{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:46:43Z","timestamp":1789908403656,"version":"4.0.1"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":327,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004933","name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Toxinas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004933","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.niox.2017.01.004","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T18:17:56Z","timestamp":1484072276000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["The synthetic peptide PnPP-19 induces peripheral antinociception via activation of NO\/cGMP\/KATP pathway: Role of eNOS and nNOS"],"prefix":"10.1016","volume":"64","author":[{"given":"A.C.N.","family":"Freitas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.C.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.F.","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.C.","family":"Pimenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1234-9325","authenticated-orcid":false,"given":"V.S.","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.D.G.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2017.01.004_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0014-2999(02)02275-6","article-title":"The kappa-opioid agonist (+\/-)-bremazocine elicits peripheral antinociception by activation of the L-arginine\/nitric oxide\/cyclic GMP pathway","volume":"454","author":"Amarante","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.peptides.2015.04.011","article-title":"Angiotensin-(1-7) through Mas receptor activation induces peripheral antinociception by interaction with adrenoreceptors","volume":"69","author":"Castor","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.niox.2017.01.004_bib3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-5793(92)81318-G","article-title":"The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian \u2018armed\u2019 spider Phoneutria nigriventer (Keys)","volume":"310","author":"Cordeiro","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1016\/j.niox.2017.01.004_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.niox.2013.12.007","article-title":"Ang-(1-7) activates the NO\/cGMP and ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats","volume":"37","author":"Costa","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2017.01.004_bib5","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1073\/pnas.0914733107","article-title":"Morphine peripheral analgesia depends on activation of the PI3Kgamma\/AKT\/nNOS\/NO\/KATP signaling pathway","volume":"107","author":"Cunha","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.niox.2017.01.004_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.niox.2011.06.004","article-title":"Pain and analgesia: the dual effect of nitric oxide in the nociceptive system","volume":"25","author":"Cury","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2017.01.004_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2015.02.038","article-title":"Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to NO\/cGMP and ATP-sensitive K(+) channels pathway activation in mice","volume":"755","author":"De Carvalho Veloso","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib8","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.niox.2017.01.004_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejphar.2015.10.012","article-title":"Serotonin induces peripheral mechanical antihyperalgesic effects in mice","volume":"767","author":"Diniz","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0014-2999(90)90446-D","article-title":"Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway","volume":"186","author":"Duarte","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejphar.2003.11.021","article-title":"Participation of the L-arginine-nitric oxide-cyclic GMP-ATP-sensitive K+ channel cascade in the antinociceptive effect of rofecoxib","volume":"484","author":"D\u00e9ciga-Campos","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0014-2999(91)90333-L","article-title":"The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release","volume":"201","author":"Ferreira","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur. Heart J."},{"issue":"9","key":"10.1016\/j.niox.2017.01.004_bib14","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/bph.13448","article-title":"PnPP-19, a spider toxin analogue, induces peripheral antinociception through opioid and cannabinoid receptors and inhibition of Neutral endopeptidase","volume":"173","author":"Freitas","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib15","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1586\/14737175.2014.962518","article-title":"Venom-based biotoxins as potential analgesics","volume":"14","author":"Gazerani","year":"2014","journal-title":"Expert Rev. Neurother."},{"issue":"4","key":"10.1016\/j.niox.2017.01.004_bib16","first-page":"1137","article-title":"Antinociceptive effect of vardenafil on carrageenan-induced hyperalgesia in rat: involvement of nitric oxide\/cyclic guanosine monophosphate\/calcium channels pathway","volume":"14","author":"Gediz","year":"2015","journal-title":"Iran. J. Pharm. Res. IJPR"},{"key":"10.1016\/j.niox.2017.01.004_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.niox.2017.01.004_bib18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/FBP.0b013e32834eafbc","article-title":"The peripheral L-arginine-nitric oxide-cyclic GMP pathway and ATP-sensitive K+ channels are involved in the antinociceptive effect of crotalphine on neuropathic pain in rats","volume":"23","author":"Gutierrez","year":"2012","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib19","doi-asserted-by":"crossref","first-page":"H1545","DOI":"10.1152\/ajpheart.01052.2001","article-title":"ATP-sensitive