{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:59:49Z","timestamp":1790222389342,"version":"4.1.0"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.niox.2015.06.002","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T11:01:11Z","timestamp":1436871671000},"page":"67-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Inhaled nitric oxide in cardiac surgery: Evidence or tradition?"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5653-8542","authenticated-orcid":false,"given":"Maria","family":"Benedetto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiana","family":"Baca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Sarridou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandor","family":"Marczin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8776","key":"10.1016\/j.niox.2015.06.002_bib1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/0140-6736(91)92033-X","article-title":"Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension","volume":"338","author":"Pepke-Zaba","year":"1991","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib2","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.83.6.2038","article-title":"Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction","volume":"83","author":"Frostell","year":"1991","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1056\/NEJM199302113280605","article-title":"Inhaled nitric oxide for the adult respiratory distress syndrome","volume":"328","author":"Rossaint","year":"1993","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib4","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1097\/00000542-199506000-00020","article-title":"Aerosolized prostacyclin versus inhaled nitric oxide in children with severe acute respiratory distress syndrome","volume":"82","author":"Pappert","year":"1995","journal-title":"Anesthesiology"},{"issue":"8823","key":"10.1016\/j.niox.2015.06.002_bib5","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/0140-6736(92)92686-A","article-title":"Inhaled nitric oxide in persistent pulmonary hypertension of the newborn","volume":"340","author":"Roberts","year":"1992","journal-title":"Lancet"},{"issue":"4 Pt 1","key":"10.1016\/j.niox.2015.06.002_bib6","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1542\/peds.98.4.698","article-title":"Acute response to inhaled nitric oxide in newborns with respiratory failure and pulmonary hypertension","volume":"98","author":"Day","year":"1996","journal-title":"Pediatrics"},{"issue":"2 Pt 1","key":"10.1016\/j.niox.2015.06.002_bib7","first-page":"344","article-title":"Committee on Fetus and Newborn. Use of inhaled nitric oxide","volume":"106","author":"American Academy of Pediatrics","year":"2000","journal-title":"Pediatrics"},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1053-0770(05)80220-4","article-title":"Nitric oxide: has it progressed from molecule of the year to wonder drug of the decade?","volume":"9","author":"Konstadt","year":"1995","journal-title":"J.\u00a0Cardiothorac. Vasc. Anesth."},{"issue":"9","key":"10.1016\/j.niox.2015.06.002_bib9","first-page":"555","article-title":"Inhaled nitric oxide: a magic bullet?","volume":"86","author":"Higenbottam","year":"1993","journal-title":"Q.\u00a0J. Med."},{"issue":"5 Pt 1","key":"10.1016\/j.niox.2015.06.002_bib10","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1164\/ajrccm.157.5.96-10089","article-title":"Inhaled nitric oxide versus conventional therapy: effect on oxygenation in ARDS","volume":"157","author":"Michael","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib11","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/00003246-199905000-00012","article-title":"Low-dose inhaled nitric oxide and oxygenation in pediatric hypoxic respiratory failure. Wrong bullet, wrong target","volume":"27","author":"Tibby","year":"1999","journal-title":"Crit. Care Med."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/00003246-199905000-00042","article-title":"Low-dose inhaled nitric oxide improves the oxygenation and ventilation of infants and children with acute, hypoxemic respiratory failure","volume":"27","author":"Ream","year":"1999","journal-title":"Crit. Care Med."},{"issue":"5 Pt 1","key":"10.1016\/j.niox.2015.06.002_bib13","first-page":"1361","article-title":"Is nitric oxide inhalation a \u201ccosmetic\u201d therapy in acute respiratory distress syndrome?","volume":"157","author":"Payen","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.niox.2015.06.002_bib14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0008-6363(02)00327-9","article-title":"Vasoprotection by nitric oxide: mechanisms and therapeutic potential","volume":"55","author":"Gewaltig","year":"2002","journal-title":"Cardiovasc Res."