{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:07:26Z","timestamp":1791691646352,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30570789"],"award-info":[{"award-number":["30570789"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Hebei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["C 2004000582"],"award-info":[{"award-number":["C 2004000582"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.niox.2017.07.005","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T19:31:24Z","timestamp":1501183884000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Exogenous nitric oxide enhances the prophylactic effect of aminoguanidine, a preferred iNOS inhibitor, on bleomycin-induced fibrosis in the lung: Implications for the direct roles of the NO molecule in\u00a0vivo"],"prefix":"10.1016","volume":"70","author":[{"given":"Chao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-ze","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.niox.2017.07.005_bib1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1164\/rccm.201403-0509PP","article-title":"New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses","volume":"190","author":"Ahluwalia","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.niox.2017.07.005_bib2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrd2958","article-title":"Strategies for treating idiopathic pulmonary fibrosis","volume":"9","author":"du Bois","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.niox.2017.07.005_bib3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pupt.2016.07.009","article-title":"Pirfenidone, nintedanib and N-acetylcysteine for the treatment of idiopathic pulmonary fibrosis: a systematic review and meta-analysis","volume":"40","author":"Rogliani","year":"2016","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.niox.2017.07.005_bib4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/resp.12683","article-title":"Idiopathic pulmonary fibrosis: diagnosis, epidemiology and natural history","volume":"21","author":"Sgalla","year":"2016","journal-title":"Respirology"},{"key":"10.1016\/j.niox.2017.07.005_bib5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1465-9921-6-58","article-title":"Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury","volume":"6","author":"Genovese","year":"2005","journal-title":"Respir. Res."},{"key":"10.1016\/j.niox.2017.07.005_bib6","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1164\/ajrccm.155.5.9154889","article-title":"Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis","volume":"155","author":"Saleh","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.niox.2017.07.005_bib7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.niox.2004.07.011","article-title":"Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats","volume":"11","author":"Yildirim","year":"2004","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2017.07.005_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1440-1843.2006.00894.x","article-title":"Overexpression of nitric oxide synthase by the endothelium attenuates bleomycin-induced lung fibrosis and impairs MMP-9\/TIMP-1 balance","volume":"11","author":"Yoshimura","year":"2006","journal-title":"Respirology"},{"key":"10.1016\/j.niox.2017.07.005_bib9","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/15287390490447296","article-title":"Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis","volume":"67","author":"Zeidler","year":"2004","journal-title":"J.\u00a0Toxicol. Environ. Health A"},{"key":"10.1016\/j.niox.2017.07.005_bib10","first-page":"711","article-title":"Inhibitory effect of aminoguanidine on bleomycin-induced pulmonary toxicity in rat","volume":"22","author":"Chen","year":"2001","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.niox.2017.07.005_bib11","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1021\/jm00115a013","article-title":"Complexes of.NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects","volume":"34","author":"Maragos","year":"1991","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.niox.2017.07.005_bib12","first-page":"564","article-title":"Nitric oxide\/nucleophile complexes inhibit the in\u00a0vitro proliferation of A375 melanoma cells via nitric oxide release","volume":"53","author":"Maragos","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.niox.2017.07.005_bib13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0041-008X(03)00193-5","article-title":"The safety of aerosolized diethylenetriamine nitric oxide adduct after single-dose administration to anesthetized piglets and multiple-dose administration to conscious rats","volume":"190","author":"Lam","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.niox.2017.07.005_bib14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1378\/chest.123.3.869","article-title":"Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension","volume":"123","author":"Lam","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.niox.2017.07.005_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0008-6363(95)00172-7","article-title":"Nebulized nitric oxide\/nucleophile adduct reduces chronic pulmonary hypertension","volume":"31","author":"Hampl","year":"1996","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.niox.2017.07.005_bib16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.niox.2011.07.001","article-title":"S-Nitroso-N-acetylcysteine induces de-differentiation of activated hepatic stellate cells and promotes antifibrotic effects in\u00a0vitro","volume":"25","author":"Stefano","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.niox.2017.07.005_bib17","first-page":"114","article-title":"Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study","volume":"145","author":"Zhang","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.niox.2017.07.005_bib18","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1378\/chest.06-2568","article-title":"Molecular targets in pulmonary fibrosis: the myofibroblast in focus","volume":"132","author":"Scotton","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.niox.2017.07.005_bib19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1177\/1753465810379801","article-title":"The