K(+) channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytes","volume":"283","author":"Han","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.niox.2017.01.004_bib20","doi-asserted-by":"crossref","first-page":"22140","DOI":"10.1074\/jbc.M010103200","article-title":"Modulation of ATP-sensitive potassium channels by cGMP-dependent protein kinase in rabbit ventricular myocytes","volume":"276","author":"Han","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.niox.2017.01.004_bib21","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1073\/pnas.052712499","article-title":"Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection","volume":"99","author":"Hurt","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.niox.2017.01.004_bib22","doi-asserted-by":"crossref","first-page":"8103","DOI":"10.1073\/pnas.90.17.8103","article-title":"Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine","volume":"90","author":"Ignarro","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.niox.2017.01.004_bib23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0006-8993(01)02673-7","article-title":"Sildenafil-induced peripheral analgesia and activation of the nitric oxide\u2013cyclic GMP pathway","volume":"909","author":"Jain","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.niox.2017.01.004_bib24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0031-6997(24)01514-X","article-title":"Animal models of nociception","volume":"53","author":"Le Bars","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.niox.2017.01.004_bib25","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1476-5381.1994.tb13108.x","article-title":"Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation","volume":"112","author":"Kawabata","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib26","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"NC3Rs reporting guidelines working group","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxicon.2008.05.020","article-title":"A\u00a0rational nomenclature for naming peptide toxins from spiders and other venomous animals","volume":"52","author":"King","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.niox.2017.01.004_bib28","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1073\/pnas.86.13.5159","article-title":"Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase","volume":"86","author":"Knowles","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.niox.2017.01.004_bib29","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0960-9822(99)80371-6","article-title":"The Akt kinase signals directly to endothelial nitric oxide synthase","volume":"9","author":"Michell","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.niox.2017.01.004_bib31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ijir.2011.47","article-title":"Increased cavernosal relaxation by Phoneutria nigriventer toxin, PnTx2-6, via activation at NO\/cGMP signaling","volume":"24","author":"Nunes","year":"2012","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.niox.2017.01.004_bib32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10787-015-0240-5","article-title":"Involvement of NO\u2013cGMP pathway in anti-hyperalgesic effect of PDE5 inhibitor tadalafil in experimental hyperalgesia","volume":"23","author":"Otari","year":"2015","journal-title":"Inflammopharmacol"},{"key":"10.1016\/j.niox.2017.01.004_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2005.02.018","article-title":"Delta-opioid receptor agonist SNC80 induces peripheral antinociception via activation of ATP-sensitive K+ channels","volume":"512","author":"Pacheco","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.lfs.2005.04.032","article-title":"delta-Opioid receptor agonist SNC80 elicits peripheral antinociception via delta(1) and delta(2) receptors and activation of the l-arginine\/nitric oxide\/cyclic GMP pathway","volume":"78","author":"Pacheco","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2017.01.004_bib35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.lfs.2003.12.024","article-title":"Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a delta- and kappa-opioid receptor agonist","volume":"75","author":"Picolo","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2017.01.004_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-2999(02)01413-9","article-title":"Dual effect of local application of nitric oxide donors in a model of incision pain in rats","volume":"441","author":"Prado","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib37","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/0041-0101(95)00096-5","article-title":"A\u00a0novel analgesic toxin (hannalgesin) from the venom of king cobra (Ophiophagus hannah)","volume":"33","author":"Pu","year":"1995","journal-title":"Toxicon"},{"key":"10.1016\/j.niox.2017.01.004_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2004.04.014","article-title":"Toxins in anti-nociception and anti-inflammation","volume":"44","author":"Rajendra","year":"2004","journal-title":"Toxicon"},{"key":"10.1016\/j.niox.2017.01.004_bib39","doi-asserted-by":"crossref","first-page":"14307","DOI":"10.1074\/jbc.M311103200","article-title":"Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-methyl-D-aspartate receptor","volume":"279","author":"Rameau","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.niox.2017.01.004_bib40","first-page":"209","article-title":"A\u00a0method for measurement of analgesia activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch. Int. Pharmacodyn."