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2174\/1570161052773933","article-title":"Evidence for, and importance of, cGMP-independent mechanisms with NO and NO donors on blood vessels and platelets","volume":"3","author":"Wanstall","year":"2005","journal-title":"Curr. Vasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.niox.2015.06.002_bib16","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCRESAHA.109.207381","article-title":"S-nitrosylation in cardiovascular signaling","volume":"106","author":"Lima","year":"2010","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib17","doi-asserted-by":"crossref","first-page":"e23896","DOI":"10.4161\/tisb.23896","article-title":"S-nitrosation of proteins: an emergent regulatory mechanism in microvascular permeability and vascular function","volume":"1","author":"Sanchez","year":"2013","journal-title":"Tissue Barriers"},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib18","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.athoracsur.2006.06.081","article-title":"Clinical indication for use and outcomes after inhaled nitric oxide therapy","volume":"82","author":"George","year":"2006","journal-title":"Ann. Thorac. Surg."},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib19","doi-asserted-by":"crossref","first-page":"E584","DOI":"10.1532\/HSF98.20041136","article-title":"Collective review: perioperative uses of inhaled nitric oxide in adults","volume":"7","author":"Oz","year":"2004","journal-title":"Heart Surg. Forum"},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib20","doi-asserted-by":"crossref","first-page":"H379","DOI":"10.1152\/ajpheart.01172.2005","article-title":"Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury","volume":"291","author":"Hataishi","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"8","key":"10.1016\/j.niox.2015.06.002_bib21","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00134-005-2675-4","article-title":"Inhaled nitric oxide therapy in adults: European expert recommendations","volume":"31","author":"Germann","year":"2005","journal-title":"Intensive Care Med."},{"issue":"11","key":"10.1016\/j.niox.2015.06.002_bib22","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00134-014-3458-6","article-title":"Our paper 20 years later: inhaled nitric oxide for the acute respiratory distress syndrome\u2013discovery, current understanding, and focussed targets of future applications","volume":"40","author":"Rossaint","year":"2014","journal-title":"Intensive Care Med."},{"issue":"4","key":"10.1016\/j.niox.2015.06.002_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00246-012-0172-4","article-title":"Review of inhaled nitric oxide in the pediatric cardiac surgery setting","volume":"33","author":"Checchia","year":"2012","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.niox.2015.06.002_bib24","series-title":"Cardiac Surgery- A Commitment to Science, Technology and Creativity","article-title":"Use of inhaled nitric oxide in cardiac surgery: what is going on?","author":"JR","year":"2014"},{"issue":"18","key":"10.1016\/j.niox.2015.06.002_bib25","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.jacc.2010.05.046","article-title":"Medical and surgical treatment of acute right ventricular failure","volume":"56","author":"Lahm","year":"2010","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib26","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1053\/j.semtcvs.2012.08.001","article-title":"Right ventricular failure after cardiac surgery: management strategies","volume":"24","author":"Itagaki","year":"2012","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"issue":"25","key":"10.1016\/j.niox.2015.06.002_bib27","doi-asserted-by":"crossref","first-page":"3106","DOI":"10.1161\/01.CIR.0000134595.80170.62","article-title":"Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential","volume":"109","author":"Ichinose","year":"2004","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.niox.2015.06.002_bib28","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1056\/NEJMra051884","article-title":"Inhaled nitric oxide therapy in adults","volume":"353","author":"Griffiths","year":"2005","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"15","key":"10.1016\/j.niox.2015.06.002_bib29","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMcibr023045","article-title":"Hemoglobin and the paracrine and endocrine functions of nitric oxide","volume":"348","author":"Schechter","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"2","key":"10.1016\/j.niox.2015.06.002_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1172\/JCI200112761","article-title":"Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery","volume":"108","author":"Cannon","year":"2001","journal-title":"J.\u00a0Clin. Invest."},{"issue":"12","key":"10.1016\/j.niox.2015.06.002_bib31","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/nm954","article-title":"Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation","volume":"9","author":"Cosby","year":"2003","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/cc7734","article-title":"Bench-to-bedside review: inhaled nitric oxide therapy in adults","volume":"13","author":"Creagh-Brown","year":"2009","journal-title":"Crit. Care"},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0967-2109(99)00089-7","article-title":"Postoperative acute refractory right ventricular failure: incidence, pathogenesis, management and prognosis","volume":"8","author":"Kaul","year":"2000","journal-title":"Cardiovasc. Surg."