{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:13:43Z","timestamp":1771028023183,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"vor","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["140859\/2014-4"],"award-info":[{"award-number":["140859\/2014-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["201177\/2015-3"],"award-info":[{"award-number":["201177\/2015-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","award":["2013NE003405"],"award-info":[{"award-number":["2013NE003405"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.niox.2017.04.006","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T11:00:17Z","timestamp":1492081217000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Potential anti-inflammatory effect of LQFM-021 in carrageenan-induced inflammation: The role of nitric oxide"],"prefix":"10.1016","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6646-3057","authenticated-orcid":false,"given":"Iziara F.","family":"Florentino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiany P.B.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayane M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina Sofia","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 L.E.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clayton L.","family":"Borges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia M. de A.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablinny M.","family":"Galdino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano M.","family":"Li\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo C.","family":"Ghedini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Menegatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elson A.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2017.04.006_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejmech.2012.06.048","article-title":"New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies","volume":"55","author":"Hanna","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejphar.2015.11.034","article-title":"Nicorandil inhibits neutrophil recruitment in carrageenan-induced experimental pleurisy in mice","volume":"769","author":"Matsui","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.04.006_bib3","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/jphp.12024","article-title":"Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from the red algae Hypnea musciformis via the suppression of neutrophil migration by the nitric oxide signalling pathway","volume":"65","author":"Brito","year":"2013","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.niox.2017.04.006_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0159151","article-title":"Assessment of anti-TNF-\u03b1 activities in keratinocytes expressing inducible TNF- \u03b1: a novel tool for anti-TNF-\u03b1 drug screening","volume":"11","author":"Udommethaporn","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.niox.2017.04.006_bib5","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bbalip.2014.09.016","article-title":"Cyclooxygenase inhibitors: from pharmacology to clinical read-outs","volume":"1851","author":"Patrignani","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.niox.2017.04.006_bib6","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1734-1140(10)70308-X","article-title":"Vane's discovery of the mechanism of action of aspirin changed our understanding of its clinical pharmacology","volume":"62","author":"Botting","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.niox.2017.04.006_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.20452\/pamw.2715","article-title":"New insight into the mechanisms of gastroduodenal injury induced by nonsteroidal anti-inflammatory drugs: practical implications","volume":"125","author":"Kwiecie\u0144","year":"2015","journal-title":"Pol. Arch. Med. Wewn."},{"key":"10.1016\/j.niox.2017.04.006_bib8","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1001\/jama.296.13.jrv60011","article-title":"Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2","volume":"296","author":"McGettigan","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.niox.2017.04.006_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.18433\/J3T886","article-title":"Evolution of nonsteroi-dal anti-inflammatory drugs (NSAIDs): cyclooxygenase(COX) inhibition and beyond","volume":"11","author":"Rao","year":"2008","journal-title":"J.\u00a0Pharm. Pharm. Sci."},{"key":"10.1016\/j.niox.2017.04.006_bib10","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/cbdd.12324","article-title":"Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivative as selective COX-2 inhibitors: molecular docking study","volume":"84","author":"Dube","year":"2014","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.niox.2017.04.006_bib11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ejmech.2016.04.077","article-title":"The therapeutic voyage of pyrazole and its analogs: a review","volume":"120","author":"Khan","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib12","first-page":"43","article-title":"Synthesis and antimicrobial activity of some new pyrazole containing cyanopyridone derivatives","volume":"4","author":"Malladi","year":"2012","journal-title":"Der. Pharm. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib13","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ejmech.2014.12.023","article-title":"Recent advanced in bioactive systems containing pyrazole fused with a five membered heterocycle","volume":"97","author":"Raffa","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1590\/S0100-879X2006000600013","article-title":"A\u00a0pyrazolyl-thiazole derivative causes antinociception in mice","volume":"39","author":"Prokopp","year":"2006","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.niox.2017.04.006_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.lfs.2013.12.005","article-title":"Antinociceptive, anti-inflammatory and antipyretic effects of 1.5-diphenyl-1H-Pyrazole-3-carbohydrazide, a new heterocyclic pyrazole derivative","volume":"95","author":"Malvar","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2017.04.006_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2009.06.008","article-title":"Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats","volume":"616","author":"Sauzem","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.04.006_bib17","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1016\/j.bmcl.2015.10.028","article-title":"Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents","volume":"25","author":"Li","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.niox.2017.04.006_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10787-016-0270-7","article-title":"Evaluation of anti-inflammatory, analgesic activities, and side effects of some pyrazole derivatives","volume":"24","author":"Domiati","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.niox.2017.04.006_bib19","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1590\/S0100-879X2010007500139","article-title":"Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats","volume":"43","author":"Pasin","year":"2010","journal-title":"Braz J. Med. Biol. Res."},{"key":"10.1016\/j.niox.2017.04.006_bib20","doi-asserted-by":"crossref","first-page":"5400","DOI":"10.1073\/pnas.0808793106","article-title":"Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound","volume":"106","author":"Kiyonaka","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.niox.2017.04.006_bib21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ejmech.2015.09.021","article-title":"Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII","volume":"103","author":"Ibrahim","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ejmech.2016.01.013","article-title":"Identification of N-(6-mercaptohexyl)-3-(4-pyridyl)-1H-pyrazole-5-carboxamide and its disulfide prodrug as potent histone deacetylase inhibitors with in\u00a0vitro and in\u00a0vivo anti-tumor efficacy","volume":"109","author":"Wen","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib23","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1248\/cpb.c12-01016","article-title":"Synthesis, docking studies, pharmacological activity and toxicity of a novel pyrazole derivative (LQFM 021)-possible effects on phosphodiesterase","volume":"61","author":"Martins","year":"2013","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.niox.2017.04.006_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.niox.2015.02.146","article-title":"Involvement of the NO\/cGMP\/KATP pathway in the antinociceptive effect of the new pyrazole 5-(1-(3-fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM-021)","volume":"47","author":"Florentino","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2017.04.006_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10787-016-0282-3","article-title":"Pharmacological and toxicological evaluations of the new pyrazole compound (LQFM-021) as potential analgesic and anti-inflammatory agentes","volume":"24","author":"Florentino","year":"2016","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.niox.2017.04.006_bib26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nrd2466","article-title":"The nitrate\u2013nitrite\u2013nitric oxide pathway in physiology and therapeutics","volume":"7","author":"Lundber","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.niox.2017.04.006_bib27","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.4155\/fmc.12.168","article-title":"iNOS-selective inhibitors for cancer prevention: promise and progress","volume":"4","author":"Janakiram","year":"2012","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.niox.2003.11.001","article-title":"Neutrophil migration in inflammation: nitric oxide inhibits rolling, adhesion and induces apoptosis","volume":"9","author":"Dal Secco","year":"2003","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2017.04.006_bib29","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.4049\/jimmunol.166.4.2734","article-title":"Selective inhibition of inducible nitric oxide synthase exacerbates erosive joint disease","volume":"166","author":"McCartney-Francis","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.niox.2017.04.006_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/682879","article-title":"Involvement of nitric oxide in a rat model of carrageenin-induced pleurisy","volume":"2010","author":"Iwata","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.niox.2017.04.006_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yexcr.2010.08.011","article-title":"Nitric oxide modulates the expression of endothelial cell adhesion molecules involved in angiogenesis and leukocyte recruitment","volume":"317","author":"Carreau","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.niox.2017.04.006_bib32","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1021\/jm200715n","article-title":"Novel analgesic\/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties","volume":"54","author":"Biava","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib33","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/cmdc.201300105","article-title":"Water-soluble nitric-oxide-releasing acetylsalicylic acid (ASA) prodrugs","volume":"8","author":"Rolando","year":"2013","journal-title":"Chem. Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ejmech.2015.12.044","article-title":"Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity","volume":"109","author":"Di Capua","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.niox.2017.04.006_bib35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jep.2006.09.032","article-title":"Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verben\u00e1cea","volume":"110","author":"Passos","year":"2007","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.niox.2017.04.006_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.2042-7158.2012.01582.x","article-title":"E.A.Costa, Anti-inflammatory effect of (E)-4-(3,7-dimethylocta-2,6-dienylamino)phenol, a new derivative of 4-nerolidylcatechol","volume":"65","author":"Lino","year":"2013","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.niox.2017.04.006_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.trim.2006.04.001","article-title":"Antiinflammatory effects of Tacrolimus in a mouse model of pleurisy","volume":"16","author":"Pereira","year":"2006","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.niox.2017.04.006_bib38","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.clinbiochem.2010.12.011","article-title":"A\u00a0simple and inexpensive automated technique for measurement of serum nitrite\/nitrate","volume":"44","author":"Tatsch","year":"2011","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.niox.2017.04.006_bib39","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cyto.2000.0816","article-title":"The modulatory role played by TNF-alpha and IL-1 beta in the inflammatory responses induced by carrageenan in the mouse model of pleurisy","volume":"13","author":"Fr\u00f6de","year":"2001","journal-title":"Cytokine"},{"key":"10.1016\/j.niox.2017.04.006_bib40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.intimp.2014.08.017","article-title":"Diethylcarbamazine inhibits NF-\u03baB activation in acute lung injury induced by carrageenan in mice","volume":"23","author":"Santos","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.niox.2017.04.006_bib41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.lfs.2012.12.003","article-title":"Anti-inflammatory and antinociceptive activities of LQFM002-A 4-nerolidylcatechol derivative","volume":"92","author":"Costa","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.niox.2017.04.006_bib42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0022-3565(24)29258-2","article-title":"FR167653, a cytokine synthesis inhibitor, exhibits anti-inflammatory effects early in rat carrageenin-induced pleurisy but no effect later","volume":"299","author":"Hatanaka","year":"2001","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.niox.2017.04.006_bib43","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jep.2013.12.003","article-title":"Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L.","volume":"151","author":"Wang","year":"2014","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.niox.2017.04.006_bib44","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.bmcl.2012.12.094","article-title":"Design, synthesis, characterization and anti-inflammatory evaluation of novel pyrazole amalgamated flavones","volume":"23","author":"Chavan","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.niox.2017.04.006_bib45","article-title":"New pyrazole derivative 5-[1-(4-fluorphenyl) -1H-pyrazol-4-yl]-2H-tetrazole: synthesis and assessment of some biological activities","author":"De Oliveira","year":"2016","journal-title":"Chem. Biol. Drug. Des."},{"key":"10.1016\/j.niox.2017.04.006_bib46","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.intimp.2005.09.016","article-title":"The effect of overexpression of endothelial nitric oxide synthase on eosinophilic lung inflammation in a murine model","volume":"6","author":"Kobayashi","year":"2006","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.niox.2017.04.006_bib47","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.niox.2017.04.006_bib48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.bjp.0707224","article-title":"Recent developments in nitric oxide donor drugs","volume":"151","author":"Miller","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"S2","key":"10.1016\/j.niox.2017.04.006_bib49","first-page":"1","article-title":"Nitric oxide in inflammation and pain associated with osteoarthritis","volume":"10","author":"Abramson","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.niox.2017.04.006_bib50","first-page":"1","article-title":"Selected cytokine pathways in rheumatoid arthritis","author":"Noack","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.niox.2017.04.006_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.niox.2017.04.006_bib52","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1096\/fj.03-0473com","article-title":"Cyclooxygenase 2 is a key enzyme for inflammatory cytokine induced angiogenesis","volume":"18","author":"Kuwano","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.niox.2017.04.006_bib53","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1063-4584(03)00156-0","article-title":"Influence of pro-inflammatory (IL-1\u03b1, IL-6, TNF-\u03b1, IFN-\u03b3) and anti-inflammatory (IL-4) cytokines on chondrocyte function","volume":"11","author":"Schuerwegh","year":"2003","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.niox.2017.04.006_bib54","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.joca.2012.04.002","article-title":"IL-4 alone and in combination with IL-10 protects against blood-induced cartilage damage","volume":"20","author":"Van Meegeren","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.niox.2017.04.006_bib55","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arteriosclerosis, Thrombosis Vasc. Biol."},{"key":"10.1016\/j.niox.2017.04.006_bib56","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1016\/j.bmcl.2014.08.062","article-title":"Synthesis of novel pyrazole-thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors","volume":"24","author":"Alegaon","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860316302178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860316302178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T22:17:51Z","timestamp":1750198671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860316302178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":56,"alternative-id":["S1089860316302178"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2017.04.006","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential anti-inflammatory effect of LQFM-021 in carrageenan-induced inflammation: The role of nitric oxide","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2017.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}