},{"key":"10.1016\/j.niox.2017.01.004_bib41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.lfs.2009.06.012","article-title":"Opioid receptor and NO\/cGMP pathway as a mechanism of peripheral antinociceptive action of the cannabinoid receptor agonist anandamide","volume":"85","author":"Reis","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2017.01.004_bib42","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.lfs.2011.01.017","article-title":"Endogenous cannabinoid receptor agonist anandamide induces peripheral antinociception by activation of ATP-sensitive K+ channels","volume":"88","author":"Reis","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2017.01.004_bib43","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1055\/s-0035-1557775","article-title":"Dihydrogoniothalamin, an endothelium and NO-dependent vasodilator drug isolated from Aniba panurensis","volume":"81","author":"Rezende","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.niox.2017.01.004_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2009.04.031","article-title":"alpha(2)-Adrenoceptor agonist xylazine induces peripheral antinociceptive effect by activation of the L-arginine\/nitric oxide\/cyclic GMP pathway in rat","volume":"613","author":"Romero","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib45","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1254\/jphs.09103FP","article-title":"Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by the alpha(2)-adrenoceptor agonist xylazine","volume":"111","author":"Romero","year":"2009","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.niox.2017.01.004_bib46","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/vaa.12024","article-title":"Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by ketamine","volume":"40","author":"Romero","year":"2013","journal-title":"Vet. Anaesth. Analg."},{"key":"10.1016\/j.niox.2017.01.004_bib47","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/jnr.22797","article-title":"Involvement of the L-arginine\/nitric oxide\/cyclic guanosine monophosphate pathway in peripheral antinociception induced by N-palmitoyl-ethanolamine in rats","volume":"90","author":"Romero","year":"2012","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.niox.2017.01.004_bib48","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1213\/ANE.0b013e3182285dda","article-title":"Ketamine activates the L-arginine\/Nitric oxide\/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats","volume":"113","author":"Romero","year":"2011","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.niox.2017.01.004_bib49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.niox.2012.01.006","article-title":"Noradrenaline activates the NO\/cGMP\/ATP-sensitive K(+) channels pathway to induce peripheral antinociception in rats","volume":"26","author":"Romero","year":"2012","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2017.01.004_bib50","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.niox.2011.08.002","article-title":"The neuronal NO synthase participation in the peripheral antinociception mechanism induced by several analgesic drugs","volume":"25","author":"Romero","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2017.01.004_bib51","doi-asserted-by":"crossref","first-page":"e11278","DOI":"10.1371\/journal.pone.0011278","article-title":"Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling","volume":"5","author":"S\u00e1nchez-Bl\u00e1zquez","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2017.01.004_bib52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.lfs.2015.03.011","article-title":"NSAIDs induce peripheral antinociception by interaction with the adrenergic system","volume":"130","author":"Silva","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2017.01.004_bib53","first-page":"1481","article-title":"PnPP-19, a synthetic and non toxic peptide designed from a P. nigriventer toxin, potentiates erectile function via NO\/cGMP","volume":"194","author":"Silva","year":"2015","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.niox.2017.01.004_bib54","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-2999(00)00355-1","article-title":"Activation of ATP-sensitive K(+) channels: mechanism of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside","volume":"400","author":"Soares","year":"2000","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.01.004_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-8993(01)01995-3","article-title":"The dual effect of a nitric oxide donor in nociception","volume":"897","author":"Sousa","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.niox.2017.01.004_bib56","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00011-006-6109-8","article-title":"Role of NO\/cGMP\/KATP pathway in antinociceptive effect of sildenafil in zymosan writhing response in mice","volume":"56","author":"Vale","year":"2007","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.niox.2017.01.004_bib57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neulet.2008.06.011","article-title":"Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of rats","volume":"441","author":"Yoon","year":"2008","journal-title":"Neurosci. Lett."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860316300659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860316300659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T06:20:55Z","timestamp":1749882055000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860316300659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":57,"alternative-id":["S1089860316300659"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2017.01.004","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The synthetic peptide PnPP-19 induces peripheral antinociception via activation of NO\/cGMP\/KATP pathway: Role of eNOS and nNOS","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2017.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}