},{"issue":"2","key":"10.1016\/j.niox.2015.06.002_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ccl.2012.03.005","article-title":"Right ventricular dysfunction in chronic lung disease","volume":"30","author":"Kolb","year":"2012","journal-title":"Cardiol. Clin."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0735-1097(00)01102-5","article-title":"Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure","volume":"37","author":"Ghio","year":"2001","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib36","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0300-8932(10)70092-0","article-title":"The right heart and pulmonary circulation (III). The pulmonary circulation in heart failure","volume":"63","author":"Delgado","year":"2010","journal-title":"Rev. Esp. Cardiol."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/ACO.0b013e32831a4394","article-title":"Update on anesthetic management for pneumonectomy","volume":"22","author":"Slinger","year":"2009","journal-title":"Curr. Opin. Anesthesiol."},{"issue":"11","key":"10.1016\/j.niox.2015.06.002_bib38","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1164\/rccm.2203034","article-title":"A\u00a0randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation","volume":"167","author":"Meade","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib39","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0003-4975(99)01104-2","article-title":"Lowering reperfusion pressure reduces the injury after pulmonary ischemia","volume":"69","author":"Halldorsson","year":"2000","journal-title":"Ann. Thorac. Surg."},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib40","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.jtcvs.2009.04.063","article-title":"A\u00a0prospective, randomized, crossover pilot study of inhaled nitric oxide versus inhaled prostacyclin in heart transplant and lung transplant recipients","volume":"138","author":"Khan","year":"2009","journal-title":"J.\u00a0Thorac. Cardiovasc Surg."},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib41","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1510\/icvts.2009.211730","article-title":"Controlled antegrade single lung reperfusion during double lung transplant","volume":"9","author":"Khalpey","year":"2009","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib42","first-page":"353","article-title":"The effects of inhaled nitric oxide after lung transplantation","volume":"76","author":"Pasero","year":"2010","journal-title":"Minerva Anestesiol."},{"issue":"9","key":"10.1016\/j.niox.2015.06.002_bib43","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.healun.2012.05.001","article-title":"A\u00a0panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation","volume":"31","author":"Shah","year":"2012","journal-title":"J.\u00a0Heart Lung Transpl."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib44","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/s-0033-1348474","article-title":"Primary graft dysfunction","volume":"34","author":"Suzuki","year":"2013","journal-title":"Semin. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib45","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1164\/ajrccm.162.5.9910064","article-title":"Dynamic changes in apoptotic and necrotic cell death correlate with severity of ischemia-reperfusion injury in lung transplantation","volume":"162","author":"Fischer","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib46","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1378\/chest.113.5.1360","article-title":"The therapeutic potential of nitric oxide in lung transplantation","volume":"113","author":"Meyer","year":"1998","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib47","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0003-4975(96)00744-8","article-title":"Inhaled nitric oxide reveals and attenuates endothelial dysfunction after lung transplantation","volume":"62","author":"Lindberg","year":"1996","journal-title":"Ann. Thorac. Surg."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib48","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/0003-4975(94)91382-X","article-title":"Inhaled nitric oxide in the treatment of postoperative graft dysfunction after lung transplantation","volume":"57","author":"Adatia","year":"1994","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib49","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0022-5223(95)70125-7","article-title":"Successful treatment of life-threatening acute reperfusion injury after lung transplantation with inhaled nitric oxide","volume":"110","author":"Macdonald","year":"1995","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"issue":"8","key":"10.1016\/j.niox.2015.06.002_bib50","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1053-2498(02)00809-4","article-title":"Safety of inhaled nitric oxide after lung transplantation","volume":"22","author":"Cornfield","year":"2003","journal-title":"J.