia"},{"key":"10.1016\/j.niox.2014.08.003_bib0535","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/sj.bjc.6604003","article-title":"Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells","volume":"97","author":"Hamamura","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0540","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4161\/cbt.26720","article-title":"Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition","volume":"15","author":"Budina-Kolomets","year":"2014","journal-title":"Cancer Biol. Ther"},{"key":"10.1016\/j.niox.2014.08.003_bib0545","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1158\/1535-7163.MCT-04-0234","article-title":"Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays","volume":"4","author":"Nakatsu","year":"2005","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.niox.2014.08.003_bib0550","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1161\/01.ATV.0000248914.21018.f1","article-title":"Nitric oxide-dependent suppression of thioredoxin-interacting protein expression enhances thioredoxin activity","volume":"26","author":"Schulze","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"10.1016\/j.niox.2014.08.003_bib0555","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1186\/1471-2407-13-468","article-title":"FOXO\/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801","volume":"13","author":"Yamaguchi","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0560","first-page":"377","article-title":"Rare sugar D-allose induces specific up-regulation of TXNIP and subsequent G1 cell cycle arrest in hepatocellular carcinoma cells by stabilization of p27kip1","volume":"32","author":"Yamaguchi","year":"2008","journal-title":"Int. J. Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0565","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10549-013-2684-x","article-title":"Analysis of phyllodes tumor recurrence according to the histologic grade","volume":"141","author":"Kim","year":"2013","journal-title":"Breast Cancer Res. Treat"},{"key":"10.1016\/j.niox.2014.08.003_bib0575","doi-asserted-by":"crossref","first-page":"10845","DOI":"10.1073\/pnas.191207498","article-title":"Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway","volume":"98","author":"Oyadomari","year":"2001","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0580","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-5793(01)02898-8","article-title":"Induction of CHOP and apoptosis by nitric oxide in p53-deficient microglial cells","volume":"506","author":"Kawahara","year":"2001","journal-title":"FEBS Lett"},{"key":"10.1016\/j.niox.2014.08.003_bib0585","doi-asserted-by":"crossref","first-page":"12343","DOI":"10.1074\/jbc.M107988200","article-title":"Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP","volume":"277","author":"Gotoh","year":"2002","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.niox.2014.08.003_bib0590","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00019501-200311000-00002","article-title":"Endothelin, hypercholesterolemia and atherosclerosis","volume":"14","author":"Barton","year":"2003","journal-title":"Coron. Artery Dis"},{"key":"10.1016\/j.niox.2014.08.003_bib0595","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1006\/jmcc.2000.1109","article-title":"Endothelin-1 stimulates cardiac fibroblast proliferation through activation of protein kinase C","volume":"32","author":"Piacentini","year":"2000","journal-title":"J. Mol. Cell. Cardiol"},{"key":"10.1016\/j.niox.2014.08.003_bib0600","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-3782(02)00038-5","article-title":"Vasoactive and natriuretic mediators in umbilical cord blood: a report of our observation and review of the literature","volume":"69","author":"Tsukahara","year":"2002","journal-title":"Early Hum. Dev"},{"key":"10.1016\/j.niox.2014.08.003_bib0605","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/pros.22639","article-title":"Characterization of osteoblastic and osteolytic proteins in prostate cancer bone metastases","volume":"73","author":"Larson","year":"2013","journal-title":"Prostate"},{"key":"10.1016\/j.niox.2014.08.003_bib0610","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1093\/cvr\/28.10.1519","article-title":"Selective changes in natriuretic peptide and early response gene expression in isolated rat atria following stimulation by stretch or endothelin-1","volume":"28","author":"Bruneau","year":"1994","journal-title":"Cardiovasc. Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0615","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mc.20462","article-title":"Endothelin-1 enhances the expression of the androgen receptor via activation of the c-myc pathway in prostate cancer cells","volume":"48","author":"Lee","year":"2009","journal-title":"Mol. Carcinog"},{"key":"10.1016\/j.niox.2014.08.003_bib0620","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/bjp.2008.92","article-title":"Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET(B) receptor-mediated G(i)- and G(q)-pathways and MAP kinase activation","volume":"154","author":"Rauh","year":"2008","journal-title":"Br. J. Pharmacol"},{"key":"10.1016\/j.niox.2014.08.003_bib0625","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.physiol.61.1.391","article-title":"Pathophysiology of endothelin in the cardiovascular system","volume":"61","author":"Miyauchi","year":"1999","journal-title":"Annu. Rev. Physiol"},{"key":"10.1016\/j.niox.2014.08.003_bib0630","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1196\/annals.1282.040","article-title":"Relaxin stimulates multiple signaling pathways: activation of cAMP, PI3K, and PKCzeta in THP-1 cells","volume":"1041","author":"Dessauer","year":"2005","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"10.1016\/j.niox.2014.08.003_bib0635","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0640","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2958.2003.03307.x","article-title":"Molecular analysis of fusidic acid resistance in Staphylococcus aureus","volume":"47","author":"Besier","year":"2003","journal-title":"Mol. Microbiol"},{"key":"10.1016\/j.niox.2014.08.003_bib0645","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.RES.0000082524.34487.31","article-title":"Regulation of nitric oxide-sensitive guanylyl