pathogenesis of idiopathic pulmonary fibrosis","volume":"4","author":"Coward","year":"2010","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.niox.2017.07.005_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-2999(93)90357-N","article-title":"Selective inhibition of the inducible nitric oxide synthase by aminoguanidine","volume":"233","author":"Misko","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.07.005_bib21","first-page":"697","article-title":"Role of endogenous peroxynitrite in pulmonary injury and fibrosis induced by bleomycin A5 in rats","volume":"24","author":"Chen","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.niox.2017.07.005_bib22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.biocel.2007.08.011","article-title":"The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?","volume":"40","author":"Moeller","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.niox.2017.07.005_bib23","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MCP.0b013e328349ac2b","article-title":"Modeling pulmonary fibrosis with bleomycin","volume":"17","author":"Mouratis","year":"2011","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.niox.2017.07.005_bib24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1164\/rccm.200505-717OC","article-title":"Pharmacologic differentiation of inflammation and fibrosis in the rat bleomycin model","volume":"173","author":"Chaudhary","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.niox.2017.07.005_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1054-3589(08)61079-0","article-title":"Reactions between nitric oxide, superoxide, and peroxynitrite: footprints of peroxynitrite in\u00a0vivo","volume":"34","author":"Crow","year":"1995","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.niox.2017.07.005_bib26","first-page":"L699","article-title":"The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide","volume":"268","author":"Pryor","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.niox.2017.07.005_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/019021400408308","article-title":"Effects of peroxynitrite on pulmonary edema and the oxidative state","volume":"26","author":"Beckman","year":"2000","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.niox.2017.07.005_bib28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/MAJ.0b013e31821a9d66","article-title":"Nonresolving fibrotic disorders: idiopathic pulmonary fibrosis as a paradigm of impaired tissue regeneration","volume":"341","author":"Hecker","year":"2011","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.niox.2017.07.005_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1440-1827.2003.01446.x","article-title":"Pulmonary fibrosis: cellular and molecular events","volume":"53","author":"Razzaque","year":"2003","journal-title":"Pathol. Int."},{"key":"10.1016\/j.niox.2017.07.005_bib30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1254\/jjp.78.69","article-title":"Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model","volume":"78","author":"Yamazaki","year":"1998","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.07.005_bib31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jcp.41.4.467","article-title":"Simple method of estimating severity of pulmonary fibrosis on a numerical scale","volume":"41","author":"Ashcroft","year":"1988","journal-title":"J.\u00a0Clin. Pathol."},{"issue":"Suppl 7","key":"10.1016\/j.niox.2017.07.005_bib32","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00005344-199306227-00003","article-title":"Nitric oxide\/nucleophile complexes: a unique class of nitric oxide-based vasodilators","volume":"22","author":"Morley","year":"1993","journal-title":"J.\u00a0Cardiovasc Pharmacol."},{"key":"10.1016\/j.niox.2017.07.005_bib33","doi-asserted-by":"crossref","first-page":"286S","DOI":"10.1378\/chest.122.6_suppl.286S","article-title":"The myofibroblast in pulmonary fibrosis","volume":"122","author":"Phan","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.niox.2017.07.005_bib34","first-page":"483","article-title":"Promotion of pulmonary fibroblast proliferation and apoptosis by sodium nitroprusside","volume":"53","author":"Chen","year":"2001","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.niox.2017.07.005_bib35","doi-asserted-by":"crossref","first-page":"L212","DOI":"10.1152\/ajplung.00475.2006","article-title":"Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells","volume":"293","author":"Vyas-Read","year":"2007","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.niox.2017.07.005_bib36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejphar.2007.06.036","article-title":"Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase","volume":"572","author":"Dunkern","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.niox.2017.07.005_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/CIRCRESAHA.107.157677","article-title":"Atrial natriuretic peptide inhibits transforming growth factor beta-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts","volume":"102","author":"Li","year":"2008","journal-title":"Circ. Res."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860316302543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860316302543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T22:57:26Z","timestamp":1535583446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860316302543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":37,"alternative-id":["S1089860316302543"],"URL":"https:\/\/doi.org\/10.1016\/j.niox.2017.07.005","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exogenous nitric oxide enhances the prophylactic effect of aminoguanidine, a preferred iNOS inhibitor, on bleomycin-induced fibrosis in the lung: Implications for the direct roles of the NO molecule in\u00a0vivo","name":"articletitle","label":"Article Title"},{"value":"Nitric Oxide","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.niox.2017.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}