\u00a0Heart Lung Transpl."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/00007890-200107150-00022","article-title":"A\u00a0prospective trial of inhaled nitric oxide in clinical lung transplantation","volume":"72","author":"Ardehali","year":"2001","journal-title":"Transplantation"},{"issue":"9","key":"10.1016\/j.niox.2015.06.002_bib52","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/00007890-200105150-00019","article-title":"Preventive effect of inhaled nitric oxide and pentoxifylline on ischemia\/reperfusion injury after lung transplantation","volume":"71","author":"Thabut","year":"2001","journal-title":"Transplantation"},{"issue":"11","key":"10.1016\/j.niox.2015.06.002_bib53","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1164\/rccm.2303001","article-title":"Inhaled nitric oxide after lung transplantation: no more cosmesis?","volume":"167","author":"Glanville","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1164\/rccm.201210-1865OC","article-title":"Clinical risk factors for primary graft dysfunction after lung transplantation","volume":"187","author":"Diamond","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"8","key":"10.1016\/j.niox.2015.06.002_bib55","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s00134-005-2674-5","article-title":"Inhaled nitric oxide therapy in adults\u2013opinions and evidence","volume":"31","author":"Bigatello","year":"2005","journal-title":"Intensive Care Med."},{"issue":"7","key":"10.1016\/j.niox.2015.06.002_bib56","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/EJA.0b013e3283614061","article-title":"Creating guidelines and treating patients when there are no trials or systematic reviews","volume":"30","author":"Smith","year":"2013","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.niox.2015.06.002_bib57","series-title":"Simpson's Contemporary Quotations","author":"Szilard","year":"1988"},{"issue":"4","key":"10.1016\/j.niox.2015.06.002_bib58","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1378\/chest.129.4.1024","article-title":"Inhaled nitric oxide does not prevent pulmonary edema after lung transplantation measured by lung water content: a randomized clinical study","volume":"129","author":"Perrin","year":"2006","journal-title":"Chest"},{"issue":"11","key":"10.1016\/j.niox.2015.06.002_bib59","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.healun.2007.08.008","article-title":"Inhaled nitric oxide for modulation of ischemia-reperfusion injury in lung transplantation","volume":"26","author":"Botha","year":"2007","journal-title":"J.\u00a0Heart Lung Transpl."},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib60","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1016\/j.transproceed.2009.05.019","article-title":"Effects of inhaled nitric oxide on primary graft dysfunction in lung transplantation","volume":"41","author":"Moreno","year":"2009","journal-title":"Transpl. Proc."},{"issue":"10","key":"10.1016\/j.niox.2015.06.002_bib61","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1111\/j.1600-6143.2008.02354.x","article-title":"Impact of human donor lung gene expression profiles on survival after lung transplantation: a case-control study","volume":"8","author":"Anraku","year":"2008","journal-title":"Am. J. Transpl."},{"issue":"10","key":"10.1016\/j.niox.2015.06.002_bib62","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1111\/j.1600-6143.2007.01918.x","article-title":"Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation","volume":"7","author":"Ray","year":"2007","journal-title":"Am. J. Transpl."},{"issue":"10","key":"10.1016\/j.niox.2015.06.002_bib63","doi-asserted-by":"crossref","first-page":"e45506","DOI":"10.1371\/journal.pone.0045506","article-title":"Microarray meta-analysis identifies acute lung injury biomarkers in donor lungs that predict development of primary graft failure in recipients","volume":"7","author":"Hu","year":"2012","journal-title":"PLoS One"},{"issue":"25","key":"10.1016\/j.niox.2015.06.002_bib64","doi-asserted-by":"crossref","first-page":"12086","DOI":"10.1073\/pnas.91.25.12086","article-title":"The nitric oxide\/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation","volume":"91","author":"Pinsky","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib65","doi-asserted-by":"crossref","first-page":"L1071","DOI":"10.1152\/ajplung.2000.278.5.L1071","article-title":"Alterations of nitric oxide synthase expression and activity during rat lung transplantation","volume":"278","author":"Liu","year":"2000","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib66","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1164\/ajrccm.157.1.97-03057","article-title":"The role of endogenous nitric oxide in modulating ischemia-reperfusion injury in the isolated, blood-perfused rat lung","volume":"157","author":"Lu","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib67","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1053-0770(05)80144-2","article-title":"Avoidance of cardiopulmonary bypass during bilateral sequential lung transplantation using inhaled nitric oxide","volume":"9","author":"Myles","year":"1995","journal-title":"J.