cyclase","volume":"93","author":"Friebe","year":"2003","journal-title":"Circ. Res"},{"key":"10.1016\/j.niox.2014.08.003_bib0650","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1073\/pnas.96.26.14753","article-title":"A molecular basis for nitric oxide sensing by soluble guanylate cyclase","volume":"96","author":"Zhao","year":"1999","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.niox.2014.08.003_bib0655","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1038\/sj.onc.1210394","article-title":"Integrating signals from RTKs to ERK\/MAPK","volume":"26","author":"McKay","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.niox.2014.08.003_bib0660","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1038\/sj.onc.1210407","article-title":"G protein regulation of MAPK networks","volume":"26","author":"Goldsmith","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.niox.2014.08.003_bib0665","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/humu.20748","article-title":"The RAS\/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders","volume":"29","author":"Aoki","year":"2008","journal-title":"Hum. Mutat"},{"key":"10.1016\/j.niox.2014.08.003_bib0670","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/(SICI)1097-4652(200002)182:2<150::AID-JCP3>3.0.CO;2-E","article-title":"Role of HER2 gene overexpression in breast carcinoma","volume":"182","author":"Menard","year":"2000","journal-title":"J. Cell. Physiol"},{"key":"10.1016\/j.niox.2014.08.003_bib0675","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1677\/erc.0.0080011","article-title":"The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification","volume":"8","author":"Prenzel","year":"2001","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.niox.2014.08.003_bib0680","first-page":"165","article-title":"The biology of erbB-2\/neu\/HER-2 and its role in cancer","volume":"1198","author":"Hynes","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2014.08.003_bib0685","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tcb.2006.10.008","article-title":"ErbB receptors: new insights on mechanisms and biology","volume":"16","author":"Linggi","year":"2006","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.niox.2014.08.003_bib0690","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1053\/srao.2002.35248","article-title":"Molecular biology and genetics of breast cancer development: a clinical perspective","volume":"12","author":"Buchholz","year":"2002","journal-title":"Semin. Radiat. Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0695","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1053\/j.seminoncol.2007.03.015","article-title":"New generation of molecular prognostic and predictive tests for breast cancer","volume":"34","author":"Pusztai","year":"2007","journal-title":"Semin. Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0700","first-page":"1","article-title":"Novel treatment options in the management of metastatic breast cancer","volume":"9","author":"Twelves","year":"2011","journal-title":"Clin. Adv. Hematol. Oncol"},{"key":"10.1016\/j.niox.2014.08.003_bib0705","first-page":"978","article-title":"[Inducible nitric oxide synthase and basic fibroblast growth factor expression as prognostic factors in supraglottic squamous cell carcinoma]","volume":"22","author":"Huang","year":"2003","journal-title":"Ai Zheng"},{"key":"10.1016\/j.niox.2014.08.003_bib0710","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00401-004-0860-0","article-title":"Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: correlation with angiogenesis and prognostic significance","volume":"108","author":"Hara","year":"2004","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.niox.2014.08.003_bib0715","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/labinvest.3700144","article-title":"Role of differential and cell type-specific expression of cell cycle regulatory proteins in mediating progressive glomerular injury in human IgA nephropathy","volume":"84","author":"Qiu","year":"2004","journal-title":"Lab. Invest"},{"key":"10.1016\/j.niox.2014.08.003_bib0720","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.3748\/wjg.v11.i17.2539","article-title":"Inducible nitric oxide synthase, nitrotyrosine and apoptosis in gastric adenocarcinomas and their correlation with a poor survival","volume":"11","author":"Li","year":"2005","journal-title":"World J. Gastroenterol"},{"key":"10.1016\/j.niox.2014.08.003_bib0725","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.3748\/wjg.v11.i30.4644","article-title":"Nitrative and oxidative DNA damage in intrahepatic cholangiocarcinoma patients in relation to tumor invasion","volume":"11","author":"Pinlaor","year":"2005","journal-title":"World J. Gastroenterol"},{"key":"10.1016\/j.niox.2014.08.003_bib0730","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1615\/ForumImmunDisTher.2012006108","article-title":"S-Nitrosation mediates multiple pathways that lead to tumor progression in estrogen receptor-negative breast cancer","volume":"3","author":"Switzer","year":"2012","journal-title":"For. Immunopathol. Dis. Ther"},{"key":"10.1016\/j.niox.2014.08.003_bib0735","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.humpath.2010.09.020","article-title":"Inducible nitric oxide synthase expression correlates with angiogenesis, lymphangiogenesis, and poor prognosis in gastric cancer patients","volume":"42","author":"Zhang","year":"2011","journal-title":"Hum. Pathol"},{"key":"10.1016\/j.niox.2014.08.003_bib0740","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.molcel.2009.12.022","article-title":"RORalpha attenuates Wnt\/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer","volume":"37","author":"Lee","year":"2010","journal-title":"Mol. Cell"}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860314002778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860314002778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T08:04:53Z","timestamp":1746345893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860314002778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":145,"alternative-id":["S1089860314002778"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2014.08.003","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2014.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}