\u00a0Cardiothorac. Vasc. Anesth."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib68","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jtcvs.2002.08.001","article-title":"Supplemental nitric oxide and its effect on myocardial injury and function in patients undergoing cardiac surgery with extracorporeal circulation","volume":"127","author":"Gianetti","year":"2004","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib69","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/0003-4975(96)00146-4","article-title":"Pulmonary vasoconstriction due to impaired nitric oxide production after cardiopulmonary bypass","volume":"61","author":"Morita","year":"1996","journal-title":"Ann. Thorac. Surg."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib70","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S1053-0770(00)90048-X","article-title":"A\u00a0comparison of inhaled nitric oxide and milrinone for the treatment of pulmonary hypertension in adult cardiac surgery patients","volume":"14","author":"Solina","year":"2000","journal-title":"J.\u00a0Cardiothorac. Vasc. Anesth."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib71","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1213\/00000539-199911000-00007","article-title":"Inhaled nitric oxide versus intravenous vasodilators in severe pulmonary hypertension after cardiac surgery","volume":"89","author":"Schmid","year":"1999","journal-title":"Anesth. Analg."},{"issue":"2","key":"10.1016\/j.niox.2015.06.002_bib72","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0022-5223(97)70334-9","article-title":"Effective control of refractory pulmonary hypertension after cardiac operations","volume":"113","author":"Fullerton","year":"1997","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib73","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/08941930252807732","article-title":"Response to nitric oxide during adult cardiac surgery","volume":"15","author":"Solina","year":"2002","journal-title":"J.\u00a0Invest Surg."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib74","first-page":"98","article-title":"Variable response to inhaled nitric oxide in postoperative patients of mitral stenosis with pulmonary hypertension","volume":"21","author":"Razzaq","year":"2009","journal-title":"J.\u00a0Ayub Med. Coll. Abbottabad"},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib75","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1053\/j.jvca.2007.10.015","article-title":"Comparison of inhaled iloprost and nitric oxide in patients with pulmonary hypertension during weaning from cardiopulmonary bypass in cardiac surgery: a prospective randomized trial","volume":"22","author":"Winterhalter","year":"2008","journal-title":"J.\u00a0Cardiothorac. Vasc. Anesth."},{"issue":"2","key":"10.1016\/j.niox.2015.06.002_bib76","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.0886-0440.2005.200383w.x","article-title":"Inhaled prostacyclin, nitric oxide, and nitroprusside in pulmonary hypertension after mitral valve replacement","volume":"20","author":"Fattouch","year":"2005","journal-title":"J.\u00a0Card. Surg."},{"issue":"2","key":"10.1016\/j.niox.2015.06.002_bib77","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2459\/01.JCM.0000203850.97890.fe","article-title":"Treatment of pulmonary hypertension in patients undergoing cardiac surgery with cardiopulmonary bypass: a randomized, prospective, double-blind study","volume":"7","author":"Fattouch","year":"2006","journal-title":"J.\u00a0Cardiovasc. Med. Hagerst."},{"issue":"7","key":"10.1016\/j.niox.2015.06.002_bib78","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.amjcard.2010.11.030","article-title":"Comparison of inhaled nitric oxide versus oxygen on hemodynamics in patients with mitral stenosis and severe pulmonary hypertension after mitral valve surgery","volume":"107","author":"Fernandes","year":"2011","journal-title":"Am. J. Cardiol."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib79","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/CIRCHEARTFAILURE.111.963314","article-title":"Inhaled NO and sildenafil combination in cardiac surgery patients with out-of-proportion pulmonary hypertension: acute effects on postoperative gas exchange and hemodynamics","volume":"5","author":"Matamis","year":"2012","journal-title":"Circ. Heart Fail."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib80","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1053\/j.jvca.2012.07.020","article-title":"Hemodynamic effects of combination therapy with inhaled nitric oxide and iloprost in patients with pulmonary hypertension and right ventricular dysfunction after high-risk cardiac surgery","volume":"27","author":"Antoniou","year":"2013","journal-title":"J.\u00a0Cardiothorac. Vasc. Anesth."},{"issue":"7","key":"10.1016\/j.niox.2015.06.002_bib81","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/j.transproceed.2013.07.044","article-title":"Inhaled nitric oxide versus sodium nitroprusside for preoperative evaluation of pulmonary hypertension in heart transplant candidates","volume":"45","author":"Pasero","year":"2013","journal-title":"Transpl. Proc."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib82","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/ejcts\/ezs102","article-title":"Pulmonary artery hypertension in heart transplant recipients: how much is too much?","volume":"42","author":"De Santo","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"7","key":"10.1016\/j.niox.2015.06.002_bib83","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/ctr.12387","article-title":"Pattern of resolution of pulmonary hypertension, long-term allograft right ventricular function, and exercise capacity in high-risk heart transplant recipients listed under oral sildenafil","volume":"28","author":"De Santo","year":"2014","journal-title":"Clin. Transpl."},{"issue":"4","key":"10.1016\/j.niox.2015.06.002_bib84","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0735-1097(01)01486-3","article-title":"The evolving management of acute right-sided heart failure in cardiac transplant recipients","volume":"38","author":"Stobierska-Dzierzek","year":"2001","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib85","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00000539-200003000-00005","article-title":"Inhaled nitric oxide reduces pulmonary vascular resistance more than prostaglandin E(1) during heart transplantation","volume":"90","author":"Rajek","year":"2000","journal-title":"Anesth. Analg."},{"issue":"4","key":"10.1016\/j.niox.2015.06.002_bib86","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/00007890-200108270-00013","article-title":"Inhaled nitric oxide for pulmonary hypertension after heart transplantation","volume":"72","author":"Ardehali","year":"2001","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib87","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.healun.2010.12.007","article-title":"Heart transplantation in children with markedly elevated pulmonary vascular resistance: impact of right ventricular failure on outcome","volume":"30","author":"Ofori-Amanfo","year":"2011","journal-title":"J.\u00a0Heart Lung Transpl."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib88","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jtcvs.2009.08.020","article-title":"Acute right ventricular failure after pediatric cardiac transplant: predictors and long-term outcome in current era of transplantation medicine","volume":"139","author":"Hoskote","year":"2010","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib89","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.transproceed.2013.02.069","article-title":"Anesthesia for cardiac transplantation: experience from a single center","volume":"45","author":"Askar","year":"2013","journal-title":"Transpl. Proc."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib90","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jtcvs.2009.11.020","article-title":"Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes","volume":"139","author":"Kormos","year":"2010","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"issue":"4","key":"10.1016\/j.niox.2015.06.002_bib91","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/026765910001500407","article-title":"Complications of circulatory assist","volume":"15","author":"El-Banayosy","year":"2000","journal-title":"Perfusion"},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib92","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1067\/mtc.2001.118274","article-title":"Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation","volume":"122","author":"Frazier","year":"2001","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"issue":"5","key":"10.1016\/j.niox.2015.06.002_bib93","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/0003-4975(95)00086-Z","article-title":"Use of aprotinin in LVAD recipients reduces blood loss, blood use, and perioperative mortality","volume":"59","author":"Goldstein","year":"1995","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib94","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0003-4975(01)03406-3","article-title":"Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem","volume":"73","author":"Kavarana","year":"2002","journal-title":"Ann. Thorac. Surg."},{"issue":"9","key":"10.1016\/j.niox.2015.06.002_bib95","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1161\/01.CIR.95.9.2250","article-title":"Influence of inhaled nitric oxide on systemic flow and ventricular filling pressure in patients receiving mechanical circulatory assistance","volume":"95","author":"Hare","year":"1997","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.niox.2015.06.002_bib96","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0003-4975(97)01307-6","article-title":"Randomized, double-blind trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension","volume":"65","author":"Argenziano","year":"1998","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib97","first-page":"312","article-title":"Adjunctive use of inhaled nitric oxide during implantation of a left ventricular assist device","volume":"17","author":"Macdonald","year":"1998","journal-title":"J.\u00a0Heart Lung Transpl."},{"issue":"8","key":"10.1016\/j.niox.2015.06.002_bib98","first-page":"870","article-title":"Inhaled nitric oxide after left ventricular assist device implantation: a prospective, randomized, double-blind, multicenter, placebo-controlled trial","volume":"30","author":"Potapov","year":"2011","journal-title":"J.\u00a0Heart Lung Transpl."},{"issue":"22","key":"10.1016\/j.niox.2015.06.002_bib99","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1161\/CIR.0b013e3182769a54","article-title":"Recommendations for the use of mechanical circulatory support: device strategies and patient selection: a scientific statement from the American Heart Association","volume":"126","author":"Peura","year":"2012","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/01.mjt.0000183567.13876.d7","article-title":"A\u00a05-year survey of nitric oxide use in a pediatric intensive care unit","volume":"14","author":"Ryan","year":"2007","journal-title":"Am. J. Ther."},{"issue":"9","key":"10.1016\/j.niox.2015.06.002_bib101","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1111\/j.1651-2227.2010.01847.x","article-title":"Re: 'The use of iNO in the newborn period: results from the European iNO registry'","volume":"99","author":"Golombek","year":"2010","journal-title":"Acta Paediatr."},{"issue":"6","key":"10.1016\/j.niox.2015.06.002_bib102","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1111\/j.1651-2227.2010.01722.x","article-title":"European Inhaled Nitric Oxide R. Use of inhaled nitric oxide in the new born period: results from the European Inhaled Nitric Oxide Registry","volume":"99","author":"Dewhurst","year":"2010","journal-title":"Acta Paediatr."},{"issue":"9","key":"10.1016\/j.niox.2015.06.002_bib103","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrd2038","article-title":"NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential","volume":"5","author":"Evgenov","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.niox.2015.06.002_bib104","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-3-662-45805-1_12","article-title":"Soluble guanylate cyclase stimulators in pulmonary hypertension","volume":"218","author":"Stasch","year":"2013","journal-title":"Handb. Exp. Pharmacol."},{"issue":"9","key":"10.1016\/j.niox.2015.06.002_bib105","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2174\/138945012802002348","article-title":"Cardiovascular therapeutics targets on the NO-sGC-cGMP signaling pathway: a critical overview","volume":"13","author":"Evora","year":"2012","journal-title":"Curr. Drug Targets"},{"issue":"2","key":"10.1016\/j.niox.2015.06.002_bib106","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10741-012-9323-1","article-title":"Soluble guanylate cyclase: a potential therapeutic target for heart failure","volume":"18","author":"Gheorghiade","year":"2013","journal-title":"Heart Fail Rev."},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib107","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00003246-199801000-00002","article-title":"Nitric oxide inhalation in acute respiratory distress syndrome: it works, but can we prove it?","volume":"26","author":"Zapol","year":"1998","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib108","first-page":"106","article-title":"Correlation of plasma endothelin-1 levels with pulmonary hypertension after inhaled nitric oxide therapy","volume":"21","author":"Razzaq","year":"2009","journal-title":"J.\u00a0Ayub Med. Coll. Abbottabad"},{"issue":"1","key":"10.1016\/j.niox.2015.06.002_bib109","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.athoracsur.2006.08.051","article-title":"Effect of sildenafil on pulmonary artery pressure, systemic pressure, and nitric oxide utilization in patients with left ventricular assist devices","volume":"83","author":"Klodell","year":"2007","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.niox.2015.06.002_bib110","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.athoracsur.2012.04.046","article-title":"Inhaled nitric oxide plus iloprost in the setting of post-left assist device right heart dysfunction","volume":"94","author":"Antoniou","year":"2012","journal-title":"Ann. Thorac. Surg."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108986031530001X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S108986031530001X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T01:45:49Z","timestamp":1652838349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S108986031530001X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":110,"alternative-id":["S108986031530001X"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2015.06.002","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhaled nitric oxide in cardiac surgery: Evidence or tradition?","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2015.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}